Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers "General Considerations" and Volume II is devoted to "Specific Metals." A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.

Named a 'Best Book of the Year' by Kirkus Reviews 'Urgent and eye-opening, the book serves as a loud-and-clear alarm.' - The Boston Globe From an MIT scientist, mounting evidence that the active ingredient in the world's most commonly used weedkiller is contributing to skyrocketing rates of chronic disease. Glyphosate is the active ingredient in Roundup, the most commonly used weedkiller in the world. Over 300 million pounds of glyphosate-based herbicide are sprayed on farms - and food - every year. Agrochemical companies claim that glyphosate is safe for humans, animals and the environment. But emerging scientific research on glyphosate's deadly disruption of the gut microbiome, its crippling effect on protein synthesis and its impact on the body's ability to use and transport sulfur - not to mention several landmark legal cases - tells a very different story. In Toxic Legacy, senior research scientist Stephanie Seneff, PhD, delivers compelling evidence based on countless published, peer-reviewed studies - all in frank, illuminating and always accessible language. As Rachel Carson did with DDT in the 1960's with Silent Spring, Seneff sounds the alarm on glyphosate, giving you guidance on simple changes you can make right now and essential information you need to protect your health, your family's health and the planet on which we all depend. 'A game-changer that we would be foolish to ignore.' - Kirkus Reviews (starred) 'Toxic Legacy will stand shoulder to shoulder with Rachel Carson's Silent Spring. [This is] unquestionably, one of the most important books of our time.' - David Perlmutter, MD, #1 New York Times bestselling author of Grain Brain 'Dr. Seneff's work will change the way we all think about food.' - Mark Hyman, MD, New York Times bestselling author

In Infertile Environments, Janelle Lamoreaux investigates how epigenetic research into the effects of toxic exposure conceptualizes and configures environments. Drawing on fieldwork in a Nanjing, China, toxicology lab that studies the influence of pesticides and other pollutants on male reproductive and developmental health, Lamoreaux shows how the lab's everyday research practices bring national, hormonal, dietary, maternal, and laboratory environments into being. She situates the lab's work within broader Chinese history as well as the contemporary cultural and political moment, in which declining fertility rates and reproductive governance and technology are growing concerns. She also points to how toxicology in China is a transnational endeavor tied to both local conditions and international research agendas and infrastructures, which highlights the myriad scales and scope of epigenetic environments. At a moment of growing concerns about toxins, endocrine-disrupting chemicals, and climate change, Lamoreaux demonstrates that epigenetic research's proliferation of environments produces new kinds of toxic relations that impact multiple generations of humans.

Climate Change and Mycotoxins highlights the importance of the continuous study of climate change impacts on mycotoxigenic fungi and their toxins in food and feed crops. Changing climate conditions across every geographical zone greatly affect rainfall, temperature and concentration of greenhouse gases leading to loss in yield and quality of food crops. In outstanding contributions, the authors compile current evidence on the influence of climate change on mycotoxigenic fungi and mycotoxins in food crops pre- and postharvest and during storage of food and animal feed. The chemistry and biology of toxin production is revised and an outlook on control and prevention of the toxin's impact on food and animal feed is given. The editors recommend this book to mycologists, mycotoxicologists, pathologists, epidemiologists, toxicologists, physicians, veterinarians, nutritionists, the food and feed industries, legislators, analytical chemists, microbiologists, or students of these fields. * Unique compilation on the impact of climate change on mycotoxins based on observed trends over the last 10 years. * Special focus on the implications for food and feed safety. * Latest advances on prediction and prevention of mycotoxin threats to human and animal health. About the Editors Luis M. Botana Is a full Professor of Pharmacology at the University of Santiago, from 2004-2012 director of the Department of Pharmacology and former Fogarty Fellow at the School of Medicine of the Johns Hopkins University. He has been director of the European Reference Laboratory for Marine Toxins from 2004 to 2009. He is author of 25 international patents, over 300 scientific papers and editor of 10 international books. Maria J. Sainz Is an associate Professor of Agriculture and Forage Production and Conservation at the University of Santiago de Compostela. She has been a visiting scientist at the Rothamsted Experimental Station and for ten years head of the department of Plant Production. Her research interests focus on fungal pathogen detection and diagnostics, mycorrhizal fungi in crop protection and production, and mycotoxigenic fungi and mycotoxins on forage crops and animal feed.

