Our aim in producing a colour atlas of toxicological guidelines itemize the investigations to be carried out pathology was to present a catalogue of histopathologi during the course of the study and they normally include: cal lesions which we had encountered over the years in clinical observations and behaviour; food intake and body various laboratory animal species exposed to a vast weight measurements; serum biochemistry; haema range of pharmaceuticals, agrochemicals and industrial tology; ECG and ophthalmology. At the end of a study, chemicals. While we believe a colour atlas is the ideal full macroscopic and microscopic examinations of the way to share our experiences with others, it quickly organ weight analyses together with tissues are essen became clear to us that for the atlas to be meaningful tial. By far the greater part of the material used in this the associated text must be comprehensive and contain book is from toxicity studies conducted in recent years ample literature references. and performed in compliance with the Good Laboratory The atlas is intended for both the trainee and the Practice standards of governmental regulatory bodies in experienced toxicological pathologist working with lab Europe, Japan and North America. oratory animals in the pharmaceutical, agrochemical or Toxicity studies are commonly carried out in rats, chemical environment."

Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology.

First published in 1989, this book acknowledges that new drugs, food additives and other compounds need to be carefully screened for toxic side-effects. The bulk of this study is devoted to the practical questions of 'what toxicological studies should we perform?' and 'how should we perform them?' Compounds which undergo toxicity testing may be conveniently categorised as those which are intended for administration to man and those which are not. The former include pharmaceuticals to be used medicinally or prophylactically and chemicals which are added to our food, drinks or medicine to improve their stability, appearance or palatability. Since it is on pharmaceuticals that the most comprehensive toxicological evaluations are generally performed, this book has been directed primarily towards to toxicological evaluation of potential new drugs. The principles and methodology of toxicological evaluation of other types of compounds are essentially similar.

"A Textbook of Modern Toxicology" is a unique resource that provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses in environmental, pharmacological, medical, and veterinary toxicology, this essential text features chapters written by experts who address a range of key topics.

The Fourth Edition includes additional chapters on new approaches to toxicology - molecular methods (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and systems biology - and continues the legacy of its predecessors to provide up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment, and many other areas of toxicology that help foster a solid comprehension of the field.

Also featured in the Fourth Edition are end-of-chapter questions and a Solutions Manual available separately for academic adopters.

Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: * Colour diagrams explaining how lesions are caused by either external compounds or spontaneously * The anatomic variations and background lesions of laboratory animals * Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data * A chapter on the haematology and biochemistry of laboratory animals * Full colour photographs of common macroscopic lesions encountered in laboratory animals * A comprehensive glossary

This book discusses basic principles of pharmacology and toxicology and their application to environmental problems. Topics covered include air pollution, alteration of the earth's atmosphere, water and land pollution, health and environmental effects of ionizing radiation, and the environmental and social impact of rapidly growing population. It concludes with a chapter on environmental regulatory policy.

Interest and information in the field of medical toxicology has grown rapidly, but there has never been a concise, authoritative reference focused on the subjects of natural substances, chemical and physical toxins, drugs of abuse, and pharmaceutical overdoses. "Medical Toxicology of Natural Substances" finally gives you an easily accessible resource for vital toxicological information on foods, plants, and animals in key areas in the natural environment.

This book brings together key features of the toxicology and occupational hazards of pesticides and the way their use is regulated in the main trading regions of the world. There are chapters on each of the main groups of insecticides, namely organochlorines, anticholinesterases and pyrethrins and pyrethroids. The book also covers fungicides and herbicides, as well as more specialised agents such as microbial pesticides. The risks and hazards to humans are considered, both occupational and through the consumption of contaminated foodstuffs. Additionally, clinical aspects of pesticide poisoning are discussed.

The possibility of harm from pesticide exposure has led to the development of national and international regulations governing the application of pesticides. The book describes the regulatory systems in three major economic areas: the North American Free Trade Area (USA, Canada and Mexico), the European Union and Japan.

This book should be of interest to all individuals working on the development and application of pesticides anywhere in the world. All those involved in the manufacture, regulation and toxicology of pesticides should also benefit from reading this book.

