Cancer is a disease related to ageing, and the proportion of senior patients increases worldwide. While the proportion of persons beyond age 70 is still small in developing countries, their numerous population means that there are more "elderlies" in India than in Europe. This book reflects the state of the art in the management of senior adults with cancer. This handbook leaves ample space for chapters that help in the delicate decisionmaking process, which should lead to the best therapy, adapted not only to the disease but also to the person who suffers from it.

This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

Effective care of the cancer patient increasingly involves systemic treatment, and as the range of available therapeutic agents continues to expand, the medical oncologist must be fully aware of the rationale for choosing specific drugs and combinations. Textbook of Medical Oncology, 4th edition, is written by a highly acclaimed list of international authors and is a key source of reference for all working in the field of oncology.

An informative handbook on the staging of cancer and the selection and evaluation of cancer treatment. ESMO Handbook on Treatment Evaluation in Cancer is an ideal resource for medical oncologists and those involved in screening and chemotherapy programs.

The text demonstrates how to judge various prognostic and predictive factors, how to determine the relevance of staging, and how to measure patient response for each cancer type.

Written by an international team of experts, this progressive text incorporates the fast-moving world of research into the field of cancer genetics and prevention.

Topics discussed include:

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• epidemiology
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• genetics of cancer
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• sporadic cancers
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• hereditary cancers
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• primary prevention of cancer
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• screening programmes for the general population
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• screening programmes for those at higher risk
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• the role of prevention
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• secondary prevention of cancer

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world's foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

With increasing emphasis on the early diagnosis and management of urologic tumours, it is imperative that the practising urologist comprehend the relevance of the morphology for the clinical diagnostic and therapy. Moreover, the clinician should be fully informed of the importance of modern morphological methods for the diagnosis and management of urological tumours. Not only is this highly illustrated text a necessary adjunct in the attending urologist's armamentarium, it will also satisfy the needs of residents in pathology or even of pathologists, who are not daily faced with urological tumours. The structure of the chapters follows a uniform schema: short introduction with the definition of the tumour/ tumours, clinical history epidemiology, aetiology, gross morphology, microscopy, tumour genetics, importance of ancillary methods for the diagnosis, differential diagnosis, principles of grading and staging, morphological prognostic factors, and clinical course. The tables showcase the latest WHO histological classification of the tumours of the single organs, the integral (or complete) form of the latest TNM staging version, and the principles of the international accepted grading systems (kidney, bladder, prostate, penis ). A short chapter is devoted to handling procedures for surgical specimens and biopsies by clinicians.

Prognostic and Predictive Factors in Gynecologic Oncology takes a fresh look at a critical aspect of cancer treatment planning. An international team of authors reviews the traditional prognostic and predictive factors such as tumor grade, histologic subtype, and grade and then goes a step further to review the growing number of molecular discoveries that have increasing clinical significance. The book is organized into comprehensive sections on ovarian, endometrial and cervical cancer and includes up to date reviews, newly discovered molecular pathways, genetic markers, molecular imaging techniques, and their relevance to clinical medicine.

Prognostic and Predictive Factors in Gynecologic Oncology is illustrated with over 100 figures and is essential reading for oncologists, translational and basic scientists, as well as fellows, residents and students with a special interest in gynecologic oncology.

Over the past decade interventional radiology techniques have replaced surgical and clinically guided diagnostic procedures such that the vast majority of patients have a non surgical diagnosis of a breast problem. Interventional Ultrasound of the Breast, written by a collection of well-established and respected authors from the UKa (TM)s leading cancer centres, is an invaluable reference for all medical and clinical oncologists, breast surgeons and radiologists.

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. * A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease * An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies * Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics * Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs * Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

"Textbook of Lung Cancer, 2nd edition, " published in association with the European Society of Medical Oncology, is a comprehensive and multidisciplinary text, which examines all aspects of this disease, with contributions from a multinational team of authors on etiology, epidemiology, molecular biology, pathology, smoking, detection and management, clinical features, staging and prognostic factors, surgery, radiotherapy and chemotherapy. It provides essential information and guidance for specialist trainees in oncology, and for the many physicians and specialists involved in the field of lung cancer.

