This book contains selected papers from the First International Conference on the Ontology of Spacetime. Its fourteen chapters address two main questions: first, what is the current status of the substantivalism/relationalism debate, and second, what about the prospects of presentism and becoming within present-day physics and its philosophy? The overall tenor of the four chapters of the book's first part is that the prospects of spacetime substantivalism are bleak, although different possible positions remain with respect to the ontological status of spacetime. Part II and Part III of the book are devoted to presentism, eternalism, and becoming, from two different perspectives. In the six chapters of Part II it is argued, in different ways, that relativity theory does not have essential consequences for these issues. It certainly is true that the structure of time is different, according to relativity theory, from the one in classical theory. But that does not mean that a decision is forced between presentism and eternalism, or that becoming has proved to be an impossible concept. It may even be asked whether presentism and eternalism really offer different ontological perspectives at all. The writers of the last four chapters, in Part III, disagree. They argue that relativity theory is incompatible with becoming and presentism. Several of them come up with proposals to go beyond relativity, in order to restore the prospects of presentism.
- Space and time in present-day physics and philosophy
- Introduction from scratch of the debates surrounding time
- Broad spectrum of approaches, coherently represented

This book is devoted to an important branch of the dynamical systems theory: the study of the fine (fractal) structure of Poincare recurrences -instants of time when the system almost repeats its initial state. The authors were able to write an entirely self-contained text including many insights and examples, as well as providing complete details of proofs. The only prerequisites are a basic knowledge of analysis and topology. Thus this book can serve as a graduate text or self-study guide for courses in applied mathematics or nonlinear dynamics (in the natural sciences). Moreover, the book can be used by specialists in applied nonlinear dynamics following the way in the book. The authors applied the mathematical theory developed in the book to two important problems: distribution of Poincare recurrences for nonpurely chaotic Hamiltonian systems and indication of synchronization regimes in coupled chaotic individual systems.

* Portions of the book were published in an article that won the title "month's new hot paper in the field of Mathematics" in May 2004
* Rigorous mathematical theory is combined with important physical applications
* Presents rules for immediate action to study mathematical models of real systems
* Contains standard theorems of dynamical systems theory

This book describes the advanced stability theories for magnetically confined fusion plasmas, especially in tokamaks. As the fusion plasma sciences advance, the gap between the textbooks and cutting-edge researches gradually develops.

This book reports on the extraordinary observation of TeV gamma rays from the Crab Pulsar, the most energetic light ever detected from this type of object. It presents detailed information on the painstaking analysis of the unprecedentedly large dataset from the MAGIC telescopes, and comprehensively discusses the implications of pulsed TeV gamma rays for state-of-the-art pulsar emission models. Using these results, the book subsequently explores new testing methodologies for Lorentz Invariance Violation, in terms of a wavelength-dependent speed of light. The book also covers an updated search for Very-High-Energy (VHE), >100 GeV, emissions from millisecond pulsars using the Large Area Telescope on board the Fermi satellite, as well as a study on the promising Pulsar Wind Nebula candidate PSR J0631. The observation of VHE gamma rays is essential to studying the non-thermal sources of radiation in our Universe. Rotating neutron stars, also known as pulsars, are an extreme source class known to emit VHE gamma rays. However, to date only two pulsars have been detected with emissions above 100 GeV, and our understanding of their emission mechanism is still lacking.

The article by Fulde, Thalmeier and Zwicknagl traces many of the recent developments in the field of strongly correlated many electron systems. It is very useful both as a reference and a pedagogical exposition since it places these developments into a historical context beginning with early developments in the electron theory of solids. The second article in this volume, by Brechet and Hutchinson, concerns pattern formation in metals and alloys. Spontaneous pattern formation is the development of a regularity, either in the spatial distribution of the material in a system or in its development in time, of a lower symmetry than that of its cause. These phenomena have been of considerable interest to the non-linear physics community, in particular in fluid dynamics and in chemical reactions.
- Continuation of prestigious serial
- Covers cutting edge research and topics in solid state physics
- Studies strongly correlated electron systems and pattern formation in metal and alloys"

