An Introduction to Aquatic Toxicology is an introductory reference for all aspects of toxicology pertaining to aquatic environments. As water sources diminish, the need to understand the effects that contaminants may have on aquatic organisms and ecosystems increases in importance. This book will provide you with a solid understanding of aquatic toxicology, its past, its cutting-edge present and its likely future. An Introduction to Aquatic Toxicology will introduce you to the global issue of aquatic contamination, detailing the major sources of contamination, from where they originate, and their effects on aquatic organisms and their environment. State-of-the-art toxicological topics covered include nanotoxicology, toxicogenomics, bioinformatics, transcriptomics, metabolomics, as well as water management and the toxicological effects of major environmental issues such as algal blooms, climate change and ocean acidification. This book is intended for anyone who wants to know more about the impact of toxicants on aquatic organisms and ecosystems, or to keep up to date with recent and future developments in the field.

This book provides an overview of Asphyxial Deaths which includes hanging, strangulation, choking, smothering, gagging, drowning, aspiration, mechanical and chemical asphyxiants, etc. Postmortem examination often leads to doubts as a clear distinction between the different type of asphyxia cannot be made easily. Forensic and physiological aspects are discussed with the help of illustrative cases. The author discusses the different aspects of asphyxia deaths and substantiates multiple case studies to establish a scientific approach that can act as a guideline to the autopsy surgeon in providing a precise opinion and clarify doubts for the judiciary involved in such criminal justice cases. Key Features * Presents individual case studies of Asphyxial deaths. * Covers the guidelines to be followed by the autopsy surgeons in different cases. * Discusses the physiological aspects of Asphyxial deaths in detail. * Illustrates the cases in a stepwise manner with more than 350 colored photographs of postmortem examination.

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.

A mycotoxin is a toxin produced by a fungus under special conditions of moisture and temperature. These fungi are aerobic and microscopic and, moreover, may colonize many kinds of food from the field to the table. Mycotoxins are not only a spoilage issue for food, but in high doses can be a serious health threat for humans. The book will be similar to Weidenborner's previous two books - "Mycotoxins in Feedstuffs" and "Mycotoxins in Foodstuffs" - in that it will be a review of the literature to create a comprehensive reference for mycotoxin levels. It will be his third (and last) book on the topic, this time focusing on the incidence of a mycotoxin in humans and/or animals (natural or artificial incidence). Each entry will include contamination, concentration rate, mean concentration of organs (humans and animals) with a mycotoxin, as well as sample constitution (where possible) and country of origin of the sample.

This book provides a structured account of the existing knowledge of toxic algae, the chemistry of the toxins they produce, the effects these substances exert in humans and wildlife, as well as the strategies envisaged to protect public health and the environment. It covers recent advances in the understanding of the biology of toxin producers and the factors involved in the appearance and dynamics of harmful algae blooms, the factors affecting toxin production, the synthesis of toxins both in natural producers and by chemical means in a lab, and the toxin groups posing continuing and novel hazards to living systems.

Foodborne viruses are an important group of pathogens recognized to cause significant disease globally, in terms of both number of illnesses and severity of disease. Contamination of foods by enteric viruses, such as human norovirus and hepatitis A and E viruses, is a major concern to public health and food safety. Food Virology is a burgeoning field of emphasis for scientific research. Many developments in foodborne virus detection, prevention and control have been made in recent years and are the basis of this publication. This second edition of Viruses in Foods provides an up-to-date description of foodborne viruses of public health importance, including their epidemiology and methods for detection, prevention and control. It uniquely includes case reports of past outbreaks with implications for better control of future outbreaks, a section that can be considered a handbook for foodborne virus detection, and updated and expanded information on virus prevention and control, with chapters on natural virucidal compounds in foods and risk assessment of foodborne viruses.

What do the following have in common: the promise of Botox as the key to everlasting youthful looks; E. coli O157 hamburger disease; a mysterious illness which killed 35 heroin users in 2000; and the assassination by poisoned umbrella-tip of a Bulgarian dissident in the 1970s? The answer is that all of these are caused by toxins, the powerful biological poisons released by bacteria and some plants.
In Toxin, Alistair Lax reveals the panoply of ways in which bacterial toxins overcome the defenses of our cells. He explains how they work, how they are so successful in causing major diseases, the terrible human impact they have had, and how apparently "new" diseases arise from them. He also discusses how we can combat toxins, and how we can harness their actions for beneficial purposes. Enlivened by the very human story of the persistence, rivalries, and insights from which modern microbiology grew, Toxin is the first widely accessible account of this exciting and important topic.

