This book gives a comprehensive overview on the use of image-guided radiation therapy (IGRT) in the treatment of lung cancer, covering step-by-step guidelines for clinical implementations, fundamental principles and key technical advances. It covers benefits and limitations of techniques as well as quality and safety issues related to IGRT practice. Addresses imaging simulation, treatment planning, verification, and delivery Discusses important quality assurance issues Describes current methods using specialized machines and technologies Jing Cai, PhD, is an Associate Professor of Radiation Oncology at Duke University Medical Center. Joe Y. Chang, MD, PhD, is Professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. Fang-Fang Yin, PhD, is Chief of the Division of Radiation Physics, Professor of Radiation Oncology, and Director of the Medical Physics program at Duke University.

This book summarizes the etiology, presentation, and treatment of the complex symptoms, infections, and opportunistic cancers of people living with HIV/AIDS. Presents therapies that strike a balance between controlling and eliminating cancer and minimizing the damage to the immune system. Illustrates points with clear and easily read figures, tables, and flow charts! Written to survey the magnitude of the impact HIV and AIDS have had on public health and oncology, AIDS-Related Cancers and Their Treatment -identifies types of cancer and gives evidence for their associations with immunosuppression -compares and contrasts AIDS-related cancer with non-HIV malignancies -investigates the pathogenesis of malignancy in HIV/AIDS patients -provides guidelines for recognizing possible symptoms and making accurate diagnoses -supplies algorithms for evaluating and staging patients at presentation -outlines potential problems and obstacles in caring for AIDS-related cancer patients -suggests optimal therapeutic approaches for the care of patients with AIDS and cancer -discusses prognostic factors in response to therapy and survival statistics -describes preliminary experience with emerging therapies and projects new approaches -advises how to enroll patients to participate in clinical trials of new therapies -considers the psychological impact on patients and their need for counseling and support -reviews access-to-care issues in AIDS and the community burden of this epidemic -provides information sources for both AIDS patients and their physicians -and more With contributions from nearly 25 clinicians and citing more than 1200 references to support and elaborate on text material, AIDS-RelatedCancers and Their Treatment is a crucial reference for oncologists, immunologists, infectious disease specialists, hematologists, internists, microbiologists, virologists, epidemiologists, molecular and cell biologists, pathologists, and medical students in these disciplines.

A bracing account that challenges current medical thinking. This book makes urgently clear that winning the war on cancer will not be accomplished by physicians, scientists, pharmaceutical corporations, epidemiologists and geneticists, nor by the thousands employed in governmental agencies and universities at home and abroad. It will be won by people who understand the connection between the loss of personal health and the unchecked boundaries of worldwide pollution.

This compact, illustrated handbook is a concise but comprehensive resource that introduces medical students, general medical practitioners and gynecologists to the significance of the human papillomaviruses in the etiology of cervical cancer. All chapters are fully referenced and written by experts in the field and review virus structure, the epidemiology of HPV, the latest advances in HPV vaccination, and new markers for cervical disease.

Despite a decline in developed countries, cancer has consistently maintained its status as one of the top killers since time immemorial. Exploring cancer management and treatment at the molecular level, Biology of Oral Cancer: Key Apoptotic Regulators presents a key molecular event-apoptosis-in relation to genesis and progression of oral cancer. The book uses oral cancers as the specific means to demonstrate the use of apoptotic regulators for controlling cancers. The book comprehensively deals with the different aspects of oral cancer. The authors discuss strategies to leverage apoptotic regulatory mechanisms for better management along with state-of-the-art medical options available for management and treatment. Using an informal writing style that makes the information accessible to a wider audience, each chapter begins with a prologue followed by detailed discussion and concludes with a glimpse into future approaches and challenges. The book examines detection techniques that leverage molecular events associated with oral carcinogenesis to effectively detect oral cancer. A thorough examination of the internal (genetics) and external (carcinogens, radiation, and smoking) factors that cause cancer, the book provides an enhanced understanding of why oral cancer has consistently ranked among the top ten causes of cancer-related mortalities worldwide. It furthers the effective identification of the causal factors and their modulation that can restore cells' normal state and be used to develop increasingly effective modalities.

