The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students

Designed to assist chemists in integrating the results of calculations on molecules and ions into their general body of chemical knowledge. Contains recent contributions from theoretical and computational chemistry to the development of the concept of aromaticity (antiaromaticity) and its expansion into new areas such as organometallic and cluster compounds and three-dimensional structures. Updates the modern status of aromaticity and covers basic principles and experimental applications.

Drug repurposing is the development of existing drugs for new uses: given that 9 in 10 drugs that enter drug development are never marketed and therefore represent wasted effort, it is an attractive as well as inherently more efficient process. Three repurposed drugs can be brought to market for the same cost as one new chemical entity; and they can also be identified more quickly, an important benefit for patients whose diseases are progressing faster than therapeutic innovation. But repurposing also requires a fresh look at configuring pharmaceutical R&D, considering clinical, regulatory and patent issues much earlier than would otherwise be the case; a holistic gedanken experiment almost needs to be undertaken at the very start of any repurposing development. In addition to new ways of thinking, the discovery of repurposing opportunities can take advantage of artificial intelligence techniques to match the perfect new use for an existing drug. And while repurposing of medicines has been in the mind of every doctor since Hypocrates, modern clinical practice will simply have to adapt to new repurposing techniques in an age where the number of known diseases is increasing much faster than the healthcare dollars available.

Each volume reviews the total synthesis of a set of compounds looking at syntheses reported historically and at the practice current at the time of publication. From volume 1 focusing on carbohydrates, prostagladins, nucleic acids, antibiotics, naturally occurring oxygen ring compounds and pyrrole pigments, the series continues with coverage of aromatic steroids, monoterpenes, triterpenes, sesquiterpenes, cannabinoids, natural inophores, insect pheromones and alkaloids. Volumes revisit the total synthesis of key compounds such as carbohydrates, nucleic acids and pyrrole pigments several times during the series building a picture of the historic development of total synthesis techniques for these major groups. Chapters are edited by experts in their field to give a complete overview of the best in the field at the time.

Reactive and functional polymers are manufactured with the aim of improving the performance of unmodified polymers or providing functionality for different applications. These polymers are created mainly through chemical reactions, but there are other important modifications that can be carried out by physical alterations in order to obtain reactive and functional polymers. This volume presents a comprehensive analysis of these reactive and functional polymers. Reactive and Functional Polymers Volume Two considers the coupling, crosslinking and grafting reactions to improve the compatibility of reactive and functional polymer blends. In this book, world-renowned researchers have participated, including Dr. Sabu Thomas (Editor-in-chief for the journal 'Nano-Structures & Nano-Objects'). With its comprehensive scope and up-to-date coverage of issues and trends in Reactive and Functional Polymers, this is an outstanding book for students, professors, researchers and industrialists working in the field of polymers and plastic materials.

Traditionally heat and light are thought as energy sources to drive a particular chemical reaction, but now ultrasound is a promising energy source for this purpose. The collapse of a bubble generates a wide range of high temperatures and pressures, and therefore, use of ultrasound has a considerable potential in chemical and allied sciences. Ultrasound-assisted reactions are green and economically viable alternatives to conventional techniques. This new volume presents a complete picture of ultrasound-assisted reactions and technologies that can be used in organic synthesis, polymer synthesis and degradation, nanomaterials, wastewater treatment, food ingredients and products, pharmaceutical applications, bioenergy applications, and more. This volume aims to shed light on the diversified applications of ultrasound and its significant role as a green chemical pathway. Sonochemistry deals with the effect of ultrasonic waves on chemical systems. It has green value because of non-hazardous acoustic radiation and is therefore duly recognized as a green chemistry by synthetic chemists as well as environmentalists. There is no direct interaction of ultrasound with molecular species, but the observed chemical and physical effects of ultrasound are due to the cavitational collapse, which produces drastic conditions of temperature and pressure locally. It induces the formation of various chemical species, which cannot be easily attained under conventional conditions. Sometimes, these species are responsible for driving towards an unusual reactivity in molecular entities. This book, Sonochemistry: An Emerging Green Technology, provides the complete development of sonochemistry, starting with an introduction and basic concepts of sonochemistry and proceeding on to different types of sonochemical reactions, instrumentation, use of ultrasound in driving particular chemical reactions, and its applications in various fields, such as polymer synthesis, decontamination of water and wastewater, preparation of nanomaterials, food technology, pharmaceutical sciences, etc. The book also briefly discusses some areas that utilize ultrasounds of different frequencies. These include food products and their processing; anaerobic digestion of waste; and medical applications such as ultrasonography, sonodynamic therapy, drug delivery, etc. Sonochemistry will be successfully used on an industrial scale in pharmaceutical drugs, polymers, nanomaterials, food technology, material science, biogas production, etc. in years to come and will be an established green chemical technology of the future.