This book is dedicated to the multifaceted description of the crucial issue of arsenic contamination and its effect on human health. From soil to man, this book describes the several steps from arsenic speciation in rocks, water and environment in general, through the contamination of rice-based foods in infants diet, up to the devastating effects on human health. The axis soil-food-health raises more issues than ever imagined and the book is aimed at linking all the interdisciplinary aspects involved while giving a complementary interpretation of the phenomenon. Medical geology has recently emerged as a new discipline trying to explain the events with an interdisciplinary approach and to solve the related problems for human health. Far from being exhaustive, this book is aimed at briefly addressing the 'arsenic issue' and concerns for human health while presenting the different techniques employed for arsenic removal, from natural or polymeric adsorbents to biological filtration.

Nicotine has been developed as a medication to assist smoking cessation, and is being considered as a possible drug for long-term maintenance of non-smoking. It is also undergoing evaluation as a possible treatment for several medical disorders, including ulcerative colitis, Alzheimer's disease, Parkinson's disease, Tourette's syndrome, attention deficit disorder, spasticity, and sleep apnea. Understanding its safety and toxitity is essential for drug developers, drug regulators, and clinicians making risk/benefit decisions about long-term nicotine therapy. Research on nicotine toxicity is also relevant to ongoing research on tobacco and health aimed at understanding the role of nicotine in contributing to tobacco-induced diseases. This book reviews the current scientific understanding of the safety and toxicity of nicotine. The discussion ranges from chemistry, studies in animals and human experimental research to the results of large clinical trials. Among the topics covered are cardiovascular disease, cancer, reproductive toxicity (including fetal toxicity and Sudden Infant Death Syndrome), behavioral toxicity (including abuse liability and addiction to nicotine medication), and gastrointestinal disease. Finally, contributions explore the risks and benefits of nicotine as a medication. The authors are world-renowned experts on their respective topics. No other book addresses nicotine toxicity in the depth or breadth of this volume. A book on the cutting edge of contemporary public health discourse, Nicotine Safety is an up-to-date and lucid overview of current knowledge on the subject. It will be a necessary addition to the bookshelves of clinicians with an interest in tobacco and health, drug developers and researchers, pharmacologists and toxicologists, public health researchers and policy-makers.

"Venomous" Bites from "Non-Venomous" Snakes, Second Edition thoroughly examines the potential hazards associated with bites by non-front-fanged snakes (popularly, but inaccurately, called "rear-fanged snakes"). This diverse group contains approximately 80% of living snake species (approximately 2,900 species). A large proportion of these snakes were previously assigned to the family Colubridae but, as a consequence of expanding systematics investigations, have been split into multiple families and subfamilies. Many of these snakes produce venoms or oral secretions that contain toxins and other biologically active substances. A large variety of non-front-fanged snakes figure in the pet industry, yet little documented information or formal study of their potential medical importance has been published. Therefore, although the possible medical importance of many of these species has been subjected to speculation since the mid-19th century, there is a limited amount of useful descriptive information regarding the real hazard (or lack thereof) of this wide variety of snakes. The first edition of this book provided "one-stop shopping" by offering information regarding their possible toxicity and clinical relevance as well as recommendations for medical management of their bites. The second edition expands and updates the content with detailed information about the effects and medical management of bites by a broad representation of non-front-fanged species. The hypothetical venomous nature of some lizards considered as non-venomous such as the Komodo monitor or dragon and their allies, as well as the medical effects of their bites, is also examined. The dynamic taxonomy of advanced snakes is updated, and the bases for some of these fluid changes are discussed. Likewise, terminology is also updated in order to reflect the ongoing debates regarding the definition of "venom" and the balanced reinforcement of nonmedical criteria used to define the biological basis of the term "venomous."

ndoor Air Pollution addresses the problems arising from pollutants that all too commonly contaminate the indoor environment, including biological sources such as bacteria, fungi and molds, common combustion products, radon and other sources of radiation, solvents used in industry and the home, asbestos and dust pollution. The aim is to provide a balanced account of the health risks associated with these major pollutants and to quantify the scale of the problem on a pollution-by-pollution basis. Each chapter covers exposure levels, sources of pollution, and routes of uptake, health effects, control measures, and regulatory guidelines.

