It started with a simple question: How can we help them? It became an international movement called NEGU: Never Ever Give Up. When Jessica Joy Rees was diagnosed with an inoperable brain tumor at age 11, she chose to focus not on herself but on bringing joy and hope to other children suffering from cancer. During the ten months she battled cancer, she and her family worked in the "Joy Factory" (originally their garage) making JoyJars (R)-packages filled with toys, games, and love for other kids with cancer. Jessie first handed them out personally at the hospital where she was being treated, but the effort blossomed quickly and there were soon thousands of JoyJars (R) being distributed across the United States and to over fifteen countries. Today, more than 100,000 kids have received JoyJars (R), and they continue shipping each week to kids in over 200 children's hospitals and 175 Ronald McDonald Houses. Jessie lost her battle with cancer in January 2012, but her message lives on in the Jessie Rees Foundation, which has become a beacon of hope for families fighting pediatric cancer. Join the movement at www.negu.org.

Each year nearly 35,000 men are diagnosed with prostate cancer. Of these, more than 10,000 die from the disease, and figures are rising. But better awareness, earlier diagnosis and more sophisticated treatments can save lives, and have already reduced death rates in some countries. This new edition of Coping Successfully with Prostate Cancer presents the latest research on prostate cancer and describes the many treatments available. Topics include; symptoms and stages of the disease, other prostate problems, the possible influence of diet, geography and viral factors, screening and investigation, including PSA, the decision to treat, or not to treat, treatments, including surgery and radiation therapy, branchytherapy and laser, dealing with advanced prostate cancer, lifestyle measures, coping with sex, research and the future. In this thoroughly updated and positive book, Dr Tom Smith says that it is possible for men with prostate cancer to lead successful, happy and fufilled lives.

"Alison, I’ve got bad news."

The voice of the pathologist at the other end of the telephone confirmed for Alison Tucker the news no woman ever wants to hear: she had breast cancer. Once the shock had settled, Alison decided that she would take charge. Not only would she take ownership of the dreaded disease, but she would do so with a positive mindset and prepare herself as best she could for what was to come. She did detailed research and paid close heed to what she was told by others who had walked the path before her. As she navigated her way through surgery and the chemotherapy and radiotherapy that followed, Alison’s determination paid off. Not only did she make new friends, but she learnt valuable life lessons too: acceptance of the illness for what it was, the amazing impact of ongoing advances in medical science, and the importance of being able to ask for – and receive – help.

In My Best Worst Year – A Breast Cancer Story, Alison gives us an authentic account of her experience, offering insights and advice for others who might one day face the same diagnosis. You will accompany her on her highs, empathise with her lows, and be amused by humorous anecdotes along the way. Through the generous support of family and friends, she has amassed a collection of practical tips for both patients and supporters which she shares with open-hearted honesty:

• What to take to chemotherapy sessions
• What to look for when choosing a wig
• What side effects a person can expect when having the various types of cancer treatment
• What to say, and what not to say, to a cancer patient
• How to remove stress from a cancer patient’s life
• What kind of gifts and gestures are most appreciated

Contrary to Alison’s expectations, her year of treatment turned out to be her best worst year. By telling her story, she underlines the importance of a positive attitude and hopes to show that a person can still lead a productive and enjoyable life even after being diagnosed with cancer.

Once a certain death sentence and often a cause for shame, cancer is now a treatable disease. "Cancer" provides a broad introduction to this complex family of diseases, tracing the fascinating history of scientific discoveries that led to today's sophisticated treatments.

This extraordinary new volume, coauthored by three leaders in cancer research and surgery at Harvard Medical School, uses scientifically accurate yet accessible language to give readers a firm grounding in such essential concepts as angiogenesis and the genetics of cancer. In addition to information about types of cancer, diagnosis, and treatment, "Cancer" places special emphasis on new frontiers in research, psychological aspects of a cancer diagnosis, and quality-of-life issues for those living with disease. Useful features include a comprehensive glossary, a timeline of milestones in cancer research, and an appendix for students on how to pursue a career in science or medicine.

