Scientific advances have led to the recognition that many chronic diseases such as cancer may be preventable. In this volume, 36 contributions test cancer prevention hypotheses, attempt to interpret their results, and provide a guide to the background, rationale, and selection of cancer prevention agents, as well as the design, im>plementation, and evaluation of cancer prevention studies. It will offer assistance to many in the conduct of investigations and will be of interest to all in the in>terpretation of research results in the scientific literature.

Prominent specialists champion the view that contemporary management of breast, or any, cancer requires the partnership of physicians, nurses, social workers, and all others whose special training and talents should be integrated for treating the whole patient. Here is the book that sets forth the rationale for this nationwide emerging concept and the means for accomplishing it.
Dealing with total care of the whole patient, this new classic text is written by and for surgeons, radiation oncologists, medical oncologist, pathologists, radiologists, nurses, social workers, and others involved with the care and management of the patient with breast cancer.

Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same.Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute with extensive original reporting, including more than thirty-five interviews to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it.The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers."

Since 2002, The Breast Reconstruction Guidebook has been the best resource on this topic for women who have had a mastectomy. Equal parts science and support, it is filled with stories that illustrate the emotional and physical components of breast reconstruction. Kathy Steligo, a gifted writer and breast cancer survivor who has twice had breast reconstruction, compassionately answers women's questions about how they will respond emotionally and physically to losing a breast, whether to treat or prevent breast cancer. Steligo provides detailed descriptions of the various surgical options for mastectomy and reconstruction, as well as information on choosing and paying for a surgeon, preparing for and recovering from surgery, and handling the many practical details and difficult decisions women will face along the way. A road map of the mastectomy and reconstruction journey, this book gives women the comprehensive, unbiased details they need to make their own informed decisions about whether reconstruction-and which reconstructive option-is right for them. Readers learn how breasts can be recreated using implants or their own tissue and the advantages and disadvantages of each option. Surgery timelines, recovery, and potential problems (and how they can be resolved) are also explained. A new foreword by Dr. Minas Chrysopoulo, MD, of the PRMA Plastic Surgery Center for Advanced Breast Reconstruction, highlights the book's strengths and offers a medical perspective on breast cancer and reconstructive surgery. The extensively updated text includes new discussions of* innovative reconstructive procedures* contralateral mastectomy* the benefits and limitations of nipple- and areola-sparing mastectomies* nipple delay procedure* patient-controlled tissue expansion* cohesive gel silicone implants* microsurgical advances that improve tissue flap procedures* fat grafting* nipple reconstruction* nipple and areola tattooing* reconstruction with the BRAVA system* pregnancy after TRAM* male mastectomy and reconstruction* decision making and solving cosmetic and medical post-op problems* surgical procedures that reduce the risk of cancer* the latest research data on mastectomy and reconstruction* and much more

While the first healers were musicians who relied on rhythm and song to help cure the sick, over time Western thinkers and doctors lost touch with these traditions. In the West, for almost two millennia, the roles of the healer and the musician have been strictly separated. Until recently, that is. Over the past few decades there has been a resurgence of interest in healing music. In the midst of this nascent revival, Ted Gioia, a musician, composer, and widely praised author, offers the first detailed exploration of the uses of music for curative purposes from ancient times to the present. Gioia's inquiry into the restorative powers of sound moves effortlessly from the history of shamanism to the role of Orpheus as a mythical figure linking Eastern and Western ideas about therapeutic music, and from Native American healing ceremonies to what clinical studies can reveal about the efficacy of contemporary methods of sonic healing. Gioia considers a broad range of therapies, providing a thoughtful, impartial guide to their histories and claims, their successes and failures. He examines a host of New Age practices, including toning, Cymatics, drumming circles, and the Tomatis method. And he explores how the medical establishment has begun to recognize and incorporate the therapeutic power of song. Acknowledging that the drumming circle will not-and should not-replace the emergency room, nor the shaman the cardiologist, Gioia suggests that the most promising path is one in which both the latest medical science and music-with its capacity to transform attitudes and bring people together-are brought to bear on the multifaceted healing process. In Healing Songs, as in its companion volume Work Songs, Gioia moves beyond studies of music centered on specific performers, time periods, or genres to illuminate how music enters into and transforms the experiences of everyday life.

