Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.

Natural compounds obtained from plants represent a tremendous global market due to their use as food additives, cosmetics, in agriculture and in pharmaceuticals. This book provides up-to-date information on various strategies and methods for producing compounds of interest. Leading researchers discuss the latest advances in environmentally friendly natural compound production from plants, making the book a valuable resource for biotechnologists, pharmacists, food technologists and researchers working in the medical and healthcare industries.

Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells from patient referral to post-therapy management in a concise and practical format. Providing clinical guidance on the implementation and management of CAR T-cell therapy, this clinical resource keeps you up-to-date on the latest developments in this rapidly evolving area. Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.

This issue of PET Clinics focuses on Evolving Role of PET in Assessing the Efficacy of Immunotherapy and Radiation Therapy in Malignant Disorders, and is edited by Drs. Charles B. Simone II, Nicolas Aide, and Abass Alavi (the Consulting Editor of PET Clinics). Articles will include: The Value of PET Imaging to Guide Target Delineation for Radiation Oncology; PET Imaging to Determine Radiation Dose, Adapt Radiation Plans, and Predict Patterns of Failure and Overall Survival for Non-small Cell Lung Cancer; The Utility of PET/CT for Radiation Oncology Planning, Surveillance, and Prognosis Prediction for Gastrointestinal Tumors; Evolving Role of PET Based Novel Quantitative Techniques to Detect Radiation-induced Complications; Current and Future PET Based Quantitative techniques to Assess Response to Radiation Therapy; Diagnosis, Staging, Radiation Treatment Response Assessment, and Prognostication; FDG PET/CT for Assessing Tumour Response to Immunotherapy and Detecting Immune-related Side Effects: A Checklist for the PET Reader; PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers; FDG PET/CT for Assessing Tumour Response to Immunotherapy in Lymphomas; FDG PET/CT for Assessing Tumour Response to Immunotherapy in Solid Tumours: Melanoma and Beyond; and more!

This issue of Radiologic Clinics of North America focuses on Imaging the Hospitalized Patient, and is edited by Drs. Travis S. Henry and Vincent M. Mellnick. Articles will include: Imaging of bowel wall thickening in the hospitalized patient; Imaging of acute hepatobiliary dysfunction; Imaging of GI tract perforation; Imaging of abdominal postoperative complications; Imaging of acute renal failure in the hospital setting; Imaging of diffuse lung disease in the ICU patient; Perioperative complications of cardiothoracic surgery; Approach to abnormal chest CT contrast enhancement in the hospitalized patient; Imaging of the misplaced venous catheter; Altered mental status in the hospitalized patient; Neuroimaging in the ICU patient: Pearls and pitfalls; Imaging of cardiovascular support; and more!

This book is partly based on research funded by Wereld Kanker Onderzoek Fonds based in the Netherlands and administered by the World Cancer Research Fund International grant program. Every year half a million of people worldwide are diagnosed with bladder cancer. With the recent zeitgeist of the self-empowered, intelligent patient who wishes to be well-informed, many cancer patients do not solely want to rely on decisions taken by medical practitioners, but actively participate in the journey from sickness to health or disease. While no books about the relationship between diet and bladder cancer currently exist, the poor quality of the existing information about the relationship between diet and health is shocking. Much of the information is exaggerated, not evidence-based, misleading and sometimes even incorrect. Dr. Maurice Zeegers, one of the world leading bladder cancer epidemiologists, and his co-authors set the record straight with this book on Diet and Fighting Bladder Cancer. Their aim is to provide purely evidence-based information about the relationship between diet and bladder cancer. The primary audience is bladder cancer patients who wish to be well-informed, although clinicians and healthcare workers may also find the book an interesting read. The book gives an honest reflection on what scientists know, but also what they don't yet know about how diet contributes to all stages of this important disease. Although science-based, the book is written in an easy-to-read format, illustrated with practical recipes.

Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine.

This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy. Nanomaterials have recently emerged as a remarkable and promising tool for cancer therapy and diagnosis, due to their broad range of intrinsic molecular properties. To overcome the current limitations of nanoparticles in drug delivery systems, attempts have been made to synthesize nanoparticles from biological materials for targeted cancer therapy. This book provides concise evaluations of various potential bio-inspired platforms that mimic natural components of the body and offer effective and versatile drug delivery systems for cancer therapy. It also assesses the potential of nanoparticles to enhance the outcomes of cancer immunotherapy via immune cell activation and tumor microenvironment modulation. The book also summarizes in the applications of nanomaterials for the detection, prevention, and treatment of solid tumors and in the treatment of leukemia and lymphomas. In closing, it discusses ethical issues in nanomedicine, including risk assessment, risk management, and risk communication during clinical trials. The book offers offers a valuable source of information for students, academics, researchers, scientists, clinicians, and healthcare professionals working in nanotechnology and cancer research.

New Techniques for Management of 'Inoperable' Gliomas radically challenges the assumption that certain gliomas cannot be removed with modern techniques, contesting stereotypical thinking and establishing new paradigms in the field. Gliomas are primary brain tumors which are often fatal. Recent data has demonstrated that despite the fact that surgery cannot cure gliomas, patient survival is substantially improved by removing as much of the tumor as possible. This fact has raised the imperative that neurologists try to improve techniques to bring surgical resection to as many patients as possible. This book brings new insights and technologies to the forefront, giving hope to patients.

This book will contain a series of review articles that focus on retroviral models of human and animal cancers. Each article will be written by an expert in the field of retrovirology. The reviews will summarize current work on a particular retrovirus, with particular emphasis on the relevance of this research to human disease.

This book describes and illustrates an approach to surgery for spinal cord tumors that is based on a refined concept of anatomic compartmentalization. The aim of this approach is to enable maximum preservation of spinal cord function through confinement of the surgical work to the involved compartment or compartments. Importantly, this involvement differs according to tumor type, and the classification favored by the author takes this fully into account. After introductory chapters on epidemiology and pathology, the anatomy of the spinal cord relevant to surgery for spinal cord tumors is discussed in detail and the proposed classification is clearly explained. The surgical approach to each of the identified anatomic compartments is then described, with attention to the roles of intraoperative mapping techniques, diffusion tensor imaging, and electrophysiologic studies in ensuring that spinal cord functions are spared. Examples of the author's experience when applying the proposed approach are presented. The book is meant for neurosurgeons at all levels of experience.

This issue of Radiologic Clinics of North America focuses on Imaging of the Upper Limb and is edited by Drs. Giuseppe Guglielmi and Alberto Bazzocchi. Articles will include: Functional and surgical anatomy of the upper limb: what the radiologist needs to know; Overuse injuries of the shoulder; The acutely injured shoulder; Overuse injuries of the elbow; The acutely injured elbow; Overuse injuries of the wrist; The acutely injured wrist; Imaging of rheumatic diseases affecting the upper limb; Imaging of upper limb tumours and tumour-like pathology; Imaging the post-surgical upper limb, the radiologist perspective; MR imaging of the upper limb: pitfalls, tricks & tips; Ultrasound imaging dynamic evaluation of the upper limb; Upper limb intervention; Imaging of peripheral nerves; and more!