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Agammaglobulinemia (Paperback, Softcover reprint of the original 1st ed. 2015) Loot Price: R3,407
Discovery Miles 34 070
Agammaglobulinemia (Paperback, Softcover reprint of the original 1st ed. 2015): Alessandro Plebani, Vassilios Lougaris

Agammaglobulinemia (Paperback, Softcover reprint of the original 1st ed. 2015)

Alessandro Plebani, Vassilios Lougaris

Series: Rare Diseases of the Immune System, 4

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Loot Price R3,407 Discovery Miles 34 070 | Repayment Terms: R319 pm x 12*

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This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton's tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia. Patients' management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are discussed. The book's closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.

General

Imprint: Springer International Publishing AG
Country of origin: Switzerland
Series: Rare Diseases of the Immune System, 4
Release date: August 2016
First published: 2015
Editors: Alessandro Plebani • Vassilios Lougaris
Dimensions: 235 x 155mm (L x W)
Format: Paperback
Pages: 119
Edition: Softcover reprint of the original 1st ed. 2015
ISBN-13: 978-3-319-37249-5
Categories: Books > Medicine > Clinical & internal medicine > Haematology
Books > Medicine > Clinical & internal medicine > Rheumatology
Books > Medicine > Clinical & internal medicine > Paediatric medicine > General
Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
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LSN: 3-319-37249-1
Barcode: 9783319372495

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