Your complete resource for handling the physical and emotional effects of breast cancer treatments. At the time of diagnosis, breast cancer patients are faced with many overwhelming decisions about possible treatments. Living with Breast Cancer provides you with an overview of what to expect from testing and treatment, which cancer specialists you may need to see, and common terms to use to help communicate your needs to your team. This empathetic resource full of relatable stories teaches patients and caregivers how to ask the right questions to get the best possible care. The authors explain how to minimize the symptoms and side effects of treatment and outline coping strategies to deal with the stress of breast cancer treatment, including the changes in your body from cancer and its therapies. The book helps readers * make sense of their diagnosis * set goals and prepare for treatment * understand the different types of therapies, tests, and scans * manage the symptoms and side effects of treatment, such as nausea, fatigue, shortness of breath, weight fluctuations, and depression * learn what medications and lifestyle modifications can help with symptoms * live and cope with progressive cancer Living with Breast Cancer is your definitive resource for handling the physical and emotional effects of breast cancer and treatment.

Infectious Diseases: Smart Study Guide for Medical Students, Residents, Physicians and Clinical Pharmacists consolidates knowledge and information into a step-by-step process that is easy to understand, remember and apply in a clinical setting. The information presented is necessary for medical students and includes comprehensive coverage of the information needed during residency and beyond. The book's content is organized to provide an overview of microbiology and its different microbes. Diseases are discussed in-depth, including cause and microbe, thus guiding the audience from microbe recognition, disease diagnosis and treatments. This is the only book that can be used throughout the lifecycle of treatment. It is appropriate for medical students, residents, practicing physicians, and clinical pharmacists who need to understand the diagnosis, treatment and cure of infectious diseases.

This book focuses on public health and epidemiologic aspects of cancer, and explores the sources of information concerning the frequency of occurrence of human cancer. It describes statistical methods useful in studying problems arising in the field of cancer and its concurrent development.

The discovery of the two inherited susceptibility genes BRCA1 and BRCA2 in the mid-1990s created the possibility of predictive genetic testing and led to the establishment of specific medical programmes for those at high risk of developing breast cancer in the UK, US and Europe. The book provides a coherent structure for examining the diversity of practices and discourses that surround developments linked to BRCA genetics, and to the evolving field of genetics more broadly. It will be of interest to students and scholars of anthropology, sociology, history of science, STS, public health and bioethics. Chapter 8 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9780415824064_oachapter8.pdf

This book presents ideas and procedures for regression analysis of survival data in cancer chemotherapy based on regression-based approaches for improvements in the quality of care through the effective location of optimal treatment levels. It is useful for cancer chemotherapists.

When Eric Wendel was diagnosed with acute lymphoblastic leukemia in 1966, the survival rate was 10 percent. Today, it is 90 percent. Even as politicians call for a "Cancer Moonshot," this accomplishment remains a pinnacle in cancer research. The author's daughter, then a medical student at Georgetown Medical School, told her father about this amazing success story. Tim Wendel soon discovered that many of the doctors at the forefront of this effort cared for his brother at Roswell Park in Buffalo, New York. Wendel went in search of this extraordinary group, interviewing Lucius Sinks, James Holland, Donald Pinkel, and others in the field. If there were a Mount Rushmore for cancer research, they would be on it. Despite being ostracized by their medical peers, these doctors developed modern-day chemotherapy practices and invented the blood centrifuge machine, helping thousands of children live longer lives. Part family memoir and part medical narrative, Cancer Crossings explores how the Wendel family found the courage to move ahead with their lives. They learned to sail on Lake Ontario, cruising across miles of open water together, even as the campaign against cancer changed their lives forever.

From the essential background physics and radiobiology to the latest imaging and treatment modalities, the updated second edition of Handbook of Radiotherapy Physics: Theory & Practice covers all aspects of the subject. In Volume 1, Part A includes the Interaction of Radiation with Matter (charged particles and photons) and the Fundamentals of Dosimetry with an extensive section on small-field physics. Part B covers Radiobiology with increased emphasis on hypofractionation. Part C describes Equipment for Imaging and Therapy including MR-guided linear accelerators. Part D on Dose Measurement includes chapters on ionisation chambers, solid-state detectors, film and gels, as well as a detailed description and explanation of Codes of Practice for Reference Dose Determination including detector correction factors in small fields. Part E describes the properties of Clinical (external) Beams. The various methods (or 'algorithms') for Computing Doses in Patients irradiated by photon, electron and proton beams are described in Part F with increased emphasis on Monte-Carlo-based and grid-based deterministic algorithms. In Volume 2, Part G covers all aspects of Treatment Planning including CT-, MR- and Radionuclide-based patient imaging, Intensity-Modulated Photon Beams, Electron and Proton Beams, Stereotactic and Total Body Irradiation and the use of the dosimetric and radiobiological metrics TCP and NTCP for plan evaluation and optimisation. Quality Assurance fundamentals with application to equipment and processes are covered in Part H. Radionuclides, equipment and methods for Brachytherapy and Targeted Molecular Therapy are covered in Parts I and J, respectively. Finally, Part K is devoted to Radiation Protection of the public, staff and patients. Extensive tables of Physical Constants, Photon, Electron and Proton Interaction data, and typical Photon Beam and Radionuclide data are given in Part L. Edited by recognised authorities in the field, with individual chapters written by renowned specialists, this second edition of Handbook of Radiotherapy Physics provides the essential up-to-date theoretical and practical knowledge to deliver safe and effective radiotherapy. It will be of interest to clinical and research medical physicists, radiation oncologists, radiation technologists, PhD and Master's students.

