Contents:
1. Inverse Detection Applied to the ^T1H and 13C Assignment and to the Regiochemical Characterization of ß-substituted Alpha, Alpha Coupled Oligo- and Polythiophenes L. Schenetti and A. Mucci 2. ^T17O NMR of Enol Ethers ^TM.A.P. Martins, G.M. Sigueira, A.F.C. Flores, H.G. Bonacorso, R.A. Freitag and N. Zanatia 3. Monitoring Interaction of Heterocyclic Drugs with Biological Systems: Combined Approach by Magnetic Relaxation, NOE, and Other Spectroscopic Modalities V.E. Yushmanov 4. Solvent/Water Suppression in NMR W.S. Price 5. Mass Spectrometry in Protein Study Mitsuo Takayama and Akira Tsugita 6. Some Aspects of Mass Spectrometry of Natural ProductsD.A. Ponomarev, V.V. Takhistov and P. Vainiotalo 7. Luminiscence Techniques in Pharmaceutical Analysis. Recent Advances in Experiemental Methods and Chemometric Applications Garciela M. Escandar and Alejandro C. Olivieri 8. Asphaltenes: The "Dark Side" of Petroleum M. Nali

High-Resolution Solid-State NMR of Silicates and Zeolites Günter Engelhardt and Dieter Michel "I strongly recommend this book as an important reference for scientists concerned with the structural properties of siliceous materials." —Applied Spectroscopy This well-organized and up-to-date text gives a thorough account of the wide range of applications of multinuclear high-resolution solid-state NMR spectroscopy in silicate and zeolite science, with emphasis on the kinds of chemical information retrievable from NMR experiments. 1988 (0 471-91597-1) 485 pp. The Chemistry of Silica Solubility, Polymerization, Colloid and Surface Properties, and Biochemistry Ralph K. Iler A major component of the earth’s solid surface and the constituent of sand, silica—an ageless natural staple—is also integral to industries as diverse as chemistry, biology, medicine, agriculture, metallurgy, and mining. This landmark reference details the chemistry surrounding the research and development of silica as well as information on its production and production control. 1979 (0 471-02404-X) 866 pp. The Chemistry of Organic Silicon Compounds Parts 1 and 2 Edited by Saul Patai and Zvi Rappoport "This volume will probably become the first reference consulted for C-Si chemistry…" —Choice This authoritative account of organic compounds containing carbon-silicon bonds brings specialists up-to-date to the field’s latest innovative turns. The emphasis in this compilation of studies—from 17 prominent researchers—is on small molecules, single bonds, analysis, structure, synthesis, spectroscopy, and reaction mechanisms. Part 1:1989 (0 471-91441-X) 892 pp. Part 2:1989 (0 471-91992-6) 1,668 pp.

This classic and bestselling landmark publication, originally published in 1965, examines the dynamic mechanisms, fundamental principles, and physical properties of various chromatographic procedures. It offers methods to characterize, identify, and predict chromatographic phenomena - providing strategies to select the most appropriate separation tools and techniques for specific applications in chemistry, physics, biology, and forensic and environmental science. Written by a world-renowned pioneer in the field, Dynamics of Chromatography contains many worked equations and real-world examples in gas and liquid chromatography. It includes numerous schematic figures for visualization of key concepts, introduces the means to control migration rate differences and zone spreading, and presents a detailed random-walk model for clarification of column processes. It also analyzes flow, diffusion, and kinetic events, stresses the link between theory and practice, and summarizes mathematical quantities and parameters.

Electrochemical Biosensors summarizes fundamentals and trends in electrochemical biosensing. It introduces readers to the principles of transducing biological information to measurable electrical signals to identify and quantify organic and inorganic substances in samples. The complexity of devices related to biological matrices makes this challenging, but this measurement and analysis are critically valuable in biotechnology and medicine. Electrochemical biosensors combine the sensitivity of electroanalytical methods with the inherent bioselectivity of the biological component. Some of these sensor devices have reached the commercial stage and are routinely used in clinical, environmental, industrial and agricultural applications.

The chemistry of flavours and fragrances is of great interest to academics and industrialists alike. Bringing together international contributors, this book presents the most recent research in this key area. Diverse topics such as structure-activity relationships; analytical techniques; natural products and essential oils; and organic and bioorganic chemistry are discussed, along with flavours and foods. Advances in Flavours and Fragrances: From the Sensation to the Synthesis will be a welcome addition to the bookshelves of all practitioners with a common interest in this fascinating area.