The subject of aluminium and Alzheimer's disease has been plagued with controversy. This controversy has served to obscure much of the scientific research in this field, and subsequently has obscured the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.
This book brings together many of the world's leading scientists researching aluminium and life and contains their critical summaries on the known facts about aluminium toxicity in man and to offer an opinion on the implications of this knowledge on a link between aluminium and Alzheimer's disease. The subject areas of the chapters were chosen to reflect the myriad of ways that aluminium is known to impact upon mammalian physiology and function and range from clinical studies, through animal models of disease to the detailed biochemistry of aluminium toxicity. Chapters are also included on epidemiology and other factors involved in the aetiology of Alzheimer's.
This is the first time that this subject has been treated in such a comprehensive manner. The research detailed in each chapter, includes the latest research in the field, it has been critically appraised and this appraisal has been used by each author to present an informed opinion of its relevance to aluminium and Alzheimer's disease. The chapters are much more than reviews; they are a statement of the state of the art and of what the future may hold for research in this field. As a whole they show the high quality of research that has been carried out in our efforts to understand the toxicity of aluminium in man and that we are far away from discounting the possibility that aluminium is a contributory factor in the aetiology of Alzheimer's disease.

In the first handbook to comprehensively cover the emerging area of systems toxicology, the "Handbook of Systems Toxicology" provides an authoritative compilation of up-to-date developments presented by internationally recognised investigators. Focusing on two rapidly developing cutting edge technologies - "omics" technology and nanotechnology with special emphasis on their applications - the scope and structure reflects the multidimensional character of these areas of toxicological research. Cutting edge molecular technologies such as microarray, proteomics, metabolomics, informatics, biomarkers, in vivo and in vitro models as well as the use of these new technologies in regulatory environments are addressed. An insight into the current trends and future directions of research in this rapidly developing field is also provided, offering an excellent source of authoritative and up-to-date information for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

New online resource available now

In 2011, the content from the "Handbook of Systems Toxicology" merged with the third edition of the six-volume "General and Applied Toxicology." The result? "General, Applied and Systems Toxicology" - a new online resource combining traditional toxicology with the latest developments to present the ultimate reference in toxicology For full details visit wileyonlinelibrary.com/ref/gast

This book examines social processes that have contributed to growing pesticide use, with a particular focus on the role governments play in urban aerial pesticide spraying operations. Beyond being applied to sparsely populated farmland, pesticides have been increasingly used in densely populated urban environments, and when faced with invasive species, governments have resorted to large-scale aerial pesticide spraying operations in urban areas. This book focuses on New Zealand's 2002-2004 pesticide campaign to eradicate the Painted Apple Moth, which is the largest operation of its kind in world history, whether we consider its duration (29 months), its scope (at its peak the spraying zone was 10,632 hectares/26,272 acres), the number of sprayings that were administered (the pesticide was administered on 60 different days), or the number of people exposed to the spraying (190,000+). This book provides an in-depth understanding of the social processes that contributed to the incursion, why the government sought to eradicate the moth through aerial pesticide spraying, the ideological strategies they used to build and maintain public support, and why those strategies were effective. Urban Aerial Pesticide Spraying Campaigns will be of great interest to students and researchers of pesticides, environmental sociology, environmental history, environmental studies, political ecology, geography, medical sociology, and science and technology studies.

Comprehensive coverage of the field of toxicology which illustrates its importance to and impact on society; Uses pertinent examples, tables and diagrams to aid understanding with learning objectives, and summaries, questions and answers for each chapter; Clearly and concisely written and presented concepts for easy comprehension by toxicology, biomedical, and health science students; Examines the complex interactions associated with toxicological events; Covers effect of toxins on biological and physiological systems;

