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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Antimicrobial Resistance - A Crisis in Health Care (Paperback, Softcover reprint of the original 1st ed. 1995)
Loot Price: R4,003
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Antimicrobial Resistance - A Crisis in Health Care (Paperback, Softcover reprint of the original 1st ed. 1995)
Series: Advances in Experimental Medicine and Biology, 390
Expected to ship within 10 - 15 working days
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Development and Implications of Antimicrobial Resistance One of the
most ominous trends in the field of antimicrobial chemotherapy over
the past decade has been the increasing pace of development of
antimicrobial resistance among microbial pathogens. The hypothesis
that man can discover a magic bullet to always cure a particular
infection has proved false. Physicians are now seeing and treating
patients for which there are few therapeutic alternatives, and in
some cases, none at all. Until recently there was little concern
that physicians might be losing the war in our ability to compete
with the evolving resistance patterns of microbial pathogens. Now
the general public is very aware of the threat to them if they
become infected, thanks to cover story articles in major magazines
such as Time, Newsweek, newspapers, and other news sources.
Antimicrobial resistance is not a novel problem. Shortly after the
widespread introduction of penicillin in the early 1940s, the first
strains of penicillin-resistant staphylococci were described. Today
it is an uncommon event for a clinical laboratory to isolate an S.
aureus that is sensitive to penicillin. Other gram-positive strains
of bacteria have become resistant, including the exquisitely
sensitive Streptococcus pneumoniae. Sensitivity to vancomycin was
once so uniform that it was used in routine clinical laboratories
as a surrogate marker for whether an organism should be classified
as a gram-positive. That criterion can no longer be relied upon
because of emerging resistance among some species. Gram-negative
bacteria, viruses, fungi, and parasites all have succeeded in
developing resistance.
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