The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including RUNX Genes in Development and Cancer; The RNA Continent; The c-myc Promoter; Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond; and Dendritic Cells in Cancer. Immunotherapy

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer.

With cancer-related deaths projected to rise to 10.3 million people by 2020, the need to prevent, diagnose, and cure cancer is greater than ever. This book presents readers with the most up-to-date imaging instrumentation, general and diagnostic applications for various cancers, with an emphasis on lung and breast carcinomas--the two major worldwide malignancy types. This book discusses the various imaging techniques used to locate and diagnose tumors, including ultrasound, X-ray, color Doppler sonography, PET, CT, PET/CT, MRI, SPECT, diffusion tensor imaging, dynamic infrared imaging, and magnetic resonance spectroscopy. It also details strategies for imaging cancer, emphasizing the importance of the use of this technology for clinical diagnosis. Imaging techniques that predict the malignant potential of cancers, response to chemotherapy and other treatments, recurrence, and prognosis are also detailed.
Concentrates on the application of imaging technology to the diagnosis and prognosis of lung and breast carcinomas, the two major worldwide malignancies
Addresses the relationship between radiation dose and image quality
Discusses the role of molecular imaging in identifying changes for the emergence and progression of cancer at the cellular and/or molecular levels"

Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells from patient referral to post-therapy management in a concise and practical format. Providing clinical guidance on the implementation and management of CAR T-cell therapy, this clinical resource keeps you up-to-date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

This book is partly based on research funded by Wereld Kanker Onderzoek Fonds based in the Netherlands and administered by the World Cancer Research Fund International grant program. Every year half a million of people worldwide are diagnosed with bladder cancer. With the recent zeitgeist of the self-empowered, intelligent patient who wishes to be well-informed, many cancer patients do not solely want to rely on decisions taken by medical practitioners, but actively participate in the journey from sickness to health or disease. While no books about the relationship between diet and bladder cancer currently exist, the poor quality of the existing information about the relationship between diet and health is shocking. Much of the information is exaggerated, not evidence-based, misleading and sometimes even incorrect. Dr. Maurice Zeegers, one of the world leading bladder cancer epidemiologists, and his co-authors set the record straight with this book on Diet and Fighting Bladder Cancer. Their aim is to provide purely evidence-based information about the relationship between diet and bladder cancer. The primary audience is bladder cancer patients who wish to be well-informed, although clinicians and healthcare workers may also find the book an interesting read. The book gives an honest reflection on what scientists know, but also what they don't yet know about how diet contributes to all stages of this important disease. Although science-based, the book is written in an easy-to-read format, illustrated with practical recipes.

This issue of PET Clinics focuses on Evolving Role of PET in Assessing the Efficacy of Immunotherapy and Radiation Therapy in Malignant Disorders, and is edited by Drs. Charles B. Simone II, Nicolas Aide, and Abass Alavi (the Consulting Editor of PET Clinics). Articles will include: The Value of PET Imaging to Guide Target Delineation for Radiation Oncology; PET Imaging to Determine Radiation Dose, Adapt Radiation Plans, and Predict Patterns of Failure and Overall Survival for Non-small Cell Lung Cancer; The Utility of PET/CT for Radiation Oncology Planning, Surveillance, and Prognosis Prediction for Gastrointestinal Tumors; Evolving Role of PET Based Novel Quantitative Techniques to Detect Radiation-induced Complications; Current and Future PET Based Quantitative techniques to Assess Response to Radiation Therapy; Diagnosis, Staging, Radiation Treatment Response Assessment, and Prognostication; FDG PET/CT for Assessing Tumour Response to Immunotherapy and Detecting Immune-related Side Effects: A Checklist for the PET Reader; PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers; FDG PET/CT for Assessing Tumour Response to Immunotherapy in Lymphomas; FDG PET/CT for Assessing Tumour Response to Immunotherapy in Solid Tumours: Melanoma and Beyond; and more!

Cancer is one of the most devastating diseases in the world today, but early prevention remains the key to controlling it. Charles H. Chen shows that through a strict regime of diet, exercise, and other healthy lifestyle changes, you can increase your chances of keeping cancer from your doorstep.

Diagnosed with colon cancer in 1998, Chen decided to tackle the disease head on and was determined to learn the causes of cancer, the treatments, and prevention methods. Chen brings a unique perspective to this subject as both a medical doctor and a cancer survivor, breaking down the various aspects of this worldwide epidemic. Practical and concise, "An Intimate Relationship" covers topics such as: Screenings for men and women Benefits of early diagnosis Treatment options Prevention and healthy lifestyle choices

As a gynecologist, Chen also focuses on women's cancer issues, including breast cancer and hormone replacement therapy. He also provides tips to help you achieve good health through the consumption of organic foods, antioxidants, and nutritional supplements.

Don't become a statistic-increase your chances of avoiding cancer and improve your overall health with "An Intimate Relationship."

