Oxidation of polyunsaturated fatty acids by lipoxygenases leads to
a variety of fatty acid metabolites which play important roles in
physiology but also in pathophysiology. Data accumulated during the
last decade point to the fact that lipoxygenase metabolites are
involved in host defence reactions, cardiovascular system and
contribute to the development of inflammatory and allergic
diseases, cardiovascular disease and cancer. This PIR volume
summarizes the physiological and pathophysiological functions of
lipoxygenases.
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