The purpose of "Ligand Efficiency Indices for Drug Discovery: Towards an Atlas-Guided Paradigm" is to introduce in a concise and self-contained form the concepts, ideas, applications and examples of efficiency-driven drug discovery to the biomedical community at large. The book emphasizes the use of 'new variables' and more objective numerical methods to drive drug discovery in an encompassing way. These 'new variables' are based on Ligand Efficiency Indices (LEIs) formulated in a way that permits mapping Chemico-Biological Space (CBS) in an Atlas-like representation. It provides a practical and timely discussion of the concepts, ideas, applications and examples of efficiency-driven drug discovery. This book emphasizes the use of a graphical representation and objective numerical methods to drive drug discovery more effectively. It presents the definition of LEIs and the corresponding efficiency planes within an atlas-like environment to provide a robust graphical and numerical framework for medicinal chemists and drug-discoverers.
Provides a practical and timely discussion of the concepts, ideas, applications and examples of efficiency-driven drug discoveryEmphasizes the use of new variables and more objective numerical methods to drive quicker and more effective drug discoveryPresents the definition of Ligand Efficiency Indices (LEIs) and the corresponding efficiency planes as key concepts to provide a graphical and numerical framework"

Modern technology using state-of-the-art equipment can now identify almost any toxin relevant to a legal issue. Techniques include gas chromatography, mass spectrometry, high-pressure liquid chromatography, and the combination of these methods. Forensic Toxicology: Medico-legal Case Studies demonstrates how the science of forensic toxicology acts as a bridge between medicine and law. Tracking the progression of toxicology findings from the laboratory to the courtroom, it prepares practicing toxicologists to write reports and testify at depositions and in court.

The book explains the organization of clinical laboratories and includes sections on accreditation, quality control, method validation, and other critical topics. It provides an overview of the U.S. legal system, describes the process of writing a toxicology report, and offers techniques for deposition and courtroom testimony.

Covering a broad range of topics, the book offers detailed analysis of situations ranging from the rare and unusual to those that toxicologists most often confront, including:

• Determining serum/blood ethanol levels
• Ethylene glycol poisoning
• Plant and animal toxins
• Alcohol intoxication and breathalyzer tests
• Synergistic effects of alcohol and drugs
• Prescription drug overdose
• Toxic torts
• Workers compensation issues

Written in an accessible and well-organized style, this volume is an essential guide for forensic toxicologists at all levels who need to understand how to best present the science of toxicology in the forensic arena.

Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.

The book provides easy-to-understand diverse specialized topics in toxicology using self- study questions and answers. The answers are in the form of text along with custom made diagrams and explanations that help the student audience to understand and grasp the matter easily. It is written specifically as a study guide for the toxicology board and other examinations.

The "Side Effects of Drugs Annual" was first published in 1977. It has been continually published since then, as a yearly update to the voluminous encyclopedia "Meyler's Side Effects of Drugs." Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

*Provides a critical yearly survey of new data and trends *Special reviews in this Annual include, among other topics: Epidemiology of the use of ecstasy, Paracetamol and the risk of asthma, Combination vaccines/multiple immunizations, Interactions of herbal medicines with warfarin, and Tyrosine kinase inhibitors.

The most talked about metalloid in the modern world, arsenic affects the liver, kidney, and lungs; leads to cardiovascular diseases, cancer, and diabetes; and may cause blindness with long-time exposure. With naturally occurring arsenic boosted by mining and other industrial processes contaminating soil and drinking water, arsenic toxicity is a major challenge to health professionals and scientists around the world. Arsenic Toxicity: Prevention and Treatment reviews current understanding of arsenic poisoning and the health consequences resulting from exposure. The book paints a vivid picture of the sources of arsenic toxicity including ground water; food such as rice, fruits and vegetables, fish, and chicken as well as occupational exposures from industries using inorganic arsenic such as glass production, non-ferrous alloy, wood preservation, and semiconductor manufacturing units. The text details the health hazards of arsenic toxicity and then examines removal, mainly from soil and water, highlighting eco-friendly bioremediation techniques. It discusses classical and modern treatment methods for arsenic toxicity, emphasizing the use of nutraceuticals and functional foods. With its focus on the remediation of arsenic toxicity using nutraceutical and functional food, the book provides a unique resource for combatting this global scourge. It provides strategies for defending arsenic toxicity naturally without causing any additional adverse effects.

The link between reproductive health and the environment has been strengthened by the findings of recent studies. It is becoming increasingly important to link results and data from such studies into a model that aids in the explanation of phenomena observed in the field and facilitates predictability. To this end, the aim of this book is to review recent trends and developments in the study of the impact that the environment has on human reproduction. These issues are thoroughly examined, using the most modern techniques and methods available, to analyze the manner in which both male and female fertility can be affected and assessed. Such diverse factors as toxic environmental contaminants, air pollution, and exposure to medical drugs are examined. The book includes both a historical overview and a look towards the future, aiming to integrate health concerns into policy-making and legislation.

