This is an excellent introduction for graduate students and nonspecialists to the field of mathematical and computational neurosciences. The book approaches the subject via pulsed-coupled neural networks, which have at their core the lighthouse and integrate-and-fire models. These allow for highly flexible modeling of realistic synaptic activity, synchronization and spatio-temporal pattern formation. The more advanced pulse-averaged equations are discussed.

From x-rays to lasers to magnetic resonance imaging, developments in basic physics research have been transformed into medical technologies for imaging, surgery and therapy at an ever-accelerating pace. Physics has joined with genetics and molecular biology to define much of what is modern in modern medicine and allied health. Covering a wide range of applications, Introduction to Physics in Modern Medicine, Third Edition builds further on the bestselling second edition. Based on the courses taught by the authors, the book provides medical personnel and students with an exploration of the physics-related applications found in state-of-the-art medical centers. Requiring no previous acquaintance with physics, biology, or chemistry and keeping mathematics to a minimum, the application-dedicated chapters adhere to simple and self-contained qualitative explanations that make use of examples, illustrations, clinical applications, sample calculations, and exercises. With an enhanced emphasis on digital imaging and computers in medicine, the text gives readers a fundamental understanding of the practical application of each concept and the basic science behind it. This book provides medical students with an excellent introduction to how physics is applied in medicine, while also providing students in physics with an introduction to medical physics. Each chapter includes worked examples and a complete list of problems and questions. That so much of the technology discussed in this book was the stuff of dreams just a few years ago, makes this book as fascinating as it is practical, both for those in medicine as well as those in physics who might one day discover that the project they are working on is the basis for the next great medical application. Features: * Introduces state-of-the-art and emerging medical technologies such as optical coherence tomography, x-ray phase contrast imaging, and ultrasound-mediated drug delivery * Covers hybrid scanners for cancer imaging and the interplay of molecular medicine with MRI, CT and PET in addition to intensity-modulated radiation therapy and new forms of cancer treatments such as proton and heavy-ion therapies * Offers an enhanced emphasis on digital imaging and dosimetry including recent innovations in the pixel-array x-ray detectors, ultrasound matrix transducers and direct-ion storage dosimeters

Nowadays we are facing numerous and important imaging problems: nondestructive testing of materials, monitoring of industrial processes, enhancement of oil production by efficient reservoir characterization, emerging developments in noninvasive imaging techniques for medical purposes - computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), X-ray and ultrasound tomography, etc. In the CIME Summer School on Imaging (Martina Franca, Italy 2002), leading experts in mathematical techniques and applications presented broad and useful introductions for non-experts and practitioners alike to many aspects of this exciting field. The volume contains part of the above lectures completed and updated by additional contributions on other related topics.

The second in a three-volume set exploring Problems and Solutions in Medical Physics, this volume explores common questions and their solutions in Nuclear Medicine. This invaluable study guide should be used in conjunction with other key textbooks in the field to provide additional learning opportunities. Topics include radioactivity and nuclear transformation, radionuclide production and radiopharmaceuticals, non-imaging detectors and counters, instrumentation for gamma imaging, SPECT and PET/CT, imaging techniques, radionuclide therapy, internal radiation dosimetry, and quality control and radiation protection in nuclear medicine. Each chapter provides examples, notes, and references for further reading to enhance understanding. Features: Consolidates concepts and assists in the understanding and applications of theoretical concepts in medical physics Assists lecturers and instructors in setting assignments and tests Suitable as a revision tool for postgraduate students sitting medical physics, oncology, and radiology sciences examinations

MRI Physics for Radiologsits: A Visual Approach, Third Edition delineates the principles of magnetic resonance imaging in a format that can be understood by readers who do not have a sophisticated physics or mathematics background. It is organized in three sections: sections one and two present the contrast and spatial characteristics of the image; section three deals with topics such as Half Fourier imaging, motion, aliasing, artifacts, and coils. The third edition has sections on new techniques now in common use, such as rectangular field of view and fast spin-echo (or echo-planar) sequences, a chapter on the effect of MR equipment parameters on image resolution, a chapter with a simplified mathematical discussion of the Fourier transform and an enhanced section on magnetic resonance angiography.

