The progressive ageing of the general population and the consequent increase of the number of old people has made the typical medical problems of aged people more frequently observed, and particularly the problems related to the ageing brain. This new book is an updated overview of relevant aspects of cognitive decline associated with ageing. Within the wide landscape of brain ageing the authors reconsider the role of the main predisposing factors and risk factors on the development of various form of mental decline, from mild cognitive impairment to dementia. The strength of this book is the large, updated overview of the most recent data of scientific literature regarding the role of genetic, metabolic and environmental factors on the predisposition and onset of cognitive decline. Particular attention is paid to the dietary micro- and macronutrients and to their possible role in the pathogenesis of the various form of dementigen disorders.

'Open, honest, straight talking on mental health and motherhood.' - Tik Tok's Dr Julie 'I absolutely love it - it doesn't matter who you are, what you've been through and how much you've changed - there is always room for growth'. - Ant Middleton 'This book will become your bible.' - Gaby Roslin, Virgin Radio In GROW, Sunday Times bestselling author Frankie Bridge opens up about her journey with her maternal mental health. Part narrative exploration, part first aid manual for mothers this book will discuss the hidden growing pains which take place when you become a parent. Its chapters cover the HOW TOs, WHAT IFs?, WILL Is? and WHY DOs? anxious questions all mothers ask themselves when they believe they are doing it wrong whilst also offering a brutally honest account of how hard it can be to grow a baby and raise a child whilst you are still growing into yourself. The book will combine Frankie's mental health journey into motherhood with the notes of psychologist, Maleha Khan, who will unpack the problems she experienced as she became a mother. It will also include additional guidance and parental advice from the UK's leading paediatrician Dr Ed Abrahamson. Fans of OPEN: 'Brave and beautiful... a first aid manual for your mind.' - Adam Kay, bestselling author of This is Going To Hurt 'Very readable. Very relatable. Intensely moving but also full of practical advice.' - Alastair Campbell

The advances of basic sciences combined with the perspectives of developmental neurology have recently modified the traditional outlook on the evolution of motor behavior. The maturation of neuro-anatomic structures is studied nowadays as just one facet of a complex process: the various elements of innate global patterns, the acquisition of antigravitary schemes as well as manipulative and praxic skills, control of posture and gait, ocular motility and motricity, converge to create the present picture of a continuous adaptive interaction between the child's genotype and its environment. This book stimulates the debate and the exchange of concepts between researchers and clinical specialists.

The Age-Well Project dived deep into the science of ageing well, and authors Annabel and Susan explained how they overhauled their own lives to prioritise healthy longevity. In The Age-Well Plan, Susan draws on almost a decade of extensive research into healthy longevity and her experience as a health coach to give you the tools you need to live your own age-well life. Her simple, clear and easy-to-follow six-week plan will show you how to make changes -- small and large -- to support healthy ageing, and prioritise the changes most appropriate for your body, lifestyle and circumstances. The first week of the plan guides you to understand your goals as you age and explains how to evaluate your current health and risk factors, in order to devise a bespoke plan for your body and brain. The subsequent weeks focus on the key elements of healthy ageing -- diet, exercise, sleep, engagement and the environment -- to help you build a personalised plan that will kickstart your age-well life.

This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.

The conceptualization of dementia has changed dramatically in recent years with the claim that, through early detection and by controlling several risk factors, a prevention of dementia is possible. Although encouraging and providing hope against this feared condition, this claim is open to scrutiny. This volume looks at how this new conceptualization ignores many of the factors which influence a dementia sufferers’ prognosis, including their history with education, food and exercise as well as their living in different epistemic cultures. The central aim is to question the concept of prevention and analyze its impact on aging people and aging societies.

The graying of the U.S. population draws increasing focus to historically unattended segments of society, including sexual and gender minorities. In this first comprehensive volume to address the challenges of aging in the gay, lesbian, bisexual, transgender, and intersex populations, this text presents what is currently known about aging GLBT individuals and what services are needed to support them.

The editors first provide an introductory overview comparing caregiving in GLBT and normative aging communities. In chapters devoted to the issues of each alternative sexuality and gender identity community, top experts in the field discuss biomedical, psychological, social/sexual, spiritual, socioeconomic, and service topics related to that community's aging needs.

