The?rsttwovolumesinthis"TemplatesinChemistry"serieshavefocused on templates that controlsolution-phase reactions. Among the templates d- cussed in these two volumes were convex and concave templates that mediate the formation of (macro)cyclic molecules and mechanically bound molecules withtheir intriguingintertwined topology.Also,three-dimensional templates that are used to imprint polymers and that organize compounds in the solid state for predestined reactions have been included in the earlier volumes. In the present volume, we extend thetemplate topologytosurfaces that act asmatricesforthecontrolledgrowthoftwo-dimensionalarrays.Naturally,the typical methods for the characterization of surfaces such as scanning probe microscopyare prominently represented in this volume. Differentlateralinteractionssuchascoordinativebondsorhydrogenbo- ing play a major role in assembling the 2D networks on surfaces in addition to the interaction of the samples with the underlying substrates. Many p- nomena that are also encountered in solution can be directly visualized on surfaces: Reversible self-assembly processes lead to the formation of large structures through multiple recognition of small building blocks and cul- nate in the engineering of crystals in two dimensions. Self-sorting processes drive the formation of highly ordered arrays through the geometric ?t of the available components. Either the surface itself is the template, for example, when clusters grow on metal oxide ?lms, or colloidal templates control the formationof macroporousnetworksonthe substrate. This volume highlightsa selection of actual complementary aspects of s- facetemplates.Webelievethatthescopeandthevarietyoftopicscoveredinthis volume will attract readers fromdifferent communities such as supramole- larchemistry,materialsciences,surfacechemistry,surfacephysicsandsurface technologyandwehopetheywillenjoythisnewvolumeonTemplatesinCh- istry.

This book explores the remarkable information correspondences and probability structures of proteins. Correspondences are pervasive in biochemistry and bioinformatics: proteins share homologies, folding patterns, and mechanisms. Probability structures are just as paramount: folded state graphics reflect Angstrom-scale maps of electron density. The author explores protein sequences (primary structures), both individually and in sets (systems) with the help of probability and information tools. This perspective will enhance the reader's knowledge of how an important class of molecules is designed and put to task in natural systems, and how we can approach class members in hands-on ways.

For more than a century, bioactive heterocycles have formed one of the largest areas of research in organic chemistry. They are important from a biological and industrial point of view as well as to the understanding of life processes and efforts to improve the quality of life. Heterogeneous Catalysis: A Versatile Tool for the Synthesis of Bioactive Heterocycles highlights the recent methodologies used in the synthesis of such bioactive systems and focuses on the role of heterogeneous catalysis in the design and synthesis of various biologically active heterocyclic compounds of pharmacological interest. Topics include: Synthetic protocols for the construction of heterocyclic systems employing silica-bound catalysts Recent advances in heterogeneous copper-catalyzed reactions for the synthesis of bioactive heterocycles Features of silica-based heterogeneous catalysts, such as abundance, ease of use, and stability Ultrasound as an effective tool for accelerating reactions Organic transformations catalyzed by nano-ZnO as a valuable heterogeneous catalyst Heterogeneous catalysts employed in the synthesis of coumarins Heterocyclizations in the presence of silver salts Home-made organometallic silica sources, known as silatranes Reflecting the focused studies currently conducted in these areas, the book also examines anticancer, antifungal, antibacterial, anti-HIV, anti-inflammatory, antioxidant, and many more biological activities of heterocyclic compounds. It is essential reading for postgraduate and research scholars in the fields of biochemistry, chemical biology, medicinal chemistry and pharmaceutical chemistry.