Despite a decline in developed countries, cancer has consistently maintained its status as one of the top killers since time immemorial. Exploring cancer management and treatment at the molecular level, Biology of Oral Cancer: Key Apoptotic Regulators presents a key molecular event-apoptosis-in relation to genesis and progression of oral cancer. The book uses oral cancers as the specific means to demonstrate the use of apoptotic regulators for controlling cancers. The book comprehensively deals with the different aspects of oral cancer. The authors discuss strategies to leverage apoptotic regulatory mechanisms for better management along with state-of-the-art medical options available for management and treatment. Using an informal writing style that makes the information accessible to a wider audience, each chapter begins with a prologue followed by detailed discussion and concludes with a glimpse into future approaches and challenges. The book examines detection techniques that leverage molecular events associated with oral carcinogenesis to effectively detect oral cancer. A thorough examination of the internal (genetics) and external (carcinogens, radiation, and smoking) factors that cause cancer, the book provides an enhanced understanding of why oral cancer has consistently ranked among the top ten causes of cancer-related mortalities worldwide. It furthers the effective identification of the causal factors and their modulation that can restore cells' normal state and be used to develop increasingly effective modalities.

Provides the information necessary to guide clinicians to more efficient and appropriate use of the cardiac imaging modalities at their disposal Most books currently available on cardiac imaging focus on just modality. As the number of imaging options has increased, the choice of procedure has become more complicated. This comprehensive book will guide the practitioner in choosing the most appropriate test when confronted by various cardiac symptoms and diseases and to understand the benefits and limitations of each imaging modality. It demonstrates the advantages and disadvantages of various imaging modalities such as echocardiography, computer tomography, MRI, and nuclear cardiology in the evaluation of various disease states both commonly and infrequently seen in a standard practice. Comparative Cardiac Imaging--A Case-based Guide utilizes actual case examples to demonstrate the state of the art in comparative cardiac imaging. It offers in-depth chapter coverage of Aortic Diseases; Aortic Valvular Diseases; Mitral Valvular Diseases; Prosthetic Valves; Coronary Artery Disease; Pulmonary Artery Diseases; Congenital Heart Disease; Cardiac Tumor; Infective Disease; Cardiomypathy; and Cardiac Trauma. Uniquely focuses on and compares the many different modalities for cardiac imaging Breaks the topic down by anatomy and pathophysiology in order to cover all aspects of non-invasive cardiac imaging Covers newer and lesser known modalities like speckle tracking and velocity vector imaging Offers coverage of more controversial topics, such as CT angiography Comparative Cardiac Imaging--A Case-based Guide presents a level of data that is appropriate for the practicing cardiologist and cardiology trainee, as well as residents, internists, and other primary care clinicians.

This text provides a comprehensive overview of the essential concepts and malignancies of hematology. Now in its second edition, the book reviews every major hematologic disorder and disease entity in thorough detail, from incidence and prevalence to patient and treatment-related issues. Formatted in an organized and easy-to-read outline style to facilitate rapid learning and information processing, the book allows readers to easily locate topics of immediate interest without wading through entire sections to obtain the desired data. Written by a diverse range of experts in the field, Concise Guide to Hematology, Second Edition is a valuable resource for clinicians, residents, trainees, and entry-level fellows who work in or are just entering the field of hematology.

Significantly expanded, expertly and beautifully illustrated, The AJCC Cancer Staging Atlas, 2nd Edition, offers more than 600 illustrations created exclusively for this new edition and is fully updated to reflect the concepts discussed in the 7th Edition of both the AJCC Cancer Staging Manual and its companion Handbook. This Atlas illustrates the TNM classifications of all cancer sites and types included in the 7th Edition of the Manual and visually conceptualizes the TNM classifications and stage groupings. Specifically designed for simplicity and precision, the drawings have been verified through multi-disciplinary review to ensure accuracy and relevancy for clinical use. Every illustration provides detailed anatomic depictions to clarify critical structures and to allow the reader to instantly visualize the progressive extent of malignant disease. In addition, nodal maps are included for each site, appropriate labeling has been incorporated to identify significant anatomic structures, and each illustration is accompanied by an explanatory legend. The AJCC Cancer Staging Atlas, 2nd Edition, is an official publication of the American Joint Committee on Cancer, the recognized international leader in state-of-the-art information on cancer staging. This Atlas has been created as a companion to the updated 7th Edition of the AJCC Cancer Staging Manual, which continues to disseminate the importance of anatomical and pathological staging in the management of cancer. This state-of-the-art, invaluable 2nd Edition includes a CD containing PowerPoint slides of all illustrations, additional color, and a user-friendly, easy-to-read layout. The AJCC Cancer Staging Atlas, 2nd Edition will serve as an indispensable reference for clinicians, registrars, students, trainees, and patients.

