Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Discover fresh perspectives on alcoholism treatment and research with this enlightening new book describing the work of researchers at the Novosibirsk Medical Institute, USSR. By using specific examples of their studies in Siberia, the reserachers offer an innovative approach to the treatment of addictive disorders in general. Instead of focusing on the drinking behavior itself, the treatment focuses on the relation of the problem to the interaction of economic, social, and psychological factors. To address the question of whether alcoholics should all be treated in the same way, or if alcholism treatment should be more individualized in approach, chapters are devoted to the differences between alcoholism in women, adolescents, and alchoholics who are afflicted with "rapid development of alcholism syndrome." The research examples in Addictive Disorders in Arctic Climates benefits professionals involved in the treatment of alcholism by introducing new perspectives and broadening contemporary research.

A compilation of questions with answers for students of toxicology. The questions are a mixture of short answer, problem-solving, data interpretation and multiple choice and cover all the major areas of toxicology.

Providing material for practitioners and students alike, Chemical Exposure and Toxic Responses is a clear and straightforward presentation of industrial toxicology.
Exposure to toxic chemicals is of major concern to health professionals. In recent years, the scope and importance of hazardous materials toxicology has expanded and now impacts financial institutions, government, private corporations, and many other organizations as well. Chemical Exposure and Toxic Responses presents the myriad health implications of hazardous chemicals in a single source. This book is organized so that readers can proceed from a general perspective on the problem of chemical exposure and toxic responses to an understanding of toxicology and a method of inquiry.
Written for anyone who needs practical toxicological information, the book compactly and efficiently presents the scientific basis of toxicology as it applies to the workplace. It covers the diverse chemical hazards encountered in the work environment and provides a practical understanding of these hazards for those charged with protecting the health and well being of people at work.
Chemical Exposure and Toxic Responses consists of three parts: Part I establishes the general principles of industrial toxicology; Part II addresses specific effects of toxic agents on specific physiological organs and systems; and Part III is devoted to the evaluation of hazards in the workplace.

This excellent book is a concise yet thorough examination of the important and emerging field of the study of biological risk factors in drug abuse. Historically, drug abuse research has concentrated on the contributions of environmental and behavioral factors as the major influences on addiction. The revelatory studies in this volume examine the genetic contributions to drug taking behavior through the use of animal models, cellular experiments and human clinical studies. Behavioral and Biochemical Issues in Substance Abuse provides for the first time in one volume, up-to-date, easily digested reviews of topics concerning biological and genetic factors in drug abuse. Medical researchers in all areas of alcoholism and drug abuse, researchers in pharmacology, psychology, psychiatry and neuroscience, and clinicians interested in biological approaches to alcoholism and drug abuse problems will benefit greatly from this valuable resource. Authoritative contributors clearly demonstrate the capability of genetic factors to modulate the reinforcing or rewarding effects of drugs, thereby altering their addictive potential. In addition to gaining comprehension of the biological factors affecting addiction, a greater understanding of genetics related to drug abuse will enable future research to control biological factors, leading to more accurate studies of behavioral and environmental influences on drug and alcohol abuse.

Provides up-to-date, objective analyses of important topics, based on the work of a triumvirate: the author, an acknowledged authority in the field; the referee, capable of undertaking a critical appraisal of the strengths and weaknesses of the review; and the editor who attempts to ensure that the crucial issues of special importance are given adequate attention.

Contents:
An introduction to inhalation toxicology; Inhalation exposure systems; Generation and characterization of gases and vapours; Generation and characterization of test atmospheres: particles and droplets; Morphology of the respiratory tract; Lung biochemistry and intermediary metabolism; Metabolic characteristics of the respiratory tract; Deposition and clearance of inhaled particles; Pulmonary retention of particles and fibres: biokinetics and effects of exposure concentrations; Regional deposition of inhaled reactive gases; Factors modifying the disposition of inhaled organic compounds; Carcinogenic responses of the respiratory tract to inhaled toxicants; Assessment of pulmonary function and the effects of inhaled toxicants; Immunological responses of respiratory tract to inhaled materials; Biological markers in the respiratory tract; Role of cytocines in pulmonary inflammation and fibrosis; Applications of behavioural measures to inhalation toxicology; Non-carcinogenic responses of the respiratory tract to inhaled toxicants; Risk assessment for inhaled toxicants.

