Named a 'Best Book of the Year' by Kirkus Reviews 'Urgent and eye-opening, the book serves as a loud-and-clear alarm.' - The Boston Globe From an MIT scientist, mounting evidence that the active ingredient in the world's most commonly used weedkiller is contributing to skyrocketing rates of chronic disease. Glyphosate is the active ingredient in Roundup, the most commonly used weedkiller in the world. Over 300 million pounds of glyphosate-based herbicide are sprayed on farms - and food - every year. Agrochemical companies claim that glyphosate is safe for humans, animals and the environment. But emerging scientific research on glyphosate's deadly disruption of the gut microbiome, its crippling effect on protein synthesis and its impact on the body's ability to use and transport sulfur - not to mention several landmark legal cases - tells a very different story. In Toxic Legacy, senior research scientist Stephanie Seneff, PhD, delivers compelling evidence based on countless published, peer-reviewed studies - all in frank, illuminating and always accessible language. As Rachel Carson did with DDT in the 1960's with Silent Spring, Seneff sounds the alarm on glyphosate, giving you guidance on simple changes you can make right now and essential information you need to protect your health, your family's health and the planet on which we all depend. 'A game-changer that we would be foolish to ignore.' - Kirkus Reviews (starred) 'Toxic Legacy will stand shoulder to shoulder with Rachel Carson's Silent Spring. [This is] unquestionably, one of the most important books of our time.' - David Perlmutter, MD, #1 New York Times bestselling author of Grain Brain 'Dr. Seneff's work will change the way we all think about food.' - Mark Hyman, MD, New York Times bestselling author

Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 3,"Environmental Toxicologic Pathology and Major Toxicant Classes,'' covers the toxicologic pathology of major classes of environmental toxicants. Other volumes in this work round out the depth and breadth of coverage. Volume 1, Principles and the Practice of Toxicologic Pathology, covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment. Volumes 4 and 5 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

Since 1980 there has been an accumulation of new information concerning DNA-damage-inducible processes in eukaryotic cells. It is clear that changes in the concentrations of activities of specific protein molecules play central roles in toxicological response of cells to chemical and radiation damage to DNA. Identification of inducible proteins may be crucial in helping to explain target organ toxicity and species differences. Detection of these proteins or their mRNA's in humans may be useful in assessing human exposure or cellular injury.

Quantal response (sometimes called dose-reponse) data arise in many areas, both through experimental and observational studies. Particular emphasis is placed in this book on applications in bioassay and toxicology. For instance, data for analysis may arise from routine clinical trials, or from studies of safe doses of drugs. Throughout the material is motivated by a wide range of practical examples.

A dangerous byproduct of industrial progress is often an increase of pollutants discharged into the environment. These pollutants are often harmful to plants and animals, including humans. They also damage buildings and architectural and cultural monuments. This handbook describes many of the important physico-chemical properties of inorganic and organic substances found in industrial wastes and describes their toxic effects on humans.

This book describes advances in the thinking of experts in the field of combustion toxicology through 1991. It emphasizes contributions due to the efforts of the working groups of ISO/TCQ2/SC3, along with presentation of the most up-to-date strategy for minimizing the risk of toxic hazards in fires.

This 5-volume set allows you to assess the health and environmental effects of chemicals by determining the routes of exposure of the chemical to sensitive organisms. Environmental Fate and Exposure of Organic Chemicals provides relevant facts on how individual chemicals behave in the environment and how humans and environmental organisms are exposed to the chemicals during their production, rise, transport, and disposal.
Each chemical is prepared by one of the best-known organizations in environmental fate and exposure and is peer-reviewed by a panel of expert scientists. The information on each chemical includes all experimental values and references for physical properties, all chemical fate studies, and all available monitoring data and interpretative summaries.