Accurate uranium analysis, and particularly for isotope measurements, is essential in many fields, including environmental studies, geology, hydrogeology, the nuclear industry, health physics, and homeland security. Nevertheless, only a few scientific books are dedicated to uranium in general and analytical chemistry aspects in particular. Analytical Chemistry of Uranium: Environmental, Forensic, Nuclear, and Toxicological Applications covers the fascinating advances in the field of analytical chemistry of uranium. Exploring a broad range of topics, the book focuses on the analytical aspects of industrial processes that involve uranium, its presence in the environment, health and biological implications of exposure to uranium compounds, and nuclear forensics. Topics include: Examples of procedures used to characterize uranium in environmental samples of soil, sediments, vegetation, water, and air Analytical methods used to examine the rigorous specifications of uranium and its compounds deployed in the nuclear fuel cycle Health aspects of exposure to uranium and the bioassays used for exposure assessment Up-to-date analytical techniques used in nuclear forensics for safeguards in support of non-proliferation, including single particle characterization Each chapter includes an overview of the topic and several examples to demonstrate the analytical procedures. This is followed by sample preparation, separation and purification techniques where necessary. The book supplies readers with a solid understanding of the analytical chemistry approach used today for characterizing the different facets of uranium, providing a good starting point for further investigation into this important element.

Phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal action. Discusses chemical structure-activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi. Contains a selection of botanical plates and useful bibliographic references A useful research tool for postgraduates, academics, and the pharmaceutical, herbal, or nutrition industries.

Phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal action. Discusses chemical structure-activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi. Contains a selection of botanical plates and useful bibliographic references A useful research tool for postgraduates, academics, and the pharmaceutical, herbal, or nutrition industries.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

This book is a welcome response to the general concerns for the generation and conservation of energy in the future.

It gives a comprehensive overview of both the fundamental and applied aspects of solid polymer electrolytes.
Topics discussed include:
* Polymer Electrolyte-based Devices
* Homopolymer Hosts
* The Interaction between Polymer and Salt
* Conductivity in Polymer Electrolytes
* Polymer Electrolyte Architecture
* Transport Properties Effects of Dynamic Disorder
* The Electrode-Electrolyte Interface

Newcomers and experts alike will greatly benefit from the lucid and objective analysis this book provides.

The newest volume in the prestigious series "The Chemistry of Heterocyclic Compounds," this work covers synthesis, reactions, properties, structure, physical chemistry and utility of monocyclic azepines.

Recent Advances in the Science of Cannabis describes progress in a variety of significant areas of cannabis science. This unique book covers topics in cultivation and secondary metabolites, aroma and chemotypes, cannabinoid structures, physiology and pharmacology, as well as the development of unique topical products. State-of-the-art analytical methods and instrumentation are covered, including current developments in mass spectrometry and chromatography, as well as microbial testing. Given the popularity of smoking and vaporizing cannabis, the chemistry of vaping cannabinoid and terpene concentrates is also presented, along with emerging regulatory issues. Key Features: A guide to emerging modern cannabis technology in a dynamic regulatory climate and appealing to both novices and specialists. Building upon pioneering studies of terpene and cannabinoid chemistry, this distinctive volume describes current best practices, technological breakthroughs and historical context. Written by researchers in industry and academia, a greater understanding of the risks of exposure to emissions from vaping or dabbing cannabis concentrates is provided here. A selection of the book content reviewing Thermal Degradation of Cannabinoids and Cannabis Terpenes has been included in "Hot 2021" RSC Advances.

Describes 'real life' examples in Medicinal Chemistry. Integrates the use of physical, chemical, and biological concepts that are important in drug design. Highlights the "ips" and "downs" that come with drug discovery. Aims to inspire students who may be struggling with the challenges and thought process in drug design. Intends to be an excellent companion text, illustrating real life experiences, for graduate and postgraduate students.

The Properties of Solvents Yizhak Marcus Hebrew University of Jerusalem, Israel The Properties of Solvents contains extensively annotated tables of physical, chemical and related properties for over 250 solvents. Factual knowledge of solvent effects on solvation, solubility, chemical equilibria and reaction rate is important for theoretical and practical applications. This volume will enable chemists to choose solvents rationally, taking into account solvent properties and the expected results. The Properties of Solvents is a valuable source of information for all who are interested in the behaviour of solutions. These include solution, organic, analytical and physical chemists. Contents
* Introduction
* Solvent effects
* Physical properties
* Chemical properties
* Applications
The Wiley Series in Solution Chemistry fills the increasing need to present authoritative, comprehensive and fully up-to-date accounts of the many aspects of solution chemistry. Internationally recognized experts from research or teaching institutions in various countries are invited to contribute to the series.

