"Provides both historical information and the latest toxicological data on various classes of food additives--examining the production, application, and safety of numerous compounds used to enhance and preserve the quality of foods."

This work offers concise, detailed information on the toxicological properties of, and safe handling practices for, pesticides. It provides an overview of the registration process, registration procedures and supplemental registration. An alphabetic listing of over 800 chemicals, including their applications - from insecticides and growth regulators to herbicides, repellents and synergists - is provided.

Dr. Goldstein has authored more than 50 publications and co-edited two books. Her latest contribution to the field of nephrology, Mechanisms of Injury in Renal Disease and Toxicity, promotes an understanding of the pathophysiologic mechanisms mediating renal dysfunction in disease. It provides an important perspective in understanding mechanisms of chemically induced renal injury.
Over the past decade, understanding of the pathophysiologic and molecular basis of renal disease has grown tremendously. New and evolving concepts on the pathophysiology of glomerulonephritis, chronic glomerular injury, diabetic nephropathy, and acute renal failure are changing the clinical management of these disease states.

The Third Edition of this standard text has been revised and updated to reflect the most current approaches to the management of acute poisonings. The editors have taken into account the numerous changes in protocols for managing poison ingestions and have again provided under one cover an indispensable resource for all students of pharmacy and the health sciences on the basic principles of clinical toxicology. The book's unique focus on the fundamentals provides an essential understanding of the bases for events that occur and the reasons why a treatment is used or not used. Each chapter presents pertinent information on classes of toxic agents, their common sources and usual methods of intoxication, incidence and frequency of poisoning, mechanism(s) of action, clinical signs and symptoms of poisoning, and management guidance. The text includes illustrative case studies carefully selected to reinforce the information covered. Each chapter concludes with review questions to further enhance comprehension.

Continuing a long tradition, Lu's Basic Toxicology, Seventh Edition, combines relatively comprehensive coverage of toxic substances in food, air, and water with brevity, thereby continuing to serve as an updated introductory text for toxicology students and for those involved in allied sciences that require a background in toxicology. The new edition, which now becomes an edited work with contributions from experts around the globe, features four new chapters and a number of existing chapters that have been updated and expanded, notably those on mechanisms of toxic effects, conventional toxicity studies, the cardiovascular system, and risk assessment and regulatory toxicology. The book consists of four parts (Part I-Part IV) that provide guidance on principles of toxicology and testing procedures for toxicities as well as a concise, yet detailed, mechanism of both target organ and nontarget organ toxicities. The book is rounded off with a final section (Part IV) on the toxic effects of chemicals and risk assessment, giving toxicologists, both students and practicing professionals, the necessary tools to enhance their practice. This edition includes new chapters on Clinical Toxicology, Systems Toxicology, Chemicals and Children, and Toxicology of Reproductive Systems, providing the essentials of these topics in the same style as the other chapters in the book. With separate subject and chemical indexes, this is a useful, quick shelf reference for everyone working in toxicology today.

A compilation of questions with answers for students of toxicology. The questions are a mixture of short answer, problem-solving, data interpretation and multiple choice and cover all the major areas of toxicology.

"This valuable resource provides detailed health and safety information on the hazardous and toxic properties of over 1,000 heavily used industrial and consumer chemicals. Lists chemicals both alphabetically and numerically according to their Chemical Abstract Service number permitting rapid access to specific data!"

Basic Environmental Toxicology provides a thorough, systematic introduction to environmental toxicology and addresses many of the effects of pollutants on humans, animals, and the environment. Readers are introduced to the fundamentals of toxicology and ecotoxicology, the effects of different types of toxicants, and how toxicants affect different compartments of the environment. Fundamental aspects of environmental health, occupational health, detection of pollutants, and risk assessment are discussed. The book is excellent for anyone involved in risk assessment or risk management, toxicologists, state and local public health officials, environmental engineers, industrial managers, consultants, and students taking environmental toxicology courses.

Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more - Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

Since the publication of the original edition in 1982, pesticide-related poisonings, both single cases and epidemic-scale situations, have continued to occur unabated. This new edition of Pesticides and Neurological Diseases reviews current literature describing the effects of insecticides (chlorinated hydrocarbons, organophosphorus and carbamate esters, and the pyrethroid esters), fungicides (organomercurials, dithiocarbamates), and herbicides (chlorophenoxy acids and esters) on the mammalian nervous system. Acute and chronic exposures have resulted in both subtle and serious neurological deficits in the peripheral and central nervous systems, marked by transient effects preceding those of delayed onset and of persistent duration. The chapters have been largely revised and rewritten to introduce newer theories of mechanism(s) of action studied at the laboratory bench. New findings and observations on human intoxications are included as well.
This reference will interest physicians involved in environmental medicine and occupational health, as well as graduate students and researchers in the fields of neurophysiology, pharmacology, and the toxicology of pesticides. It may also be useful to the layperson interested in learning more about chemicals routinely used in the home, garden, greenhouse, orchards, and fields.

Household Chemicals and Emergency First Aid is an essential manual that covers 386 household chemicals, discusses their hazards when mixed with other chemicals, describes the symptoms of overexposure, and provides instructions for emergency first aid treatment. The book is intended to be used in the event that label instructions on household chemicals have not been followed. It describes what may possibly happen and how to handle the situation if it does occur. Poison control centers are listed by state with phone numbers and addresses.
Because household accidents involving chemicals are so prevalent, this manual is a "must have" book for all emergency medical technicians, paramedics, and other emergency first aid providers. It is also useful for anyone wanting detailed information regarding emergency situations with household chemicals.

Since 1980 there has been an accumulation of new information concerning DNA-damage-inducible processes in eukaryotic cells. It is clear that changes in the concentrations of activities of specific protein molecules play central roles in toxicological response of cells to chemical and radiation damage to DNA. Identification of inducible proteins may be crucial in helping to explain target organ toxicity and species differences. Detection of these proteins or their mRNA's in humans may be useful in assessing human exposure or cellular injury.

Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

A dangerous byproduct of industrial progress is often an increase of pollutants discharged into the environment. These pollutants are often harmful to plants and animals, including humans. They also damage buildings and architectural and cultural monuments. This handbook describes many of the important physico-chemical properties of inorganic and organic substances found in industrial wastes and describes their toxic effects on humans.

Quantal response (sometimes called dose-reponse) data arise in many areas, both through experimental and observational studies. Particular emphasis is placed in this book on applications in bioassay and toxicology. For instance, data for analysis may arise from routine clinical trials, or from studies of safe doses of drugs. Throughout the material is motivated by a wide range of practical examples.

This book describes advances in the thinking of experts in the field of combustion toxicology through 1991. It emphasizes contributions due to the efforts of the working groups of ISO/TCQ2/SC3, along with presentation of the most up-to-date strategy for minimizing the risk of toxic hazards in fires.

This 5-volume set allows you to assess the health and environmental effects of chemicals by determining the routes of exposure of the chemical to sensitive organisms. Environmental Fate and Exposure of Organic Chemicals provides relevant facts on how individual chemicals behave in the environment and how humans and environmental organisms are exposed to the chemicals during their production, rise, transport, and disposal.
Each chemical is prepared by one of the best-known organizations in environmental fate and exposure and is peer-reviewed by a panel of expert scientists. The information on each chemical includes all experimental values and references for physical properties, all chemical fate studies, and all available monitoring data and interpretative summaries.

Although the media focus on the rise of cocaine use and the evils of its abuse, the public receives little real information about the scope of the problem and its treatment. This timely, practical, and honest volume gets to the heart of the cocaine addiction problem. Cocaine Solutions not only addresses the difficulties experienced by addicts and their families in coping with the devastating financial, emotional, and psychological toll that addiction takes, it also identifies specific sources of help that exist for addicts and their families. Both recovered drug addicts themselves, the authors discuss some of the obstacles to recovery and the ways to overcome them. Cocaine Solutions includes the stories of recovering addicts to illustrate firsthand what addicts'lives are like, giving you a better understanding of the people who are afflicted with the disease of addiction. This important book is required reading for a wide audience--cocaine addicts, potential addicts, the families of addicted or potentially addicted persons, professionals who see addiction daily in their patients, and anyone who is interested in the problem of cocaine addiction.