Although the media focus on the rise of cocaine use and the evils of its abuse, the public receives little real information about the scope of the problem and its treatment. This timely, practical, and honest volume gets to the heart of the cocaine addiction problem. Cocaine Solutions not only addresses the difficulties experienced by addicts and their families in coping with the devastating financial, emotional, and psychological toll that addiction takes, it also identifies specific sources of help that exist for addicts and their families. Both recovered drug addicts themselves, the authors discuss some of the obstacles to recovery and the ways to overcome them. Cocaine Solutions includes the stories of recovering addicts to illustrate firsthand what addicts'lives are like, giving you a better understanding of the people who are afflicted with the disease of addiction. This important book is required reading for a wide audience--cocaine addicts, potential addicts, the families of addicted or potentially addicted persons, professionals who see addiction daily in their patients, and anyone who is interested in the problem of cocaine addiction.

Polyvinylpyrrolidone is widely used in medicine, pharmaceuticals, cosmetics, foods, printing inks, textiles, and many more diverse applications. This book describes the 50 years of research, published and unpublished, on the absorption, distribution, storage, and excretion of PVP. The toxicology of PVP is critically evaluated. The author's involvement in the recent reevaluation of PVP by the Joint Expert Committee on Food Additives of the World Health Organization (WHO) and the Food and Agriculture Organization (FOA) led them to undertake this comprehensive review of all the information on the subject. This book will be invaluable for anyone who is involved with polyvinylpyrrolidone. Included is a broad review of the toxicological studies performed on PVP, including acute, subchronic, chronic, reproductive, mutagenicity, and carcinogenicity studies. There is also an appendix listing the key studies, with references, on the absorption, renal elimination, distribution, acute toxicity, subchronic toxicity, chronic toxicity, teratogenicity, mutagenicity, and carcinogenicity of PVP.

Reference to the design of new insecticides nontoxic to the environment and the public emphasizing optimal food production with greater safety. Some 30 international experts examine topics including new types of active molecules among natural products and animal toxins; insect metabolic and organ sy

This 5-volume set allows you to assess the health and environmental effects of chemicals by determining the routes of exposure of the chemical to sensitive organisms. Environmental Fate and Exposure of Organic Chemicals provides relevant facts on how individual chemicals behave in the environment and how humans and environmental organisms are exposed to the chemicals during their production, rise, transport, and disposal.
Each chemical is prepared by one of the best-known organizations in environmental fate and exposure and is peer-reviewed by a panel of expert scientists. The information on each chemical includes all experimental values and references for physical properties, all chemical fate studies, and all available monitoring data and interpretative summaries.

Discover fresh perspectives on alcoholism treatment and research with this enlightening new book describing the work of researchers at the Novosibirsk Medical Institute, USSR. By using specific examples of their studies in Siberia, the reserachers offer an innovative approach to the treatment of addictive disorders in general. Instead of focusing on the drinking behavior itself, the treatment focuses on the relation of the problem to the interaction of economic, social, and psychological factors. To address the question of whether alcoholics should all be treated in the same way, or if alcholism treatment should be more individualized in approach, chapters are devoted to the differences between alcoholism in women, adolescents, and alchoholics who are afflicted with "rapid development of alcholism syndrome." The research examples in Addictive Disorders in Arctic Climates benefits professionals involved in the treatment of alcholism by introducing new perspectives and broadening contemporary research.

This 5-volume set allows you to assess the health and environmental effects of chemicals by determining the routes of exposure of the chemical to sensitive organisms. Environmental Fate and Exposure of Organic Chemicals provides relevant facts on how individual chemicals behave in the environment and how humans and environmental organisms are exposed to the chemicals during their production, rise, transport, and disposal.
Each chemical is prepared by one of the best-known organizations in environmental fate and exposure and is peer-reviewed by a panel of expert scientists. The information on each chemical includes all experimental values and references for physical properties, all chemical fate studies, and all available monitoring data and interpretative summaries.

