Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of treatment approaches for breast cancer, including conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. This book compiles the most important information on the state-of-the-art therapeutics, including breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, sections cover basic and receptor mediated targeting approaches and examine tumor microenvironment mediated approaches. This is a useful book for pharmaceutical scientists and basic and clinical scientists working in the research area of breast cancer and drug discovery both from academics and industry. Worldwide, breast cancer is the most common cancer in women, however, breast cancer therapy is always challenging. This book aims to help researchers remain updated on the most targeted nanomedicine research available.

Stem cell research is one of the fascinating areas of contemporary biology, but, as with many expanding fields of scientific inquiry, research on stem cells raises scientific questions as rapidly as it generates discoveries. Research on stem cell treatment continues to advance knowledge about how an organism develops from a single cell and how healthy cells replace damaged cells in adult organisms. The most important potential application of human stem cells is the generation of cells and tissues that could be used for cell-based therapies, especially oncology. The Faculty of Medicine, Universitas Sumatera Utara, collaborated with the center of excellence and innovation (Pusat Unggulan Inovasi /PUI). The Stem Cell center of the Universitas Sumatera Utara (USU) organized an International Conference. The International Stem Cell and Oncology Conference (ISCOC) 2017 was a comprehensive academic conference in the field of stem cell and oncology research and also tropical medicine and related scientific topics. We expect Stem Cell Oncology will benefit academics and practitioners in the field of health sciences in Indonesia. This is an Open Access ebook, and can be found on www.taylorfrancis.com.

Biomedical Science Chinese herbal medicine represents complementary or adjunctive therapies that often can improve the efficacy of Western medicine to achieve the pharmacological effects, especially in cancer treatment. However, the combination of herbs with therapeutic drugs can raise potential health risk. Building a bridge between Western medicine and herbal medicines, Active Phytochemicals from Chinese Herbal Medicines: Anti-Cancer Activities and Mechanisms gives you useful information on how integrated medicines can work for cancer therapy. It discusses the therapeutic uses of phytochemicals, adverse effects, and interactions with (Western) cancer drugs. The author takes a unique approach to integrated pharmacology of herbal medicines, examining the development of phytochemicals and their mechanisms of action in the context of the cancers and diseases they are used to treat. He covers biologic action of the active phytochemicals at the molecular, cellular, and organ levels. The book covers the principles of the interaction of phytochemicals and the related drug actions. It also addresses the common pathways affecting cancer development before discussing the phytochemical classes and specific phytochemicals that have been recently reported in journal papers for the management of cancer and other diseases. Highlighting the increasingly important aspects of pharmacology, including health benefit and drawbacks of phytochemicals, the book presents the relevant background of the biochemistry of the cancer. It includes illustrations and tables with adverse reactions that highlight important issues related to phytochemical actions. These features and more make the book a useful reference on phytochemicals obtained from herbal medicines. It blends coverage of fundamental mechanisms of anti-cancer action and the use of phytochemicals to manage cancers and other human diseases, allowing you to explore how herbal medicines can enhance conventional protocols.

Appraising cancer as a major medical market in the 2010s, Wall Street investors placed their bets on single-technology treatment facilities costing $100-$300 million each. Critics inside medicine called the widely-publicized proton-center boom "crazy medicine and unsustainable public policy." There was no valid evidence, they claimed, that proton beams were more effective than less costly alternatives. But developers expected insurance to cover their centers' staggeringly high costs and debts. Was speculation like this new to health care? Cancer, Radiation Therapy, and the Market shows how the radiation therapy specialty in the United States (later called radiation oncology) coevolved with its device industry throughout the twentieth-century. Academic engineers and physicians acquired financing to develop increasingly powerful radiation devices, initiated companies to manufacture the devices competitively, and designed hospital and freestanding procedure units to utilize them. In the process, they incorporated market strategies into medical organization and practice. Although palliative benefits and striking tumor reductions fueled hopes of curing cancer, scientific research all too often found serious patient harm and disappointing beneficial impact on cancer survival. This thoroughly documented and provocative inquiry concludes that public health policy needs to re-evaluate market-driven high-tech medicine and build evidence-based health care systems.

This book covers all various research areas using nano systems in the field of bio nanotechnology to fight against cancer for diagnosis and therapy including drug delivery from fundamentals to advanced levels. Book has designed such a way that, anyone who is interested to understand, learn or start his/her research career in the field of bio nanotechnology in cancer, can use as a gateway to enter in to the field as well as a serious advanced researcher can use as the reference text book. Due to multidisciplinary nature of the subject, the book has written so that advanced undergraduate, graduate, postgraduate and researchers from different fields can follow and understand the subject very easily. Plenty of figures and art works are used to convey the idea visibly and effortlessly

Gives a convenient summary of trials in Gynecologic Oncology Supplies an invaluable revision primer for those undertaking certification Provides a uniquely up-to-date resource

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential.

