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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Applied Toxicology: Approaches Through Basic Science - Proceedings of the 1996 EUROTOX Congress Meeting Held in Alicante, Spain, September 22-25, 1996 (Paperback, Softcover reprint of the original 1st ed. 1997)
Loot Price: R2,967
Discovery Miles 29 670
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Applied Toxicology: Approaches Through Basic Science - Proceedings of the 1996 EUROTOX Congress Meeting Held in Alicante, Spain, September 22-25, 1996 (Paperback, Softcover reprint of the original 1st ed. 1997)
Series: Archives of Toxicology, 19
Expected to ship within 10 - 15 working days
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Ultraviolet radiation, a component of sunlight, has been recognized
by photobiologists, dermatologists, and oculists as a potential
hazard for human health because of its genotoxic, carcinogenic and
immunotoxic properties. Its effects on human health include the
induction of skin cancers, ocular damage and impairment of immunity
to certain infections. A few decennia ago it was demonstrated that
UV photons can affect the activity of the immune system through
interactions with the skin. This means that UV not only changes
normal cells into cancer cells but also permits the outgrowth of
the UV -transformed cells by depressing the immune system. An
intriguing question is what interactions between UV radiation and
the skin initiates alterations in immune function in the exposed
skin and systemically, i. e. in other places than the exposed skin.
During the last 20 years many studies have been performed in order
to investigate the immunosuppressive activities of UVB in
laboratory animals and in human volunteers. In particular effects
of UVB radiation on resistance to tumours and skin associated
infections have been examined. In addition, effects of UVB
radiation on immune parameters such as contact hypersensitivity and
delayed-type hypersensitivity (both type IV hypersensitivity
reactions), mixed lymphocyte reactions, mixed skin lymphocyte
reactions, antigen presentation and numbers and function of
Langerhans cells have been studied intensively. The antigenicity of
murine tumours which are caused by UVB radiation was one of the
first items to be investigated (Kripke, 1974).
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