This excellent book is a concise yet thorough examination of the important and emerging field of the study of biological risk factors in drug abuse. Historically, drug abuse research has concentrated on the contributions of environmental and behavioral factors as the major influences on addiction. The revelatory studies in this volume examine the genetic contributions to drug taking behavior through the use of animal models, cellular experiments and human clinical studies. Behavioral and Biochemical Issues in Substance Abuse provides for the first time in one volume, up-to-date, easily digested reviews of topics concerning biological and genetic factors in drug abuse. Medical researchers in all areas of alcoholism and drug abuse, researchers in pharmacology, psychology, psychiatry and neuroscience, and clinicians interested in biological approaches to alcoholism and drug abuse problems will benefit greatly from this valuable resource. Authoritative contributors clearly demonstrate the capability of genetic factors to modulate the reinforcing or rewarding effects of drugs, thereby altering their addictive potential. In addition to gaining comprehension of the biological factors affecting addiction, a greater understanding of genetics related to drug abuse will enable future research to control biological factors, leading to more accurate studies of behavioral and environmental influences on drug and alcohol abuse.

This book addresses the three basic areas of combustion toxicology: combustion of materials, assessment of the toxicity of smoke, and understanding of hazards to humans. It is based on the papers published in the Journal of Fire Sciences during 1983-1987.

Different from other books, this unique volume presents basic toxicology principles and applications in a sophisticated yet nontechnical style. It provides an understanding of both the strengths and limitations of the discipline of toxicology and its benefits. This primer is valuable for virtually any non-toxicologist.

This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.

This book explains how the computer programs work and why and when they can be applied to problems in toxicology. It discusses the statistical models used and their applications in a general fashion. The book overviews the problems that can arise from the blind use of the statistical models.

This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses.Written by authoritative contributors who bring many years of personal laboratory/clinical experience to the book, this interdisciplinary work : presents the principlesof TDM, sampling techniques, and various instrumentation topics, including computerinterfacing, mass spectrometry, fluorescence , electrochemical detection, and bloodcollection devices . .. examines six primary classes of drugs, complete with recommendedLC procedures and emphasizing recently introduced drugs and their LC analyses. .. and documents medicolegal guidelines and laboratory management considerations,providing a contemporary assessment of today's laboratory needs.The only practical, current guide available on the subject, Therapeutic Drug Monitoringand Toxicology by Li([uid Chromatography belongs in the personal libraries of clinicaland analytical chemists and biochemists, clinical pharmacologists, clinical toxicologists,clinical pathologists, immunologists, liquid chromatographers, mass spectroscopists, laboratorydirectors, laboratory instrument manufacturers , and medical technologists. Thebook is also vital supplementary reading for advanced undergraduate and graduate-levelclinical chemistry, toxicology, clinical pathology, and liquid chromatography course.

This is the final volume in a three-volume work that has addressed the scientific methodologies relevant to clinical neurobehavioral toxicology. Volume I focused on basic concepts and methodologies in Neurobehavioral Toxicology, with Volume II focusing on the peripheral nervous system. Volume III attends to what is known about industrial and environmental chemicals, medicines, and substances of abuse and how these agents affect the central nervous system. All substances have the capacity to be toxic, depending on factors that include the physical properties of the chemical or compound, organism related variables, or interaction between the two. These substances on the other hand and as a result of these same factors might be used therapeutically or even recreationally. The difference between medicine, recreational drug, or poison depends often on a careful balance between adverse and intended effects. How to determine that a specified substance has caused harm is emphasized in the present volume by way of case examples and discussion. Illnesses and behavioral variations that compete with toxicant-induced explanations for findings in a given case, as well as the various controversies that can arise around issues of diagnosis and causal determination, are treated comprehensively in this volume.