This 1992 volume addresses the problems arising from pollutants that all too commonly contaminate the indoor environment, including biological sources such as bacteria, fungi and moulds, common combustion products, radon and other sources of radiation, solvents used in industry and the home, asbestos and dust pollution. The aim is to provide a balanced account of the health risks associated with these major pollutants and to quantify the scale of the problem on a pollutant-by-pollutant basis. Each chapter covers exposure levels, sources of pollution and routes of uptake, health effects, control measures, and regulatory guidelines.

For most of us, life is spent in one vast electromagnetic field. In the office we sit in front of computer terminals, at home, in front of the television. We cook our meals in microwave ovens, trim our hedges with electric shears, illuminate our houses, workplaces, and streets with incandescent and fluorescent lighting. And until only recently, the potential hazards imposed by life in the shadows of high-voltage power lines have hardly been considered. First published in 1973, Power Over People was the first book to address the frightening potential side effects of our dependence on electrical energy. Now brought up to date with a new introduction, and including an epilogue that offers the most current studies and findings available today, this classic book is more timely than ever. Louise Young here lays bare the short-sighted, materialistic policies of the electric power industry, showing how power and the conglomerates that produce it have clearly won out over rights and safety concerns of people. She provides disturbing documentary evidence that demonstrates how long-term exposure to radiation from power lines can cause brain cancer, childhood leukemia, as well as damage to the nervous system. Through the course of the book we come to understand that what is often blindly accepted as "progress" can mean the inexorable advance of environmental destruction and the withering-rather than enhancing-of the quality of life in America. Based on a case-study of a small, rural community in Ohio, Young shows in compelling fashion what happens when a grass-roots group of concerned citizens resists the construction of the world's largest electrical transmission towers, literally in their own backyards. Her story of their ultimate failure becomes a stinging indictment of indifferent government agencies and the lax laws that fail to protect the environment. Lively, readable, and, at times, even shocking, this is a book for environmentally-minded and safety-conscious readers of the 1990s. Its wealth of information, its incisive analysis, and its bold confrontation of facts we can no longer afford to ignore make Power Over People a book everyone should read and reflect upon.

This book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypothetical case studies. Toxicological Risk Assessment for Beginners aims not to create an expert, but rather to provide readers with their first understanding of the risk assessment topic. This book was designed with the student in mind. We simplify a complex process for beginners and balance theory with practical aspects, but remain fluid enough to increase difficulty with case studies. By incorporating an action based, step by step approach to learning the risk assessment process, this book provides its readers with an elementary understanding of how the risk assessment process is initiated, developed and finished, making it a valuable guide for graduate students, post-doctoral fellows and early career scientists in industry.

The hands-on study companion for the most respected, rigorous medical toxicology text available-with 1,400 practice questions/answers Goldfrank's Toxicologic Emergencies has long been the go-to guide for accurately diagnosing and effectively treating poisoned and overdosed patients. Now, this practical companion provides everything you need to get even more out of Goldfrank's. Study Guide for Goldfrank's Toxicologic Emergencies provides 1,400 questions/answers for testing your knowledge-a process that increases information retention and serves as invaluable practice for board exams. Each chapter has its own question set using both general factual and case-based questions. Study Guide for Goldfrank's Toxicologic Emergencies covers: General approach to the poisoned patient Principles of medical toxicology Clinical basis of medical toxicology Poison prevention and education Research principles Legal and forensic considerations

The monographs in this volume summarize the safety data on 11 pesticides that could leave residues in food commodities. These pesticides are aminopyralid, atrazine, azinphos methyl, lamba-cyhalothrin, difenoconazole, dimethomorph, flusilazole, procymidone, profenofos, pyrimethanil and zoxamide. The data summarized in the toxicological monographs served as the basis for the acceptable daily intakes and acute reference doses that were established by the Meeting.This volume and previous volumes of JMPR toxicological evaluations, many of which were published in the "FAO Plant Production and Protection Paper" series, contain information that is useful to companies that produce pesticides, government regulatory officers, industrial testing laboratories, toxicological laboratories and universities.

