The present volume of "Current Topics in Microbiology and
Immunology" is a series of papers on subjects that are relevant to
the growing use of 'wild mice' in immunological, microbiological
and genetical research. 'Wild mice' is a jargonistic term that is
used chiefly in the laboratory to refer to the naturally living
forms of house mice (Mus musculus) and also other species closely
related to M. musculus. This group of species is designated by
systematists as the genus Mus. Immunologists began 20 years ago to
study the polymorphisms of 1mmunoglobulins and major
histocompatibility complex antigens in wild mice. An extrordinary
extension of the highly polymorphic array of phenotypes known in
inbred mice was encountered. Breeding stocks of wild mice were
brought into the laboratory. This included not only M. musculus but
a)so many of the available species in the genus Mus-from Southeast
Asia ~nd Europe. This availability led to other comparisons of
'wild' and inbred mice and the discovery of other new and
interesting phenotypes and genotypes. It became apparent that
inbred strains of mice provided only a limited window for viewing
the genetic diversity of Mus musculus.
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