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Aquaporins in Health and Disease - New Molecular Targets for Drug Discovery (Paperback)
Loot Price: R1,457
Discovery Miles 14 570
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Aquaporins in Health and Disease - New Molecular Targets for Drug Discovery (Paperback)
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Since the discovery of Aquaporin-1 (AQP1) as a water channel, many
studies have revealed the importance of aquaporins in mammalian
physiology and pathophysiology as well as plant and microbial
biology. The studies have also shown aquaporins as potential drug
targets and targets for improving crop properties. Written by an
international group of contributors at the forefront of the field,
Aquaporins in Health and Disease: New Molecular Targets for Drug
Discovery presents the latest research advances in aquaporins and
other major intrinsic protein (MIP) channels. The first section of
the book describes the general concepts of aquaporin channel
function, genomic research, structure-function analysis of
aquaporins and glycerol facilitators, and regulation by gating and
trafficking, including yeast aquaporin regulation and function. The
second section discusses the physiological and pathophysiological
roles of aquaporins in humans and microbes. The final section
covers the development of inhibitors of aquaporin function. The
book's epilogue offers future perspectives and directions, mainly
in the area of aquaporin-based diagnostics and therapeutics.
Stimulating future research on this important protein family, this
book facilitates a paradigm shift in the understanding and roles of
aquaporin membrane proteins in all biological settings. It
encourages scientists to develop novel approaches for the treatment
of human diseases based on aquaporin function or dysfunction.
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