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Whole Organ Approaches to Cellular Metabolism - Permeation, Cellular Uptake, and Product Formation (Paperback, Softcover reprint of the original 1st ed. 1998)
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Whole Organ Approaches to Cellular Metabolism - Permeation, Cellular Uptake, and Product Formation (Paperback, Softcover reprint of the original 1st ed. 1998)
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The field of capillary-tissue exchange physiology has been
galvanized twice in the past 25 years. A 1969 conference at the
National Academy of Sciences in Copenhagen resulted in the book
Capillary Permeability: The Transfer of Mole cules and Ions Between
the Capillary Blood and the Tissue (Crone and Lassen, 1970). It
focused on the physiochemical aspects of transcapillary water and
solute transport. The field has matured considerably since. This
volume was designed as the successor to the 1970 book, and was
created at a gathering of the authors at McGill University. It too
captures the breadth of a field that has been dramatically enriched
by numerous technical and conceptual advances. In 1970 it was
already known that the capillary wall was not merely a "cellophane
bag" exerting steric hindrances on solute particles. Instead, the
endothelial surface was recognized as the site of binding reactions
and permeation by passive or carrier-mediated trans port.
Furthermore, the cells of the blood could traverse evanescent wide
openings in the "zippered" clefts. Today, research priorities have
turned more to cell-cell interactions, toward understanding the
utility of the gap junctional connections between endothelial cells
and neighboring smooth muscle cells, neuronal twigs, and the
parenchymal cells of organs. New discoveries in the past few years
have revealed the critical importance of the close relationships
between the endothelial cells and the parenchymal cells."
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