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In Vivo Models to Study Angiogenesis (Paperback)
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In Vivo Models to Study Angiogenesis (Paperback)
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In Vivo Models to Study Angiogenesis provides the latest
information and an overview of the most common assays for studying
angiogenesis in vivo. Under physiological conditions, angiogenesis
is tightly controlled, whereas increased production of angiogenic
stimuli and/or reduced production of angiogenic inhibitors leads to
abnormal neovascularization, such as occurs in cancer, chronic
inflammatory disease, diabetic retinopathy, macular degeneration
and cardiovascular disorders. Several genetic and epigenetic
mechanisms are involved in the early development of the vascular
system. This book presents the latest information from the
extensive literature and research available. Evidence is now
emerging that blood vessels themselves have the ability to provide
instructive regulatory signals to surrounding non-vascular target
cells during organ development. Thus, endothelial cell signaling is
currently believed to promote fundamental cues for cell fate
specification, embryo patterning, organ differentiation and
postnatal tissue remodeling.
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