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Molecular Autoimmunity (Paperback, 2005 ed.)
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Discovery Miles 46 120
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Molecular Autoimmunity (Paperback, 2005 ed.)
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2004 marks the 100th anniversary of the first description of the
autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic
disorder, by Julius Donath and Karl Landsteiner. After a century of
research, the list of autoimmune diseases has become impressive.
With a prevalence of approximately 5% of the world-wide population,
these chronic, debilitating conditions affect almost every major
organ of the body and, for reasons that remain unclear, are much
more prevalent in woman than in men. Despite our rapidly expanding
knowledge of the cellular and molecular pathways that govern a
normal immune response, deciphering the precise etiology of
autoimmune diseases remains an important challenge. Over the last
few years, our understanding of the pathogenesis of autoimmune
diseases has improved rapidly, leading to the emergence of elegant
immunointervention strategies. Molecular Autoimmunity illustrates
how cutting-edge research is continuing to advance our
understanding of autoimmune disease mechanisms and identifies novel
therapeutic targets that provide a hope for effective future
treatments. This volume contains a selected number of exciting
advances in unraveling autoimmune reactions, and the resulting new
armory of experimental immunotherapies that may lead to new ways of
controlling autoimmune reactions.
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