The last few years have seen major advances in all aspects of the understanding and treatment of kidney cancer, particularly the commonest variant clear cell carcinoma of the kidney. This book brings the reader up to date with these developments, covering aetiology, epidemiology, pathogenesis, prognostic factors, presentation, interventional radiology, minimally invasive surgery, surgery for locally advanced tumours and for metasatic disease, adjuvant medical therapies, therapies for advanced disease, radiotherapy and palliation of symptoms. Each chapter is written by acknowledged experts in the field. The reader gains an excellent idea of the state of the art in the treatment of kidney cancer in an accessible format.

This book provides a comprehensive visual review of pathologic disease variations of the five main types of gynecologic cancers: ovarian, endometrial, cervical, vaginal, and vulvar. Through the use of cross-sectional imaging modalities, including computed tomography, magnetic resonance imaging, ultrasound, and positron emission tomography, it depicts normal anatomy as well as common gynecological tumors. For each type of cancer, aspects such as primary staging, recurrence patterns, and findings from different yet complementary imaging modalities are explored. Atlas of Gynecologic Oncology Imaging presents a coherent perspective of the roles of standard and cutting-edge imaging techniques in gynecologic oncology via a multidisciplinary approach to cancer care. Featuring over 600 images, this book is a valuable resource for diagnostic radiologists, radiation oncologists, and gynecologists.

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

Exploring a technology that is significantly impacting the noninvasive evaluation of the physiology and anatomy of tumors, as well as the diagnosis of infectious processes and cardiac diseases, this source presents recent advances and clinical applications of sequential, single session single-photon emission computed tomography and computed tomography imaging. This source is written by pioneers in hybrid imaging and offers authoritative sections on state-of-the-art breakthroughs in sentinel lymph node identification, cardiac imaging, and the study and treatment of a variety of disorders including lymphoma, thyroid and parathyroid tumors, neuroendocrine tumors, prostatic cancer, and bone metastases.

Bladder cancer is the fifth most common cancer of American men and the eighth most common cancer of American women, with sixty thousand new cases of the disease diagnosed each year in the US alone. Disease prevalence is high in western nations due to the predominance of the chronic relapsing form of cancer that occurs in these countries (USA prevalence estimated to be 600,000; NCI-SEER database), and this single fact makes bladder cancer one of the most expensive cancers to treat. expertise of an international community of experts in the area. All aspects of disease biology, diagnosis and treatment are addressed. Appropriate for scholars and students of medicine at all levels, it promises to become a key text in the field.

Written by over 250 of the world's leading urologists and uro-oncologists from the USA, Canada, UK, Austria, Belgium, Finland, France, Germany, Ireland, Italy, the Netherlands and Singapore, who tackle prostate cancer on a daily basis, this comprehensive and fully up-to-date illustrated text reference covers the etiology, pathophysiology, diagnosis, management and treatment of early and advanced prostate cancer. advanced non-surgical procedures, Prostate Cancer: Principles and Practice focuses on the following key areas: * the pathology and etiology of prostate cancer assessing the prostate, whether qualified or in training.

Although a wealth of information can be found scattered throughout periodicals and research papers, tracking down the most effective treatment for a heterogeneous syndrome such as cachexia can be problematic. Edited by experts in the field, with contributions from a multidisciplinary panel, Pharmacotherapy of Cachexia is the first book devoted solely to the treatment of cachexia with a focus on pharmacotherapeutic aspects. The book discusses the various aspects of the syndrome and compares and contrasts its diverse treatment options. It explores the topic from a theoretical and practical perspective and provides an overview of currently available and future treatment. The first half of the book includes coverage of pathophysiology, associated diseases, and general therapeutic aspects. The subsequent sections devoted to pharmacotherapy cover drugs in clinical use, drugs in research and development, and the final section focuses on potential future advancements. Numerous internationally recognized specialists have contributed chapters on the various aspects of cachexia to this book. Their critical evaluation of pathophysiological mechanisms, clinical features, and therapeutic options make it a valuable source of information on all aspects of this serious and life-threatening condition. Expert editorial guidance ensures minimal repetition of information and uniform presentation. Addressing the multiple disease processes associated with cachexia in an organized and useful way, the book is a comprehensive reference for the management of this recalcitrant and hard-to-treat syndrome.

