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Books > Medicine > Other branches of medicine > Pharmacology > Medical toxicology
In this book, the authors present current research in the study of the characteristics, uses and health implications of pesticides. Topics discussed include the evaluation of pesticide-induced DNA damage and oxidative stress on human and wildlife populations in Argentina; analytical methods of various families of pesticides in biological matrices; implications of pesticide use in the olive sector; pesticides and endangered sea turtles; monitoring emissions and atmospheric degradations of pesticides in the atmosphere; and adverse effects of pesticides in human health.
A mycotoxin is a toxic secondary metabolite produced by organisms of the fungus kingdom, commonly known as moulds. Agricultural products, particularly a wide variety of grains, in the field as well as during storage, are the main source of mycotoxin production in the food chain. Contact with mycotoxins can produce acute and chronic effects which span from serious injurious effects on the central nervous, pulmonary and cardiovascular systems to death. In this book, the authors present topical research in the study of the properties, applications and hazards of mycotoxins including: the impact of deoxynivalenol on human cells; electroanalytical properties of mycotoxins and their determinations in the agroalimentary system; the chemistry and biology of myctotoxins from rice false smut pathogen and the quecher method for the extraction of trichothecenes in coffee and spices.
Human biomonitoring has developed from a research tool in occupational and environmental health to identify and quantify exposures to harmful substances in urine and blood. The analytical methods for detection of substances in biological media have considerably improved with smaller detection limits and more precise and specific measurements. Human biomonitoring is a valuable tool in exposure estimation of selected populations and currently used in surveillance programs all over the world. This two volume set provides an overview of current available biomarkers and human biomonitoring programs in environmental health, which is timely given the present debate on adverse health effects from environmental exposures. The books decribe both previous and ongoing studies as well as the newer biomarkers of exposure and effects. Volume one describes current human biomonitoring programs in Germany, Romania, France, Canada, India and Belgium, providing convincing evidence of a global decline in human exposures to lead and increasing concern from exposure to endocrine disruptors and the genotoxic compound. Biomarkers of specific exposures to a wide range of widely used everyday compounds such as phthalates, PFCs, bisphenol A, brominated flame retardants, PAHs, dioxins, mercury and arsenic are also discussed. Volume two decribes human biomonitoing of exposures to environmental tobacco smoke, mycotoxins, physiological stress, hormone activity, oxidative stress and ionizing radiation, as well as effect biomarkers of hemoglobin adducts, germ cells, micronuclei and individual susceptability. The books will be essential reading for toxicologists, environmental scientists and all those working in the safety and risk assessment of chemicals.
Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed.
This is a comprehensive monograph on the problems of intoxication incurred by snake venom. This publication is primarily intended for those at all levels of health care, for members of rescue teams, surgeries and emergency hospitals, as well as specialised workplaces and intensive care units. Providing didactic instructions for first aid and treatment procedures, information is also presented on venomous snakes, the fundaments of their morphology and behaviour, snakebite prevention, the composition of snake venom, symptoms of envenoming, plus first aid in the event of snakebite for non-professionals, travellers, terrain biologists, and breeders. This book features an updated alphabetical list of types and sub-types of all venomous snakes, including their home ranges, as well as a comprehensive index, list of abbreviations, glossary, and colour picture insert with one hundred photographs of venomous snakes.
This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone!
In this book, the authors summarise basic and experimental knowledge on sources and toxicity of cadmium and overview mechanisms of toxicity and detoxification for various trophic aquatic organisms exposed to cadmium different routes, which will assist ecological risk assessments involving cadmium toxicity. Cadmium is known to be both extremely toxic and ubiquitous in natural environments. It exists most commonly as a trace constituent in natural ecosystems, where its natural occurrence appears to not cause harm to the environment. However, it can be mobilised by a number of processes especially human activities. Anthropogenic sources of cadmium have contributed large amounts of this potentially toxic metal to the water cycle with ultimate impacts on aquatic ecosystems.
Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed.
This is a 47-chapter non-fiction story about Mercury poisoning from
my eight dental amalgams and one root canal. I had fillings since
age eight at least. The World Health Organization states that 87%
of Mercury poisoning in humans comes from their mouth. Amalgam
fillings are 50-52% Mercury.
This is a 47-chapter non-fiction story about Mercury poisoning from
my eight dental amalgams and one root canal. I had fillings since
age eight at least. The World Health Organization states that 87%
of Mercury poisoning in humans comes from their mouth. Amalgam
fillings are 50-52% Mercury.
Formed as a word and a chemical compound in an culturally diverse Europe, calomel came to America as a solution to epidemics also imported. It grew into a primary gesture, both medical and commercial, of the healing professions. Opposition to its use, founded on experience with the effects of consuming it, took the form of song and satire that echoed faintly after the drug was forgotten.
"Advances in Molecular Toxicology" features the latest advances in
all of the subspecialties of the broad area of molecular
toxicology. Toxicology is the study of poisons, and this series
details the study of the molecular basis by which a vast array of
agents encountered in the human environment and produced by the
human body itself manifest themselves as toxins. Not strictly
limited to documenting these examples, the series is also concerned
with the complex web of chemical and biological events that give
rise to toxin-induced symptoms and disease. The new technologies
that are being harnessed to analyze and understand these events
will also be reviewed by leading workers in the field.