This book treats essentials from neurophysiology (Hodgkin-Huxley equations, synaptic transmission, prototype networks of neurons) and related mathematical concepts (dimensionality reductions, equilibria, bifurcations, limit cycles and phase plane analysis). This is subsequently applied in a clinical context, focusing on EEG generation, ischaemia, epilepsy and neurostimulation. The book is based on a graduate course taught by clinicians and mathematicians at the Institute of Technical Medicine at the University of Twente. Throughout the text, the author presents examples of neurological disorders in relation to applied mathematics to assist in disclosing various fundamental properties of the clinical reality at hand. Exercises are provided at the end of each chapter; answers are included. Basic knowledge of calculus, linear algebra, differential equations and familiarity with MATLAB or Python is assumed. Also, students should have some understanding of essentials of (clinical) neurophysiology, although most concepts are summarized in the first chapters. The audience includes advanced undergraduate or graduate students in Biomedical Engineering, Technical Medicine and Biology. Applied mathematicians may find pleasure in learning about the neurophysiology and clinic essentials applications. In addition, clinicians with an interest in dynamics of neural networks may find this book useful, too.

A mind-bending excursion to the limits of science and mathematics
Are some scientific problems insoluble? In Beyond Reason, internationally acclaimed math and science author A. K. Dewdney answers this question by examining eight insurmountable mathematical and scientific roadblocks that have stumped thinkers across the centuries, from ancient mathematical conundrums such as "squaring the circle," first attempted by the Pythagoreans, to G?del's vexing theorem, from perpetual motion to the upredictable behavior of chaotic systems such as the weather.
A. K. Dewdney, PhD (Ontario, Canada), was the author of Scientific American's "Computer Recreations" column for eight years. He has written several critically acclaimed popular math and science books, including A Mathematical Mystery Tour (0-471-40734-8); Yes, We Have No Neutrons (0-471-29586-8); and 200% of Nothing (0-471-14574-2).

For some time immunotherapy has been heralded as a breakthrough approach for cancer treatment. Although the potential of this strategy remains solid, the approach needs considerable refinement. Whilst some programmes are looking to increase the understanding of molecular and cellular mechanisms underlying the stimulation of antitumor immunity, others are trying to find the most appropriate clinical setting that will reveal the role of the immune system in combating cancer. Among the most important discoveries have been tumor-specific antigens.
This thematic volume highlights some key issues and discusses where they may move forward. It has been put together by two leading cancer immunotherapists from two eminent institutions that focus on cancer research.

Have you ever seen a comet? It is a marvelous experience, one that all humans can share, that spawns a deep yearning to understand the spectacle. Have you ever wondered what comets are and why astronomers spend so much time studying them? Now, a comet expert and an astronomical historian have come together to produce the unique book that you now hold in your hands. Using their several decades of teaching experience, the authors have concisely presented the information you need to comprehend these majestic apparitions that grace our night skies. No mathematical proficiency is needed, in fact, this book doesn't contain a single equation! Comets are cosmic Rosetta stones, bridging our current knowledge by digging back to the earliest days of our Solar Systems. How did life arise on Earth? Did comets play a significant role in bringing water and the necessary organic matter to our early Earth? How about the dinosaurs? Were they driven to extinction by a cometary impact 66 million years ago? Comets may be both the enablers and destroyers of life on Earth as we know it. These are some of the tantalizing questions discussed here. If you so desire, steps are given to join the ranks of amateur comet hunters. Astronomy is one of the last sciences where amateurs play a significant role. Your reward for discovery? A comet officially bearing your name in the history books! The next Great Comet is on its way, we just do not know when it will arrive. Armed with this book, you will be ready to enjoy this unforgettable event.