The rapid rate of development in the fields of prevention, early detection and management for colorectal cancer means that the successful first edition of this accessible guide has needed to be updated and revised throughout. Primary care physicians and specialists alike will continue to find this an indispensable synopsis of the issues and options.

This authoritative reference compiles the latest studies on the epidemiology, diagnosis, and treatment of uterine cancer and offers an extensive review of the molecular pathogenesis of endometrial and uterine disorders-analyzing patterns of disease presentation as population demographics change and considering the challenges this will place on future healthcare procedures.

Drawing on the real-world experience of leading experts in oncological medicine, this reference serves as an invaluable source of guidance for anyone specializing in the care of acutely ill cancer patients-providing quick reference to effective techniques, therapies, and approaches for surgical, medical, pediatric, pain, and general oncology issues.

This compact, illustrated handbook is a concise but comprehensive resource that introduces medical students, general medical practitioners and gynecologists to the significance of the human papillomaviruses in the etiology of cervical cancer. All chapters are fully referenced and written by experts in the field. The content review virus structure, the epidemiology of HPV, the latest advances in HPV vaccination, and new markers for cervical disease.

.,"it is increasingly clear that cancer is also a disease of inertia. In this book, a broadly multidisciplinary group presents the evidence and provides the recommendations. ... The antidote to diseases of inertia is movement - let's move!"

"John Potter, M.D., Ph.D., from the Foreword"

The American Cancer Society estimates that a third of all cancer deaths could be prevented through avoidance of obesity and the rejection of sedentary lifestyles. The World Health Organization also supports this claim. Additionally, these and other organizations now recognize the role that activity can play in improving the quality of life for cancer patients.

Cancer Prevention and Management through Exercise and Weight Control provides us with the support necessary to make a "call to action," Itbrings together the contributions of world-class researchers to lay out the evidence and a plan of attack for coping with this crisis. The text begins by focusing on the research methods used in assessing the complex associations between activity, energy balance, and risk and prognosis. In comprehensive literature reviews, the authors consider the role of physical activity in the incidence of individual cancers, then explore the mechanisms that might explain this connection. They continue with a look at the relation between weight and cancer incidence, including a consideration of genetics.

Research is also provided linking physical activity and weight control to a cancer patient's quality of life and prognosis. The work concludes with ideas on how a plan of action might be implemented at the individual, clinical, and public health levels. It also provides guidance on incorporating exercise and dietrecommendations into clinical oncology practice.

Integrative Oncology is a comprehensive, evidence-based approach to cancer care that addresses all individuals involved in the process, and can include the use of complementary and alternative medicine (CAM) therapies alongside conventional modalities such as chemotherapy, surgery and radiation therapy. The number of integrative care programs is increasing worldwide and this book forms a foundation text for all who want to learn more about this growing field. Bringing together some of the most progressive and important thinking in the area, key features of the book include: - insightful descriptions of models of integrative care, and of the perspectives and practices of alternative systems of healing - discussions of the transformational experience that the cancer care process may bring for physicians and patients - clear summaries of research, business, clinical and legal considerations - reviews of the contributions of CAM therapies to preventive, supportive, antineoplastic, palliative and end-of-life care - comprehensive references regarding the research evidence-base. generous perspective on integrative care, an outstanding overview of the exciting clinical opportunities these techniques can offer, and a guide to the new territories that all oncologists and CAM practitioners need to explore and understand.

Young medical oncologists, who may often find themselves faced by major complications caused by cancer or by cancer treatment, will welcome this handbook as a highly useful tool to develop their knowledge and skills in the area.

Initiated by the European Society for Medical Oncology's (ESMO) Young Medical Oncologists Working Group, this succinct text has been written by a distinguished team of young medical oncologists and senior figures in the field, and is designed to provide oncologists with a secure practical grounding in the correct courses of action to follow in an emergency.

The key topics covered include:

* cardiovascular complications

* neurological complications

* renal and urologic complications

* metabolic complications

* respiratory complications

* gastro-intestinal complications

* hematologic complications

* cancer pain.