Synergic Influence of Gaseous, Particulate, and Biological Pollutants on Human Health is a unique merger of two divergent parts. The first part is a presentation of the existing knowledge on the characteristics of basic air pollutants and their documented impact on human health. The focus is on the main gaseous, airborne particles (including fiber particles) and biological pollutants. The first part is a literature review conducted by the authors who are actively engaged in studying the described pollutants. The second part contains a study of methods used for the evaluation and prognosis of health effects to exposure to particular pollutants. Most of the chapters of this book go beyond the well-documented, solid facts and contain the authors' own evaluation of the utility and limitations of particular methods, as well as their suggestions for further studies. The reader who manages to wade through this part is sure to understand that the main drawback of the described methods is the impossibility to precisely assess the health effects of exposure to the combination of a few/many air pollutants, while one of the biggest problems is the effect of synergy. The last chapters of the book focus on the attempts to consider the effect of synergy and the analysis of the tedious work of many researchers to construct the tools enabling, to some extent, the prognosis of the health effects of simultaneous exposure to many air pollutants. The book also reveals the synergism of pollutants and social problems, reinforcing the adverse health effect of the population living not only in highly industrialized areas, but also in postindustrial areas. According to the authors, the construction of suitable tools which would at least partially allow for the evaluation of the collective impact of social factors and the conglomerate of the air pollutants on health of particular communities constitutes a great challenge and may inspire t

The third edition of the "Encyclopedia of Toxicology" presents entries devoted to key concepts and specific chemicals, and is updated to reflect current advances in the field. It contains new information on nanotoxicology, epigenetics, persistent organic pollutants, computational toxicology and bioinformatics, controversial chemicals, and much more. Along with the traditional scientific entries, new articles focus on worldwide initiatives, the potential health and environmental effects of new technologies, and the societal implications of global legal and regulatory issues.

With thoroughly updated articles, references, and resources for recommended reading, the third edition has been expanded in length, breadth, and depth, and continues to provide an extensive overview of the many facets of toxicology.
Provides easy access to content on chemicals and all core areas of toxicologyThoroughly updated with the latest advances in toxicology, including epigenetics, nanotoxicology, computational toxicology, and translational toxicology New topics include implications of global legal and regulatory issues, persistent organic pollutants, REACH, SAICM, e-waste, and many more

This book presents a review of the existing literature on natural mycotoxins to create a comprehensive reference for mycotoxin levels. Each entry includes contamination, concentration rate, mostly mean mycotoxin concentration of organs (human and animal) and country of origin of the sample. Due to the serious spoilage and health issues the presence of mycotoxins can cause, it is imperative that corresponding scientists, health institutions and the food and feed industries have a more qualified understanding of mycotoxins in living things. To this end, Natural Mycotoxin Contamination in Humans and Animals provides an excellent resource. The present book complements the series of the author's previous books, Mycotoxins in Feedstuffs and Mycotoxins in Foodstuffs, in that it is a review of the literature to create a comprehensive reference for mycotoxin levels. As with Mycotoxins and their Metabolites in Humans and Animals, the focus remains the same, but the scope now covers natural mycotoxins only. Comprehensive reference of natural mycotoxin levels in humans and animals Easy-to-use database of mycotoxins Each entry is comprehensive

Kingship and Masculinity in Late Medieval England explores the dynamic between kingship and masculinity in fifteenth century England, with a particular focus on Henry V and Henry VI. The role of gender in the rhetoric and practice of medieval kingship is still largely unexplored by medieval historians. Discourses of masculinity informed much of the contemporary comment on fifteenth century kings, for a variety of purposes: to praise and eulogise but also to explain shortcomings and provide justification for deposition. Katherine J. Lewis examines discourses of masculinity in relation to contemporary understandings of the nature and acquisition of manhood in the period and considers the extent to which judgements of a king's performance were informed by his ability to embody the right balance of manly qualities. This book's primary concern is with how these two kings were presented, represented and perceived by those around them, but it also asks how far Henry V and Henry VI can be said to have understood the importance of personifying a particular brand of masculinity in their performance of kingship and of meeting the expectations of their subjects in this respect. It explores the extent to which their established reputations as inherently 'manly' and 'unmanly' kings were the product of their handling of political circumstances, but owed something to factors beyond their immediate control as well. Consideration is also given to Margaret of Anjou's manipulation of ideologies of kingship and manhood in response to her husband's incapacity, and the ramifications of this for perceptions of the relational gender identities which she and Henry VI embodied together. Kingship and Masculinity in Late Medieval England is an essential resource for students of gender and medieval history.