- First book to focus on deep learning-based approaches in the field of cancer diagnostics. - Covers the state of the art across a wide-range of topics. - Topics include preprocessing data, prediction of cancer susceptibility and reoccurence, detection of different cancers, complexity and challenges.

When this book first appeared in 1981, it was the first to deal comprehensively with major issues in the psychotherapeutic treatment of cancer patients. It remains the standard volume in the field, drawing together a broad spectrum of work using psychological approaches to treatment of cancer patients and to understanding the disease's sociological and psychological implications. Distinguished contributors from medicine, psychiatry, psychoanalysis, psychology, social work, family and group therapy, and nursing examine key issues, including the role of aggression in the onset and treatment of cancer; sexual functioning of patients; cancer as an emotionally regressive experience, cancer in children, and the countertransference responses of a therapist working with a cancer patient. This volume will be of particular value to helping professionals who deal with cancer patients and their families.

There is extremely compelling evidence to suggest that if people are physically active before, during and after cancer treatment, their outcomes are likely to be better. Their risk of recurrence (and death) is lower and their ability to deal with the myriad side effects is improved significantly. Increasingly people with cancer understand this but they are often unsure of what exercise would be best, what is safest, what would be most effective and what to avoid. This book offers very practical, targeted information to enable people to exercise in whatever way they feel ready for. It provides guidance on effective and appropriate exercise for anybody who has received a diagnosis of cancer, including those receiving active treatment and those living with incurable cancer of all types, with the emphasis on the proven benefits of exercise and activity.

The treatment of cancer in young women and men is increasingly turning from focusing purely on survival to a recognition of the long-term effects of treatment on subsequent quality of life. In this regard, fertility is a very high priority for patients. This is the first book to explain the latest techniques in fertility preservation. Chapters cover fertility preservation in both women and men, management of cancer in pregnancy, egg donation and surrogacy, hormone replacement options, counselling and ethical issues. A multidisciplinary team of over 60 specialists were involved in this work, with contributions from leading obstetricians, medical oncologists, gynaecological oncologists, urologists and fertility specialists. The book is formally supported by the Association of Cancer Physicians (ACP). This highly patient-centred, readable text will be of value to a wide range of clinicians and physicians, and doctors in training, in their daily work.

The second edition of this easy-to-understand pocket guide remains an invaluable tool for students, assistant practitioners and radiographers. Providing an accessible introduction to the subject in a reader-friendly format, it includes diagrams and photographs to support the text. Each chapter provides clear learning objectives and a series of MCQs to test reader assimilation of the material. The book opens with overviews of image production, basic mathematics and imaging physics, followed by detailed chapters on the physics relevant to producing diagnostic images using X-rays and digital technologies. The content has been updated throughout and includes a new chapter on CT imaging and additional material on radioactivity, dosimetry, and imaging display and manipulation. Clark's Essential Physics in Imaging for Radiographers supports students in demonstrating an understanding of the fundamental definitions of physics applied to radiography ... all you need to know to pass your exams!

This easy-to-understand pocketbook in the highly respected Clark’s stable of imaging texts is an invaluable tool and training aid, providing essential information for mammographic positioning, technique and interpretation for mammography practitioners at all levels. Adopting a systematic and structured approach facilitating rapid reference in the clinical setting, the book covers general principles and all routine mammographic projections, including additional and adapted projections covered in a separate section, and is highly illustrated with clear explanatory line diagrams and imaging photographs. Clark’s Essential Guide to Mammography is ideal as an educational tool for trainee mammographers, trainee assistant and associate apprenticeship mammographers, mammography training teams and universities delivering mammography education and a convenient clinical guide for practising mammographers, including assistant and associate apprenticeship mammographers.

Soft tissue tumours are extremely common although difficult to understand due to a large number of sub-types, leading to a significant increase in their imaging in the last decade. This highly illustrated practical book provides a simplified, systematic approach to imaging, reporting and diagnosing these tumours. It covers all the modalities with emphasis on ultrasound and MRI, along with the newer techniques in these modalities. This concise guide to soft tissue lesions, will help clinicians to quickly understand the spectrum of tumours and identify the appropriate imaging techniques to best serve their patients. Key Features: * Provides guidance by international experts on various types of soft tissue tumours (benign, malignant and tumour mimics), their relevant imaging features to help suggest specific or differential diagnosis and when to biopsy and when to refer to specialist centres. * Proves to be an excellent resource for general and specialist radiologists, radiology trainees, sonographers, sarcoma surgeons and oncologists for day-to-day reporting. * Discusses the importance of proper imaging and biopsy of tumors and the implications of unplanned excisions in sarcoma.