Aptamers Engineered Nanocarriers for Cancer Therapy details the selection technologies, biological characteristics, and clinical uses of aptamer-based nano agents for cancer therapeutics. The book helps facilitate speedy solutions for some of the problems pertaining to the manufacture of nano-aptamers - such as toxicity, thermal stability, cost efficiency, tumor penetration and blood stability. Key chapters cover cell-SELEX technology for aptamer selection, mechanisms of multi-drug resistance of cancer, the relevance of aptamers as anticancer therapies, as well as the broad range of aptamer-functionalized nanostructures available. This book provides exciting insights into this relatively new approach to cancer therapeutics, and will be of interest to materials scientists, biomedical engineers, molecular biologists, biochemists and clinical scientists, with a focus on cancer therapy.

Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume Two: Diagnosis, Therapeutic Targets and Molecular Mechanisms for Hepatocellular Carcinoma Progression provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. The volume discusses topics such as computational approaches for identification of biomarkers, enzymes and pathways of HCC, circulating and epigenetic biomarkers, drug resistance, metabolic pathways, and small molecule-target therapies. In addition, it discusses immunotherapies, immune check point inhibitors and nanotechnology-based therapies. This book is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting.

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy.

A clear, concise, and essential guide providing key information about cancer survivors and their needs-and how those needs can best be met. Excellent Care for Cancer Survivors: A Guide to Fully Meet Their Needs in Medical Offices and in the Community is edited by the director of the Lance Armstrong Cancer Survivorship Program at the Dana Farber Cancer Institute and comprised of articles by experts from that prestigious institution, from the Harvard Medical School, and other leading cancer programs. Its goal is simple: to assure that the millions of cancer survivors in the United States get the help they need to live life to its fullest. This timely work, enriched by conversations with cancer survivors themselves, explains the array of challenges that may affect survivors, from physical needs to psychological, spiritual, sexual, and financial issues. Topics such as nutrition and exercise are also addressed, as are risk assessment, rehabilitation, and possible cognitive dysfunction after chemotherapy. A final section explains the nuts and bolts of starting a professional cancer survivorship program, from staffing to fundraising, exploring what can and is being done to help cancer survivors in different settings achieve optimal health and quality of life. Conversations with cancer survivors explaining the physical and psychological challenges/obstacles they face A listing of current cancer survivorship programs across the United States

Inflammation and Oral Cancer: From Bench to Bedside discusses all aspects surrounding the relationship between inflammation and oral cancer, from basic science to the translational research that helps in the optimization of clinical management strategies. The book discusses topics such as chronic inflammation and cancer in oral cavity, the role of HPV in oral inflammation and cancer, rodent models of oral cancer, and epigenetics in oral inflammation and cancer. This is a valuable resource for cancer researchers, oncologists and members of biomedical field who are interested in learning more about the diverse aspects of inflammation and oral cancer. Inflammation in oral mucosa can remodel the topography of the overlying epithelium. If such inflammation is chronic, it can have fundamental clinical consequences, the principal of which can be premalignant lesions throughout the alimentary tract. Furthermore, mucosal inflammation, even if subtle, is the single most common pathway for oral cancer - therefore it is very important to understand these interactions in detail.

Advances in Cancer Research, Volume 152, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research.

A magnificent, beautifully written biography of cancer -- from its first documented appearances thousands of years ago through the epic battles to cure, control and conquer it, to a radical new understanding of its essence.

In The Emperor of All Maladies, Siddhartha Mukherjee, doctor, researcher and award-winning science writer, examines cancer with a cellular biologist's precision, a historian's perspective, and a biographer's passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with - and perished from - for more than five thousand years.

The story of cancer is a story of human ingenuity, resilience and perseverance, but also of hubris, arrogance and misperception, all leveraged against a disease that, just three decades ago, was thought to be easily vanquished in an all-out 'war against cancer'. Mukherjee recounts centuries of discoveries, setbacks, victories and deaths, told through the eyes of predecessors and peers, training their wits against an infinitely resourceful adversary.

From the Persian Queen Atossa, whose Greek slave cut off her malignant breast, to the nineteeth-century recipient of primitive radiation and chemotherapy and Mukherjee's own leukemia patient, Carla, The Emperor of All Maladies is about the people who have soldiered through toxic, bruising, and draining regimes to survive and to increase the store of human knowledge.

Riveting and magesterial, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments and a brilliant new perspective on the way doctors, scientists, philosophers and lay people have observed and understood the human body for millennia.

Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research.

Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully.

'Non-coding RNAs in cancer therapy: Pre-clinical and clinical implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.