This book covers a range of new research on computational quantum chemistry, along with a special section devoted to exotic carbon allotropes and spiro quantum theory. The section on spiro quantum theory covers the technical presentation of the ideas surrounding the emergence of a synthetic, analytical, and theoretical spiro quantum chemistry edifice, as well as a chemical topology scheme that successfully describes molecules and patterns, including the hydrocarbons and allotropes of carbon. The second part of the book covers a range of new research on computational quantum chemistry.

Progress in Organic and Physical Chemistry: Structures and Mechanisms provides a collection of new research in the field of organic and physical properties, including new research on: The physical principles of the conductivity of electrical conducting polymer compounds The dependence on constants of electromagnetic interactions upon electron spacial-energy characteristics Effects of chitosan molecultural weight on rehological behavior of chitosan modified nanoclay at hight hydrated state Bio-structural energy criteria of functional states in normal and pathological conditions Potentiometric study on the international between devalent cations and sodium carboxylates in aqueous solutions Structural characteristic changes in erythrocyte membranes of mice bearing Alzheimer's-like disease caused by the olfactory bulbetomy This volume is intended to provide an overview of new studies and research for engineers, faculty, researchers, and upper-level students in the field of organic and physical chemistry.

Chemistry and Technology of Plant Substances: Chemical and Biochemical Aspects demonstrates the progress and promise of developing new chemical substances from renewable sources of chemical raw materials. The volume brings together new achievements in the field of research and processing of plant raw materials and the synthesis of natural compounds for the production of biologically active substances and drugs. The volume looks closely at the rational use of renewable raw materials, which is the source of new compounds and intermediates for the chemical industry. It covers a wide range of problems associated with the use of the components of plants to produce new substances with a wide variety of purposes. According to the latest estimates, plants form about a million chemical substances. In some cases, plant products have pharmacological or biological activity that can be of therapeutic benefit in treating diseases. In addition, due to the structural diversity of plant material, chemical synthesis is easily reachable. Synthetic analogs of natural products with improved potency and safety can be prepared by chemical synthesis. Such synthetic analogs are safer for humans. Plant materials are often used as starting points for drug discovery. Chemistry and Technology of Plant Substances: Chemical and Biochemical Aspects presents the theoretical trends and recent practical achievements on complex processing of plant-based raw materials. Low molecular weight components, isolated from plant material, are widely used in fine organic synthesis. High molecular weight polysaccharides of conifers and other greens, such as pectin and hemicellulose, are the basis for the creation of anticoagulants and other drugs. The range of research papers presented in the book is quite wide: from fundamental and applied problems of wood chemistry and organic synthesis to biological activity of natural compounds. The book provides valuable information for those skilled in organic chemistry, chemical engineers, researchers and scientists as well as for faculty and upper-level students. This volume, Chemistry and Technology of Plant Substances: Chemical and Biochemical Aspects, was created on the initiative of Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences (Moscow) and the Institute of Chemistry of Komi Scientific Center of Ural Branch of the Russian Academy of Sciences (Syktyvkar).

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.

