Understanding phytochemical-gene interactions provides the basis for individualized therapies to promote health as well as prevent and treat disease. The authors of Phytochemicals: Nutrient-Gene Interactions examine the interactions between phytochemicals and the human genome and discuss the impact these interactions have on health, aging, and chronic conditions such as inflammation, heart disease, obesity, type II diabetes mellitus, and cancer.

Keeping pace with the most important trends in phytochemical research, the authors accentuate the latest understanding on the use of controlled clinical trials, new screening technologies, and the completed human genome project for researching the pharmacokinetics, safety, and efficacy of phytochemicals. The book covers a balanced range of topics beginning with experimental strategies and methodologies for identifying significant interactions between diet, genetic variants, and different markers of cardiovascular disease, inflammation, and obesity. Different authors explain the mechanisms of protective action that link diets rich in omega-3 fatty acids, unsaturated fats, fruits, vegetables, and whole grains with a decreased risk of chronic and degenerative diseases. They also review and summarize epidemiological research on plant-based foods and dietary patterns supporting the beneficial role of phytochemicals in health promotion and disease prevention.

Phytochemicals: Nutrient-Gene Interactions illustrates the growing role of nutrigenomics and nutrigenetics in disease prevention and in the responsible development of safe and effective phytochemical products within the food, pharmaceutical, and supplement industries.

How did human thought evolve into the highly complex process it is today? In the field of evolutionary cognitive archaeology, cognitive science and archaeology intersect to provide a more complete and grounded picture of the mind. With the combination of cognitive theories and archaeological evidence, this burgeoning field is only beginning to tap into the potential for a better understanding of the development of specific cognitive abilities. Cognitive Models in Palaeolithic Archaeology explores hominin cognitive development by applying formal cognitive models to analyze prehistoric remains from the entire range of the Palaeolithic, from the earliest stone tools 3.3 million years ago to artistic developments that emerged 50,000 years ago. Several different cognitive models are presented, including expert cognition, information processing, material engagement theory, embodied/extended cognition, neuroaesthetics, visual resonance theory, theory of mind, and neuronal recycling. By examining archaeological remains, and thereby past activities and behavior, through the grounded lenses of these models, a mosaic pattern of human cognitive evolution emerges. This volume, authored by many leading authorities in the field of cognitive archaeology, will attract scholars and students of cognitive evolution and paleoanthropology, who will find a new understanding of hominin cognitive evolution and substantive conclusions about our hominin evolution as opportunities for further research.

This up-to-date and important new work describes the relationship between psychological and hormonal factors found in human sexual behavior across the lifespan. The author's discussion of human sexual behavior is organized according to developmental stage, starting with the fetus and concluding with senescence. Persky proposes that human sexual behavior is determined by a variety of factors, e.g. social, psychological, and endocrine, and ascertains the relative contribution of each of these factors to a range of sexual behaviors, attitudes, and feelings. Furthermore, he provides documentation that these determinants are interrelated in reciprocal fashion. In addition, by organizing his material within the Life Development model, Persky is able to present normal and abnormal psychoendocrine relationships which lead to sexual disorders.

The Last Years of Long Lives is a unique account of that period of old age which precedes death. Based on 400 complete individual histories and covering a twenty-year period, it looks at the experiences of people over eighty years old in three important areas: disability, family life and health care. Using the life-course approach to research, it reveals rich data about the contributions of formal and informal care and how life expectancy and experiences of disability interact with experiences of care.

The reader is invited to conceptualise these phenomena as processes in continuous time - processes that are sometimes long and complex, sometimes short and simple - and learns about the four types of disability career before death. At the same time, the author presents a three-stage model of informal care and examines the main patterns of formal service use.

The Last Years of Long Lives presents a new way of looking at old age for students, researchers, practitioners and policy makers and gives a comprehensive picture of what has been called 'the fourth age'.

As individuals age, their ability to respond to andclear pathogens and to control unwanted immune reactions declines, leading to a greater incidence of certain infectious diseases, autoimmunity and general immune dysfunctions. Most remarkably, the efficacy of vaccines is frequently decreased in elderly persons. Therefore, age-associated dysfunctions of the humoral and cellular immune responses have a strong clinical impact. Improving our understanding of the aged immune system is crucial in developing effective prevention and treatment programs that will facilitate healthy aging and improve the quality of life of the elderly population.

The aim of this volume is to summarize current knowledge on the cellular and molecular aspects of the aging immune system, with an emphasis on infectious diseases and new therapeutic approaches.

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Congratulations! You have been given about 20 more years to live than your grandparents. But does that just mean a longer decline? Berit Lewis shows that the story we so often tell ourselves about ageing – that it’s all downhill from 50 – is simply wrong. In fact, research reveals we are at our happiest aged 80! Combining her extensive experience in teaching mindfulness with her knowledge of how to live and age well, she reveals a simple framework that can help you make the most out of those extra years of living. Rather than wait for society to solve the challenges of longevity, she invites us to explore what each of us can do to take responsibility for our own life and ageing process. Ageing Upwards will help you navigate life after 50 with acceptance, self-compassion and mental flexibility. It’s also invaluable to leaders who wants overcome unconscious beliefs, limitations and discriminations related to age to create more diverse organizations.

