The first annotated edition of the scientific papers that created
the foundation of modern neuroscience and physiology The origin of
everything known about how neurons and muscles generate electrical
signals can be traced back to five revolutionary papers, published
in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew
Huxley. The principles they revealed remain cornerstones of the
discipline, summarized in every introductory neuroscience and
physiology course. Since that era, however, scientific practice,
technology, and presentation have changed extensively. It is
difficult for the modern reader to appreciate Hodgkin and Huxley's
rigorous scientific thought, elegant experimental design, ingenious
analysis, and beautiful writing. This book provides the first
annotated edition of these papers, offering essential background on
everything, from terminology, equations, and electronics, to the
greater historical and scientific context surrounding the work. The
original journal pages are displayed opposite detailed notes
explaining content, process, and background, with copies of the
figures replotted according to modern conventions. Indispensable
for scientists, teachers, and trainees alike, The Annotated Hodgkin
and Huxley makes an essential body of knowledge-and an unparalleled
approach to research-accessible to a new generation of readers.
Reproduces the original articles paired with extensive annotations
on facing pages Replots figures with modern conventions of data
display Explains the development of the voltage clamp and the
discovery of ionic currents and action potential generation,
foundational to the study of neuroscience and physiology Summarizes
the history of electrophysiology leading to Hodgkin and Huxley's
work Includes appendices on relevant concepts from mathematics,
physics, electronics, chemical kinetics, and numerical methods
General
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