This book will be of interest to researchers, health professionals, environmental scientists, and policy-makers.

Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk assessment of chemical substances. It illustrates each step in the process: hazard identification, a dose response assessment, and exposure assessment. The book also summarizes the basic concepts of interaction of chemicals in mixtures and discusses various approaches to testing such mixtures. Features: Addresses standards from all international regulatory agencies Presents the steps in risk assessment, including hazard identification, exposure assessment, and risk characterization Covers the assessment of multiple chemical exposures or chemical mixtures Contains data from both human and animal studies Explains the linearized multi-stage mathematical model widely used by the US EPA for characterizing

Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information.
This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks.
* Reviews some of the first really fruitful studies made in this area
* Covers different organisms ranging from humans to model species and environmental sentinels
* Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

Integrating ecotoxicological concepts across a range of hierarchical levels, Ecotoxicology: A Comprehensive Treatment focuses on the paradigms and fundamental themes of ecotoxicology while providing the detail and practical application of concepts often found in more specialized books. By synthesizing the best qualities of a general textbook and the narrower, more specific scope of a technical reference, the authors create a volume flexible enough to cover a variety of instructional vantages and thorough enough to engender a respect for the importance of understanding and integrating concepts from all levels of biological organization. Divided into six sections, the book builds progressively from the biomolecular level toward a discussion of effects on the global biosphere. It begins with the fundamentals of hierarchical ecotoxicology and vantages for exploring ecotoxicological issues. The second section introduces organismal ecotoxicology and examines effects to biochemicals, cells, organs, organ systems, and whole organisms, and bioaccumulation and bioavailability of contaminants. Population ecotoxicology, section three, places the discussion in the larger context of entire populations by analyzing epidemiology, population dynamics, demographics, genetics, and natural selection. Section four encompasses issues of community ecotoxicology. This section presents biotic and abiotic factors influencing communities, biomonitoring and community response, and the application of multimetric and multivariate approaches. Section five evaluates the entire ecosystem by describing assessment approaches, identifying patterns, analyzing relationships between species, and reviewing the effects of global atmospheric stressors. A detailed conclusion integrating the concepts discussed and promoting a balanced assessment of the overarching paradigms rounds out the coverage in section six.

This new manual provides a convenient source of experimental procedures, including the most modern and frequently used molecular and cellular techniques. Experimental protocols have been carefully selected by developmental toxicologists for developmental toxicologists. The most important new trends, such as evaluation of the safety of therapeutic antisense oligonucleotides, studies of the role of cell death in abnormal development, and the identification of sparingly expressed developmental control genes are featured. This is the perfect manual for scientists trained in classical developmental toxicology who want to add molecular and cellular methods to their research.

Furnishing essential data on all areas of toxicity testing, this "Second Edition" provides guidance on the design and evaluation of product safety studies to help ensure regulatory acceptance. Every chapter highlights regulatory requirements specific to the United States, Europe, and Japan, and in addition to expanded information on data interpretation, hazard assessment, carcinogenicity studies, and Good Laboratory Practices, new chapters regarding safety pharmacology, juvenile studies, the health safety assessment of pharmaceuticals, and health assessment strategies in the food and cosmetic industry have been added to reflect changes to regulatory requirements. "Toxicological Testing Handbook, Second Edition" is a must-have reference for individuals responsible for assuring the safety of new pharmaceutical, biotechnical, and chemical products and materials.

Key features: Serves as the detailed, authoritative source of the clinical chemistry of the most commonly used laboratory animals Includes detailed chapters dedicated to descriptions of clinical chemistry-related topics specific to each laboratory species as well as organ/class-specific chapters Presents information regarding evaluation and interpretation of a variety of individual clinical chemistry end points Concludes with detailed chapters dedicated to descriptions of statistical analyses and biomarker development of clinical chemistry-related topics Provides extensive reference lists at the end of each chapter to facilitate further study Extensively updated and expanded since the publication of Walter F. Loeb and Fred W. Quimby's second edition in 1999, the new The Clinical Chemistry of Laboratory Animals, Third Edition continues as the most comprehensive reference on in vivo animal studies. By organizing the book into species- and organ/class-specific chapters, this book provides information to enable a conceptual understanding of clinical chemistry across laboratory species as well as information on evaluation and interpretation of clinical chemistry data relevant to specific organ systems. Now sponsored by the American College of Laboratory Animal Medicine (ACLAM), this well-respected resource includes chapters on multiple laboratory species and provides pertinent information on their unique physiological characteristics, methods for sample collection, and preanalytical sources of variation for the particular species. Basic methodology for common procedures for each species is also discussed. New Chapters in the Third Edition Include: The Laboratory Zebrafish and Other Fishes Evaluation of Cardiovascular and Pulmonary Function and Injury Evaluation of Skeletal Muscle Function and Injury Evaluation of Bone Function and Injury Vitamins Development of Biomarkers Statistical Methods The Clinical Chemistry of Laboratory Animals, Third Edition is intended as a reference for use by veterinary students, clinical veterinarians, verterinary toxicologists, veterinary clinical pathologists, and laboratory animal veterinarians to aid in study design, collection of samples, and interpretation of clinical chemistry data for laboratory species.