In Neurosis and Human Growth, Dr. Horney discusses the neurotic process as a special form of the human development, the antithesis of healthy growth. She unfolds the different stages of this situation, describing neurotic claims, the tyranny or inner dictates and the neurotic's solutions for relieving the tensions of conflict in such emotional attitudes as domination, self-effacement, dependency, or resignation. Throughout, she outlines with penetrating insight the forces that work for and against the person's realization of his or her potentialities. First Published in 1950. Routledge is an imprint of Taylor & Francis, an informa company.

This book brings together in one volume selected important topics in craniofacial growth. Topics include: principles of skeletal growth; osteogenesis and its control; formation of the cranial base and craniofacial joints; prenatal development of the facial skeleton; growth of the mandible, nasomaxillary complex, orbit, cranial base, ear capsule, and cranial vault; bone remodeling; muscles; soft tissues; and blood vessels.
Fundamentals of Craniofacial Growth contains detailed illustrations and extensive reference lists. Independently authored chapters provide comprehensive reviews encompassing both contemporary and historical perspectives. In addition to medicine and dentistry, contributors provide expertise from such diverse backgrounds as anatomy, biology, biomathematics, embryology, orthodontics, physical anthropology, and plastic and reconstructive surgery.

Carefully delineating each step in the formation of the lung, Lung Growth and Development examines prenatal and postnatal lung development...the regulation of surfactant protein gene expression and models for the analysis of epithelial gene transcription and function...cellular differentiation and the role of mesenchymal cells...airway gland growth and differentiation...growth regulation in the tracheobronchial epithelium and mucociliary differentiation...embryonic precursors of the pulmonary nervous system and the development of lung innervation...Clara cells, airway smooth muscle development, cell interactions in vessel formation, and the surfactant system...respiratory distress syndrome, bronchopulmonary dysplasia, and compensatory lung growth...and more. Written by over 30 international experts, Lung Growth and Development is a practical guide for pulmonologists and pulmonary disease specialists, physiologists, molecular and cellular biologists, pathologists, neonatalogists and pediatricians, anatomists, pathologists, and graduate-level and medical school students in these disciplines.

Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.

This important monograph summarizes a comprehensive study on the maturation of walking in normal children. Research, undertaken at one of the world's leading gait analysis centers, involved over 400 studies on a total of nearly 300 children in ten age-groups from one to seven years. Data are presented on anthropometric measurements; tests of developmental progress; time/distance parameters such as stride length and walking velocity; twelve joint angles on each side measured throughout the gait cycle; dynamic electromyography of phasic activity in seven lower-extremity muscle groups; and force measurements including vertical force, fore/aft shear, medial/lateral shear and torque. At each age, composite joint-angle graphs and time/distance parameters are brought together with film tracings of a representative child in that age group. In addition, advanced methods of statistical analysis have been applied to the joint-angle data to define prediction regions within which ninety-five percent of normal children should lie throughout the gait cycle. Finally, a 'decision tree' is presented from which a fitted age can be inferred for a subject based on non-age-specific data gathered in a motion analysis lab. Practical applications are demonstrated in a chapter devoted to two case studies.

The conceptualization of dementia has changed dramatically in recent years with the claim that, through early detection and by controlling several risk factors, a prevention of dementia is possible. Although encouraging and providing hope against this feared condition, this claim is open to scrutiny. This volume looks at how this new conceptualization ignores many of the factors which influence a dementia sufferers' prognosis, including their history with education, food and exercise as well as their living in different epistemic cultures. The central aim is to question the concept of prevention and analyze its impact on aging people and aging societies.

The conceptualization of dementia has changed dramatically in recent years with the claim that, through early detection and by controlling several risk factors, a prevention of dementia is possible. Although encouraging and providing hope against this feared condition, this claim is open to scrutiny. This volume looks at how this new conceptualization ignores many of the factors which influence a dementia sufferers’ prognosis, including their history with education, food and exercise as well as their living in different epistemic cultures. The central aim is to question the concept of prevention and analyze its impact on aging people and aging societies.

Does Aging Stop? reveals the most paradoxical finding of recent aging research: the cessation of demographic aging. The authors show that aging stops at the level of the individual organism, and explain why evolution allows this. The implications of this counter-intuitive conclusion are profound, and aging research now needs to accept three uncomfortable truths. First, aging is not a cumulative physiological process. Second, the fundamental theory that is required to explain, manipulate, and probe the phenomena of aging comes from evolutionary biology. Third, strong-inference experimental strategies for aging must be founded in evolutionary research, not cell or molecular biology.
The result of fifteen years of research bringing together new applications of evolutionary theory, new models for demography, and massive experimentation, Does Aging Stop? advances an entirely new foundation for the scientific study of aging.

Focusing on the contemporary period, this book brings together critical age studies and contemporary science fiction to establish the centrality of age and ageing in dystopian, speculative and science-fiction imaginaries. Analysing texts from Europe, North America and South Asia, as well as television programmes and films, the contributions range from essays which establish genre-based trends in the representation of age and ageing, to very focused studies of particular texts and concerns. As a whole, the volume probes the relationship between speculative/science fiction and our understanding of what it is to be a human in time: the time of our own lives and the times of both the past and the future.