Achieving Quality in Brachytherapy addresses the main issues that often prevent correct delivery of brachytherapy treatment. The book explains how to set up a functional quality assurance program in brachytherapy and covers all the steps needed to undertake particular treatment plans, from the initial planning required to the detailed specification. It highlights the importance of planning as a means of controlling and dealing with errors during the treatment process and advises on what to check and how to check during treatment to ensure effective quality assurance. This comprehensive reference is ideal for professionals working in brachytherapy, physics, and radiation oncology, and serves as an introduction for trainees with an undergraduate degree in medical physics or clinical radiation oncology.

Brief Cognitive Behavior Therapy for Cancer Patients is a practical, clinical guide that allows for the integration of techniques from multiple newer CBT models, organized around a clear conceptual foundation and case conceptualization. The book targets those cognitive, emotional, and behavioral processes that research suggests are instrumental in the maintenance of human psychological suffering. Author Scott Temple also draws on newer models that build on strengths and resilience and brings clinical work to life through vivid case examples, worksheets, and case conceptualization forms. Detailed vignettes show clinicians how to create a case conceptualization as a guide to treatment, as well as how to integrate Beckian and newer CBT techniques.

A Guide to Cancer: Origins and Revelations unfolds the complex and fascinating topic of cancer in two ways: firstly, no specialist knowledge is assumed on the part of the reader, and secondly, despite the serious nature of the topics, the book aims to stimulate interest, provoke thought, and paradoxically entertain. It takes an array of complex topics and breaks them down in clear, concise terms, so that anyone with a basic knowledge of science can understand. The book is aimed at the general public as well as students of biological subjects, first and second year university students, and researchers in the nascent field of cancer genomics.

A Guide to Cancer: Origins and Revelations unfolds the complex and fascinating topic of cancer in two ways: firstly, no specialist knowledge is assumed on the part of the reader, and secondly, despite the serious nature of the topics, the book aims to stimulate interest, provoke thought, and paradoxically entertain. It takes an array of complex topics and breaks them down in clear, concise terms, so that anyone with a basic knowledge of science can understand. The book is aimed at the general public as well as students of biological subjects, first and second year university students, and researchers in the nascent field of cancer genomics.

For more than 30 years, the majority of researchers has assumed quiescence to be the default state of all cells and so have provided cells in culture with 'growth factors' to stimulate them to proliferate. During this time, many putative growth factors have been identified and ever more complex mechanisms through which they could interact and stimulate cells have been proposed. However, quiescence as the default state does not make evolutionary sense and many sets of data do not support this hypothesis. In The Society of Cells, an alternative explanation for these results is proposed by applying the premise that the default state must be proliferation, with multiplication being a 'built in' property of all forms of life. The authors begin by reviewing the concepts and theories that guide research on the control of cell proliferation and cancer, and asking the question 'what is the nature of the default state of all cells - quiescence or proliferation?'. Later chapters concern cancer, where control of cell proliferation and the tissue organisation are defective. Despite decades of work and financial support to explore the somatic mutation theory of carcinogenesis, we appear no nearer to explaining how cancer arises. This requires researchers to take stock and consider new hypotheses and alternative approaches to the study of control of cell proliferation, and cancer in particular. The Society of Cells is intended to encourage such a revaluation and proposes the adoption of new premises to explore these important subjects.

This timely new reference integrates the latest clinical results and laboratory studies on the resistance of specific cancers to chemotherapeutic drugs-covering drug resistance in lung, breast, ovary, and colon cancer as well as hematological malignancies.

Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Neonatal hematology is a fast-growing field, and the majority of sick neonates will develop hematological problems. This is an essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values. Chapters have been thoroughly revised according to the latest advances in the field for this updated third edition. Topics discussed include erythrocyte disorders, platelet disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Coverage of oncological issues has been expanded to two separate chapters on leukemia and solid tumors, making information more easily accessible. Approaches to identifying the cause of anemia in a neonate are explained, with detailed algorithms provided to aid clinicians in practice. Covering an important hematologic niche with an ever increasing amount of specialized knowledge, this book is a valuable resource for hematologists, neonatologists and pediatricians.