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

"Deceit and Denial" details the attempts by the chemical and lead industries to deceive Americans about the dangers that their deadly products present to workers, the public, and consumers. Gerald Markowitz and David Rosner pursued evidence steadily and relentlessly, interviewed the important players, investigated untapped sources, and uncovered a bruising story of cynical and cruel disregard for health and human rights. This resulting expose is full of startling revelations, provocative arguments, and disturbing conclusions - all based on remarkable research and information gleaned from secret industry documents. This book reveals for the first time the public relations campaign that the lead industry undertook to convince Americans to use its deadly product to paint walls, toys, furniture, and other objects in America's homes, despite a wealth of information that children were at risk for serious brain damage and death from ingesting this poison. This book highlights the immediate dangers ordinary citizens face because of the relentless failure of industrial polluters to warn, inform, and protect their workers and neighbors. It offers a historical analysis of how corporate control over scientific research has undermined the process of proving the links between toxic chemicals and disease. The authors also describe the wisdom, courage, and determination of workers and community members who continue to voice their concerns in spite of vicious opposition. Readable, ground-breaking, and revelatory, "Deceit and Denial" provides crucial answers to questions of dangerous environmental degradation, escalating corporate greed, and governmental disregard for its citizens' safety and health. After eleven years, Markowitz and Rosner update their work with a new epilogue that outlines the attempts these industries have made to undermine and create doubt about the accuracy of the information in this book.

This book offers an important reference source about the most common classes of pesticides for researchers engaged in the area of neurotoxicology, metabolism, and epidemiology. The book presents details about thorough characterization of target and non-target enzymes and proteins involved in toxicity and metabolism; and epidemiology of poisonings and fatalities in people from short- and long- term exposures to these pesticides in different occupational settings on an individual country basis as well as on a global basis. The early portion of the book deals with metabolism, mechanisms and biomonitoring of anticholinesterase pesticides, while the later part deals with epidemiological studies, regulatory issues, and therapeutic intervention.

Ibuprofen is widely used throughout the world for a variety of conditions. This reference work provides a comprehensive and critical review of the basic science and clinical aspects of the drug. The book begins with the history and development of the drug and its current patterns of use world- wide before moving on to examine its basic pharmaceutical attributes and medicinal chemistry. The properties of various formulations are described (oral prescription and OTC, topical and others) are described. The pharmacokinetics of ibuprofen in animals and humans is discussed - highlighting the factors affecting absorption, distribution, metabolism and elimination. The clinical pharmacology and toxicology and the drug's mechanisms of action in different disease states and conditions are covered. The therapeutic uses in various acute and inflammatory conditions is detailed. Also considered are the safety versus efficacy issues and the pharmacoepidemiological data.

Histological techniques form the basis of many areas of research, yet they can often be poorly understood. Aimed at postgraduate students and those at an early stage of their career, this title provides a detailed and comprehensive introduction to histological techniques. With detailed images and slides, this book provides a unique overview of the area while providing the reader with a guide to how to use and incorporate histological techniques within their own research. Written by experts working within the field, this book is an essential handbook for anyone wanting to learn more about histological methods and how to apply them successfully.

Now in its thirteenth edition, Dreisbach's Handbook of Poisoning is long established as the definitive handbook of poisoning for all physicians, nurses, crisis and hotline workers, paramedics, and students. Rapid response is critical during the initial management of poison cases. This ready-reference guide provides antidotes, antivenins, and more for a vast number of substances. It covers medical toxicology - including prevention and management of exposures, poisonings, adverse effects, abuse and withdrawal from pharmaceuticals - and household, environmental, and natural hazards.

The book begins by providing general information about the prevention, diagnosis, and treatment of poisoning. Then it considers the important medicolegal aspects of poisoning. The remainder of the book focuses on specific poisons, organized into agricultural, industrial, household, medicinal, and natural hazards. Chemically- and pharmacologically-related agents have been grouped together wherever possible. For optimal care of critical or unusual poisonings, the book also contains guidelines for consultations with medical toxicologists and regional poison information centers. A concise summary of the diagnosis and treatment of poisoning, Dreisbach's Handbook of Poisoning provides an extraordinary amount of practical information in a compact format.