GLBT populations face unique challenges as they age. Despite the often severe difficulties they encounter, many live out their final years with the dignity and grace that all of us deserve. With a combination of the latest biological and social science research, moving case studies and first-person accounts, practical advice for health professionals, and research literature citations, this book represents a major step forward in addressing concerns of aging GLBT populations.

Integrating research, practice, and policy, this text is for students and professionals in gerontology, medicine, social work, psychology, nursing, public health, and related fields who wish to learn more about the life experiences and concerns of sexual- and gender-minority-identified older patients.

Focusing on the contemporary period, this book brings together critical age studies and contemporary science fiction to establish the centrality of age and ageing in dystopian, speculative and science-fiction imaginaries. Analysing texts from Europe, North America and South Asia, as well as television programmes and films, the contributions range from essays which establish genre-based trends in the representation of age and ageing, to very focused studies of particular texts and concerns. As a whole, the volume probes the relationship between speculative/science fiction and our understanding of what it is to be a human in time: the time of our own lives and the times of both the past and the future.

As life expectancy continues to increase, so does the need to understand the factors that increase health and vitality. "Physiology of Exercise and Healthy Aging" applies the science of exercise physiology to an analysis of the aging process and identifies the positive effects that regular exercise and physical activity have not only on longevity but also on delaying specific diseases, decreasing morbidity, and increasing quality of life. It presents theories on aging, the aging process, the structural and functional changes that characterize advancing age, exercise programming concerns for the aged, drug use and abuse by seniors, and the benefits of exercise and physical activity.

This text offers a more expansive discussion of the particulars of exercise physiology of aging persons than is found in other texts on the subject. With "Physiology of Exercise and Healthy Aging," readers will gain a thorough understanding of the role of physical activity on the aging process, the principles of exercise and assessment considerations for elderly adults, and training for special needs of older adults. Information is presented in the context of three groups found in the aging and health spectrum: average aging individuals, frail elderly, and master athletes. This information is organized within a three-part structure:

-Part I explores age-related changes in the major physiological systems. The effects of physical activity on these systems, as well as necessary adaptations for those with impaired abilities in each system, are also discussed.

-Part II deals with the interactive roles of nutrition; age-related diseases, such as diabetes and osteoporosis; and physical activity.

-Part III presents the physiologic adaptability that may be expected with training and physical activity of older adults. It also addresses the practical issues that must be considered when working with this population, including training for aerobic, anerobic, and muscular fitness; exercise adherence and safety measures; and potential substance abuse of commonly used medications.In addition to the presentation of foundational concepts of physiology as they relate to the process of aging, chapters of" Physiology of Exercise and Healthy Aging" contain exercise regimens related to the chapter topic, other forms of physical activity that have proven beneficial to the aging population, and contraindicated exercises. Physiological responses to acute and chronic exercise perturbations are examined, including studies of cardiorespiratory fitness, muscle metabolism and strength, neurophysiology and the senses, and the effects of exercise on older adults with the diseases of aging, including type 2 diabetes, osteoporosis, arthritis, and cardiovascular disease. Chapter-opening quotes provide the insights of selected thinkers, scientists, and fitness professionals on the topic discussed.

Practitioners who work with older adults will find programming recommendations in each chapter to help translate the science into practice. An appendix offers easy access to forms and assessments, including a Three-Day Nutritional Assessment form and a Client History form. The language used throughout the text embraces the science of exercise physiology but also welcomes practitioners to apply the information presented.

For student readers, "Physiology of Exercise and Healthy Aging" incorporates these helpful features to assist learning and retention:

-Chapter-opening outlines offer quick reference to topics.

-Chapter-ending Questions to Consider provide tools for self-study and reflection.

-Numerous tables and figures reinforce chapter concepts and add visual or statistical information related to the process of aging, fall prevention, international demographics, and theories of aging.

-References provide additional opportunities for reading and research with selected books, articles, and Web sites.