A much-needed overview of the available information now accumulating to indicate that assisted reproductive technologies are generally safe for both babies and mothers. However, the literature abounds with reports of a higher risk of obstetric and perinatal complications; regarding the long term outcomes for both women and children, the data are still scarce. The chapters summarized in this book review the current knowledge on long term safety of assisted reproduction and indicate the need for continued research to cover the lack of data in some specific patient groups and for recently developed treatments that only have a short period of follow-up.

Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives provides high level knowledge on detailed mechanisms of actions and biological interactions of different immune drugs, with an aim of offering researchers and clinicians cutting-edge therapies to overcome drug resistance. The book explains the latest immunotherapies for different types of cancer, helping users carry out research projects or create alternatives for drug development in the pharmaceutical industry. Topics discussed include the relationship between immunotherapy and macrophages, immune checkpoints in different types of cancer, immune cocktails in solid tumors, and immune-phenotyping. Additionally, the book presents basic and clinical data on immunoresistance and glycosylation. This book is a valuable source for cancer researchers, medical doctors, clinicians and members of the biomedical field who must understand certain mechanisms to fight cancer that is resistant to immunotherapy.

NEW YORK TIMES BESTSELLER 'A beautiful book' - Jo Good, BBC Radio London 'When Harry Met Minnie made me cry and made me dance with joy. It's an exquisite tale about heartbreak and healing, critters and humans, and the little miracles life hands us when we need them the most' - Jeannette Walls, New York Times bestselling author of The Glass Castle and Half Broke Horses 'Teichner's main themes are sure to warm readers in this cold coronavirus winter: the steadfast devotion between dogs and their owners, and the essential role friendship plays in sustaining both humans and their beloved pets ... Teichner has learned that we all have the capacity to create and build new friendships and attachments at whatever age or stage of life. That such rewards are possible is the inspirational lesson for all the characters in - and readers of - this touching saga' - The Washington Post 'When Harry Met Minnie is a tour-de-force of storytelling. Martha Teichner not only charts the course of two remarkable friendships, between two people and two dogs, she invites us to consider our own relationships. The stars that had to align to put someone special in our life. This is a love story, masterful, warm and funny, heartfelt and heartbreaking. I absolutely loved this book' - Louise Penny, New York Times bestselling author of All the Devils Are Here 'When Harry Met Minnie is a story of laughter and tears, of friendship and dogs. It shows us the loyalty and resilience of Bull Terriers?and of two women who love them. A book of generosity and hope for an era badly in need of both' - Jennifer Finney Boylan, author of GOOD BOY: My Life in Seven Dogs 'When Harry Met Minnie belongs on the shelf next to Travels with Charley and Marley and Me. But the unforgettable dogs we meet in these pages don't just help the people in their lives, they save each other. Martha Teichner has written an extraordinary story filled with love and humor about the transformative power of friendship, among dogs and people, in the thick of life and at its end. I fell in love with Harry, Minnie, their humans, and this marvel of a book' - Will Schwalbe, New York Times bestselling author of The End of Your Life Book Club and Books for Living 'I decided to write this book, because I didn't want to stop living the story of what happened when Harry met Minnie. I didn't want to forget any of it, even the sad parts. This story of unexpected friendship, of love, was a wonderful gift, and in the end, it made me and Minnie happy' - Martha Teichner There are true fairy tales. Stories that exist because impossible-to-explain coincidences change everything. Except in real life, not all of them have conventional, happily-ever-after endings... Carol, who is dying of cancer caused by the toxic pollution in New York in the aftermath of 9/11, needs someone to take care of Harry, who is a 'great listener but does have a problem with large dogs. He is great with smaller dogs. If he sees a hose he will destroy it to protect you. He will figure out ways to let you know exactly how he feels'. When Martha has a chance encounter with Carol's friend, he can't help but notice Minnie, 'oh those chunky little legs', and so the matchmaking begins. After a disastrous first meeting, when Minnie doesn't appear to think much of Harry (who is super keen), things improve and soon they are inseparable. As Carol's illness progresses, so a new friendship and community blossoms, Carol's Club. The bonds that grew changed Martha's life, Carol's life, Minnie's life and Harry's life. And they changed Carol's death as well. In this rich and touching narrative, Martha considers the ways our stories are shaped by the people we meet, and the profound love we can find by opening our hearts to unexpected encounters.

With chapters from globally recognized academics, General Radiography shows the multifaceted approach to general radiography and how it enhances healthcare delivery. Potentially influential to how healthcare delivery is offered, it begins with the pertinent chapters examining image acquisition and dose optimization in diagnostic radiography. Next, chapters reflect and critically discuss aspects central to patient care, and imaging within trauma, critical care and pediatric situations. The final section of this book then explores the learning, teaching and education in the field of diagnostic radiography, with novel strategies illustrated.