Fundamentals of Supramolecular Chirality is a critical description of the start and advancement of supramolecular chirality. This book focuses on the noncovalent approach with some supplementary examples of covalent supramolecular chirality.This contribution to supramolecular chirality is not intended to be a mere catalogue and description of the work done. It also traces a philosophical path following the development and possible perspectives of this topic, providing not a review but a critical examination of the field.

Drug Discovery with Privileged Building Blocks traces back PharmaBlock's founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists, and veteran medicinal chemists will find it useful as well. Key Feature The book covers privileged building blocks appearing most frequently on patents for novel drugs. The latest relevant tactics are explained in the context of drug design and medicinal chemistry. Key synthesis, especially large-scale synthesis, is described. The most recent literature references are cited.

Drug Discovery with Privileged Building Blocks traces back PharmaBlock's founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book. Each chapter may be read and studied without learning the previous chapters. This book will be a good starting point for novice medicinal chemists, and veteran medicinal chemists will find it useful as well. Key Feature The book covers privileged building blocks appearing most frequently on patents for novel drugs. The latest relevant tactics are explained in the context of drug design and medicinal chemistry. Key synthesis, especially large-scale synthesis, is described. The most recent literature references are cited.

A wide range of ?elds within supramolecular chemistry are of current and great interest ranging from nanosciences, medicinal sciences, biosciences, and even organic sciences and this is a mature and extremely active area of research. In 1978, Lehn de?ned this chemistry as the "chemistry of molecular assemblies and of the intermolecular bond." In other words, supramolecular chemistry is noncovalent chemistry based upon covalent chemistry. On the other hand, it is well known that replacing the carbon atom of cyclic compounds can lead to dramatic changes in chemical and physical properties and the principles of homocyclic chemistry are often of limited value and may even lead to incorrect results. This is often indeed the case in supramolecular chemistry. The modern explosion of nonochemistry is highly based upon the fundamental recognition of intermolecular interactions engendered by supramolecular scientists. In this volume entitled Heterocyclic Supramolecules I, a part of the series Topics in Heterocyclic Chemistry, some selected topics in noncovalent ch- istry from the last decade are highlighted, with attention particularly focused on heterocyclic supramolecules as well as heterocycle-based nanosciences. The ?rst chapter, "Molecular Recognition with designed Heterocycles and their Lanthanide Complexes" by S. Mameri, S. Shinoda, and H. Tsukube - scribes various synthetic receptors for speci?c binding of cationic anionic guests mainly in the solution states. Furthermore, special attention is directed at the heterocycle-lanthanide complexes that worked as luminescent sensory devices of biologically important anions. Thus, "rare" earth metals are making the change into "hopeful" earth metals.

Phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal action. Discusses chemical structure-activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi. Contains a selection of hand-made botanical plates and useful bibliographic references A useful research tool for postgraduates, academics, and the pharmaceutical, herbal, or nutrition industries.

Phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal action. Discusses chemical structure-activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi. Contains a selection of hand-made botanical plates and useful bibliographic references A useful research tool for postgraduates, academics, and the pharmaceutical, herbal, or nutrition industries.

Design of new processes that avoid the use of toxic reagents has been the focus of intense research of late. Catalysis by metals and non-metals offers diverse opportunities for the development of new organic reactions with promising range of selectivities-chemoselectivity, regioselectivity, diastereoselectivity, and enantioselectivity. Furthermore, these transformations frequently occur under mild conditions, tolerate a broad array of functional groups, and proceed with high stereoselectivity. The area of catalysis is sometimes referred to as a 'foundational pillar' of green chemistry. Catalytic reactions often reduce energy requirements and decrease separations because of increased selectivity; they are also capable of permitting the use of renewable feedstocks of less toxic reagents or minimizing the quantities of reagents needed. New catalytic organic synthesis methodologies have, thus, offered several possibilities for considerable improvement in the eco-compatibility of fine chemical production. Hence, these catalytic methodologies have emerged as powerful tools for the efficient and chemoselective synthesis of heterocyclic molecules. Key Features: Presents the synthesis of different five-membered heterocycles. Contains the most up-to-date information in this fast-moving field. Covers novel catalytic approaches used in the study and application of catalysts in synthetic organic reactions. Presents new methodologies for the synthesis of heterocycles.