-Appendixes contain information on specific Web sites and numerous tests and forms that may be photocopied for use with clients or patients or for course projects."Physiology of Exercise and Healthy Aging "contains a thorough discussion of the unique effects of aging on the human body and illustrates the power of exercise as a preventive tool to reduce or offset the deleterious effects of aging in order to increase the quality of life enjoyed by our aging population. With this text, both students and professionals will grasp the advantages of appropriate physical activity for the elderly and how to safely administer exercise programs that contribute to the increased health and quality of life for older adults.

Research results indicate that older adults have a higher rate of fatality and injury in motor vehicle crashes than any other age group except for teenagers. With the ageing of the American population, concern arises regarding potential increases in rates of crash involvement and injury. This book examines the association of the impairing effects of multiple medication use, drug/drug interactions and drug/disease interactions on motor vehicle crashes in individuals age fifty years and greater.

This book shows readers how they can personally direct and monitor their own health and become proactive in optimizing their quality of life. Thanks to the latest advances in genetic science, one no longer has to be a victim of genetic inheritance.

In Slavic studies, aging and old age have thus far been only marginal concerns. This volume brings together the scattered research that has been done up to now on aging as represented and narrated in Slavic literatures. The essays investigate Bosnian/Croatian/Serbian, Polish, Russian, Slovak, Slovene and Ukrainian representations of age/aging in various literary genres and epochs and analyze age as a powerful marker of difference and as constitutive of social relations and personal identity.

Known for a tradition of Confucian filial piety, East Asian societies have some of the oldest and most rapidly aging populations on earth. Today these societies are experiencing unprecedented social challenges to the filial tradition of adult children caring for aging parents at home. Marshalling mixed methods data, this volume explores the complexities of aging and caregiving in contemporary East Asia. Questioning romantic visions of a senior's paradise, chapters examine emerging cultural meanings of and social responses to population aging, including caregiving both for and by the elderly. Themes include traditional ideals versus contemporary realities, the role of the state, patterns of familial and non-familial care, social stratification, and intersections of caregiving and death. Drawing on ethnographic, demographic, policy, archival, and media data, the authors trace both common patterns and diverging trends across China, Hong Kong, Taiwan, Singapore, Japan, and Korea.

Known for a tradition of Confucian filial piety, East Asian societies have some of the oldest and most rapidly aging populations on earth. Today these societies are experiencing unprecedented social challenges to the filial tradition of adult children caring for aging parents at home. Marshalling mixed methods data, this volume explores the complexities of aging and caregiving in contemporary East Asia. Questioning romantic visions of a senior's paradise, chapters examine emerging cultural meanings of and social responses to population aging, including caregiving both for and by the elderly. Themes include traditional ideals versus contemporary realities, the role of the state, patterns of familial and non-familial care, social stratification, and intersections of caregiving and death. Drawing on ethnographic, demographic, policy, archival, and media data, the authors trace both common patterns and diverging trends across China, Hong Kong, Taiwan, Singapore, Japan, and Korea.

In this unique book emphasis is placed on tests necessary to evaluate fetal well-being and to detect those fetuses at risk of hypoxia and acidosis in utero. Written by pioneers in the neonatal field, this publication contains chapters on the pathophysiology , obstetric management, and collagen diseases of intrauterine growth retardation. Ultrasound in detection of growth retarded fetuses is explored, as well as magnetic resonance imaging and magnesium substitution for the prevention of intrauterine growth retardation. Containing never-before-published information, this volume is an excellent reference source for both investigators in the field and those entering it. Topics Include: Perinatal growth chart for international reference Ultrasound guided procedures in small for gestation fetuses Utero-placental and fetal circulation

This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

Studies of mammary gland biology are essential in the fight against breast cancer. Moreover, the mammary gland represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body. The branching morphogenesis that occurs during puberty and the alveogenesis processes during pregnancy, for example, recapitulate steps that occur in many tissues during embryogenesis and are also relevant to tumor invasion and metastasis. Similarly, analyses of breast cancer progression and the cell types that contribute to it yield findings applicable not only to breast cancer but widely to other cancers as well.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of mammary gland development, physiology, and tumor formation, emphasizing the value of the organ as a model system. The contributors examine the roles of hormones, growth factors, oncogenes, and the extracellular matrix in normal development and cancer. In addition, they discuss the nature of the mammary gland stem cell population and review the gene expression programs activated and chromatin modifications that occur as the different cell lineages present differentiate. The book also contains chapters covering the many experimental approaches that have been used in this field, including transplantation, genetic engineering, RNA interference and genomics, three dimensional culture models, and live cell imaging. It will thus be of interest to all researchers working in cell, developmental, and cancer biology, as well as those focused specifically on mammary gland biology and breast cancer.