Polyvinylpyrrolidone is widely used in medicine, pharmaceuticals, cosmetics, foods, printing inks, textiles, and many more diverse applications. This book describes the 50 years of research, published and unpublished, on the absorption, distribution, storage, and excretion of PVP. The toxicology of PVP is critically evaluated. The author's involvement in the recent reevaluation of PVP by the Joint Expert Committee on Food Additives of the World Health Organization (WHO) and the Food and Agriculture Organization (FOA) led them to undertake this comprehensive review of all the information on the subject. This book will be invaluable for anyone who is involved with polyvinylpyrrolidone. Included is a broad review of the toxicological studies performed on PVP, including acute, subchronic, chronic, reproductive, mutagenicity, and carcinogenicity studies. There is also an appendix listing the key studies, with references, on the absorption, renal elimination, distribution, acute toxicity, subchronic toxicity, chronic toxicity, teratogenicity, mutagenicity, and carcinogenicity of PVP.

Reference to the design of new insecticides nontoxic to the environment and the public emphasizing optimal food production with greater safety. Some 30 international experts examine topics including new types of active molecules among natural products and animal toxins; insect metabolic and organ sy

Discover fresh perspectives on alcoholism treatment and research with this enlightening new book describing the work of researchers at the Novosibirsk Medical Institute, USSR. By using specific examples of their studies in Siberia, the reserachers offer an innovative approach to the treatment of addictive disorders in general. Instead of focusing on the drinking behavior itself, the treatment focuses on the relation of the problem to the interaction of economic, social, and psychological factors. To address the question of whether alcoholics should all be treated in the same way, or if alcholism treatment should be more individualized in approach, chapters are devoted to the differences between alcoholism in women, adolescents, and alchoholics who are afflicted with "rapid development of alcholism syndrome." The research examples in Addictive Disorders in Arctic Climates benefits professionals involved in the treatment of alcholism by introducing new perspectives and broadening contemporary research.

This 5-volume set allows you to assess the health and environmental effects of chemicals by determining the routes of exposure of the chemical to sensitive organisms. Environmental Fate and Exposure of Organic Chemicals provides relevant facts on how individual chemicals behave in the environment and how humans and environmental organisms are exposed to the chemicals during their production, rise, transport, and disposal.
Each chemical is prepared by one of the best-known organizations in environmental fate and exposure and is peer-reviewed by a panel of expert scientists. The information on each chemical includes all experimental values and references for physical properties, all chemical fate studies, and all available monitoring data and interpretative summaries.

This excellent book is a concise yet thorough examination of the important and emerging field of the study of biological risk factors in drug abuse. Historically, drug abuse research has concentrated on the contributions of environmental and behavioral factors as the major influences on addiction. The revelatory studies in this volume examine the genetic contributions to drug taking behavior through the use of animal models, cellular experiments and human clinical studies. Behavioral and Biochemical Issues in Substance Abuse provides for the first time in one volume, up-to-date, easily digested reviews of topics concerning biological and genetic factors in drug abuse. Medical researchers in all areas of alcoholism and drug abuse, researchers in pharmacology, psychology, psychiatry and neuroscience, and clinicians interested in biological approaches to alcoholism and drug abuse problems will benefit greatly from this valuable resource. Authoritative contributors clearly demonstrate the capability of genetic factors to modulate the reinforcing or rewarding effects of drugs, thereby altering their addictive potential. In addition to gaining comprehension of the biological factors affecting addiction, a greater understanding of genetics related to drug abuse will enable future research to control biological factors, leading to more accurate studies of behavioral and environmental influences on drug and alcohol abuse.

This 5-volume set allows you to assess the health and environmental effects of chemicals by determining the routes of exposure of the chemical to sensitive organisms. Environmental Fate and Exposure of Organic Chemicals provides relevant facts on how individual chemicals behave in the environment and how humans and environmental organisms are exposed to the chemicals during their production, rise, transport, and disposal.
Each chemical is prepared by one of the best-known organizations in environmental fate and exposure and is peer-reviewed by a panel of expert scientists. The information on each chemical includes all experimental values and references for physical properties, all chemical fate studies, and all available monitoring data and interpretative summaries.

This book addresses the three basic areas of combustion toxicology: combustion of materials, assessment of the toxicity of smoke, and understanding of hazards to humans. It is based on the papers published in the Journal of Fire Sciences during 1983-1987.