The Topics Every Medical Physicist Should Know Tutorials in Radiotherapy Physics: Advanced Topics with Problems and Solutions covers selected advanced topics that are not thoroughly discussed in any of the standard medical physics texts. The book brings together material from a large variety of sources, avoiding the need for you to search through and digest the vast research literature. The topics are mathematically developed from first principles using consistent notation. Clear Derivations and In-Depth Explanations The book offers insight into the physics of electron acceleration in linear accelerators and presents an introduction to the study of proton therapy. It then describes the predominant method of clinical photon dose computation: convolution and superposition dose calculation algorithms. It also discusses the Boltzmann transport equation, a potentially fast and accurate method of dose calculation that is an alternative to the Monte Carlo method. This discussion considers Fermi Eyges theory, which is widely used for electron dose calculations. The book concludes with a step-by-step mathematical development of tumor control and normal tissue complication probability models. Each chapter includes problems with solutions given in the back of the book. Prepares You to Explore Cutting-Edge Research This guide provides you with the foundation to read review articles on the topics. It can be used for self-study, in graduate medical physics and physics residency programs, or in vendor training for linacs and treatment planning systems.

Linear Accelerators for Radiation Therapy, Second Edition focuses on the fundamentals of accelerator systems, explaining the underlying physics and the different features of these systems. This edition includes expanded sections on the treatment head, on x-ray production via multileaf and dynamic collimation for the production of wedged and other intensity modulated beams, on electron scattering systems, and on dosimetry. With high-quality illustrations and practical examples throughout, it contains a detailed description of electron beam optics and linear accelerator components. The final chapter explains how to use other equipment, such as scanners and simulators, in conjunction with linear accelerators for optimum treatment of cancers.

Written by leading American practitioners, the Oxford American Handbooks of Medicine each offer a pocket-sized overview of an entire specialty, featuring instant access to guidance on the conditions that are most likely to be encountered. Precise and prescriptive, the handbooks offer up-to-date advice on examination, investigations, common procedures, and in-patient care. These books will be invaluable resources for residents and students, as well as a useful reference for practitioners.
The essential reference for medical students, residents, and clinical oncologists seeking a current, portable resource on the delivery of sophisticated cancer care. Chapters focus on the immediate information needs in clinical decision making including treatment choices. Algorithms, best practice guidelines, highlight tables, and targeted lists of landmark references enhance concise text. The Handbook covers solid tumors and hematologic malignancies plus cancer biology, genetics, prevention and screening, cancer staging, complications, and supportive care.

Why choose the Oxford American Handbook of Oncology?
The design....
The Handbook uses a unique flexicover design that's durable and practical. Compact, light, and fits in your pocket Also has quick reference tabs, four-color presentation, and bookmark ribbons to help provide fast answers.
The interior layout....
The Handbook is a quick reference in a small, innovative package. With one to two topics per page, it provides easy access and the emergency sections are in red to stand out. Icons throughout aid quick reference.
The information....
The Handbook succinctly covers all the essential topics in a one or two-page spread format with colored headings that break up the text and provide a logical structure for readers of all levels. Common clinical questions are answered clearly and extensively.
The history....
Oxford University Press is known around the world for excellence, tradition, and innovation. These handbooks are among the best selling in the world.
The price....
You get an extremely useful tool at a great value

Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin's lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

"Read this important book to learn how cancer is an environmental, metabolic disease with many small causes that stack up-and what you can do to prevent or even reverse it."-Dave Asprey, New York Times bestselling author of The Bulletproof Diet The Optimal Terrain Ten Protocol to Reboot Cellular Health! The Metabolic Approach to Cancer offers an innovative, metabolic-focused nutrition protocol that works. Naturopathic, integrative oncologist and cancer survivor Dr. Nasha Winters and nutrition therapist Jess Higgins Kelley have identified the ten key elements of a person's "terrain" (think of it as a topographical map of our body) that are crucial to preventing and managing cancer. Each of the terrain ten elements-including epigenetics, the microbiome, the immune system, toxin exposures, and blood sugar balance-is illuminated as it relates to the cancer process, then given a heavily researched and tested, non-toxic and metabolic, focused nutrition prescription. The ketogenic diet-which relies on the body's production of ketones as fuel-is the centerpiece of The Metabolic Approach to Cancer. Further, Winters and Kelley explain how to harness the anticancer potential of phytonutrients abundant in low-glycemic plant and animal foods to address the 10 hallmarks of cancer-an approach Western medicine does with drug-based therapies. The optimized, genetically-tuned diet shuns: Grains Legumes Sugar Genetically modified foods Pesticides Synthetic ingredients The optimized, genetically-tuned diet emphasizes: Whole, wild foods Local Organic Ferments Heirloom Low-glycemic Other components of their approach include harm-reductive herbal therapies like mistletoe (considered the original immunotherapy and common in European cancer care centers) and cannabinoids (which shrink tumors and increase quality of life, yet are illegal in more than half of the United States). Through addressing the ten root causes of cancer and approaching the disease from a nutrition-focused standpoint, we can slow cancer's endemic spread and live optimized lives. "The Metabolic Approach to Cancer is a powerhouse of detailed information on how to prevent, manage, and treat cancer. . . . It is written in an intimate conversation style that comes from decades of deep personal experience, research, and genuine passion."-Travis Christofferson, author of Tripping over the Truth

