Oligodendroglioma: Clinical Presentation, Pathology, Molecular Biology, Imaging, and Treatment features the latest "cutting-edge" molecular biology, molecular therapeutics, imaging, immunotherapy, and research methods on the topic of oligodendrogliomas. The most detailed and comprehensive resource on the subject, it provides up-to-date information on clinical presentation, pathology, molecular biology, and treatment methods, including immunotherapy. This book is a critical for students, physicians and researchers in the fields of neuroscience, neuro-oncology, neurosurgery, radiation oncology, medical oncology, and others working in research or with patients.

Nasopharyngeal Carcinoma: From Etiology to Clinical Practice discusses NPC from basic science, to clinical management through the perspective of members of the Centre for Nasopharyngeal Carcinoma Research in Hong Kong. It encompasses not only the most detailed information about multiple aspects of NPC, but also the modern day research model of scientist-clinician collaboration, focusing on bench-to-bedside approach. Basic science is covered, discussing genetics and genomics in NPC and its epidemiology and the role of Epstein-Barr Virus (EBV). Translational research is also covered, presenting topics such as animal models, plasma EBV DNA, molecular imaging and immunotherapy, amongst other topics. This book is a valuable source for cancer researchers, oncologists, medical oncologists and several members of the biomedical field who are interested in learning more about NPC management from both clinical and research perspectives.

This issue of PET Clinics focuses on PET in the Management of Hematologic Malignancies and is edited by Drs. Abass Alavi (the Consulting Editor of PET Clinics), Gary Ulaner, Jakub Svoboda, and Lale Kostakoglu. Articles will include: PET-CR as a surrogate to replace PFS in assessment of efficacy of DLBCL treatments; PET-Derived Quantitative Metrics for Response and Prognosis; Evolving Role of PET Based Novel Quantitative Techniques in the Management of Hematological Malignancies; Critical Role of FDG/NaF imaging in Assessment of Skeletal Involvement in Patients with Multiple Myeloma; Response adapted treatment strategies in Hodgkin lymphoma using PET scans; FDG PET/CT as a staging tool in multiple myeloma; FDG PET/CT as a predictor of prognosis in multiple myeloma; PET/CT as a response evaluation tool in multiple myeloma; PET imaging in CLL and Richter's transformation; Current Overview and Future Directions of PET for Hematologic Malignancies; and more!

miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF- and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

This issue of Neuroimaging Clinics of North America focuses on Brain Embryology and the Cause of Congenital Malformations and is edited by Drs. Thierry A.G.M. Huisman and Avner Meoded. Articles will include: Neuroimaging of normal brain development; Ultrasound and MRI of the normal fetal brain; Spinal dysraphia, Chiari 2 malformation, unified theory and advances in fetoscopic repair; Posterior fossa malformations; Synopsis of brain embryology; Cerebral dysplasia and overgrowth syndromes; Disorders of ventral induction/spectrum of holoprosencephaly; Classification and neurogenetics of intracranial vascular anomalies; DTI of brain malformations: Exploring the internal architecture; Connectomics in brain malformations: How is the malformed brain wired?; Commissural anomalies; and more!

Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine.

New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients.

Once a certain death sentence and often a cause for shame, cancer is now a treatable disease. "Cancer" provides a broad introduction to this complex family of diseases, tracing the fascinating history of scientific discoveries that led to today's sophisticated treatments.

This extraordinary new volume, coauthored by three leaders in cancer research and surgery at Harvard Medical School, uses scientifically accurate yet accessible language to give readers a firm grounding in such essential concepts as angiogenesis and the genetics of cancer. In addition to information about types of cancer, diagnosis, and treatment, "Cancer" places special emphasis on new frontiers in research, psychological aspects of a cancer diagnosis, and quality-of-life issues for those living with disease. Useful features include a comprehensive glossary, a timeline of milestones in cancer research, and an appendix for students on how to pursue a career in science or medicine.

Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor.

Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included

This issue of Hematology/Oncology Clinics, edited by Dr. Ursula Matulonis, will focus on Ovarian Cancer. Topics include, but are not limited to, Risk factors for ovarian carcinoma; Ovarian cancer pathology; Early detection and prevention strategies for ovarian cancer; Pathogenesis, genetics and genomics of high grade serous cancer; Pathogenesis, genetics and genomics of non-high grade serous cancers; Management and Treatment of newly diagnosed ovarian cancer; Management and Treatment of recurrent ovarian cancer; Treatment of rare epithelial ovarian tumors; Targeting DNA damage response and repair as a therapeutic strategy for ovarian cancer; Mechanisms of drug resistance in ovarian cancer; The status of and targeting the immune system in ovarian cancer: current and future approaches; Antibody drug conjugates; The role of angiogenesis in ovarian cancer pathogenesis and treatment; Management and understanding of acute and long term toxicities of patients with ovarian cancer; and Palliative Care of the advanced ovarian cancer patient.

Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma, Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection, virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed.
Individual chapters have been written by an international group of experts in their own field of research.

Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It's an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. Helps you translate current research and literature into practical information for daily practice. Presents information logically organized by disease site. Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. Consolidates today's available information on this timely topic into one convenient resource.

An illuminating guide for those newly diagnosed with prostate cancer as well as their partners and caregivers-one filled with extensive details about diagnosis, treatments, and tips for thriving. The second leading cause of cancer death for men, prostate cancer affects more than a quarter of a million individuals in the United States each year. Most men with prostate cancer will go through the journey from diagnosis through treatment and beyond with a partner and family members by their side. But there are few resources available that address the needs of both those with cancer and their loved ones who want to help. Written in accessible language and backed by the latest scientific research, Prostate Cancer covers * symptoms, diagnosis, and testing; * the full range of treatment options available; * practical tools partners can use to assist their loved one; * advice on managing the side effects of treatment, including incontinence and sexual problems; * tips to help cope with the emotional challenges associated with cancer; * recommendations for keeping healthy with diet, exercise, and mindfulness; and * insights into insurance issues. With three leading experts in urology, surgery, and psychiatry as its coauthors, Prostate Cancer provides the information and guidance you need to better understand the disease, communicate with health care providers, and support yourself and your loved one through treatment and survivorship.