Recent years have witnessed an increasing number of theoretical and experimental contributions to cancer research from different fields of physics, from biomechanics and soft-condensed matter physics to the statistical mechanics of complex systems. Reviewing these contributions and providing a sophisticated overview of the topic, this is the first book devoted to the emerging interdisciplinary field of cancer physics. Systematically integrating approaches from physics and biology, it includes topics such as cancer initiation and progression, metastasis, angiogenesis, cancer stem cells, tumor immunology, cancer cell mechanics and migration. Biological hallmarks of cancer are presented in an intuitive yet comprehensive way, providing graduate-level students and researchers in physics with a thorough introduction to this important subject. The impact of the physical mechanisms of cancer are explained through analytical and computational models, making this an essential reference for cancer biologists interested in cutting-edge quantitative tools and approaches coming from physics.

This book comprehensively addresses the physics and engineering aspects of human physiology by using and building on first-year college physics and mathematics. Topics include the mechanics of the static body and the body in motion, the mechanical properties of the body, muscles in the body, the energetics of body metabolism, fluid flow in the cardiovascular and respiratory systems, the acoustics of sound waves in speaking and hearing, vision and the optics of the eye, the electrical properties of the body, and the basic engineering principles of feedback and control in regulating all aspects of function. The goal of this text is to clearly explain the physics issues concerning the human body, in part by developing and then using simple and subsequently more refined models of the macrophysics of the human body. Many chapters include a brief review of the underlying physics. There are problems at the end of each chapter; solutions to selected problems are also provided. This second edition enhances the treatments of the physics of motion, sports, and diseases and disorders, and integrates discussions of these topics as they appear throughout the book. Also, it briefly addresses physical measurements of and in the body, and offers a broader selection of problems, which, as in the first edition, are geared to a range of student levels. This text is geared to undergraduates interested in physics, medical applications of physics, quantitative physiology, medicine, and biomedical engineering.

• Can be utilized in either Algebra or Calculus-based courses and is available either as a standalone text or as a supplement for books like Cutnell PHYSICS, 5e or Halliday, Resnick, & Walker FUNDAMENTALS OF PHYSICS, 6e.
• Math level is Algebra & Trigonometry; however, a few examples require the use of integration and differentiation.
• Unlike competing supplements, Tuszinski offers both a wealth of engaging biomedical applications as well as quantitative problem-solving. The quantitative problem-solving is presented in the form of worked examples and homework problems.
• The quantitative problem-solving is presented in the form of worked examples and homework problems.
• The standard organization facilitates the integration of the material into most introductory courses.

This book recounts the developments of fundamental electrodynamics from Ampère's investigation of the forces between electric currents to Einstein's introduction of a new doctrine of space and time. Thorough accounts are given of crucial episodes such as Faraday's redefinition of charge and current, the genesis of Maxwell's field equations, and Hertz' experiments on fast electric oscillations. Darrigol provides a vivid picture of the intellectual and instrumental variety of nineteenth century physics, emphasising the diverse, evolving practices of electrodynamics, and the interactions between the corresponding scientific traditions. This richly documented, clearly written, and abundantly illustrated history should appeal to students and scholars of physics, and also to those interested in the history and philosophy of science.

This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.

This practical guide offers an accessible introduction to the principles of MRI physics. Each chapter explains the why and how behind MRI physics. Readers will understand how altering MRI parameters will have many different consequences for image quality and the speed in which images are generated. Practical topics, selected for their value to clinical practice, include progressive changes in key MRI parameters, imaging time, and signal to noise ratio. A wealth of high quality illustrations, complemented by concise text, enables readers to gain a thorough understanding of the subject without requiring prior in-depth knowledge.

PET and SPECT imaging has improved to such a level that they are opening up exciting new horizons in medical diagnosis and treatment. This book provides a complete introduction to fundamentals and the latest progress in the field, including an overview of new scintillator materials and innovations in photodetector development, as well as the latest system designs and image reconstruction algorithms. It begins with basics of PET and SPECT physics, followed by technology advances and computing methods, quantitative techniques, multimodality imaging, instrumentation, pre-clinical and clinical imaging applications.

This book describes at the introductory level how modern technology has made the scenario of the classic science-fiction movie Fantastic Voyage a reality. The movie is about a submarine and its crew members being shrunk to microscopic size and ventured into the body. Exactly 50 years following the release of the film, such reality takes the form of a medical interventional room capable of mimicking this scenario. Based on 15 years of intensive research and development by the world-leading team in this specific field, the book goes through the scenes of the movie while explaining how it is implemented in this first-of-a-kind interventional facility. This is the first book that explains the fundamentals of navigation of therapeutic agents in the vascular network. The scope of the book is twofold: (1) to initiate readers into various technologies, including, but not limited to, nanotechnology, robotics, and biochemistry (more importantly, it shows how critical the integration of all these disciplines is to solving problems that indeed require a multidisciplinary environment); (2) to inspire the younger generation by showing that science and technology can bring one everywhere with the power to transform fiction to reality that can help humankind.

These proceedings from the 2009 NSTI Nanotech conference provide the most prestigious forum in the world for leading nano scientists. The papers from the conference have been compiled into three volumes to create the most authoritative and comprehensive compendium available across all of nanotechnology. Including the latest information on industrial development, investments, and ventures, each volume explores cutting-edge research and applications. Volume II covers various aspects of cancer treatment, biomarkers, nanoparticles, drug delivery systems, nanobiotechnology, nanomedicine, nanoneurology, sensors, and soft nanotechnology.

Ultrasonic Exposimetry presents the fundamentals of ultrasonics and discusses the theoretical background of acoustic wave generation and reception. Measurements, instrumentation, and interpretation of measured data (including error analysis) are examined in detail. Ultrasound transducers, including transducers used in diagnostic imaging and therapeutic applications, are described. This section also presents a detailed description of transducers used in the recently introduced extracorporeal lithotripsy procedure. Other topics examined in the book include current trends in labeling and characterizing acoustic devices (including present regulatory requirements and future implications), the operation of state-of-the-art miniature PVDF ultrasonic hydrophones and fiber optic hydrophones, recent advances in transducer calibration and calorimeter and radiation force measurements, and the intricacies of statistical error analysis. Ultrasonic Exposimetry presents a wealth of invaluable information for students, instructors, researchers, biomedical engineers, and sonographers.

While there are many excellent texts focused on clinical medical imaging, there are few books that approach in vivo imaging technologies from the perspective of a scientist or physician-scientist using, or interested in using, these techniques in research. It is for these individuals that Essentials of In Vivo Biomedical Imaging is written. Featuring contributions from leading experts in the field, this authoritative reference text helps answer the following often-asked questions: Can imaging address my question? Which technique should I use? How does it work? What information does it provide? What are its strengths and limitations? What applications is it best suited for? How can I analyze the data? By explaining what each imaging technology can measure, describing major methods and approaches, and giving examples demonstrating the rich repertoire of modern biomedical imaging to address a wide range of morphological, functional, metabolic, and molecular parameters in a safe and noninvasive manner, Essentials of In Vivo Biomedical Imaging helps scientists and physician-scientists choose and utilize the appropriate in vivo imaging technologies and methods for their research.