The Handbook of Clinical Toxicology of Animal Venoms is the first concise, one-volume book devoted to this important subject. The editors are internationally recognized authorities in the biology and clinical aspects of venomous and poisonous animals, and the chapter authors are world leaders in their respective fields of toxicology.
All aspects of the topic are covered including information on the biology and taxonomy of poisonous animals, their venom or poison, diagnosis, and general treatment principles and specific treatment. The most up-to-date list of available antivenoms is provided. Coverage of venomous and poisonous animals is comprehensive, with thorough discussions on shellfish poisoning, ciguatera, fugu, coelenterates, stingrays, venous fish, blue-ringed octopus, sea-snakes, scorpions, spiders, insects, and gila lizards. Individual chapters focus on snakes and snakebite in Europe, Africa, Asia, Australia, North America, Central America, and South America. Nearly all clinical chapters have been written by clinicians with extensive experience treating the particular type of animal envenoming or poisoning under consideration.
No other book brings together such a wealth of information in this field, and no other book provides it in a format useful to clinicians charged with the responsibility of treating envenomed or poisoned patients. The Handbook of Clinical Toxicology of Animal Venoms is an essential addition to all medical libraries, emergency departments, toxicology departments, poison information centers, and invaluable to all professionals working in these fields.

This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria, cholera, pertussis, shigellosis, tetanus, botulism and anthrax, are discussed.;The work is aimed at microbiologists, biochemists, endocrinologists, toxicologists, infectious disease specialists, pathologists, public health officials, and upper-level undergraduate and graduate students in these disciplines.

Personal Care Products and Human Health provides background, historical context and the latest research results on personal care products (PCPs) and their impact on human health and the environment. Sections provide an overview of the functions and mechanisms of action of components of personal care products, discuss environmental toxicology, outline the problems of contamination of water systems from increasing use of personal care products and the resulting toxicities to aquatic wildlife, and offer chapters written by specialists on different aspects of concern for the effects of excessive personal care product usage on human health. This is a comprehensive reference for toxicologists, environment scientists and those interested in learning about the science behind personal care products and current concerns for environmental and human health.

"Provides both historical information and the latest toxicological data on various classes of food additives--examining the production, application, and safety of numerous compounds used to enhance and preserve the quality of foods."

This work offers concise, detailed information on the toxicological properties of, and safe handling practices for, pesticides. It provides an overview of the registration process, registration procedures and supplemental registration. An alphabetic listing of over 800 chemicals, including their applications - from insecticides and growth regulators to herbicides, repellents and synergists - is provided.

Dr. Goldstein has authored more than 50 publications and co-edited two books. Her latest contribution to the field of nephrology, Mechanisms of Injury in Renal Disease and Toxicity, promotes an understanding of the pathophysiologic mechanisms mediating renal dysfunction in disease. It provides an important perspective in understanding mechanisms of chemically induced renal injury.
Over the past decade, understanding of the pathophysiologic and molecular basis of renal disease has grown tremendously. New and evolving concepts on the pathophysiology of glomerulonephritis, chronic glomerular injury, diabetic nephropathy, and acute renal failure are changing the clinical management of these disease states.

The Third Edition of this standard text has been revised and updated to reflect the most current approaches to the management of acute poisonings. The editors have taken into account the numerous changes in protocols for managing poison ingestions and have again provided under one cover an indispensable resource for all students of pharmacy and the health sciences on the basic principles of clinical toxicology. The book's unique focus on the fundamentals provides an essential understanding of the bases for events that occur and the reasons why a treatment is used or not used. Each chapter presents pertinent information on classes of toxic agents, their common sources and usual methods of intoxication, incidence and frequency of poisoning, mechanism(s) of action, clinical signs and symptoms of poisoning, and management guidance. The text includes illustrative case studies carefully selected to reinforce the information covered. Each chapter concludes with review questions to further enhance comprehension.

"This valuable resource provides detailed health and safety information on the hazardous and toxic properties of over 1,000 heavily used industrial and consumer chemicals. Lists chemicals both alphabetically and numerically according to their Chemical Abstract Service number permitting rapid access to specific data!"