Highly Commended, BMA Medical Book Awards 2014 Chronic myeloid leukemia is a clonal disease that results from an acquired genetic change in a single pluripotential hemopoietic stem cell. Efforts to confront this disease have been assisted by advances in cellular and molecular biology and the speed at which these findings have transformed the therapeutic algorithm. Nevertheless, there is some uncertainty with regards to how best to assess efficacy of treatment, especially with regards to the most appropriate surrogate markers for overall survival. From the standpoint of biology and clinical management, this handbook provides an authoritative state-of-the-art review of current and developing progress.

Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin's lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark site of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.

Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

First Prize, BMA Medical Book Awards 2013 Breast cancers are now detected earlier and are thus more likely to be confined to the breast itself and regional nodes. Many of these tumours will have minimal proclivity for hematogenous dissemination and formation of micrometastases. On the other hand, some patients have micrometastatic diseases which can remain dormant and be activated many years after initial diagnosis. Early Breast Cancer: From Screening to Multidisciplinary Management discusses the principles and practice of breast cancer management with respect to both screen-detected and symptomatic disease. It provides readers with sound understanding and critical insight into many aspects of the disease from epidemiology, genetics, and screening to pathology, diagnosis, treatment, and prevention. This latest edition continues the general ethos of the second edition with an emphasis on early screening and continued development of the multidisciplinary team.

Images from CT, MRI, PET, and other medical instrumentation have become central to the radiotherapy process in the past two decades, thus requiring medical physicists, clinicians, dosimetrists, radiation therapists, and trainees to integrate and segment these images efficiently and accurately in a clinical environment. Image Processing in Radiation Therapy presents an up-to-date, detailed treatment of techniques and algorithms for the registration, segmentation, reconstruction, and evaluation of imaging data. It describes how these tools are used in radiation planning, treatment delivery, and outcomes assessment. The book spans deformable registration, segmentation, and image reconstruction and shows how to incorporate these practices in radiation therapy. The first section explores image processing in adaptive radiotherapy, online monitoring and tracking, dose accumulation, and accuracy assessment. The second section describes the mathematical approach to deformable registration. The book presents similarity metrics used for registration techniques, discussing their effectiveness and applicability in radiation therapy. It also evaluates parametric and nonparametric image registration techniques and their applications in radiation therapy processes. The third section assesses the efficiency, robustness, and breadth of application of image segmentation approaches, including atlas-based, level set, and registration-based techniques. The fourth section focuses on advanced imaging techniques for radiotherapy, such as 3D image reconstruction and image registration using a graphics processor unit. With contributions from an international group of renowned authors, this book provides a comprehensive description of image segmentation and registration, in-room imaging, and advanced reconstruction techniques. Through many practical examples, it illustrates the clinical rationale and implementation of the techniques.

In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy. Randomized Phase II Cancer Clinical Trials explains how to properly select and accurately use diverse statistical methods for designing and analyzing phase II trials. The author first reviews the statistical methods for single-arm phase II trials since some methodologies for randomized phase II trials stem from single-arm phase II trials and many phase II cancer clinical trials still use single-arm designs. The book then presents methods for randomized phase II trials and describes statistical methods for both single-arm and randomized phase II trials. Although the text focuses on phase II cancer clinical trials, the statistical methods covered can also be used (with minor modifications) in phase II trials for other diseases and in phase III cancer clinical trials. Suitable for cancer clinicians and biostatisticians, this book shows how randomized phase II trials with a prospective control resolve the shortcomings of traditional single-arm phase II trials. It provides readers with numerous statistical design and analysis methods for randomized phase II trials in oncology.

There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early years.

Written for pain management specialists, oncologists, pharmacologists, students, and primary care practitioners, Chemotherapy-Induced Neuropathic Pain provides insight into the important area of chemotherapy-induced neuropathic pain. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment.

The contributors comprise an impressive list of clinical and basic science experts in the fields of pain mechanisms and pain management. Included are clinical directors of pain clinics and clinical research facilities, directors of large academic pain research laboratories, analgesic drug developers, and presidents of the International Association for the Study of Pain (IASP), Association of Chronic Pain Patients (ACPP), and the British Pain Society (BPS). Through them, the book provides the reader with an exceptional opportunity to acquire a fundamental understanding of the basic concepts related to this topic.

Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers - such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy.