The first book of its kind to highlight the unique capabilities of laser-driven acceleration and its diverse potential, Applications of Laser-Driven Particle Acceleration presents the basic understanding of acceleration concepts and envisioned prospects for selected applications. As the main focus, this new book explores exciting and diverse application possibilities, with emphasis on those uniquely enabled by the laser driver that can also be meaningful and realistic for potential users. It also emphasises distinction, in the accelerator context, between laser-driven accelerated particle sources and the integrated laser-driven particle accelerator system (all-optical and hybrid versions). A key aim of the book is to inform multiple, interdisciplinary research communities of the new possibilities available and to inspire them to engage with laser-driven acceleration, further motivating and advancing this developing field. Material is presented in a thorough yet accessible manner, making it a valuable reference text for general scientific and engineering researchers who are not necessarily subject matter experts. Applications of Laser-Driven Particle Acceleration is edited by Professors Paul R. Bolton, Katia Parodi, and Joerg Schreiber from the Department of Medical Physics at the Ludwig-Maximilians-Universitat Munchen in Munchen, Germany. Features: Reviews the current understanding and state-of-the-art capabilities of laser-driven particle acceleration and associated energetic photon and neutron generation Presents the intrinsically unique features of laser-driven acceleration and particle bunch yields Edited by internationally renowned researchers, with chapter contributions from global experts

The first in a three-volume set exploring Problems and Solutions in Medical Physics, this volume explores common questions and their solutions in Diagnostic Imaging. This invaluable study guide should be used in conjunction with other key textbooks in the field to provide additional learning opportunities. It contains key imaging modalities, exploring X-ray, mammography, and fluoroscopy, in addition to computed tomography, magnetic resonance imaging, and ultrasonography. Each chapter provides examples, notes, and references for further reading to enhance understanding. Features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology sciences examinations

In the medical imaging field, clinicians and researchers are increasingly moving from the qualitative assessment of printed images to the quantitative evaluation of digital images since the quantitative techniques often improve diagnostic accuracy and complement clinical assessments by providing objective criteria. Despite this growing interest, the field lacks a comprehensive body of knowledge. Filling the need for a complete manual on these novel techniques, Quantifying Morphology and Physiology of the Human Body Using MRI presents a wide range of quantitative MRI techniques to study the morphology and physiology of the whole body, from the brain to musculoskeletal systems. Illustrating the growing importance of quantitative MRI, the book delivers an indispensable reference for readers who would like to explore in vivo MRI techniques to quantify changes in the morphology and physiology of tissues caused by various disease mechanisms. With internationally renowned experts sharing their insight on the latest developments, the book goes beyond conventional MRI contrast mechanisms to include new techniques that measure electromagnetic and mechanical properties of tissues. Each chapter offers comprehensive information on data acquisition, processing, and analysis techniques as well as clinical applications. The text organizes the techniques based on their primary use either in the brain or the body. Some of the techniques, such as diffusion-weighted imaging and diffusion tensor imaging, span several application areas, including brain imaging, cancer imaging, and musculoskeletal imaging. The book also covers up-and-coming quantitative techniques that explore tissue properties other than the presence of protons (or other MRI-observable nuclei) and their interactions with their environment. These novel techniques provide unique information about the electromagnetic and mechanical properties of tissues and introd

Designed to provide those engaged in modern medical imaging with a coherent perspective of the entire discipline so that one protocol is no longer an isolated or independent mode of imaging from others, to wit: single photon emission computed tomography (SPECT), positron emission tomography (PET) or magnetic resonance imaging (MRI). Introduces biomagnetic imaging as a third new modality.

Polymers are essential to biology because they can have enough stable degrees of freedom to store the molecular code of heredity and to express the sequences needed to manufacture new molecules. Through these they perform or control virtually every function in life. Although some biopolymers are created and spend their entire career in the relatively large free space inside cells or organelles, many biopolymers must migrate through a narrow passageway to get to their targeted destination. This suggests the questions: How does confining a polymer affect its behavior and function? What does that tell us about the interactions between the monomers that comprise the polymer and the molecules that confine it? Can we design and build devices that mimic the functions of these nanoscale systems? The NATO Advanced Research Workshop brought together for four days in Bikal, Hungary over forty experts in experimental and theoretical biophysics, molecular biology, biophysical chemistry, and biochemistry interested in these questions. Their papers collected in this book provide insight on biological processes involving confinement and form a basis for new biotechnological applications using polymers. In his paper Edmund DiMarzio asks: What is so special about polymers? Why are polymers so prevalent in living things? The chemist says the reason is that a protein made of N amino acids can have any of 20 different kinds at each position along the chain, resulting in 20 N different polymers, and that the complexity of life lies in this variety.

Physics and Instrumentation of Diagnostic Medical Ultrasound Peter Fish. University of Wales -- Bangor, School of Electronic Engineering Science, and Gwynedd and Clwyd Health Authorities, Department of Medical Physics. The field of diagnostic medical ultrasound is constantly changing as new equipment and techniques are developed and refined. The use of ultrasound is increasing rapidly throughout the world and consequently a knowledge of the underlying scientific principles and instrument operation has become an essential part of medical ultrasound courses. This book provides a concise, highly illustrated description of physics and instrumentation of diagnostic medical ultrasound and includes substantial coverage of Doppler techniques and real-time instruments. It will be of great value to sonographers, radiographers, radiologists, medical physicists and technicians as an aid to the study of the clinical use of diagnostic ultrasound, and as an excellent introduction for those intending to investigate the subject in greater depth. Other Wiley Books of Related Interest Include: Doppler Ultrasound: Physics, Instrumentation, and Clinical Applications D. H. Evans, W. N. McDicken, R. Skidmore, J. P. Woodcock 1989 Clinical Magnetic Resonance: Imaging and Spectroscopy R. Andrew, G. Bydder, J. R. Griffiths, R. A. Iles, P. Styles 1990 Ultrasound Teaching Cases Volume 1 H. B. Meire, K. C. Dewbury, D. O. Cosgrove 1988 Ultrasound Teaching Cases Volume 2 K. C. Dewbury, H. B. Meire, D. O. Cosgrove 1988

This is an introductory text for students which aims to bring them up to speed ready for first-year university level physical chemistry. The text begins by looking at atoms and their structure, and goes on to study different phases of matter and relates them to forces acting between molecules. As the book progresses, it analyzes both phase and chemical equilibria, energy and kinetics, and the final section is about reactive free radicals.

In considering ways that physics has helped advance biology and medicine, what typically comes to mind are the various tools used by researchers and clinicians. We think of the optics put to work in microscopes, endoscopes, and lasers; the advanced diagnostics permitted through magnetic, x-ray, and ultrasound imaging; and even the nanotools, that allow us to tinker with molecules. We build these instruments in accordance with the closest thing to absolute truths we know, the laws of physics, but seldom do we apply those same constants of physics to the study of our own carbon-based beings, such as fluidics applied to the flow of blood, or the laws of motion and energy applied to working muscle. Instead of considering one aspect or the other, Handbook of Physics in Medicine and Biology explores the full gamut of physics' relationship to biology and medicine in more than 40 chapters, written by experts from the lab to the clinic. The book begins with a basic description of specific biological features and delves into the physics of explicit anatomical structures starting with the cell. Later chapters look at the body's senses, organs, and systems, continuing to explain biological functions in the language of physics. The text then details various analytical modalities such as imaging and diagnostic methods. A final section turns to future perspectives related to tissue engineering, including the biophysics of prostheses and regenerative medicine. The editor's approach throughout is to address the major healthcare challenges, including tissue engineering and reproductive medicine, as well as development of artificial organs and prosthetic devices. The contents are organized by organ type and biological function, which is given a clear description in terms of electric, mechanical, thermodynamic, and hydrodynamic properties. In addition to the physical descriptions, each chapter discusses principles of related clini

Remote health monitoring using wearable sensors is an important research area involving several key steps: physiological parameter sensing and data acquisition, data analysis, data security, data transmission to caregivers, and clinical intervention, all of which play a significant role to form a closed loop system. Subject-specific behavioral and clinical traits, coupled with individual physiological differences, necessitate a personalized healthcare delivery model for around-the-clock monitoring within the home environment. Cardiovascular disease monitoring is an illustrative application domain where research has been instrumental in enabling a personalized closed-loop monitoring system, which has been showcased in this book. Health Monitoring Systems: An Enabling Technology for Patient Care provides a holistic overview of state-of-the-art monitoring systems facilitated by Internet of Things (IoT) technology. The book lists out the details on biomedical signal acquisition, processing, and data security, the fundamental building blocks towards an ambulatory health monitoring infrastructure. The fundamentals have been complimented with other relevant topics including applications which provide an in-depth view on remote health monitoring systems. Key Features: Presents examples of state-of-the-art health monitoring systems using IoT infrastructure Covers the full spectrum of physiological sensing, data acquisition, processing, and data security Provides relevant example applications demonstrating the benefits of technological advancements aiding disease prognosis This book serves as a beginner's guide for engineering students of electrical and computer science, practicing engineers, researchers, and scientists who are interested in having an overview of pervasive health monitoring systems using body-worn sensors operating outside the hospital environment. It could also be recommended as a reference for a graduate or master's level course on biomedical instrumentation and signal processing.

Das vorliegende Werk bietet eine im deutschsprachigen Raum einzigartige, umfassende und aktuelle Darstellung der Medizinischen Physik. Es liefert damit das Fundament fur die Anwendung physikalischer Methoden in der Medizin, der Entwicklung neuer oder verbesserter Verfahren zur Untersuchung und Behandlung von Patienten sowie fur die Bereitstellung und den Einsatz physikalischer Methoden in der klinischen Anwendung. Es unterstutzt als Lehrbuch den Bedarf nach einer systematischen medizinphysikalischen Aus- und Weiterbildung von Physikern, die an medizinischen Einrichtungen tatig sind. Das Buch orientiert sich am Stoffkatalog der Deutschen Gesellschaft fur Medizinische Physik (DGMP) und legt den Schwerpunkt auf die Medizinische Physik in der Radiologie und Radioonkologie. Das Werk ist in funf Teile unterteilt: * In Teil I werden die Grundlagen der Strahlenphysik, der biostatistischen Methoden, der Medizinischen Informatik, der organisatorischen und rechtlichen Aspekte sowie des Strahlenschutzes abgehandelt. * Teil II behandelt die radiologische Diagnostik und umfasst die bildgebenden Verfahren der Roentgendiagnostik, der Roentgen-Computertomographie, der Magnetresonanztomographie sowie des Ultraschalls. * Teil III beschreibt die Methoden der nuklearmedizinischen Diagnostik und Therapie. * In Teil IV wird die Medizinische Physik der Strahlentherapie in vertiefter Form dargestellt. * Teil V beschreibt ausgewahlte Themen aus dem Gebiet der Medizintechnik. Zu allen Teilen werden UEbungsaufgaben und Kontrollfragen angeboten, mit denen der Leser das Gelernte uberprufen kann. Erganzend werden auf einer Website Musterloesungen, zusatzliches vertiefendes Text- und Bildmaterial sowie Animationen und Videos zur Verfugung gestellt. Das Buch versteht sich als Lehrbuch und Nachschlagewerk, das begleitend zu Weiterbildungsveranstaltungen und Studiengangen oder auch zum Selbststudium auf dem Gebiet der Medizinischen Physik eingesetzt werden kann. Es basiert auf dem Heidelberger Weiterbildungskurs "Medizinische Physik fur Physiker" und richtet sich vornehmlich an Physik-Absolventen und Naturwissenschaftler mit grundlegenden physikalischen Kenntnissen. Die Herausgeber sind als Wissenschaftler am Deutschen Krebsforschungszentrum (dkfz) tatig und lehren als Professoren fur Medizinische Physik an der Universitat Heidelberg.

Augmented reality (AR) is transforming how we work, learn, play and connect with the world, and is now being introduced to the field of medicine, where it is revolutionising healthcare as pioneering virtual elements are being added to real images to provide a more compelling and intuitive view during procedures. This book, which had its beginnings at the AE-CAI: Augmented Environments for Computer-Assisted Interventions MICCAI Workshop in Munich in 2015, is the first to review the area of mixed and augmented reality in medicine. Covering a range of examples of the use of AR in medicine, it explores its relevance to minimally-invasive interventions, how it can improve the accuracy of a procedure and reduce procedure time, and how it may be employed to reduce radiation risks. It also discusses how AR can be an effective tool in the education of physicians, medical students, nurses and other health professionals. Features: An ideal practical guide for medical professionals and students looking to understand the implementation, applications, and future of AR Contains the latest developments and technologies in this innovative field Edited by highly respected pioneers in the field, who have been immersed in AR as well as virtual reality and image-guided surgery since their inception, with chapter contributions from subject area specialists working with AR