In Climate Change and Marine and Freshwater Toxins the editors have assembled contributions from a team of international experts to expand the framework for an appropriate assessment of climate change impacts on aquatic toxins. While the production of toxins by microalgae has been known for decades, establishing a factual link supported by scientific evidence is a very complex endeavor. The increasing frequency and distribution of toxic blooms for example continue to raise serious concerns regarding seafood and drinking water safety. This book compiles current evidence on the influence of climate change on the spreading of toxin producing species in aquatic systems. The chemistry and biology of toxin production is revised and an outlook on control and prevention of the toxin's impact on human and animal health is given. * Compelling quantitative evidence of complex interactions from primary toxin producers and along the food chain. * Latest advances on prediction and prevention of water toxin threats to human and animal health. * A must read for insights into aquatic toxins and their modification by climatic conditions. About the Editors Luis M. Botana Is a full Professor of Pharmacology at the University of Santiago, from 2004-2012 director of the Department of Pharmacology and former Fogarty Fellow at the School of Medicine of the Johns Hopkins University. He has been director of the European Reference Laboratory for Marine Toxins from 2004 to 2009. He is author of 25 international patents, over 300 scientific papers and editor of 10 international books. M. Carmen Louzao Is a Professor of Pharmacology at the University of Santiago de Compostela since 1997. She was a postdoctoral fellow in the National Institute of Environmental Health Sciences (NIEHS) from 1994 to 1995. She is author of over 70 scientific publications in the field of Toxicology, Biochemistry, and Immunology and 20 reviews and book chapters. Natalia Vilarino Currently teaches Pharmacology to Veterinary Medicine students and participates actively in the research activities of the Department of Pharmacology, University of Santiago de Compostela, since 2005. She was a postdoctoral fellow at the Johns Hopkins Asthma and Allergy Center for 4 years. She is author of over 50 scientific papers in the fields of Toxicology, Analytical Chemistry and Immunology.

This book examines Malaysia's ambitious reform agenda and educational landscape, drawing upon the eleven key shifts in the Malaysia Education Blueprint 2013-2025. It provides a comprehensive plan for a rapid and sustainable transformation of the Malaysian education system, and what is needed in shaping the educational reforms in Malaysia, especially post-COVID, through to 2025. The contributors to this volume - scholars, researchers and practitioners who possess a deep and embedded understanding of Malaysian education - focus on the interplay of prevailing and persistent problems, and what is needed in shaping the educational reforms in Malaysia. As a critical assessment of the Malaysian Education Blueprint reform efforts and policies, this edited book will be of particular interest to educators, scholars, and policymakers on the latest trends and challenges in Malaysian education policy.

A UN report presented to the UN Human Rights Council in 2017 recognized that, "although pesticide use has been correlated with a rise in food production, it has had catastrophic impacts" on human health and the environment. The report acknowledged that "increased food production has not succeeded in eliminating hunger worldwide because of the many interacting factors involved. Reliance on hazardous pesticides is a short-term solution that undermines the rights to adequate food and health for present and future generations." It is hoped that the knowledge available in Synthetic Pesticide Use in Africa: Impact on People, Animals, and the Environment will both enlighten the reader to present serious concerns on the use of synthetic pesticides, and motivate society to make the changes necessary for the sustainable production of safe, nutritious, and affordable food for the anticipated 250 billion inhabitants of this Earth in 2050. Key Features: * Explains the relationship of synthetic pesticides to escalating noncommunicable human and animal diseases in Africa and developing countries. * Discusses the impact of the herbicide glyphosate on the health of humans, animals, and the environment. * Reviews the disease causing mode of action of glyphosate and other synthetic pesticides on nutrient density and human and animal bodies. * Warns of the special vulnerability of children to synthetic pesticide toxicity. * Recommends needed legal initiatives to use synthetic pesticides more judiciously. The book is divided into seven (7) sections: I. General Impact, explains the general impact of synthetic pesticides on the African people, their animals, and environment. II. Human Health, covers the impact of synthetic pesticides on the human body, while III, Children's Health, focuses on the special vulnerability of children to synthetic pesticides. IV. Animal Health describes the synthetic pesticide threats to animal production and sustainability. V. Environmental Health presents the threat of synthetic pesticides to soil microbiota and sustainable remediations. VI. Control Strategies discusses biologically-based alternatives to synthetic pesticides. Finally, VII. Reglatory Control presents some legal initiatives to combat the misuse of synthetic pesticides.