Held at the Karolinska Instituet, in Stockholm, Sweden, a recent Nobel Minisymposium, " Molecular Oncology From Bench to Bedside, " marked a very special event the celebration of George and Eva Klein s combined 160th birthdays. To honor this occasion, Volume 97 of Advances in Cancer Research brings together a collection of contributions by their former students, colleagues, and collaborators from the past fifty years dedicated to George and Eva Klein. Over a decade ago, the editors of ACR initiated a subdivision of the series called " Foundations in Cancer Research " to distinguish chapters that reflect extraordinary and historical developments in cancer research this volume of tributes honoring the Kleins bodies of work presented at the minisymposium are especially appropriate for the series and should serve as an important resource for future generations.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, "Molecular Oncology - From Bench to Bedside," held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein's combined 160th birthday. To honor this occasion, this 2nd of two volumes brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva. Over a decade ago, a subdivision of ACR called "Foundations in Cancer Research" was initiated and the tributes honoring the Kleins' bodies of work presented at the minisymposium are especially appropriate for the series.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume stands as the first ever thematic volume in the series, focusing on the topic of genomics in cancer drug development. The chapters included in this book represent the cutting-edge information in the field and span such topics as Mass Spectrometry: Uncovering the Cancer Proteome for Diagnostics; Biomarker Discovery in Epithelial Ovarian Cancer by Genomic Approaches; The Application of siRNA Technology to Cancer Biology Discovery; Ribozyme Technology for Cancer Gene Target Identification and Validation; Cancer Cell-Based Genomic and Small Molecule Screens; Tumour Antigens as Surrogate Markers and Targets for Therapy and Vaccines; Practices and Pitfalls of Mouse Cancer Models in Drug Discovery; Biomarker Assay Translation from Discovery to Clinical Studies in Cancer Drug Development - Quantification of Emerging Protein Biomarkers; Molecular Optical Imaging of Therapeutic Targets of Cancer; Cancer Drug Approval in the United States, Europe and Japan.

The controversial Emanuel Revici, M.D., made the bones grow back in cancer patients, and restored health to AIDS patients as well as drug addicts and alcoholics. His medicines lifted debilitating migraines in as little as 3 minutes. Revici's reward? He was attacked and ostracized by the best. JAMA published false reports about his work. The American Cancer Society blasted him time and again. Meanwhile, word of mouth brought new patients to see him for decades. The smears didn't work, so something more needed to be done. This is the true story of the greatest medical scientist who has ever lived. Find out what happened to Dr. Revici and find out how you can use the principles of his discoveries to reverse even advanced cancers and many other illnesses. The final chapter provides current contact information for the Revici Clinic.

The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including NY-ESO-1: review of an immunogenic tumor antigen; Order, disorder, death: lessons from a superorganism; Control of differentiation in progression of epithelial tumors; Cancer vaccines: preclinical studies and novel strategies; Clinical results of vaccine therapy for cancer: learning from history for improving the future; Immunodominance and immunodomination: critical factors in developing effective CD8+ T-cell based cancer vaccines; NK cell receptors as tools in cancer immunotherapy; Innate immune recognition and suppression of tumors; Inhibitors of the HSP90 molecular chaperone: current status.

This issue of Radiologic Clinics of North America focuses on Imaging the Hospitalized Patient, and is edited by Drs. Travis S. Henry and Vincent M. Mellnick. Articles will include: Imaging of bowel wall thickening in the hospitalized patient; Imaging of acute hepatobiliary dysfunction; Imaging of GI tract perforation; Imaging of abdominal postoperative complications; Imaging of acute renal failure in the hospital setting; Imaging of diffuse lung disease in the ICU patient; Perioperative complications of cardiothoracic surgery; Approach to abnormal chest CT contrast enhancement in the hospitalized patient; Imaging of the misplaced venous catheter; Altered mental status in the hospitalized patient; Neuroimaging in the ICU patient: Pearls and pitfalls; Imaging of cardiovascular support; and more!

Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students.

This book will contain a series of review articles that focus on retroviral models of human and animal cancers. Each article will be written by an expert in the field of retrovirology. The reviews will summarize current work on a particular retrovirus, with particular emphasis on the relevance of this research to human disease.

This issue of Radiologic Clinics of North America focuses on Imaging of the Upper Limb and is edited by Drs. Giuseppe Guglielmi and Alberto Bazzocchi. Articles will include: Functional and surgical anatomy of the upper limb: what the radiologist needs to know; Overuse injuries of the shoulder; The acutely injured shoulder; Overuse injuries of the elbow; The acutely injured elbow; Overuse injuries of the wrist; The acutely injured wrist; Imaging of rheumatic diseases affecting the upper limb; Imaging of upper limb tumours and tumour-like pathology; Imaging the post-surgical upper limb, the radiologist perspective; MR imaging of the upper limb: pitfalls, tricks & tips; Ultrasound imaging dynamic evaluation of the upper limb; Upper limb intervention; Imaging of peripheral nerves; and more!