Common factors that lead to treatment failure in head and neck cancer are the lack of tumour oxygenation, the accelerated division of cancer cells during treatment, and radioresistance. These tumour-related challenges and possible ways to overcome them are covered in this book, authored by three medical physicists and a clinical oncologist who explain how different radiobiological findings have led to the development of various treatment techniques for head and neck cancer. Novel treatment techniques as supported by current scientific evidence are comprehensively explored, as well as the major challenges that arise in the retreatment of patients who have already undergone a form of radiotherapy for primary head and neck cancer. Features: Uses an interdisciplinary approach, encompassing clinical aspects of radiotherapy, radiation biology, and medical physics Applies content by relating all radiobiological characteristics to their respective clinical implications Explains the radiobiological rationale for all previous and current clinical trials for head and neck cancer

This book explores environmental physical agents and their potential effect on public and occupational health. It considers the theory, current research, and applications of physical agents including noise, ionizing radiation protection and non ionizing radiation protection, and explores the monitoring, measurement, modeling and mitigation of each of these. Features: Covers all three physical agents in one comprehensive book Presents the latest results from research, as well as theory Contributed to by a panel of international experts

The first MATLAB (R) programming book written specifically for clinical radiotherapy medical physicists and medical physics trainees, this much-needed book teaches users how to create their own clinical applications using MATLAB (R), as a complement to commercial software particularly when the latter does not cover specific local clinical needs. Chapters explore key radiotherapy areas such as handling volumes, 3D dose calculation, comparing dose distributions, reconstructing treatment plans and their summations, and automated tests for machine quality assurance. Readers will learn to independently analyse and process images, doses, structures, and other radiotherapy clinical data to deal with standard and non-standard situations in radiotherapy. This book will also significantly improve understanding of areas such as data nature, information content, DICOM RT standard, and data flow. It will be an invaluable reference for students of medical physics, in addition to clinical radiotherapy physicists and researchers working in radiotherapy. Features: Includes real clinical medical physics applications derived from actual clinical problems Provides commented MATLAB (R) scripts working with sample data and/or own data matching input requirements Promotes critical thinking and practical problem solving skills

The field of medical imaging seen rapid development over the last two decades and has consequently revolutionized the way in which modern medicine is practiced. Diseases and their symptoms are constantly changing therefore continuous updating is necessary for the data to be relevant. Diseases fall into different categories, even a small difference in symptoms may result in categorising it in a different group altogether. Thus analysing data accurately is of critical importance. This book concentrates on diagnosing diseases like cancer or tumor from different modalities of images. This book is divided into the following domains: Importance of big data in medical imaging, pre-processing, image registration, feature extraction, classification and retrieval. It is further supplemented by the medical analyst for a continuous treatment process. The book provides an automated system that could retrieve images based on user's interest to a point of providing decision support. It will help medical analysts to take informed decisions before planning treatment and surgery. It will also be useful to researchers who are working in problems involved in medical imaging.

Radiotherapy remains a major non-surgical treatment modality for malignant disease, and an understanding of how this treatment works is essential in ensuring optimum practice. Trainees in oncology learn about ionising radiation, but to understand it fully they must also understand the physics relevant to its use in therapy. This book is written specifically for the oncology and radiation team, supporting clinical oncologists in their understanding of the science which underpins radiotherapy. It begins with basic concepts and then explores the principles and practice of physics as it relates to radiotherapy, including discussion of specific types of therapy. Written by authors chosen for their expertise in in their respective fields, and aligned to the Royal College of Radiologists FRCR Curriculum in Oncology, this volume will provide an excellent source of information for trainee and practicing oncologists, and wider radiotherapy teams. This second edition has been fully updated to reflect advances in technology and the increased complexity in modern radiotherapy, including two new chapters on imaging and a new brachytherapy chapter.

