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Books > Medicine > General issues > Medical equipment & techniques
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Proteolysis in the Interstitial Space (Paperback)
Loot Price: R1,567
Discovery Miles 15 670
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Proteolysis in the Interstitial Space (Paperback)
Series: Protein Science
Expected to ship within 12 - 19 working days
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Most clinical laboratory tests utilize interstitial and
extravascular such as blood, urine, cerebral spinal fluid (CSF),
and saliva. For example, CSF is monitored in the context of cancer
for both diagnostic and therapeutic reasons. And yet, our
understanding of the makeup of interstitial fluids, their
relationships to disease, as well as their commercial importance in
therapeutics and diagnostics remains rudimentary. Although
sometimes perceived as static, interstitial and extravascular
fluids are surprisingly dynamic. More than half of serum albumin is
in the extravascular space. These fluids move rapidly between the
intravascular and extravascular spaces - one entire plasma volume
is exchanged very nine hours. In the first half of the book, the
authors cover fundamental concepts of interstitial fluids,
including their composition and function. They then further review
the mechanisms by which interstitial fluids are regulated,
characterizing the importance of hyaluronan - a major constituent
of interstitial spaces and an a component of synovial fluid; and,
outlining the regulation of proteolysis in the interstitial space.
In the second half of the book, the authors focus on the
coagulation system. This system has been studied extensively in the
context of vascular spaces. But many of its components exist in the
interstitial spaces. Chapters are devoted to the fibrinolytic
system, kallikrein, matrix metalloproteinases, coagulation factors,
and protease inhibitors - all are interstitial. By covering a
unique array of topics with broad application to biomedical
scientists, this book expands our understanding of the importance
of interstitial spaces and the fluids that move through and reside
in this extravascular environment.
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