Since the publication of the original edition in 1982, pesticide-related poisonings, both single cases and epidemic-scale situations, have continued to occur unabated. This new edition of Pesticides and Neurological Diseases reviews current literature describing the effects of insecticides (chlorinated hydrocarbons, organophosphorus and carbamate esters, and the pyrethroid esters), fungicides (organomercurials, dithiocarbamates), and herbicides (chlorophenoxy acids and esters) on the mammalian nervous system. Acute and chronic exposures have resulted in both subtle and serious neurological deficits in the peripheral and central nervous systems, marked by transient effects preceding those of delayed onset and of persistent duration. The chapters have been largely revised and rewritten to introduce newer theories of mechanism(s) of action studied at the laboratory bench. New findings and observations on human intoxications are included as well.
This reference will interest physicians involved in environmental medicine and occupational health, as well as graduate students and researchers in the fields of neurophysiology, pharmacology, and the toxicology of pesticides. It may also be useful to the layperson interested in learning more about chemicals routinely used in the home, garden, greenhouse, orchards, and fields.

Basic Environmental Toxicology provides a thorough, systematic introduction to environmental toxicology and addresses many of the effects of pollutants on humans, animals, and the environment. Readers are introduced to the fundamentals of toxicology and ecotoxicology, the effects of different types of toxicants, and how toxicants affect different compartments of the environment. Fundamental aspects of environmental health, occupational health, detection of pollutants, and risk assessment are discussed. The book is excellent for anyone involved in risk assessment or risk management, toxicologists, state and local public health officials, environmental engineers, industrial managers, consultants, and students taking environmental toxicology courses.

This book provides an overview of Asphyxial Deaths which includes hanging, strangulation, choking, smothering, gagging, drowning, aspiration, mechanical and chemical asphyxiants, etc. Postmortem examination often leads to doubts as a clear distinction between the different type of asphyxia cannot be made easily. Forensic and physiological aspects are discussed with the help of illustrative cases. The author discusses the different aspects of asphyxia deaths and substantiates multiple case studies to establish a scientific approach that can act as a guideline to the autopsy surgeon in providing a precise opinion and clarify doubts for the judiciary involved in such criminal justice cases. Key Features * Presents individual case studies of Asphyxial deaths. * Covers the guidelines to be followed by the autopsy surgeons in different cases. * Discusses the physiological aspects of Asphyxial deaths in detail. * Illustrates the cases in a stepwise manner with more than 350 colored photographs of postmortem examination.

Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Household Chemicals and Emergency First Aid is an essential manual that covers 386 household chemicals, discusses their hazards when mixed with other chemicals, describes the symptoms of overexposure, and provides instructions for emergency first aid treatment. The book is intended to be used in the event that label instructions on household chemicals have not been followed. It describes what may possibly happen and how to handle the situation if it does occur. Poison control centers are listed by state with phone numbers and addresses.
Because household accidents involving chemicals are so prevalent, this manual is a "must have" book for all emergency medical technicians, paramedics, and other emergency first aid providers. It is also useful for anyone wanting detailed information regarding emergency situations with household chemicals.

Since 1980 there has been an accumulation of new information concerning DNA-damage-inducible processes in eukaryotic cells. It is clear that changes in the concentrations of activities of specific protein molecules play central roles in toxicological response of cells to chemical and radiation damage to DNA. Identification of inducible proteins may be crucial in helping to explain target organ toxicity and species differences. Detection of these proteins or their mRNA's in humans may be useful in assessing human exposure or cellular injury.

Quantal response (sometimes called dose-reponse) data arise in many areas, both through experimental and observational studies. Particular emphasis is placed in this book on applications in bioassay and toxicology. For instance, data for analysis may arise from routine clinical trials, or from studies of safe doses of drugs. Throughout the material is motivated by a wide range of practical examples.

There is no current book is available in the market explaining medicinal values, toxicity responses, and other potential uses of poisonous plants exclusively. In recent years, extensive attention has been paid towards the up-gradation of medicinal and herbal plants therefore; this book includes important chapters on relevant topics. Audience - Those who are working on or have an interest in modern research especially in medicinal, herbal, and poisonous plants and is also useful for some pharmaceutical companies involved in herbal drug preparation.

A dangerous byproduct of industrial progress is often an increase of pollutants discharged into the environment. These pollutants are often harmful to plants and animals, including humans. They also damage buildings and architectural and cultural monuments. This handbook describes many of the important physico-chemical properties of inorganic and organic substances found in industrial wastes and describes their toxic effects on humans.

This book describes advances in the thinking of experts in the field of combustion toxicology through 1991. It emphasizes contributions due to the efforts of the working groups of ISO/TCQ2/SC3, along with presentation of the most up-to-date strategy for minimizing the risk of toxic hazards in fires.