"Haschek and Rousseaux's Handbook of Toxicologic Pathology" is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.
Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settingsOffers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathologyFeatures hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

The aim of this book is to provide the scientific background to using the formation of chemical categories, or groups, of molecules to allow for read-across i.e. the prediction of toxicity from chemical structure. It covers the scientific basis for this approach to toxicity prediction including the methods to group compounds (structural analogues and / or similarity, mechanism of action) and the tools to achieve this. The approaches to perform read-across within a chemical category are also described. The book will provide concise practical guidance for those wishing to apply these methods (in risk / hazard assessment) and will be illustrated with case studies. Chemical Toxicity Prediction is the first book that addresses the concept of category formation and read-across for toxicity prediction specifically. This topic has really taken off in the past few years due to concerns over dealing with the REACH legislation and also due to the availability of the OECD (Q)SAR Toolbox. Much (lengthy and complex) guidance is available on category formation e.g. from the OECD and, to a lesser extent, the European Chemicals Agency but there is no one single source of information that covers all techniques in a concise user-friendly format. There is a real need for this information as in silico toxicology has come to the fore in recent years, primarily as a result of the EU REACH legislation, but also due to many other drivers e.g. reduction of animal testing, Cosmetics regulation. Category formation is seen as the only practical approach to make rational and transparent predictions for complex (human) toxicological endpoints. The book covers all the areas required to create a robust category and perform read-across.

Sewer systems fall into the category "out of sight, out of mind" - they seldom excite interest. But when things go wrong with the air in the sewer system, they go very wrong. Consequences can be dramatic and devastating: sewer workers killed instantly by poisonous gas when they lift a sewer lid, or entire suburban blocks levelled by explosions. This book describes the atmospheric dangers commonly found in the sewer system. It provides easily-understood explanations of the science behind the hazards, combined with real-life examples of when things went dramatically wrong.

We are all just a little bit plastic. Traces of bisphenol A or BPA, a chemical used in plastics production, are widely detected in our bodies and environment. Is this chemical, and its presence in the human body, safe? What is meant by safety? Who defines it, and according to what information? "Is It Safe?" narrates how the meaning of the safety of industrial chemicals has been historically produced by breakthroughs in environmental health research, which in turn trigger contests among trade associations, lawyers, politicians, and citizen activists to set new regulatory standards. Drawing on archival research and extensive interviews, author Sarah Vogel explores the roots of the contemporary debate over the safety of BPA, and the concerns presented by its estrogen-like effects even at low doses. Ultimately, she contends that science alone cannot resolve the political and economic conflicts at play in the definition of safety. To strike a sustainable balance between the interests of commerce and public health requires recognition that powerful interests will always try to shape the criteria for defining safety, and that the agenda for environmental health research should be protected from capture by any single interest group.

Das vorliegende Werk ist im Auftrage des Arztlichen Ausschusses der Deut schen Gesellschaft fiir Arbeitsschutz geschrieben worden, um den derzeitigen Stand unserer medizinischen Kenntnisse iiber das taglich wachsende Gebiet der technischen Losungsmittel einheitlich zusammenzufassen. Es verfolgt den Zweck, die wissenschaftlichen Grundlagen darzustellen, die notwendig sind, um die mit der Verwendung dieser Stoffe verbundenen mannigfaltigen Gefahren fiir die menschliche Gesundheit zu erkennen und richtig zu beurteilen, und soIl davon ausgehend die Mittel und Wege zeigen, diesen Gefahren zweckmaBig und wirksam zu begegnen. Au. Ber den experimentellen Untersuchungen an Menschen und Tieren stiitzt es sich dabei auf die bisher vorliegenden Erfahrungen aus der Praxis iiber gesundheitliche Schadigungen von Menschen. Der Inhalt des Buches, das ein Gegenstiick zur "Chemischen Technologie der LOsungs mittel" von JORDAN bildet, ist ganz iiberwiegend medizinischer Natur. Es ist aber keineswegs nur fiir den Gebrauch des Arztes geschrieben, sondern es solI vielmehr jedem, der irgendwie in Beriihrung mit dem hier behandelten Gebiet kommt, ein Hilfsmittel bei seiner Arbeit sein. Die technischen Losungsmittel nehmen U lter den gewerblichen GUten nach vielen Richtungen hin eine eigenartige Sonderstellung ein. Die Entwicklung des ganzen Gebietes befindet sich noch in vollem Flu. B und unterliegt einem fortdauernden Wechsel. Unsere Kenntnisse auf diesem Gebiet sind nach mancher Richtung noch liickenhaft, viele Unklarheiten in der Beurteilung miissen noch beseitigt werden. Aus dieser Erkenntnis heraus wurde eine Arbeitsgemeinschaft gebildet, deren Mitgliedern bestimmte, besonders vordringlich erscheinende Teilaufgaben zugewiesen wurden."