Microfluidics-based biochips combine electronics with biochemistry,
providing access to new application areas in a wide variety of
fields. Continued technological innovations are essential to
assuring the future role of these chips in functional
diversification in biotech, pharmaceuticals, and other industries.
Revolutionary guidance on design, optimization, and testing of
low-cost, disposable biochips Microfluidic Biochips: Design
Automation and Optimization comprehensively covers the appropriate
design tools and in-system automation methods that will help users
adapt to new technology and progress in chip design and
manufacturing. Based on results from several Duke University
research projects on design automation for biochips, this book uses
real-life bioassays as examples to lay out an automated design flow
for creating microfluidic biochips. It also develops solutions to
the unique problems associated with that process. Highlights the
design of the protein crystallization chip to illustrate the
benefits of automated design flowIn addition to covering automated
design, the authors provide a detailed methodology for the testing,
use, and optimization of robust, cost-efficient, manufacturable
digital microfluidic systems used in protein crystallization and
other areas. The invaluable tools and practices presented here will
help readers to: Address optimization problems related to layout,
synthesis, droplet routing, and testing for digital microfluidic
biochips Make routing-aware, architectural-level design choices and
defect-tolerant physical design decisions simultaneously Achieve
the optimization goal, which includes minimizing time-to-response,
chip area, and test complexity Effectively deal with practical
issues such as defects, fabrication cost, physical constraints, and
application-driven design The authors present specialized
pin-constrained design techniques for making biochips with a focus
on cost and disposability. They also discuss chip testing to ensure
dependability, which is key to optimizing safety-critical
applications such as point-of-care medical diagnostics, on-chip DNA
analysis, automated drug discovery, air-quality monitoring, and
food-safety testing. This book is an optimal reference for academic
and industrial researchers in the areas of digital microfluidic
biochips and electronic design automation.
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