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Molecular Evolutionary Genetics (Paperback, Softcover reprint of the original 1st ed. 1985)
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Molecular Evolutionary Genetics (Paperback, Softcover reprint of the original 1st ed. 1985)
Series: Monographs in Evolutionary Biology
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This volume in the Monographs in Evolutionary Biology series
addresses issues that are part of an emerging area of research
loosely called "mo lecular evolution. " Its practitioners include
both molecular biologists cu rious about the evolutionary
implications of their data and evolutionary biologists pushing
their analyses to the molecular level. The union of these fields of
molecular and organismal biology has been turbulent at times, and,
as shall be seen, this dialectic has led to some very serious
challenges to long-held notions about the role of natural selection
in evolution and the economy of genome organization in eukaryotes.
As an inevitable outgrowth of molecular biology, molecular
evolution is necessarily a young discipline, but it can already
point proudly to two major discoveries. The first, is the molecular
clock, a concept that has emerged from the analysis of at least
four data sets-amino acid sequences, immunologic data, DNA
renaturation studies, and, recently, analyses of DNA sequences. The
reality of a strong stochastic component in the evolution of
nucleotide sequences can no longer be doubted, although the
accuracy of the clock with regard to particular sequences and
within particular groups of or ganisms should be independently
measured each time it is used. Never theless, molecular clocks will
assume increasingly important roles in phy logenetic
reconstructions, especially since the fossil record is so
fragmentary. The second major discovery of molecular evolution has
been the incredible complexity of the eukaryotic genome."
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