Das vorliegende Werk bietet eine im deutschsprachigen Raum einzigartige, umfassende und aktuelle Darstellung der Medizinischen Physik. Es liefert damit das Fundament fur die Anwendung physikalischer Methoden in der Medizin, der Entwicklung neuer oder verbesserter Verfahren zur Untersuchung und Behandlung von Patienten sowie fur die Bereitstellung und den Einsatz physikalischer Methoden in der klinischen Anwendung. Es unterstutzt als Lehrbuch den Bedarf nach einer systematischen medizinphysikalischen Aus- und Weiterbildung von Physikern, die an medizinischen Einrichtungen tatig sind. Das Buch orientiert sich am Stoffkatalog der Deutschen Gesellschaft fur Medizinische Physik (DGMP) und legt den Schwerpunkt auf die Medizinische Physik in der Radiologie und Radioonkologie. Das Werk ist in funf Teile unterteilt: * In Teil I werden die Grundlagen der Strahlenphysik, der biostatistischen Methoden, der Medizinischen Informatik, der organisatorischen und rechtlichen Aspekte sowie des Strahlenschutzes abgehandelt. * Teil II behandelt die radiologische Diagnostik und umfasst die bildgebenden Verfahren der Roentgendiagnostik, der Roentgen-Computertomographie, der Magnetresonanztomographie sowie des Ultraschalls. * Teil III beschreibt die Methoden der nuklearmedizinischen Diagnostik und Therapie. * In Teil IV wird die Medizinische Physik der Strahlentherapie in vertiefter Form dargestellt. * Teil V beschreibt ausgewahlte Themen aus dem Gebiet der Medizintechnik. Zu allen Teilen werden UEbungsaufgaben und Kontrollfragen angeboten, mit denen der Leser das Gelernte uberprufen kann. Erganzend werden auf einer Website Musterloesungen, zusatzliches vertiefendes Text- und Bildmaterial sowie Animationen und Videos zur Verfugung gestellt. Das Buch versteht sich als Lehrbuch und Nachschlagewerk, das begleitend zu Weiterbildungsveranstaltungen und Studiengangen oder auch zum Selbststudium auf dem Gebiet der Medizinischen Physik eingesetzt werden kann. Es basiert auf dem Heidelberger Weiterbildungskurs "Medizinische Physik fur Physiker" und richtet sich vornehmlich an Physik-Absolventen und Naturwissenschaftler mit grundlegenden physikalischen Kenntnissen. Die Herausgeber sind als Wissenschaftler am Deutschen Krebsforschungszentrum (dkfz) tatig und lehren als Professoren fur Medizinische Physik an der Universitat Heidelberg.

This is the first text specifically designed to train potential health physicists to think and respond like professionals. Written by a former chairman of the American Board of Health Physics Comprehensive Panel of Examiners with more than 20 years of professional and academic experience in the field, it offers a balanced presentation of all the theoretical and practical issues essential for a full working knowledge of radiation exposure assessments. As the only book to cover the entire radiation protection field, it includes detailed coverage of the medical, university, reactor, fuel cycle, environmental and accelerator areas, while exploring key topics in radiation basics, external and internal dosimetry, the biological effects of ionizing radiation, and much more besides.

Backed by more than 500 worked examples developed within the context of various scenarios and spanning the full spectrum of real-world challenges, it quickly instills in readers the professional acumen and practical skills they need to perform accurate radiation assessments in virtually any routine or emergency situation.

The result is a valuable resource for upper-level students and anyone preparing to take the American Board of Health Physics Comprehensive Examination, as well as for professionals seeking to expand their scope and sharpen their skills.

This book examines the health effects of exposure to static electric and magnetic fields found in selected industries, such as medical facilities with magnetic resonance imaging (MRI), high-energy physics research facilities and some transportation systems. To date, research on their health effects lags far behind the rapid advances in technology. Electric and magnetic fields are generated by natural phenomena such as the Earth s magnetic field, thunderstorms, and by man-made sources that use electricity. When such fields do not vary with time they are referred to as static. For static electric fields, studies carried out to date suggest that the main effect is discomfort from electric discharges to the body. For static magnetic fields, acute effects are only likely to occur when there is movement of a person in the field. For example, a person moving within a relatively high field can experience sensations of vertigo and nausea, and sometimes a metallic taste in the mouth and perceptions of light flashes. Although only temporary, such effects may have a safety impact for workers executing delicate procedures, e.g. surgeons performing operations within MRI units. Even when at rest, a person will experience internal body movement, such as blood flow or heart beat. When placed within a high magnetic field, electrical fields and currents are generated around the heart and major blood vessels that can impede the flow of blood. Possible effects range from minor changes in heartbeat to an increase in the risk of abnormal heart rhythms that might be life threatening."