The scientific study of aging is a relatively nascent field of inquiry. Although philosophic and literary reflections on what it means to grow older appear in the earliest historical records, the systematic study of aging began in earnest about a century ago. Scholarly interest in the topic has accelerated in recent decades, due in part to rapid population aging in developed nations. As a result, the study of aging has been incorporated into many disciplines, emphasizing concepts, theories, and methods to elucidate the antecedents and consequences of growing older. Although each discipline has key concepts and empirical generalizations about aging, there is little agreement across disciplines about the intellectual core of gerontology. Each discipline brings its own intellectual heritage and perspective to the study of aging, but the question posed by author Ken Ferraro is whether there is an emergent perspective or way of thinking about aging that transcends the disciplines. Biologists, psychologists, and sociologists may claim an interest in gerontology, but do they have a common image of aging or a set of principles to guide their research? Do they share a paradigm-a fundamental image of aging-that incorporates concepts and empirical generalizations from multiple disciplines? And when disciplinary approaches to gerontology clash, which approach or conceptualization of aging is likely to emerge as part of the paradigm? Although biologists, psychologists, and social scientists share an interest in the study of aging, they are distinctive in how they conduct their research. The Gerontological Imagination provides an integrative paradigm of aging that makes it the first book to identify intellectual common ground among scholars studying aging. Ferraro identifies an underlying set of principles that constitute a paradigm for the study of aging: causality, life course analysis, multifaceted change, heterogeneity, accumulation processes, and ageism. The proposed paradigm provides an efficient way to identify and interpret essential ideas, findings, models, and theories across multiple disciplines that study aging.

Developmental theorists have struggled with defining the relations among biology, psychology, and sociocultural context, often reducing psychological functions of a person to either biological functioning or the role of sociocultural context - nature or nurture - and considering each area of human development separately. New Perspectives on Human Development addresses fundamental questions of development with a unified approach. It encompasses theory and research on cognitive, social and moral, and language and communicative development, in various stages of life, and explores interdisciplinary perspectives. New Perspectives on Human Development revisits old questions and applies original empirical findings, offering new directions for future research in the field.

Humans and flies look nothing alike, yet their genetic circuits are remarkably similar. Here, Lewis I. Held, Jr compares the genetics and development of the two to review the evidence for deep homology, the biggest discovery from the emerging field of evolutionary developmental biology. Remnants of the operating system of our hypothetical common ancestor 600 million years ago are compared in chapters arranged by region of the body, from the nervous system, limbs and heart, to vision, hearing and smell. Concept maps provide a clear understanding of the complex subjects addressed, while encyclopaedic tables offer comprehensive inventories of genetic information. Written in an engaging style with a reference section listing thousands of relevant publications, this is a vital resource for scientific researchers, and graduate and undergraduate students.

How did human thought evolve into the highly complex process it is today? In the field of evolutionary cognitive archaeology, cognitive science and archaeology intersect to provide a more complete and grounded picture of the mind. With the combination of cognitive theories and archaeological evidence, this burgeoning field is only beginning to tap into the potential for a better understanding of the development of specific cognitive abilities. Cognitive Models in Palaeolithic Archaeology explores hominin cognitive development by applying formal cognitive models to analyze prehistoric remains from the entire range of the Palaeolithic, from the earliest stone tools 3.3 million years ago to artistic developments that emerged 50,000 years ago. Several different cognitive models are presented, including expert cognition, information processing, material engagement theory, embodied/extended cognition, neuroaesthetics, visual resonance theory, theory of mind, and neuronal recycling. By examining archaeological remains, and thereby past activities and behavior, through the grounded lenses of these models, a mosaic pattern of human cognitive evolution emerges. This volume, authored by many leading authorities in the field of cognitive archaeology, will attract scholars and students of cognitive evolution and paleoanthropology, who will find a new understanding of hominin cognitive evolution and substantive conclusions about our hominin evolution as opportunities for further research.