The limited coverage of data analysis and statistics offered in most undergraduate and graduate analytical chemistry courses is usually focused on practical aspects of univariate methods. Drawing in real-world examples, Practical Guide to Chemometrics, Second Edition offers an accessible introduction to application-oriented multivariate methods of data analysis and procedures that are highly beneficial to solving a variety of problems using analytical chemistry and statistics.

Rather than overshadowing the concepts with theoretical background, this book uses application-oriented examples to illustrate how chemometrics techniques can be applied to complex scenarios with multiple and dynamic variables. The book presents a diverse selection of topics that include sampling, modeling, experimental design, calibration, pattern recognition, data analysis techniques, algorithms, and error. This second edition has been completely revised to feature new chapters on principal component analysis, self-modeling curve resolution, and multi-way analysis methods. It includes expanded material on normal distributions, sampling theory, signal processing, and digital filtering.

Embracing the growing role of chemometrics in some of the latest research trends, such as quantitative biology, bioinformatics, and proteomics, this book also identifies several areas for future development and applications. Practical Guide to Chemometrics, Second Edition continues to offer a reliable source of useful information in a style that is accessible to all levels of students, professionals, and researchers involved in analyzing scientific data.

This volume offers a review of oil inputs to the Mediterranean Sea from sources such as shipping, and offshore exploration and exploitation activities. It discusses international measures to prepare for, respond to, and prevent oil pollution incidents, as well as the international legal framework and agencies with a role in pollution prevention and responses. It includes chapters on modeling the fate of oil pollution, oil spill response, and oil spill beaching probability, and presents data from a range of sources, including historic data on shipping accidents and oil exploration and exploitation activities, satellite and remote sensing data, and numerical modelling data, to provide an overview of oil pollution over several years. Topics covered include modelling of oil slicks in the eastern and western Mediterranean basins, oil exploration and exploitation activities in the waters of the Levantine Basin (Eastern Mediterranean), and signatures to and ratification of the Barcelona Convention and its Protocols, for example. Together with the companion volume Oil Pollution in the Mediterranean Sea: Part II - National Case Studies, it addresses both national and international measures in the region, making it of relevance to the agencies and government bodies tasked with remediating or preventing oil pollution, as well as policymakers and practitioners in the fields of shipping, ports and terminals, oil extraction and marine management. It provides researchers with essential reference material on tools and techniques for monitoring oil pollution, and serves as a valuable resource for undergraduate and postgraduate students in the field of marine oil pollution.

Amperometric sensors, biosensors included, particularly rely on suitable electrode materials. Progress in material science has led to a wide variety of options that are available today. For the first time, these novel functional electrode coating materials are reviewed in this monograph, written by and for electroanalytical chemists. This includes intrinsically conducting, redox and ion-exchange polymers, metal and carbon nanostructures, silica based materials. Monolayers and relatively thick films are considered. The authors critically discuss preparation methods, in addition to chemical and physical characteristics of these new materials. They present various examples of emerging applications in electroanalysis. Due to its comprehensive coverage, the book will become an indispensable source for researchers working on the development and even proper use of new amperometric sensor systems.

Accelerated Predictive Stability (APS): Fundamentals and Pharmaceutical Industry Practices provides coverage of both the fundamental principles and pharmaceutical industry applications of the APS approach. Fundamental chapters explain the scientific basis of the APS approach, while case study chapters from many innovative pharmaceutical companies provide a thorough overview of the current status of APS applications in the pharmaceutical industry. In addition, up-to-date experiences in utilizing APS data for regulatory submissions in many regions and countries highlight the potential of APS in support of registration stability testing for certain regulatory submissions. This book provides high level strategies for the successful implementation of APS in a pharmaceutical company. It offers scientists and regulators a comprehensive resource on how the pharmaceutical industry can enhance their understanding of a product's stability and predict drug expiry more accurately and quickly.

Bringing together expert researchers in the fields of microbiome, metabolism, and nutrition research, this book compiles the current state of knowledge from authorities specifically on how diet regulates microbial function with metabolic implications for the human host. Chapters cover the broad concepts of microbial-host interactions under the dietary influences of specific macronutrients, micronutrients, small molecule generation and bile acid circulation, with inclusion of later clinical chapters encompassing topics like bariatric surgery and our current understanding of probiotics, prebiotics, and synbiotics. Covering a timely topic from a functional standpoint, the book fills a gap in the existing literature. While increased attention is placed on descriptive work, it will importantly highlight emerging functional and mechanistic research findings that illustrate the inner workings of the dietary-microbial-host orchestration of metabolic regulation. Providing an exciting summary of the importance of current microbial function, it will also summarize the next major directions in the field of microbiome research.