Bone is a complex biological material that consists of both an inorganic and organic phase, which undergoes continuous dynamic biological processes within the body. This complex structure and the need to acquire accurate data have resulted in a wide variety of methods applied in the physical analysis of bone in vivo and in vitro. Each method has its own strengths and applications depending on the information sought by the clinician or researcher.
The Physical Measurement of Bone provides a detailed description of all the major methods of bone analysis, including brief comments on clinical evaluation. The physics of each method are introduced as well as a summary of practical procedures. The book is essential reading for practicing medical physicists and technicians who need to know about the many methods of bone analysis open to them, and, more importantly, the wide coverage provides a good introductory framework for students of medical physics and biomedical engineering.

This comprehensive and topical volume presents a number of significant advances on many fronts in this area of research, particularly emphasizing current and future biomedical applications of electromagnetic fields.

Each year, the Annual BCI Research Award recognizes the top new projects in brain-computer interface (BCI) research. This book contains summaries of these projects from the 2017 BCI Research Award. Each chapter is written by the group that submitted the BCI project that was nominated, and introduction and discussion chapters provide supporting information and explore trends that are reflected in the annual awards each year. One of the prominent trends in recent years has been BCIs for new patient groups, and many chapters in this book present emerging research directions that might become more prevalent in the near future.

Physics in Biology and Medicine, Fourth Edition, covers topics in physics as they apply to the life sciences, specifically medicine, physiology, nursing and other applied health fields. This is a concise introductory paperback that provides practical techniques for applying knowledge of physics to the study of living systems and presents material in a straightforward manner requiring very little background in physics or biology. Applicable courses are Biophysics and Applied Physics. This new edition discusses biological systems that can be analyzed quantitatively, and how advances in the life sciences have been aided by the knowledge of physical or engineering analysis techniques. The volume is organized into 18 chapters encompassing thermodynamics, electricity, optics, sound, solid mechanics, fluid mechanics, and atomic and nuclear physics. Each chapter provides a brief review of the background physics before focusing on the applications of physics to biology and medicine. Topics range from the role of diffusion in the functioning of cells to the effect of surface tension on the growth of plants in soil and the conduction of impulses along the nervous system. Each section contains problems that explore and expand some of the concepts. The text includes many figures, examples and illustrative problems and appendices which provide convenient access to the most important concepts of mechanics, electricity, and optics in the body. Physics in Biology and Medicine will be a valuable resource for students and professors of physics, biology, and medicine, as well as for applied health workers.

This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational EEG analysis from a single, well-organized resource. Following a brief introduction to the principles of EEG and acquisition techniques, the book is divided into two main sections. The first of these covers analysis methods, beginning with preprocessing, and then describing EEG spectral analysis, event-related potential analysis, source imaging and multimodal neuroimaging, and functional connectivity analysis. The following section covers application of EEG analysis to specific fields, including the diagnosis of psychiatric diseases and neurological disorders, brain-computer interfacing, and social neuroscience. Aimed at practicing medical specialists, engineers, researchers and advanced students, the book features contributions from world-renowned biomedical engineers working across a broad spectrum of computational EEG analysis techniques and EEG applications.

Concepts of Mathematical Physics in Chemistry: A Tribute to Frank E. Harris - Part B, presents a series of articles concerning important topics in quantum chemistry, including surveys of current topics in this rapidly-developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology.

The first section of this volume corresponds to courses on the cytoskeleton, its various structures and its dynamics, especially during the cell cycle. The reductionist approach is favoured in this field and considerable effort is spent on finding out how these structures are built up from their component molecules, how they grow or decrease in size, how they interact with each other and with other cell components. The second section describes the endo membrane system of a eukaryotic cell and the regulated protein traffic that flows through it. Part III deals with the onset of higher levels of organization. Topics covered include the development of the central nervous system, the role of time in biology and theoretical models to describe biochemical and cellular oscillations. The volume concludes with a reflection on physics and biology and the author shares some of his thoughts on the different ways in which physicists and biologists tackle problems in their respective fields.

Urologists have long used urinary stents in patients who have - or who are at risk of developing - an obstruction or blockage of the kidney. These rodlike devices are inserted into the ureter to keep the canal open or to help with healing after trauma, surgery or radiotherapy. More recently the use of stents for the prostate and urethra has also become more widespread, despite poor results in first generation models. Constant development has led to the introduction of second generation stents with a variety of designs, materials and coatings. These have gone a long way to counter the traditional side effects such as irritation, hematuria, infection and encrustation. Handbook of Urinary Stents has been written to provide urologists with a practical guide to the various new models for stenting. The book describes the various stents available; the criteria for their selection; their clinical application and potential complications of use. At the same time, the book provides thorough descriptions of relevant physiology and pathophysiology for those requiring deeper understanding of the subject. Key Points Provides a comprehensive, timely review for urologists needing an accessible guide to the range of stents available Chapters highlight the use of stents in special populations such as children and patients with transplanted ureter Emphasis on clinical complications following the use of stents and how to manage them effectively