The ongoing progress of science has shown that it is important for analytical scientists to determine not only the presence of particular elements, but also their species. There are many fields where this is applicable, and where there are a number of topics to be addressed. Developing separation and measurement systems for the many element species has tested the resourcefulness of analytical chemists over recent decades. A product of the EU sponsored Speciation 21 Network, this book presents a detailed review of the state-of-the-art of speciation issues in the occupational health, food and environment sectors, along with the main conclusions arising from discussions held during expert meetings. Topics covered include mercury and organotin compounds in the environment; factors affecting the health of workers; the importance of speciation of trace elements for health, and subsequent metabolism in the body; analytical methodologies; risk assessment; and legislation. Trace Element Speciation for Environment, Food and Health provides an insight into applied research in the speciation field and how it has become so important in all the fields represented. With its comprehensive coverage, it will be of particular interest to researchers in industry and academia, as well as government agencies and legislative bodies.

Laboratory automation is an increasingly important part of the job description of many laboratory scientists. Although many laboratory scientists understand the methods and principles involved in automation, most lack the necessary engineering and programming skills needed to successfully automate or interface equipment in the lab. A step-by-step, how-to reference and guide, Practical Pharmaceutical Laboratory Automation explores the processes needed to automate the majority of tasks required in research today. The author discusses topics ranging from automated mathematical analysis to robotic automation of chemical processes, to combinations of these and other processes. He presents a detailed discussion of high throughput screening and assay development and takes an in-depth look at Visual Basic as the primary programming language used in laboratories. The text has a dedicated web site (http://www.pharmalabauto.com) that contains all the sample code and examples contained within the text as well as other information related to laboratory automation. Providing a starting point for tackling automation problems, Practical Pharmaceutical Laboratory Automation helps you develop a strategy for automation that gets consistent results.

Carbocation chemistry is not only fundamental to the advancement of organic chemistry, it also has found widespread applications in organic synthesis. It is not an exaggeration to say that carbocation chemistry is part of the foundation of organic chemistry. Carbocation Chemistry: Applications in Organic Synthesis provides a panoramic view of carbocation chemistry with an emphasis on synthetic applications. This book is an invaluable tool for organic, medicinal and analytical chemists, including those working in biochemistry as well as the petroleum, plastics and pharmaceutical industries. It is also suitable for upper level undergraduates and graduates in organic chemistry, biochemistry and medicinal chemistry.

Most fields of science, applied science, engineering, and technology deal with solutions in water. This volume is a comprehensive treatment of the aqueous solution chemistry of all the elements. The information on each element is centered around an E-pH diagram which is a novel aid to understanding. The contents are especially pertinent to agriculture, analytical chemistry, biochemistry, biology, biomedical science and engineering, chemical engineering, geochemistry, inorganic chemistry, environmental science and engineering, food science, materials science, mining engineering, metallurgy, nuclear science and engineering, nutrition, plant science, safety, and toxicology.

Reference materials play an important role in analytical chemistry, where they are used by analysts for a variety of purposes, including: checking and calibrating instruments; validating methods and estimating the uncertainty of analytical measurements; checking laboratory and analyst performance; and internal quality control. This book provides guidance and information for the users of certified reference materials (CRMs), explaining how they can best be used to achieve valid analytical measurements and improve quality in the analytical laboratory. General information on CRMs and how they are produced sets the scene for readers. The statistics relating to CRM use are then explained in an easy-to-understand manner, and this is followed by sections covering the main uses of CRMs. Detailed worked examples are used throughout. Structured and comprehensive in coverage, this book will be welcomed by all users of certified reference materials.

The variety of complex terms used in the Quality Assurance aspect of analytical measurement can be the cause of considerable confusion. This unique handbook explains the most widely-used terminology in language that is readily understood, and attempts to place each term in context. Concepts are described in a way that is useful to all practitioners, particularly those concerned with quality assurance, validation and reliability of analytical measurements. Explanations of terms are always in line with the ""official definition,"" often developed by international committees. Adopting a thematic approach, Analytical Measurement Terminology is divided into six main parts. The first four parts address the logical progression of an analytical measurement, from obtaining a sample, through method and materials, to reporting the result. The two remaining parts include a variety of terms encountered in quality systems and documentation, along with definitions of ""mathematical"" terms likely to be encountered by the analyst in their everyday work. The index provides easy access to both the definitions and the accompanying examples. With its straightforward descriptions and many examples, this handbook, produced as part of the VAM (Valid Analytical Measurement) programme, will provide valuable assistance for a wide variety of new and experienced practitioners, as well as for teachers and lecturers.

The Analytical Methods Committee of the Royal Society of Chemistry has for many years been involved in national and international efforts to establish a comprehensive framework for achieving appropriate quality in chemical measurement.