First published in 1988, The Bhopal Syndrome documents one of world's worst industrial disaster: The Bhopal gas tragedy of 1984. The tragedy exposed a variety of issues plaguing rapid development such as the negligence of corporations and government, prioritizing of commercial benefits over human lives, inadequate post-disaster rehabilitation and compensation, and frightening levels of environmental pollution. The author argues that the Bhopal gas tragedy is being replicated across the globe at various intensities facilitating a dangerous normalisation. He asserts that workers and consumers should fight for their 'right to know' about working conditions, chemicals used in pesticides, the harm caused by producing such chemicals, how these chemicals end up on our food as well as the manner in which the chemicals interact in our body. Climate crisis and undeterred industrial development still haunt our reality making this book an essential read for any concerned citizen and for students of disaster management, industrial disasters, climate change, environment, toxicology and workers' rights.

This book provides an overview of Asphyxial Deaths which includes hanging, strangulation, choking, smothering, gagging, drowning, aspiration, mechanical and chemical asphyxiants, etc. Postmortem examination often leads to doubts as a clear distinction between the different type of asphyxia cannot be made easily. Forensic and physiological aspects are discussed with the help of illustrative cases. The author discusses the different aspects of asphyxia deaths and substantiates multiple case studies to establish a scientific approach that can act as a guideline to the autopsy surgeon in providing a precise opinion and clarify doubts for the judiciary involved in such criminal justice cases. Key Features * Presents individual case studies of Asphyxial deaths. * Covers the guidelines to be followed by the autopsy surgeons in different cases. * Discusses the physiological aspects of Asphyxial deaths in detail. * Illustrates the cases in a stepwise manner with more than 350 colored photographs of postmortem examination.

Statistical Models in Toxicology presents an up-to-date and comprehensive account of statistical theory topics that occur in toxicology. The attention given by statisticians to the problem of health risk estimation for environmental and occupational exposures in the last few decades has created excitement and optimism among both statisticians and toxicologists. The development of modern statistical techniques with solid mathematical foundations in the twentieth century and the advent of modern computers in the latter part of the century gave way to the development of many statistical models and methods to describe toxicological processes and attempts to solve the associated problems. Not only have the models enjoyed a high level of elegance and sophistication mathematically, but they are widely used by industry and government regulatory agencies. Features: Focuses on describing the statistical models in environmental toxicology that facilitate the assessment of risk mainly in humans. The properties and shortfalls of each model are discussed, and its impact in the process of risk assessment is examined. Discusses models that assess the risk of mixtures of chemicals. Presents statistical models that are developed for risk estimation in different aspects of environmental toxicology including cancer and carcinogenic substances. Includes models for developmental and reproductive toxicity risk assessment, risk assessment in continuous outcomes, and developmental neurotoxicity. Contains numerous examples and exercises. Statistical Models in Toxicology introduces a wide variety of statistical models that are currently utilized for dose-response modeling and risk analysis. These models are often developed based on design and regulatory guidelines of toxicological experiments. The book is suitable for practitioners or it can be used as a textbook for advanced undergraduate or graduate students of mathematics and statistics.

This book provides a comprehensive overview of the concept of "Total Exposure Health" and presents details on subject areas which make up the framework. It provides in-depth coverage of the science and technology supporting exposure and risk assessment. This includes advances in toxicology and the "-omics" as well as new techniques for exposure assessment. The book concludes with a discussion on bioethics implications, including ethical considerations related to genetic testing. Discusses advances in exposure monitoring Presents a systems biology approach to human exposures Examines how overall well-being translates to worker productivity Considers the link between work-related risk factors and health conditions Covers the study of genomics in precision medicine and exposure science Explores bioethics in genomic studies Aimed at the exposure professionals (industrial hygienists, toxicologists, public health, environmental engineers), geneticists, molecular biologists, engineers and managers in the health and safety industry as well as professionals in the public administration field.

Includes cutting edge information regarding the very lastest environmental threats to public health Provides a detailed case study based on real-world scenario that allows the reader to practice human health risk assessment Describes innovative guidance and tools to respond to chemical incidents and attacks, which facilitates the reader to tailoring a effective protection and remediation response

This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies implicated in early morbidity and mortality and disease-specific spatiotemporal, targeted, safe, and effective evidence-based personalized theranostic charnolopharmacotherapeutics to cure them. Basic DRESS and GELS principles, nanoparticles to cure chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers to curb CB molecular pathogenesis (CBMP) are described for better quality of life and longevity. Specific guidelines for environmental protection and preservation of zoological and botanical species at the verge of extinction, Triple "I" Hypothesis for mitochondrial quality control, and transcriptional regulation of CSexR and CSendoR to cure chronic diseases are presented. Novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, aging population, toxicologists, environmental protectionists, pharmaceutical industry, biomedical scientists, researchers, medical students, physicians, nurses, paramedical professionals, and global audience will be interested in this interesting book to prevent pandemics and raise healthcare awareness.