and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.

A compilation of published scientific information, including human, animal, cellular, and theoretical studies, Depleted Uranium: Properties, Uses and Health Consequences provides the most current and comprehensive collection of information on depleted uranium health hazards. The editor and her international panel of contributors are clinical and basic researchers at the forefront of toxicology, carcinogenesis, and human epidemiology. They review key findings on DU biological and health effects and comprehensively describe the research progress made during the last 11 years. The book's coverage ranges from cellular malignant transformation and carcinogenesis to animal toxicity and neurotoxicity, and concludes with human medical surveillance studies, uranium measurement methodologies, risk modeling, and environmental modeling. The chapters provide information on cellular and animal studies, in vivo carcinogenesis, risk modeling, uranium measurement methodologies, medical surveillance programs, and environmental monitoring. Focusing on current, peer-reviewed data, this volume is the only available compilation book on the current understanding of the potential health hazards of depleted uranium exposure.

Botulinum toxin A is a remarkably versatile treatment with a steadily expanding list of indications, which include strabismus, hemifacial spasm, focal dystonias such as spasmodic torticollis, dysphonia and writer's cramp, as well as adult and childhood spasticity. Recent innovations include its use in some types of pain, in autonomic and gastrointestinal disorders, and in cosmetic medicine, such as hyperhidrosis, hypersalivation, rectal fissure, achalasia and facial wrinkles. Botulinum toxin is arguably the safest and most effective treatment in movement disorders since the introduction of levodopa, and is an increasingly important option in many other fields.

The long-awaited second edition of the Handbook of Botulinum Toxin Treatment brings the reader up to date with the many advances in background knowledge and in clinical practice in both the established and the newer indications, including the use of a second serotype botulinum toxin B.

The book is an introduction and practical guide for doctors and paramedical staff who use botulinum toxin or who may want to refer patients or care for patients being treated elsewhere. Initial chapters provide historical and general information. The rest of the book concentrates on the different conditions treated with botulinum toxin. Chapters follow a standard format with a pragmatic approach based on the wide experience of the authors.

Review from Doody's Review Service - A five star rating!

Description: This is a well-written and well-illustrated book that elegantly details the utility of botulinum toxin in treating a variety of neurological conditions.

Purpose: The authors have created a superb, well-edited bookthat details the practical aspects of selecting patients for botox injections as well as technique and possible adverse effects.

Audience: Any physician who plans to use botox in his or her practice -- whether for spasticity, dystonia, pain, or cosmetic purposes will want to read and own this book.

Features: This book is well written and well edited. It consists of 18 contributions from authorities in the field. The first five contributions delineate the discovery of botox and its mechanism of action. The next nine chapters describe in detail the use of botox in a variety of movement disorders including blepharospasm, tics, dystonia, spasticity, and tremor. Two chapters deal with treatment of autonomic disorders with botox and the book concludes with three chapters on use of botox for pain, strabismus, and cosmetic purposes.

Assessment: This is a superb book that combines theory with practical application. It is easy to read and filled with useful drawings. Any physician who wishes to use botox in his or her practice will want to have this book.

Score: Weighted Numerical Score: 99

This sixth volume in this established series deals with the biochemical responses of fish to different environmental/ecological factors. Environmental Toxicology captures vital issues affecting the responses of fish to the chemical surroundings of their environment. Chapters included in this volume identify the systems found in fish to deal with xenobiotics, hormonal interactions initiated in the presence of these chemicals, the unique mechanisms used by fish to adjust to the present chemicals, and the new and evolving mixtures of chemicals in their environment. Also included, is a crucial review of the new methods being applied in fish systems to understand the effects of xenobiotics to fish fitness - a key theme in environmental health and critical to the future of fish populations.
* Entirely new topic discussion and most recent volume in the acclaimed series
* Includes chapters detailed on a cellular level
* Introduces discussion of pharmaceutical effects on fish

Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.