Written by internationally known experts in the field, Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy examines one of the fastest-developing subspecialties within radiation oncology. These procedures deliver large doses of radiation in one to five sessions to a precisely determined target. Often these techniques have proven to be as or more effective than traditional radiation therapy techniques, while at the same time being cost-efficient and convenient for the patient. These techniques, however, require careful planning, specialized equipment, and well-trained staff. This volume provides a cutting-edge look at the biological and technical underpinnings of SRS and SBRT techniques. It includes a history of the development of SRS and SBRT; clinical applications of the techniques; dedicated devices for delivering precisely shaped, high doses of radiation; use of in-room imaging for treatment planning and treatment guidance; immobilization techniques for accurate targeting; and future developments that will continue to evolve and refine existing techniques. A valuable introduction to those just learning about these specialized techniques, and an ideal reference for those who are already implementing them, this book covers a wide variety of topics, with clear discussions of each aspect of the technology employed.

This comprehensive, ground-breaking title presents, in simplifying style, the driving and organizing principles of cancer, making this multidimensional, highly complex disease easily understandable for readers. Developed out of the renowned author's many years of teaching a widely popular, several-hundred-student college course, this 12-chapter book begins with an account of the history of cancer as a medical and public health problem, as well as the major milestones and setbacks in the ongoing quest to understand the wide variety of cancers that continue to impact the world. Subsequent chapters then address pathogenesis, incidence and mortality statistics, risk factors, causal factors, screening challenges and victories, treatment strategies, and disease prevention approaches. This wealth of clinical information is further supplemented with socioeconomic discussions on the financial, social, ethical, technological, regulatory, political, and logistical challenges that limit progress in cancer research. A soon to be gold-standard text that thoroughly and expertly describes cancer as a composite, adaptive system, Cancer: The Enemy from Within equips and empowers all undergraduate students and graduate students to better understand this continually perplexing disease. Clinicians across all disciplines may also find this work of great interest.

Translated by:
Heather Goodare

Based on a Tumor Immunology Symposium held in Pittsburgh, this work provides comprehensive coverage of the most important aspects of tumor immunology. It reveals novel approaches to the immunotherapy of cancer and presents complex issues in an accessible manner.

Chinese herbal medicine (CHM), which is becoming recognized worldwide for remarkable anticancer, anticarcinogenic, and immuno-regulative properties Many new scientific results, such as the latest discoveries in cancer inhibitors, new inhibitors from structural modification, and recent explorations in the mechanisms of CHMs during lab examinations and clinical trials The first book to specifically highlight the development of cancer inhibitors derived from a selection of Chinese medicinal herbs Information on new drug design and new therapy design to improve cancer treatment and prevention

Microspheres and Regional Cancer Therapy takes an interdisciplinary approach to the subject of microspheres and regional cancer therapy. It synthesizes laboratory and clinical data to demonstrate the utility of microsphere-based strategies in the treatment of localized solid tumors (particularly in the liver) not amenable to surgery and as a component of strategies for treatment of disseminated disease. Using the same techniques that show the deficiencies of delivery strategies involving antibodies, liposomes, and synthetic polymers, clear evidence is presented describing how microspheres of appropriate size can be localized in solid tumor deposits in the liver with little exposure to other organs. To exploit this phenomenon, the extent and nature of the incorporation of active agents within microspheres is discussed in relation to release, pharmacokinetics, and tumor response achieved by intensification of therapy in the manner described. This book will benefit laboratory-based scientists and clinicians in pharmaceutics, pharmacology, physiology, surgical oncology, and nuclear medicine. In addition, cancer clinicians interested in the value of regional therapy will be able to evaluate the underlying theory and learn the necessary methodology.