Advances in Oncology reviews the year's most important findings and updates within the field in order to provide practicing oncologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Leonidas C. Platanias, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in oncology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care. Contains 25 articles on such topics as de-escalation therapy for HPV-associated oropharyngeal cancer; management of in-transit metastatic melanoma; rare gynecologic tumors; pediatric lymphoma: advances with an eye on disparities; the microbiome and CNS tumors; adjuvant therapy for patients with high-risk urothelial cancer following surgery; targeting the RAS gene for treatment of GI cancers; and more. Provides in-depth, clinical reviews in oncology, providing actionable insights for clinical practice. Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Cancer Immunotherapy, Volume 165 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to different approaches to cancer immunotherapy, with this release focusing on TNFR2 in cancer immunology and immunotherapy, From the Hellstrom paradox towards cancer cure, CAR T-cell treatment of T-cell malignancy , Immunotherapy of pancreatic cancer, Cancer stem cell immunology/immunotherapy, Cytokine release syndrome, Tumor cell-based mechanisms of resistance to immune attack, and Mushroom compounds in cancer immunotherapy.

Advances in Cancer Research, Volume 144, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research. Chapters in this new release include Gene-Environment-Microenvironment Interactions in Melanomagenesis, PP2A and the Cell Cycle, Current Progress Defining Calcium Signals as Therapeutic Targets in Cancer Cells, and much more.

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics, Volume One, Discovery and Technologies discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancer types. This first volume in the series focuses on techniques and approaches recently developed to assist in the decision of which biomarker to use for specific conditions. Topics covered include circulating tumor cells and circulating tumor DNA, exomes, tumor microenvironment, gene editing, artificial intelligence and robotics. In addition, the book discusses the development and applications of organoids and precision medicine. This book will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research.

Nanocarriers for Cancer Diagnosis and Targeted Chemotherapy reviews the principles and applications of nanocarriers for targeted drug delivery. Drug targeting involves active and passive strategies that exploit both the use of ligands for interactions and the physical and chemical properties of nanocarriers and micro-environments at target sites. Multidrug resistance and adverse side effects associated with anticancer drugs have attracted greater scientific attention and led formulation scientists to specifically target these drugs to target sites. Nanocarriers like liposomes, niosomes, gold nanorods, carbon nanotubes, and micelles are discussed for the delivery of drugs to specific disease sites. This is an important reference source for researchers in the biomedical and biomaterials fields who want to gain an understanding on how nanotechnology is used for earlier diagnoses and more effective cancer treatment.

Immunotherapy of Cancer, Volume 143, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Contributions from leading experts in the field make this a must have update on the topic.

Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines.

'Non-coding RNAs in cancer therapy: Pre-clinical and clinical implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.

Topics in this issue?include: Why does my patient have leukocytosis?; Why Is My Patient Neutropenic?; Does My Patient with a Serum Monoclonal Spike have Multiple Myeloma?; DVT and Pulmonary Embolism; Why Does My Patient Have Lymphadenopathy/Splenomegaly?; and Why Does My Patient have Thrombocytopenia?

This volume of the Urologic Clinics covers the indications, controversies, and complications of Lymphadenectomy in Urologic Oncology.? Cancer of the prostate, bladder, testicles, and kidney are covered, along with new imaging modalities and complications of open and minimally invasive lymphadenectomy.

This issue of Endocrinology Clinics brings the reader up to date on the latest information about hormones and cancer of the breast and prostate.? The first section focuses on the breast, and topics covered include the following.? The role of sex steroids and their receptors in normal breast development; estrogen carcinogenesis in breast cancer; hormonal mechanisms underlying the relationship between obesity and breast cancer; postmenopausal hormone replacement therapy and the risk of breast cancer; aromatase inhibitors, anti-estrogen and SERMS in the treatment of breast cancer; and androgens in breast cancer in men and women.? The second section is devoted to the prostate, and topics covered include the following.? Overview of prostate anatomy, histology, and pathology; the critical role of sex steroids in normal prostate development; estrogens and androgens in prostate cancer development and the rationale for hormonal chemopreventive therapies; weighing the clinical evidence regarding the timing and extent of androgen ablative therapy for prostate cancer treatment; new hormonal therapies for castration-resistant prostate cancer; and the management of the side effects of castration therapy.

Many chemotherapeutic agents are available in today's market that are highly effective against a variety of cancer types; however, the major drawbacks of these chemotherapeutic agents are the many side effects. As an alternative to these chemotherapeutic agents, there are a number of natural agents that are effective against cancer that have been tested in preclinical and clinical models over the years. These natural products must be documented and discussed in order to provide a thorough overview of all the options available for cancer treatment. The Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics emphasizes the list of natural agents against all types of cancers and discusses the current state of research in the fields of natural products and their derivatives against cancer in preclinical and clinical models. This book also provides insight into the applications of meditation and mindfulness-based interventions in clinical and non-clinical conditions. Covering topics such as cancer therapy, antioxidants, and flavonoids, it is ideal for students, research scholars, academicians, professors, scientists, oncologists, doctors, and medical practitioners.