This handbook attempts to select or define robust procedures that ensure the best use of resources and enable laboratories to generate consistent, reliable data. Written in concise, easy-to-read language and illustrated with worked examples, it is a guide to current best practice and establishes a control framework for the development and validation of laboratory-based analytical methods. Topics include samples and sampling, method selection, equipment calibration and qualification, method development and validation, evaluation of data and statistical approaches for method performance and comparison.

Valid Analytical Methods and Procedures will be welcomed by many organisations throughout the world who are required to prove that the validity of their analytical results can be established beyond reasonable doubt.

Since its inception in the early 1980s, capillary electrophoresis (CE) offers a great deal of flexibility as a modern analytical technique, and has found applications within many fields of analysis, particularly pharmaceutical science and biochemistry. Until now, food analysts have had difficulties in adopting the technique due to the lack of written guidance. Capillary Electrophoresis for Food Analysis: Method Development provides basic information and the support needed to enable food analysts to utilise the technique for the development of new separation methods. Designed specifically for the needs of food analysts, the book takes the reader step by step through the process of developing and troubleshooting CE methods. Worked examples are included to make it ideal as a laboratory companion as well as a library reference source.

Principles and Practices of Method Validation is an overview of the most recent approaches used for method validation in cases when a large number of analytes are determined from a single aliquot and where a large number of samples are to be analysed. Much of the content relates to the validation of new methods for pesticide residue analysis in foodstuffs and water but the principles can be applied to other similar fields of analysis. Different chromatographic methods are discussed, including estimation of various effects, eg. matrix-induced effects and the influence of the equipment set-up. The methods used for routine purposes and the validation of analytical data in the research and development environment are documented. The legislation covering the EU-Guidance on residue analytical methods, an extensive review of the existing in-house method validation documentation and guidelines for single-laboratory validation of analytical methods for trace-level concentrations of organic chemicals are also included. With contributions from experts in the field, any practising analyst dealing with method validation will find the examples presented in this book a useful source of technical information.

Bioremediation, or enhanced microbiological treatment, of environments contaminated with a variety of organic and inorganic compounds is one of the most effective innovative technologies to come around this century! Practical Environmental Bioremediation: The Field Guide presents updated material, case histories and many instructive illustrations to reflect the evolving image of this fast-emerging industry. Bioremediation technology has witnessed great strides towards simplifying treatability formats, finding new approaches to field application, more potent nutrient formulations, monitoring protocols and the resulting general improvement in results. This new guide condenses all current available knowledge and presents necessary technical aspects and concepts in language that can be readily comprehended by the technical student, experienced scientist or engineer, the aspiring newcomer, or anyone else interested in this exciting natural cleanup technique.

Quality and reliability are central to success in every discipline, but perhaps nowhere are they more important or more interconnected than in the practice of analytical chemistry. Here, although reliable analytical information implies quality, not all "quality" information proves reliable.
Quality and Reliability in Analytical Chemistry examines the various factors affecting these parameters in each step of the analytical process:

The Sample: Investigate the reliability of the sample, including its history and homogeneity.
The Method: See the connection between reliability and the selection of analytical methods for environmental, food, and clinical analyses.
The Instruments: Examine the relationship between reliability and your instrumentation.
Data Processing: Consider the importance of chemometrics in the reliability of data processing.
Automation: Explore automation of the analytic process through discussion of its parameters - rapidity, reproducibility, flexibility, and reliability.
Standards and Standardization: Understand how quality and reliability cannot be assured without using standards for measurement and how only reliable methods can be standardized.
The goal of the analytic process is to obtain high quality information with high reliability. Quality and Reliability in Analytical Chemistry helps you meet that goal and thereby satisfy your quality assurance and quality control requirements.

First Published in 1984, this set offers a comprehensive insight into thermolumiscence. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for radiobiologists and physicists and other practitioners in their respective fields.

First Published in 1982, this set offers a comprehensive guide into the process of analysing water for pesticides. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of toxicology and other practitioners in their respective fields.

First Published in 1984, this set offers a comprehensive insight into thermolumiscence. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for radiobiologists and physicists and other practitioners in their respective fields.

Today's industrial laboratory analyst encounters issues such as quality control, quality assurance ISO 9000, standard operating procedures, calibration, standard reference materials, statistical control, control charts, proficiency testing, validation, system suitability, chain of custody, good laboratory practices, protocol, and audits. In a well-written and readable style, A Primer on Quality in the Analytical Laboratory provides an introduction to quality, standards, and regulations in the analytical laboratory and serves as a valuable resource to a myriad of laboratory practices.