Radiomics and Radiogenomics: Technical Basis and Clinical Applications provides a first summary of the overlapping fields of radiomics and radiogenomics, showcasing how they are being used to evaluate disease characteristics and correlate with treatment response and patient prognosis. It explains the fundamental principles, technical bases, and clinical applications with a focus on oncology. The book's expert authors present computational approaches for extracting imaging features that help to detect and characterize disease tissues for improving diagnosis, prognosis, and evaluation of therapy response. This book is intended for audiences including imaging scientists, medical physicists, as well as medical professionals and specialists such as diagnostic radiologists, radiation oncologists, and medical oncologists. Features Provides a first complete overview of the technical underpinnings and clinical applications of radiomics and radiogenomics Shows how they are improving diagnostic and prognostic decisions with greater efficacy Discusses the image informatics, quantitative imaging, feature extraction, predictive modeling, software tools, and other key areas Covers applications in oncology and beyond, covering all major disease sites in separate chapters Includes an introduction to basic principles and discussion of emerging research directions with a roadmap to clinical translation

This highly-readable account of the nature of the hazards presented by ionizing radiation and the methods of protection is an ideal introductory text for those new to the field, and for the non-specialist. The seventh edition continues to cover the technical principles underlying the control of radiation hazards, radiation detection and measurement and the biological effects of radiation, followed by a consideration of industry-specific radiation protection issues. Further specialised topics include risk assessment, waste management and decommissioning, radiological emergencies, relevant legislation and organizational issues and, new to this edition, environmental radiation protection.

This is a readable and attractively presented textbook on fluid flow in biological systems that includes flow through blood vessels, pulsatile flow, and pattern formation. It bridges the divide among biomedical engineering students between those with an engineering and those with a bio-scientific background, by offering guidance in both physiological and mathematical aspects of the subject. Every chapter includes surprising, amusing, and stimulating effects that the reader may want to experiment on their own. Brief historical vignettes are also included throughout this book. We in the 21st century can so easily turn to the computer to provide a solution, that we forget the extraordinary sparks of insight that scientists in centuries past had to rely on to provide us with the foundational understanding and analytical tools that we now depend on. This book is an attempt to maintain our roots in past investigations, while giving us wings to explore future ones.

This book aims to explain radiation from a somewhat different aspect than its traditional image as something that is scary, dangerous, hazardous, and so on, to produce the correct understanding that radiation is carrying energy, and to convince readers that radiation is not "scary" but controllable and useful. As for radiation itself, many introductions or textbooks have been published, as in radiochemistry, radiobiology, and radiology. In most of them, the biological effects of radiation exposure are the main subjects, which often enhance the feeling that radiation is dangerous, and the effects produced by lower-dose exposure that are difficult to see are hardly discussed. The present volume mainly focuses on how radiation carries energy, how energy is absorbed in substances as absorbed doses (Gy) or dose equivalents (Sv), how damages or risks appear with the absorbed dose and why the effects of the exposure appear quite differently, depending on properties of the substances that were exposed.

Radiosensitizers and Radiochemotherapy in the Treatment of Cancer catalogs and describes the mechanism of action for entities characterized as radiosensitizers. Developments in the biological and physical sciences have introduced new radiosensitizers and defined novel targets for radiosensitization. As a result, a book about radiosensitization must now address a huge range of topics, covering everything from molecular oxygen and high Z elements to monoclonal antibodies and complex phytochemicals. At the molecular level, the understanding of the molecular consequences of DNA damage and the DNA damage response have informed the development of targeted radiosensitizers and shed light on the mode of action of radiochemotherapy protocols of known clinical efficacy. In this book the mechanisms of action at the molecular and cellular level are described for documented radiosensitizers including, where applicable, a brief history of their clinical use and most recent clinical results. In addition, the clinical context is addressed including the importance of factors such as dose and dose rate, normal tissue toxicity, and drug delivery. Intuitively organized by topic and application, the book includes extensive illustrations, end-of-chapter summaries, and a wealth of references.

This popular text provides a comprehensive, yet accessible, introduction to the physics and technology of medical ultrasound, with high quality ultrasound images and diagrams throughout. Covering all aspects of the field at a level that meetings the requirements of accredited sonography courses, it is ideal for both trainee and qualified healthcare professionals practising ultrasound in a clinical setting. Building on the content of previous editions, this third edition provides the latest guidance relating to ultrasound technology, quality assurance and safety and discusses the latest techniques.

The first in a three-volume set exploring Problems and Solutions in Medical Physics, this volume explores common questions and their solutions in Diagnostic Imaging. This invaluable study guide should be used in conjunction with other key textbooks in the field to provide additional learning opportunities. It contains key imaging modalities, exploring X-ray, mammography, and fluoroscopy, in addition to computed tomography, magnetic resonance imaging, and ultrasonography. Each chapter provides examples, notes, and references for further reading to enhance understanding. Features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology sciences examinations

Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.