Emergency management of acute poisoning is an emergency medicine short course that equips emergency personnel to assess acutely poisoned patients rapidly and accurately. This title is also valuable to nursing staff, senior pre-hospital health professionals and general practitioners. It provides a framework within which emergency personnel can safely work without being swamped by unnecessary details. The more commonly encountered cases of poisoning are discussed with guidelines for appropriate 'syndrome based' management of unknown toxicity while further investigations are being conducted.

Toxic production, disrupted lives and contaminated bodies. Care for unacknowledged suffering, incurable cancers, and immeasurable losses. This book bears witness to the invisible disasters provoked by the asbestos market worldwide and gives a voice to the communities of survivors who struggle daily in the name of social and environmental justice. Grounded in a profound, touching ethnography, this book offers an original contribution to understanding global health disasters and grassroots health-based activism.

A UN report presented to the UN Human Rights Council in 2017 recognized that, "although pesticide use has been correlated with a rise in food production, it has had catastrophic impacts" on human health and the environment. The report acknowledged that "increased food production has not succeeded in eliminating hunger worldwide because of the many interacting factors involved. Reliance on hazardous pesticides is a short-term solution that undermines the rights to adequate food and health for present and future generations." It is hoped that the knowledge available in Synthetic Pesticide Use in Africa: Impact on People, Animals, and the Environment will both enlighten the reader to present serious concerns on the use of synthetic pesticides, and motivate society to make the changes necessary for the sustainable production of safe, nutritious, and affordable food for the anticipated 250 billion inhabitants of this Earth in 2050. Key Features: * Explains the relationship of synthetic pesticides to escalating noncommunicable human and animal diseases in Africa and developing countries. * Discusses the impact of the herbicide glyphosate on the health of humans, animals, and the environment. * Reviews the disease causing mode of action of glyphosate and other synthetic pesticides on nutrient density and human and animal bodies. * Warns of the special vulnerability of children to synthetic pesticide toxicity. * Recommends needed legal initiatives to use synthetic pesticides more judiciously. The book is divided into seven (7) sections: I. General Impact, explains the general impact of synthetic pesticides on the African people, their animals, and environment. II. Human Health, covers the impact of synthetic pesticides on the human body, while III, Children's Health, focuses on the special vulnerability of children to synthetic pesticides. IV. Animal Health describes the synthetic pesticide threats to animal production and sustainability. V. Environmental Health presents the threat of synthetic pesticides to soil microbiota and sustainable remediations. VI. Control Strategies discusses biologically-based alternatives to synthetic pesticides. Finally, VII. Reglatory Control presents some legal initiatives to combat the misuse of synthetic pesticides.

This second volume in an exciting and detailed series on contact allergens provides monographs of all 181 fragrances and 79 essential oils which have caused contact allergy / allergic contact dermatitis, including the indicators for fragrance allergy (fragrance mixes I and II and Myroxylon pereirae resin [Balsam of Peru]) and non-fragrance allergens in botanical products used in the perfume industry. The monographs present: Identification section; Contact allergy (general population, patients with dermatitis, case reports and case series); Cross-reactions; Patch test sensitization; Presence in products and chemical analyses; Other side effects (irritant contact dermatitis, photosensitivity, immediate-type reactions, systemic side effects) and more. Key Features: Presents monographs of all known fragrance chemicals and essential oils which have caused contact allergy / allergic contact dermatitis Provides a full literature review of relevant topics of allergenic fragrances and essential oils Identifies INCI and IUPAC names, synonyms, CAS and EC numbers, structural formulas, RIFM and Merck Index monographs, SCCS opinions, IFRA and EU restrictions and advises on patch testing Presents an alphabetical list of all synonyms indicating their INCI names Covers an extensive amount of information to benefit dermatologists, allergists, and non-medical professionals involved with the research, development and marketing of fragrances and essential oils