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Books > Medicine > Clinical & internal medicine > Haematology
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Blood Cell Biochemistry - Hematopoietic Cell Growth Factors and Their Receptors (Paperback, Softcover reprint of the original 1st ed. 1996)
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Blood Cell Biochemistry - Hematopoietic Cell Growth Factors and Their Receptors (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Blood Cell Biochemistry, 7
Expected to ship within 10 - 15 working days
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Historically, the field of hematopoietic growth factor research
began with the work of Carnot and Deflandre-in 1906 they suggested
that the rate of erythropoiesis is regulated by a humoral factor
found in the blood, namely, erythropoietin. From this comparatively
early start, accelerating progress has been made in erythropoietin
research, which demon strates the general trends in this field of
study. Erythropoietin was purified to homogeneity by 1977 (from
enormous quantities of urine from aplastic anemia patients).
Subsequently, the gene for erythropoietin has been cloned (1985),
and massive quantities of this growth factor have been produced for
clinical trials (late 1980s onward). Erythropoietin has become
established as a pharmaceutical product of great value in the
treatment of a number of diseases, most notably chronic renal
failure. Once the ligand had been cloned, interest turned to the
erythropoietin receptor, which was cloned in 1989. Since then,
structure/ function studies have been performed on receptor
mutants, cellular signaling events down stream from the occupied
receptor have been identified, and the specific producer cell types
and molecular stimuli for erythropoietin production have been
thoroughly investigated, as has the regulation of erythropoietin
gene transcription. This schedule of events since the 1970s
typifies that seen for a number of hematopoietic growth factors.
Along the way, the hematopoietic growth factors have been
recognized as members of the cytokine family of signaling molecules
that are important in a number of different physiological and
patholog ical situations (see below).
General
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