The in-lab preparation of certain chemical reagents provides a number of advantages over purchasing various commercially prepared samples. This is especially true in isolated regions where acquiring the necessary substances from overseas can cause undue delay and inconvenience due to restrictions on the transportation of hazardous chemicals. An invaluable resource for chemists in a variety of environments, Small-Scale Synthesis of Laboratory Reagents with Reaction Modeling presents efficient, sensible, and versatile methods for the laboratory preparation of common chemical reagents. Rapid, reliable synthesis Designed to facilitate smooth experimentation in the lab, this volume presents preparations chosen for their short duration, availability of apparatus, high yield, and high purity of the product. Adding an educational component, the book also discusses fundamental processes in inorganic chemistry, presenting original modeling of reactions and their practical implementation. Theoretical aspects are discussed to a greater extent than is usual in synthetic literature in cases where there is a direct impact on experimental parameters, such as the reaction time, yield, and purity of the product. More than 30 convenient, time-saving preparations Focusing on simple synthesis of high-purity reagents, the book contains over 30 presentations, a substantial number of which are mathematically modeled for the first time. Most syntheses can be carried out in one day using common laboratory equipment, making this volume a valuable and time-saving tool.

This volume details the theories, mechanisms, technologies and trends for solving qualitative and quantitative problems in diverse areas of analytical research - emphasizing physicochemical principles. It focuses on deriving simpler and more extensive chemiluminescence (CL) detectors reflecting miniaturization trends, including narrow-bone and capillary liquid chromatography versus high-performance liquid chromatography and miniaturized high-performance thin-layer chromatography. It also covers the sensitivity, selectivity, wide detection range and versatility of CL-based methodologies.

Provides detailed insight into the marine microplastics pollution, fate, health impacts, and removal technology Reviews ecological risks and environmental fate of microplastics pollution to the marine ecosystem Describes control and prevention methods of the microplastics pollution Covers global legislature for the mitigation of microplastics to the marine environment Discusses role of community participation for the reduction of microplastic emissions

Over the last few decades many studies have focused on the oxygen depletion of coastal and oceanic waters. An understanding of the processes involved is fundamental to assess the effects of global and climatic changes and to support an ecosystem approach to adaptive environmental management for coastal seas and ocean basins. This timely book presents the state-of-the-art of our knowledge of the nature and chemical structure of redox interfaces in a marine water column, oxygen depletion and connected processes. The structures of the redox layers, including the distribution of certain parameters and microbiological features, are described in detail. The volume also covers studies devoted to the interannual variability of some oxygen-depleted systems, modeling and new developments in observation techniques. In addition, it identifies remaining gaps in our knowledge of the cycling of chemical elements in changing redox conditions. The chapters are based on extensive observational data, collected by the authors during sea and shore expeditions, on archive data, and on a broad range of scientific literature.

This book is an analytical treatment of the subject, that enables the reader to design successfully chemical methods (such as separations) and predict the required conditions for such methods. Part 1 describes the ways of obtaining selective effects through the use of competing reactions in aqueous media. Part 2 investigates how modifications of chemical reactivity of solutes are produced by using nonaqueous solvents. Particular consideration is given to ionized molten salts and molecular organic and inorganic solvents. This is a broad ranging study of the field. It demonstrates the theory and methodology behind practical problems in solution chemistry and enables the reader to solve them effectively, taking into account the chemistry of the system. The work is elucidated by numerous examples provided in context plus nearly 200 problems at the end of the book.

Green chemistry is a vital subject playing a key role in environmental sustainability. Despite its importance, very less has been explored in the past years. This book is a comprehensive compilation of the methods, techniques and strategies used in green chemistry. The book highlights some critical aspects of green chemistry related to agriculture and food production. It has been put together for undergraduate, graduate, and postgraduate students. Each chapter has been cited with new and updated research discoveries to help the postgraduate, and doctorate students and researchers. I hope the presented book will be an important tool for students and researchers.

"Written as a complement to the definitive work selenium in the Environment (Marcel Dekker, Inc.). Presents basic and the most recent applied research developments in selenium remediation-emphasizing field investigations as well as covering topics from analytical methods and modeling to regulatory aspects from federal and state perspectives. "

The rapidly increasing number of different ignitable liquid formulations available today poses a new challenge to fire debris analysts and other forensic chemistry specialists - that of accurately identifying and classifying ignitable liquids with unfamiliar chromatographic patterns.

GC-MS Guide to Ignitable Liquids addresses that challenge with a selection of more than 100 different ignitable liquid formulations designed to supplement the laboratory's standard collection. Both total ion chromatograms and extracted ion chromatograms (mass chromatograms) are included.

Written by authors who are also experienced forensic chemists, this complete reference is the only single source of information on ignitable liquids - a must for students of fire science, forensic chemists, and anyone conducting fire debris analysis.

This book provides updated information about applications of ion chromatography (IC) in food science, such as food quality control, food authentication and analysis of residues in certain food products. Among liquid chromatography methods, IC can be considered one of the most valuable analytical tools, an advantageous environmentally friendly technique able to provide a convenient determination of various analytes such as anions, cations, organic acids, carbohydrates, amines, amino acids, aminoglycosides, proteins, peptides, etc. Recent developments such as in-line eluent generation systems, capillary IC and combustion IC, are also described. The book is intended to serve as an organized resource for students, researchers and food analysts, but can be a relevant support for researchers from related fields. It highlights that IC can be even more powerful and effi cient when more complex equipment is available, while proper knowledge empowers the user to obtain relevant data from this.