Toxins are important virulence determinants responsible for microbial pathogenicity and/or evasion of the host immune response. Understanding the molecular and cellular biology of toxins is critical for the development of new anti-toxin strategies, particularly for those with bioterrorism capability. Indeed, potential applications of toxin research extend beyond simply combating microbial virulence and include the development of novel anti-cancer drugs and other frontline medicines, use of toxins as tools in neurobiology and cellular biology, etc. This timely volume serves as an update on important recent advances. Written by internationally respected scientists, topics reviewed include: toxins carried by mobile genetic elements, botulinum neurotoxins, anthrax, subtilase cytotoxin, Pasteurella multocida toxin, RTX toxins of vibrios, vacA toxin, staphylococcal immune evasion toxins, and fungal ribotoxins. The book is essential reading for everyone with an interest in microbial toxins, and it is recommended for other scientists with an interest in microbiology, bioterrorism, microbial pathogenesis, and microbial genomics.
A new human in vitro anti-angiogenesis assay was established and applied to identify novel angiopreventive agents. Subsequently, two chemopreventive compounds, xanthohumol (XN) from Humulus lupulus L. (hop) and sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables (Brassicaceae), were selected for detailed investigation of their angiopreventive potential and mechanisms involved in the inhibition of angiogenesis. Representative targets included effects at the transcriptional levels of pro-angiogenic factors, anti-gelatinolytic and anti-endothelial activity. In vivo, XN was shown to exhibit a strong anti-tumour potency on human breast cancer xenografts mediated by the inhibition of tumour-induced angiogenesis. These findings strongly suggest that XN and SFN represent attractive chemopreventive lead structures possessing a remarkable potential to prevent tumour development.
Advances in Molecular Toxicology features the latest advances in
all of the subspecialties of the broad area of molecular
toxicology. Toxicology is the study of poisons and this series
details the study of the molecular basis by which a vast array of
agents encountered in the human environment and produced by the
human body itself manifest themselves as toxins. Not strictly
limited to documenting these examples the series is also concerned
with the complex web of chemical and biological events that give
rise to toxin-induced symptoms and disease. The new technologies
that are being harnessed to analyze and understand these events
will also be reviewed by leading workers in the field.
This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.
Ingestion of arsenic in drinking water has been linked with the risk of bladder cancer, however, questions remain about the dose-response relationships, ranges in induction-latency intervals, and whether there are critical lifetime exposure periods of heightened susceptibility. This book describes how individual- level estimates of arsenic exposure are reconstructed using newly developed Space-Time Information System technology, and offers methodological approaches for evaluating temporal dynamics in the relationship between arsenic exposure and bladder cancer. Spatial, temporal, and spatiotemporal variability are incorporated in the assessment of lifetime exposure to arsenic. Fluid and food consumption data are joined with mobility histories and arsenic concentrations to generate a detailed lifetime assessment of arsenic exposure. These exposure estimates will be used in a population-based bladder cancer case-control study nearing completion in southeastern Michigan. This work is directed to exposure scientists, environmental epidemiologists, health geographers, GIScientists, and others interested in the links between environment, human health, and spatial technology.
This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature.
A critical expos of the health consequences of everyday chemicals contends that human beings are now one of the most polluted species on the planet, linking common products to key health issues while challenging safety reports being issued by top chemical, pharmaceutical, and processed food companies. Reprint.
The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.
Food Toxicants Analysis covers different aspects from the field of
analytical food toxicology including emerging analytical techniques
and applications to detect food allergens, genetically modified
organisms, and novel ingredients (including those of functional
foods). Focus will be on natural toxins in food plants and animals,
cancer modulating substances, microbial toxins in foods (algal,
fungal, and bacterial) and all groups of contaminants (i.e.,
pesticides), persistent organic pollutants, metals, packaging
materials, hormones and animal drug residues. The first section
describes the current status of the regulatory framework, including
the key principles of the EU food law, food safety, and the main
mechanisms of enforcement. The second section addresses validation
and quality assurance in food toxicants analysis and comprises a
general discussion on the use of risk analysis in establishing
priorities, the selection and quality control of available
analytical techniques. The third section addresses new issues in
food toxicant analysis including food allergens and genetically
modified organisms (GMOs). The fourth section covers the analysis
of organic food toxicants.
Advances in Molecular Toxicology features the latest advances in
all of the subspecialties of the broad area of molecular
toxicology. Toxicology is the study of poisons and this series
details the study of the molecular basis by which a vast array of
agents encountered in the human environment and produced by the
human body itself manifest themselves as toxins. Not strictly
limited to documenting these examples the series is also concerned
with the complex web of chemical and biological events that give
rise to toxin-induced symptoms and disease. The new technologies
that are being harnessed to analyze and understand these events
will also be reviewed by leading workers in the field. |
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