Features

This volume details the theories, mechanisms, technologies and trends for solving qualitative and quantitative problems in diverse areas of analytical research - emphasizing physicochemical principles. It focuses on deriving simpler and more extensive chemiluminescence (CL) detectors reflecting miniaturization trends, including narrow-bone and capillary liquid chromatography versus high-performance liquid chromatography and miniaturized high-performance thin-layer chromatography. It also covers the sensitivity, selectivity, wide detection range and versatility of CL-based methodologies.

In spite of the wide variety and complexity of biological materials, nucleic acids are ubiquitous. DNA is becoming the bioanalyte of choice due to the vast amount of information embedded in its sequence, its robust chemical nature and the range of highly sensitive analytical techniques that have been developed. The results of such analyses can have an important impact on our society both commercially and in terms of the quality of life. Absolute confidence in the data generated is therefore of the utmost importance. This book, produced by LGC as part of the VAM (Valid Analytical Measurement) Programme, introduces the issues of validation and quality to the bioanalytical community, specifically addressing DNA-based analyses. It aims to raise awareness of the factors that can influence the validity of DNA analysis and the production of quality data. Emphasis is placed on VAM principles, as well as additional challenges that are associated with the analysis of real samples, for example, complex food matrices or forensic samples that have been subjected to environmental insult. Information is collated from a variety of sources including literature, discussions and LGC research, and offers constructive advice where possible.

Speciation is one of the growing features of analytical chemistry of this decade. It is now widely recognized that the determination of total trace element contents is no longer sufficient - understanding pathways of trace elements depends on specific chemical forms, such as oxidation states, organometallic compounds, etc. However, lack of quality control of speciation often hampers the comparability of data within and between laboratories. Considering the high number of analyses performed by a wide range of EC laboratories, the SM&T programme (formerly BCR) of the European Commission has launched collaborative projects to improve the state-of-the-art of speciation analysis in Europe. Method Performance Studies for Speciation Analysis presents an overview of these recent studies. As well as discussion of the techniques used, their performance as applied to real-case analyses and possible sources of error, the preparation of Certified Reference Materials for the validation of methods used is also described. With its broad coverage and in-depth discussions, which encompass the work of eminent European experts, this unique book will be essential reading for laboratory staff in industry, academia and government.

"Provides practical information on the application of capillary electrophoresis (CE) to protein analysis, with an emphasis on developing and optimizing CE techniques in the laboratory. Includes separation methods bases on mass, charge, isoelectric point, molecular sieving, and affinity interactions."

An authoritative review of modern sensor technology—essential information for analytical chemists, biochemists, biotechnologists, spectroscopists, and chemical engineers

As sensors begin to realize their commercial and practical potential in fields ranging from the automobile and semiconductor industries to environmental monitoring and clinical diagnostics, this timely work offers an important survey of the principles, construction, and applications of the most popular types of chemical and biological sensors in use today.

Principles of Chemical and Biological Sensors brings together a wealth of valuable material in a single source, providing scientists and researchers with a basic grasp of the latest developments in this area, as well as information on trends and future directions.

Coverage includes:

• Amperometric, modified, potentiometric, and voltammetric electrodes
• Optrodes and direct spectroscopic methods
• Enzyme and antibody based biosensors
• Processing signals from sensors
• Miniaturization of sensors
• Sensor arrays and intelligent sensing systems

Principles of Chemical and Biological Sensors is an essential reference for scientists in research and industry aiming to make optimum use of these cutting-edge devices in their work.

Spurred by a dramatic increase in R&D support over the last twenty years, sensors are poised for a revolution similar to the one seen in microcomputers in the late 1980s. Matching enhanced performance with lower cost, new generations of sensing devices promise to gain a firm footing in many different areas, from environmental regulation to manufacturing and other industries.

Principles of Chemical and Biological Sensors offers a state-of-the-art look at the principles and applications of the most popular sensors available today, coupled with an exploration of potential directions and developments for the future of this dynamic field. From amperometric, potentiometric, and voltammetric electrodes to smart sensors, digital filtering, and more, this useful volume contains essential information across a range of sensor types and functions. Topics covered include:

• Ion-selective electrodes and optrodes
• Amperometric methods of detection
• Biomaterials for biosensors
• Optical chemical sensors
• Miniaturized chemical sensors
• Sensor signal processing

Expertly balancing breadth and depth of coverage within a single, easy-to-use resource, Principles of Chemical and Biological Sensors is essential reading for analytical chemists, biochemists, chemical engineers, and others who will benefit from the tremendous strides being made in sensor research and technology today.