Discusses the presence of microplastics in matrices prone for human consumption Includes generic information on microplastics, their origin, types, shapes, size and nomenclature Reviews microplastics in different types of human consumable items Illustrates fundamental methods and techniques used in microplastics research Explores overall impacts of microplastics in the organisms contaminated with the same

This book is a comprehensive compilation of modern and cutting-edge chromatographic techniques written by pharmaceutical industry experts, academics, and vendors in the field. This book is an inclusive guide to developing all chromatographic methods (such as liquid chromatography and gas chromatography). It covers modern techniques for developing methods using chromatographic development software, requirements for validations, discussion on orthogonality, and how to transfer methods from HPLC to UHPLC. The text introduces some newer techniques that are heavily employed by chemists analyzing proteins and RNAi, as well as novel techniques such as counter current chromatography. This book is valuable for both the novice starting out in undergraduate labs and those who are new to the pharmaceutical industry and is a useful reference for seasoned analysts.

Metal Ion Separations in Polyethylene Glycolbased Aqueous Biphasic Systems (R.D. Rogers et al.). Hydrophobic and Charge Effects in the Partitioning of Solutes in Aqueous Twophase Systems (M.A. Eiteman). Twophase Aqueous Surfactant Systems for the Purification of Biomaterials (C.L. Liu et al.). Integration of Aqueous Twophase Extraction with Other Separation Techniques (R. Kaul, B. Mattiasson). Mass Transfer in Aqueous Twophase Systems (S.S. Save, S.V. Save). Metal Extraction in Twophase Waterpoly(ethylene Glycol)Salt Systems (B.Ya. Spivakov et al.). The Behavior of Actinides in Twophase Aqueous Systems Based on Polyethylene Glycol (B.F. Myasoedov et al.). Purification of Biomolecules Using Temperatureinduced Phase Separation (F. Tjerneld et al.). Poly(ethylene Glycol)protein Interaction in Salt Containing Aqueous Solutions (A. Veide et al.). Interfacial Events in Phase Separation and Cell Partitioning in Aqueous Twophase Systems (F.D. Raymond, D. Fisher). Protein Refolding Using Chaotropic Aqueous Twophase Systems (T.A. Spears, D. Forciniti). Partitioning of Polyethylene Glycol (PEG)protein Conjugates in PEG/Dextran Aqueous Twophase Systems (C. Degado). Use of the Aqueous Twophase Partition Technique for Characterization and Quality Control of Recombinant Proteins (B.Ya. Zaslavsky). 2 additional articles. Index.

Here, experts contribute general examination techniques followed by more specific application models. Beginning with reviews of the principles of chemistry, the chapters also serve as introductions to the tasks and tools of examiners, and illustrate clandestine laboratory operations.

Heavy metals can be emitted into environment by both natural and anthropogenic sources, mainly mining and industrial activity. Human exposure occurs through all environmental media. Infants are more susceptible to the adverse effects of exposure. Increasing attention is now being paid to the mental development of children exposed to heavy metals. The purpose of this book is to evaluate the existing knowledge on intellectual impairment in children exposed to heavy metals in their living environment and to identify the research needs in order to obtain a clearer picture of the situation in countries and regions at risk, in which the economy is closely related to metallurgy and heavy metals emission, and to recommend a strategy for human protection. In greater detail the main objectives could be formulated as follows: to review the principal sources of single, and complex mixtures of, heavy metal pollutants in the environment; to identify suitable methodology for chemical analyses in the environment and in humans; to evaluate the existing methods for measuring mental impairment, including their reliability and validity; to recommend a standard testing protocol to be used in future research; to assess the future role of environmental heavy metal pollution in countries and regions at risk and its effects on children's neurological development; to recommend a prevention strategy for protecting children's health and development.

Conservation techniques for the analysis and preservation of heritage materials are constantly progressing. Building on the first edition of Conservation Science, this new edition incorporates analytical techniques and data processing methods that have emerged in the past decade and presents them alongside notable case studies for each class of material. An introductory chapter on analytical techniques provides a succinct overview to bring the reader up-to-speed with which type of material each technique is suitable for, the differing sampling techniques that can be employed, and the handling and processing of the resultant data. Subsequent chapters go on to cover all common heritage materials in turn, from natural substances such as wood and stone to modern plastics, detailing the up-to-date techniques for their analysis. With contributions by scientists working in the museum and heritage sector, this textbook will interest students, scientists involved in conservation, and conservators who want to develop their understanding of their collections at a material level.

X-Ray fluorescence analysis is an established technique for non-destructive elemental materials analysis. This book gives a user-oriented practical guidance to the application of this method. The book gives a survey of the theoretical fundamentals, analytical instrumentation, software for data processing, various excitation regimes including gracing incidents and microfocus measurements, quantitative analysis, applications in routine and micro analysis, mineralogy, biology, medicine, criminal investigations, archeology, metallurgy, abrasion, microelectronics, environmental air and water analysis. This book is the bible of X-Ray fluorescence analysis. It gives the basic knowledge on this technique, information on analytical equipment and guides the reader to the various applications. It appeals to researchers, analytically active engineers and advanced students.