Combinatorial Kalman filters are a standard tool today for pattern recognition and charged particle reconstruction in high energy physics. In this thesis the implementation of the track finding software for the Belle II experiment and first studies on early Belle II data are presented. The track finding algorithm exploits novel concepts such as multivariate track quality estimates to form charged trajectory hypotheses combining information from the Belle II central drift chamber with the inner vertex sub-detectors. The eventual track candidates show an improvement in resolution on the parameters describing their spatial and momentum properties by up to a factor of seven over the former legacy implementation. The second part of the thesis documents a novel way to determine the collision event null time T0 and the implementation of optimisation steps in the online reconstruction code, which proved crucial in overcoming the high level trigger limitations.

In two volumes, this book presents a detailed, systematic treatment of electromagnetics with application to the propagation of transient electromagnetic fields (including ultrawideband signals and ultrashort pulses) in dispersive attenuative media. The development in this expanded, updated, and reorganized new edition is mathematically rigorous, progressing from classical theory to the asymptotic description of pulsed wave fields in Debye and Lorentz model dielectrics, Drude model conductors, and composite model semiconductors. It will be of use to researchers as a resource on electromagnetic radiation and wave propagation theory with applications to ground and foliage penetrating radar, medical imaging, communications, and safety issues associated with ultrawideband pulsed fields. With meaningful exercises, and an authoritative selection of topics, it can also be used as a textbook to prepare graduate students for research. Volume 2 presents a detailed asymptotic description of plane wave pulse propagation in dielectric, conducting, and semiconducting materials as described by the classical Lorentz model of dielectric resonance, the Rocard-Powles-Debye model of orientational polarization, and the Drude model of metals. The rigorous description of the signal velocity of a pulse in a dispersive material is presented in connection with the question of superluminal pulse propagation. The second edition contains new material on the effects of spatial dispersion on precursor formation, and pulse transmission into a dispersive half space and into multilayered media. Volume 1 covers spectral representations in temporally dispersive media.

This book deals with the practice of Optical Radiation Measurements with introductory material to introduce the topics discussed. It will be most useful for students, scientists and engineers working in any academic, industrial or governmental projects related to optical radiation. The book contains chapters that treat in detail the procedures and techniques for the characterization of both sources and detectors to the highest degree of accuracy and reliability. It has a chapter devoted specifically to optical measurements of laser sources and fiberoptics for communication and a chapter devoted to uncertainty in measurement and its treatment with real examples of optical measurements. The book contains introductory materials that will allow a newcomer to radiometry to develop the expertise to perform exacting and accurate measurement. The authors stress the various causes of uncertainty in each phase of a measurement and thus allow for users to arrive at a correct assessment of their uncertainty of measurement in their particular circumstance.
. Authors are from the Standards laboratories of AUSTRALIA, CANADA, ENGLAND, GERMANY and the USA.
. Latest techniques and practice of laboratory measurements to achieve the highest accuracy in the use of sources or detectors.
. Unique illustrations of the apparatus and measurement techniques.
. Practical measurement examples of calibration with full uncertainty analysis.
. Comprehensive treatment of optical standards such as sources, detectors and radiometers.
. A complete chapter on laser power measurements and standards for fiber optic measurements
. A complete chapter on correlations in radiometry and practical examples.
. A chapter devoted to diffraction effects in radiometry"

This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients' primary cancer cells. This technique will have a high impact for widespread use of HTS in the era of personalized medicine. In this thesis, the author firstly describes the need and concept of 'partipetting' for pipetting-free HTS platform. It is realized by the one-step pipetting and self-assembly of encoded drug-laden microparticles (DLPs) on the microwells. Next, the technical implementations required for the platform demonstration are described. It includes preparation of encoded DLPs, plastic chip fabrication, and realization of automated system. Lastly, screening of sequential drug combinations using this platform is demonstrated. This shows the potential of the proposed technology for various applications.

This is an overview of single molecule physics, the study of both equilibrium and non-equilibrium properties at the single molecule level. It begins with an introduction to this fascinating science and includes a chapter on how to build the most popular instrument for single molecule biophysics, the total internal reflection fluorescence (TIRF) microscope. It concludes with the Poisson process approach to statistical mechanics, explaining how to relate the process to diverse areas and see how data analysis and error bars are integral parts of science.