Das Aachener Steinkohlengebiet zeichnet sich im Vergleich zu den Steinkohlen lagerstiitten des niederrheinisch-westfiilischen Gebietes durch eine groBe tek tonische und stratigraphische Mannigfaltigkeit aus. Trotz jahrelanger Forschungen auf dies em Gebiet ist es auch heute noch in der Praxis nicht moglich, eine sichere Identifizierung der FlOze an Hand einfacher Untersuchungsmethoden vorzuneh men. Eine gleichmiiBige Ausbildung der Gesteinsschichten ist nur flir regional eng begrenzte Riiume zu erwarten, und die Aufstellung eines fiir das gesamte Gebiet giiltigen Normalprofils ist nicht moglich. Selbst die fiir einzelne Gruben angefertig ten Schichtenprofile lassen nur anniiherungsweise Schliisse auf die Ablagerungsfol ge in diesem beschriinkten Gebiet zu. In der Hoffnung, weitere, bisher nicht beriicksichtigte, charakteristische Merk male der Gesteine aufzuspiiren, die moglicherweise zur Identifizierung der FlOze herangezogen werden konnten, wurden die Untersuchungen der Radioaktivitiit der Sedimente im Aachener Raum begonnen. In den letzten Jahren wurden eine Reihe von Arbeiten, die sich mit Radioaktivitiits messungen befassen, veroffentlicht. So beschrieb KOHL in seiner Monographie iiber das Vorkommen von Uran ( 17], 1954) und anderen Aufsiitzen ( 19], 1951) die Bemiihungen franzosicher Wissenschaftler urn die Auffindung mariner Hori zonte mittels Radioaktivitiitsmessungen. Marine Schichten weisen im Gebiet von Valenciennes eine bis zu zehnfach hoheren Radiumgehalt als nichtmarine Sedi mente auf. Als Grund fiir diese Erscheinungen werden sekundiire Absorptions effekte von Uran an Tonmineralien bzw. die Ausfiillung von Radium aus dem Meerwasser wiihrend der Sedimentation ( 18], 1951) angenommen."

Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfangen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen fur die historische wie auch die disziplingeschichtliche Forschung zur Verfugung, die jeweils im historischen Kontext betrachtet werden mussen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

3 der Spannung durchdringender, harter werden, ist also ebenfalls eine Folge der Quantengleichung (vgI. ds. Handb., 2. Auf I., Bd. XXIII/2, Kap. 2). Der lichtelektrische Effekt im Rontgengebiet, d. h. die Auslosung sekundarer Elektronen durch monochromatische Rontgenstrahlen, ist bisher noch nicht zur genauen Bestimmung von h verwertet worden. Zwar ist die beim lichtelektrischen Effekt im optischen Gebiet wesentliche "Austrittsarbeit" P von wenigen Volt gegeniiber der nach vielen tausend Volt zahlenden Geschwindigkeit der Elek tronen, die die Rontgenstrahlen erzeugen, nur eine unbedeutende Korrektions groBe; dafiir tritt aber die Ablosearbeit der fest ans Atom gebundenen, inneren Atomelektronen in Wirksamkeit, die von ahnlicher GroBe wie die Quanten energie h. y der aus16senden Rontgenstrahlen ist. Die groBte Intensitat der sekundaren Elektronen besitzen gerade die festgebundenen Elektronen, fiir deren Abtrennung die wirksame Quantenenergie eben hinreicht; zugleich treten aber auch Elektronen aus dem bestrahlten Korper aus, die aus anderen Energie stufen des Atoms stammen, und es ist bisher noch nicht gelungen, die Geschwindig keit der entstehenden, verschieden schnellen Elektronen so genau zu messen, daB die hieraus abgeleitete h-Bestimmung an die Genauigkeit der anderen Me 1 thoden heranreichte Auch die ElektronenstoBmethode ist im Rontgengebiet prinzipiell anwendbar. Es ist niimlich, ahnlich wie im optischen Gebiet, eine durch die Quantengleichung scharf bestimmte Geschwindigkeit der Elektronen erforderlich, urn die Rontgen spektrallinien zu erzeugen, allerdings entstehen alle Linien einer "Serie" (z. B. der K-Serie) auf einmal, wenn die kiirzestwellige Linie dieser Serie erregt wird."