Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems (Paperback, Softcover reprint of the original 1st ed. 2013)

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems, 4
Release date:	August 2016
First published:	2013
Authors:	Marc Thiriet
Dimensions:	235 x 155 x 54mm (L x W x T)
Format:	Paperback
Pages:	1064
Edition:	Softcover reprint of the original 1st ed. 2013
ISBN-13:	978-1-4939-5207-6
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Medicine > Nursing & ancillary services > Biomedical engineering > General Books > Science & Mathematics > Mathematics > Applied mathematics > Mathematics for scientists & engineers Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > General Books > Professional & Technical > Mechanical engineering & materials > Materials science > Mechanics of fluids > General
LSN:	1-4939-5207-2
Barcode:	9781493952076

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