This comprehensive atlas is unique in being devoted to the MRI appearances of bone marrow in the axial and appendicular skeleton of adults and children. Normal MRI findings, including common variants and degenerative changes, are first documented. MRI appearances in the entire spectrum of neoplastic and non-neoplastic infiltrative marrow disorders are then presented, with accompanying explanatory text. Among the conditions considered are multiple myeloma, the acute and chronic leukemias, diffuse metastases, diffuse lymphomas, the anemias, polycythemia vera, myelofibrosis, storage disorders, and infections. Characteristic changes to bone marrow following various forms of treatment are also displayed and discussed. The selected images reflect the use of a variety of sequences and techniques, such as fat suppression, chemical shift imaging, and contrast-enhanced imaging.

The current age of clinical medicine is witnessing biotechnological innovation at an unprecedented pace. As a result, the recently popularized clinical practice guidelines (CPG), as a tool to assist clinical decision-making, have been struggling to keep up. Thyroid Cancer: From Emergent Biotechnology to Clinical Practice Guidelines rides the wave of medical innovation, analyzing current and future CPG, and providing an up-to-date and comprehensive treatise on thyroid cancer, its diagnosis, and treatment.

A synthesis of ideas by prominent world experts in the field of thyroid cancer research and clinical practice, Thyroid Cancer covers:

• Technologically-advanced diagnostic procedures and therapeutic interventions
• Diagnostic techniques employed in the detection and follow-up of thyroid cancer including ultrasound, needle aspiration techniques, CT, PET, PET-CT, and MRI
• Basic principles of systems biology, molecular and translational medicine, CPG development, and risk stratification for thyroid cancer
• How CPG contain knowledge gaps and produce uncertainty
• Advances in the field, including new surgical techniques, molecular targeted therapies, external beam radiation therapy, and chemotherapy

A comprehensive, scientific description of current and future diagnostic and therapeutic modalities for the management of thyroid cancer, this treatise is an indispensible reference for both the specialist and referring physician.

Highly Commended in the category of Oncology at the British Medical Association Awards 2019 The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon - terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

The culmination of 30 years of research and experience in T-cell-based cancer, this book highlights and evaluates new treatments that harness the power of the T cell to attack and kill all cancer cells in our bodies. It describes how the T cell immune system can be manipulated and redirected to kill resistant cancer cells by understanding and influencing the interaction of many different immune cells in the body. Citing current experimental trials, it examines the role and pathology of T-cells and suggests additional experimental approaches to the problem.

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology. Covers cancer targets-phase 1, 2, and 3 trials and preliminary results, as well as approved therapies. Includes sections on Molecular Targets and Pathways, and Targeted and Immunotherapy Agents. Contains a section on Carcinogenesis from the Perspective of Targeted Therapy and Immunotherapy, with essential content on biology, immunology, and immunotherapy. Organizes information by tumor type, pathway, and drug name, so you can approach clinical challenges from any direction. Highlights FDA approvals throughout. Pocket-sized and color coded to help you find information quickly and easily. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Epidemiological studies show that cancer incidence is far more dependent on the conditions of life than previously supposed. Classically, cancers occurred with heavy exposure to a specific occupational hazard, or were associated with habits. In some instances, research shows, the incidence of cancer falls when the method of work or the associated habit is changed. In short, variation in incidence is now known to be the rule rather than the exception in cancer. No cancer that occurs with even moderate frequency, occurs everywhere and always to the same extent. Sometimes it is even epidemic, similar in scale to an epidemic of infectious disease, but modified by the fact that the induction period may be as much as thirty years.

Prevention of cancer is now coming to be regarded as a practicable alternative to its cure. We remain almost totally ignorant of how cancer is produced at the cellular level and, until we know this, our methods of prevention are liable to be cumbersome and inefficient. Ethical considerations and the time scale of the disease make it impossible to obtain experimental evidence in man and what action to take has been determined from observing nature's experiments and by analogy from experiments in animals.

The evidence from epidemiological studies is of particular interest. Such studies suggest relationships that would never be thought of in the ordinary course of laboratory work and results that are directly relevant to the problems of human disease. The large numbers at risk and the intensity of the medical care to which people with cancer are subjected, make it possible to recognize relatively small improvements. Such practical decisions, based on information thus obtained, have largely eliminated the risk of cancer due to occupational hazards in several industries.

"Richard Doll" (1912-2005) was a British psychologist and one of the most prominent epidemiologists of the twentieth century. Throughout out his research he was able to link smoking with health problems and was the first individual to link smoking with lung cancer and increased risk of heart disease. He also studies the relationship between asbestos and lung cancer and radiation and leukemia. He is the author of many books, including "The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today" and "Tobacco and Health."