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Modelling Protocells - The Emergent Synchronization of Reproduction and Molecular Replication (Hardcover, 1st ed. 2017)
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Modelling Protocells - The Emergent Synchronization of Reproduction and Molecular Replication (Hardcover, 1st ed. 2017)
Series: Understanding Complex Systems
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The monograph discusses models of synthetic protocells, which are
cell-like structures obtained from non-living matter endowed with
some rudimentary kind of metabolism and genetics, but much simpler
than biological cells. They should grow and proliferate, generating
offsprings that resemble in some way the parent protocells with
some variation, so that selection may take place. Sustainable
protocell populations have not yet been obtained experimentally and
mathematical models are therefore extremely important to address
key questions concerning their synthesis and behavior. Different
protocell "architectures" have been proposed and high-level
abstract models like those that are presented in this book are
particularly relevant to gain a better understanding of the
different properites. These models are able to treat all the major
dynamical phenomena in a unified framework, so they can be seen as
"virtual laboratories" for protocell research. Particular attention
is paid to the problem of synchronization of the fission rate of
the whole protocell and the duplication rate of its "protogenetic"
material, which is shown to be an emergent property that
spontaneously develops in successive generations. The book is of
interest for a broad range of scientists working in soft matter
physics, chemistry and biology, interested in the role protocells
may play on the development of new technologies with medical,
environmental and industrial applications as well as scientists
interested in the origin of life.
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