This thesis describes novel substrate embedded physical sensors
that can be used to monitor different types of cell-based assays
non-invasively and label-free. The sensors described provide
integrative information of the cells under study with an adaptable
time resolution (ranging from milliseconds to days). This
information about the dynamic cell response to chemical, physical
or biological stimuli defines a new paradigm in fundamental
biomedical research. The author, Maximilian Oberleitner, describes
approaches in which the cells are directly grown on different
sensor surfaces (gold-film electrodes, shear wave resonators or
dye-doped polymer films). This approach, with the reacting cells in
particularly close proximity and contact with the sensor surface,
is key to a remarkable sensitivity, opening the way for a variety
of new applications. This thesis not only introduces the
fundamentals of each approach, but it also describes in great
detail the design principles and elucidates the boundary conditions
of the new sensors.
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