This book provides concrete scientific basis that we can conceive the possibility of modifying or even completely canceling aging process, despite the fact that aging is commonly regarded as the result of the overall effects of many uncontrollable degenerative phenomena. The authors illustrate in detail the mechanisms by which cells and the whole organism age. Actions by which it is possible, or will be possible within a limited time, to operate for modifying aging are also debated. The discussion is conducted within the frame and the concepts of evolutionary medicine, which is also indispensable for distinguishing between the manifestations of aging and: (i) diseases that worsen with age, and (ii) acceleration of normal aging rates, caused by unhealthy lifestyle habits and other avoidable factors. The book also discusses the impact of aging on overall mortality and the strange situation that, according to official statistics, aging does not exist as cause of death. This book is a turning point between a gerontology and geriatrics conceived as the study and vain treatment of an incurable condition and one in which these disciplines examine the how and why of a physiological phenomenon that can be modified up to a possible total control. This means transforming the medical prevention and treatment of physiological aging from the greatest failure to the greatest success of medicine.

This book shows readers how they can personally direct and monitor their own health and become proactive in optimizing their quality of life. Thanks to the latest advances in genetic science, one no longer has to be a victim of genetic inheritance.

A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people.

It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan?

In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”

This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger.

Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

In this unique book emphasis is placed on tests necessary to evaluate fetal well-being and to detect those fetuses at risk of hypoxia and acidosis in utero. Written by pioneers in the neonatal field, this publication contains chapters on the pathophysiology , obstetric management, and collagen diseases of intrauterine growth retardation. Ultrasound in detection of growth retarded fetuses is explored, as well as magnetic resonance imaging and magnesium substitution for the prevention of intrauterine growth retardation. Containing never-before-published information, this volume is an excellent reference source for both investigators in the field and those entering it. Topics Include: Perinatal growth chart for international reference Ultrasound guided procedures in small for gestation fetuses Utero-placental and fetal circulation

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.

Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.

Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.

Known for a tradition of Confucian filial piety, East Asian societies have some of the oldest and most rapidly aging populations on earth. Today these societies are experiencing unprecedented social challenges to the filial tradition of adult children caring for aging parents at home. Marshalling mixed methods data, this volume explores the complexities of aging and caregiving in contemporary East Asia. Questioning romantic visions of a senior's paradise, chapters examine emerging cultural meanings of and social responses to population aging, including caregiving both for and by the elderly. Themes include traditional ideals versus contemporary realities, the role of the state, patterns of familial and non-familial care, social stratification, and intersections of caregiving and death. Drawing on ethnographic, demographic, policy, archival, and media data, the authors trace both common patterns and diverging trends across China, Hong Kong, Taiwan, Singapore, Japan, and Korea.

The United Nations Madrid International Plan of Action on Ageing (MIPAA) offers a bold new agenda for handling the issue of ageing in the 21st-century. It focuses on three priority areas: older persons and development; advancing health and well-being into old age; and ensuring enabling and supportive environments. This book brings together global perspectives on the MIPAA and focusses on and assesses the success and failures of governments to implement its recommendations. Despite its pivotal importance in international ageing policy, the MIPAA has been relatively neglected by academics in their writings and studies. This book mitigates this analytical and empirical cavity. Each chapter focuses on one specific geographical region and addresses five key themes: National ageing situation; Twenty years of MIPAA; Ensuring ageing with dignity; Healthy and active ageing in a sustainable world; and Priorities for the future. It presents an overall summary of the findings, future challenges and opportunities related to ageing, recommendations for future actions to be taken, and policy adjustments needed. The authors also present lessons that were learnt from managing the impact of COVID-19 on older people, together with an outlook on the most immediate priorities for the future so that the recommendations in the MIPAA are achieved in post-COVID-19 and sustainable ethical scenarios. An important contribution towards the advancement of ageing policy, the book will be indispensable to students and researchers of gerontology, ageing, and health. It will also be of interest to policy makers, geriatricians, dementia care specialists, social policy makers responsible for ensuring active and healthy ageing, and all public sector departments which have specific responsibilities towards improving the quality of life of older adults.

Inherited disorders of the kidney are becoming important, not only in pediatric nephrological practice, but also in adult nephrology, representing a high proportion of patients with end-stage renal failure. In almost 50% of all children and in 15% of adults accepted for renal replacement therapy, the causative disorders have a hereditary basis. Many of these disorders are apparent at birth but may not cause renal failure until adolescence. Others may not present until adult life. The contribution of these disorders to adult nephrological practice has so far been understated in most of the existing textbooks. This book presents a practical approach to the investigation and management of patients with inherited renal disorders. The book is aimed at both established pediatric and adult nephrologists, as well as nephrologists in training, and will also be of interest to pediatricians, geneticists, and research workers in this field.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal nervous system development 3) Appeals to neuroanatomists, developmental biologists, and clinical practioners. 4) Persistent relevance - archival reference work that will be usable for decades.