This completely new and innovative textbook provides a comprehensive account of pericyclic reactions and organic photochemistry for undergraduate and postgraduate courses. The approach is based on mechanism and reaction type, and the subject matter is developed and concentrated on better understanding rather than on merely grasping factual knowledge. Basics of the subject are explained in thorough details in this title. Important points are revisited and mentioned wherever they are relevant. This title provides over 200 excellent thought-provoking textual problems. Glossary and questions for self-assessment are given at the end of each chapter. The most important aspect of this book is Chapter 14 which contains about 400 problems and their solutions based on pericyclic reactions and photochemistry. Applied photochemistry is also discussed in the book.

The Medicinal Chemist's Guide to Solving ADMET Challenges summarizes a series of design strategies and tactics that have been successfully employed across pharmaceutical and academic laboratories to solve common ADMET issues. These are exemplified with a curated collection of concrete examples displayed in a highly visual "table-of-contents" style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges. Each ADMET parameter is introduced in a concise yet comprehensive manner and includes background, relevance and screening strategies. Medicinal chemistry knowledge of how best to modify molecular structure to solve ADMET issues is challenging to retrieve from the literature, public databases and even corporate data warehouses. The Medicinal Chemist's Guide to Solving ADMET Challenges addresses this gap by presenting state-of-the-art design strategies put together by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.

As one of the most extensive and important protein post-translational modifications, glycosylation plays a vital role in regulating organisms and is associated with various physiological and pathological processes. Recently, researchers have focused on the need to characterize protein glycosylation sites, structures, and their degree of modification, to better understand their biological functions while also looking for potential biomarkers for diagnosis and treatment of disease. Mass spectrometry (MS) is one of the most powerful tools used to study biomolecules including glycoproteins and glycans. With the continuous development of glycoproteomics and glycomics based on MS analysis, more techniques have evolved and contribute to understanding the structure and function of glycoproteins and glycans. This book reviews advancements achieved in MS-based glycoproteomic analysis, including a wide range of analytical methodologies and strategies involved in selective enrichment; as well as qualitative, quantitative, and data analysis, together with their clinical applications. Significant examples are discussed to illustrate the principles, laboratory protocols, and advice for key implementation to ensure successful results. Mass Spectrometry-Based Glycoproteomics and Its Clinic Application will serve as a valuable resource to elucidate new techniques and their applications for students, postdocs, and researchers working in proteomics, glycoscience, analytical chemistry, biochemistry, and clinical medicine. Editor: Haojie Lu is a professor at Fudan University, specializing in proteomics based on mass spectrometry with particular emphasis on novel technologies for separation and identification of low-abundant proteins and post-translationally modified proteins (including glycosylation), as well as relative and absolute quantification methods for proteomics.

Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors' medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.

The Pigments from Microalgae Handbook presents the current state of knowledge on pigment production using microalgae-based processes, and covers both the scientific fundamentals of this technology and its practical applications. It addresses biology, chemistry, biochemistry, analysis and engineering aspects, as well as applications of natural pigments in photosynthetic organisms. The book also describes the analytical procedures associated with the characterization of pigments and the engineering aspects of microalgal pigment production. It considers the three major classes of pigments(chlorophylls, carotenoids and phycobiliproteins) produced and surveys the main commercial applications of these chemicals. The book offers a valuable source of information for industrial researchers and practitioners in industrial biotechnology, as it covers various engineering aspects of microalgal pigment production, such as bioreactors and bioprocesses, industrial extraction processes, and the bioeconomy of production including life-cycle assessment. The book will also be of interest to undergraduate and graduate students of biochemistry, food chemistry, and industrial microbiology.

The 105th volume in this series for organic chemists in academia and industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method.