The International Conference on Phytochemistry, Textile, & Renewable Energy Technologies for Sustainable Development (ICPTRE 2020) was hosted by the World bank funded Africa Centre of Excellence in Phytochemicals, Textile and Renewable Energy (ACEII-PTRE) based at Moi University in conjunction with Donghua University, China and the Sino-Africa International Symposium on Textiles and Apparel (SAISTA). The theme of the conference was Advancing Science, Technology and Innovation for Industrial Growth. The research relationships between universities and industry have enabled the two entities to flourish and, in the past, have been credited for accelerated sustainable development and uplifting of millions out poverty. ICPTRE 2020 therefore provided a platform for academic researchers drawn from across the world to meet key industry professionals and actively share knowledge while advancing the role of research in industrial development, particularly, in the developing nations. The conference also provided exhibitors with an opportunity to interact with professionals and showcase their business, products, technologies and equipment. During the course of the conference, industrial exhibitions, research papers and presentations in the fields of phytochemistry, textiles, renewable energy, industry, science, technology, innovations and much more were presented.

This book focuses on recent topics of quantum science in both physics and chemistry. Until now, quantum science has not been fully discussed from the interdisciplinary vantage points of both physics and chemistry. This book, however, is written not only for theoretical physicists and chemists, but also for experimentalists in the fields of physical chemistry and condensed matter physics, as collaboration and interplay between construction of quantum theory, and experimentation has become more important. Tips for starting new types of research projects will be found in an understanding of cutting-edge quantum science. In Part I, quantum electronic structures are explained in cases of strongly correlated copper oxides and heavy elements. In Part II, quantum molecular dynamics is investigated by computational approaches and molecular beam experiments. In Part III, after lithium problem in big bang nucleosynthesis scenario is considered using supersymmetric standard model, quantum theories in atomic and molecular systems are reviewed. Finally, in Part IV, the development of quantum computational method is introduced.

The chemistry of heterocyclic compounds constitutes one of the broadest and most complex branches of chemistry. The diversity of synthetic methods utilized in this field, coupled with the immense physiological and industrial significance of heterocycles, combine to make the general heterocyclic arena of central importance to organic chemistry.

This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students.

Cell surface molecules are critically important in regulating cell structure and function. Recent advances on the functional role of cell surface molecules, particularly glycoconjugates are presented in this book. Comprising of 22 chapters from the 2011 International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules, it covers topics on the analysis of glycome, biophysical approaches to study cell surface molecules, glycoconjugate metabolism and its dysregulation, and molecular mechanisms involved in cell-cell and cell-matrix interaction.

The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two -the chemical linker- also plays an essential role in mode-of-action, efficacy, pharmacokinetics and safety profile of an ADC, but is often underappreciated in considerations of ADC design. Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety. Ideal for postgraduate students and active researchers in drug discovery and development, this book provides a comprehensive description of linkers used in ADCs (clinical and late preclinical), insight into key quality attributes of linkers for ADCs, and aids the reader in understanding the role of linker chemistry and designing new ADCs.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Chemical synthesis is one of the key technologies underlying modern drug discovery and development. For the design and accessibility of novel structures and the rapid preparation of new test compounds and development candidates with often highly complex chemical architecture, it is essential to use state-of-the-art chemical synthesis technologies. Recent developments in the field of asymmetric catalysis point to a third class of catalysts besides the established enzymes and metal complexes, so-called organocatalysts. These low-molecular-weight, organic molecules enable highly chemo- and stereoselective chemical transformations for the rapid assembly of complex bioactive molecules of interest for the pharmaceutical industry.

This book presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It illustrates current progress in organocatalysis in functional group interconversions, organocatalytic CC- and CX-bond formations with small molecules as well as peptide-based catalysts and genetically engineered enzymes and their applications in natural product and drug syntheses. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state of the art, current trends and perspectives in this highly dynamic field of research.

The 4e of "The Science and Technology of Rubber" provides a broad survey of elastomers with special emphasis on materials with a rubber-like elasticity. As in previous editions, the emphasis remains on a unified treatment of the material, exploring chemical aspects such as elastomer synthesis and curing, through recent theoretical developments and characterization of equilibrium and dynamic properties, to the final applications of rubber, including tire engineering and manufacturing. Updated material stresses the continuous relationship between ongoing research in synthesis, physics, structure and mechanics of rubber technology and industrial applications. Special attention is paid to recent advances in rubber-like elasticity theory and new processing techniques for elastomers. Exciting new developments in green tire manufacturing and tire recycling are covered.
Provides a complete survey of elastomers for engineers and researchers in a unified treatment: from chemical aspects like elastomer synthesis and curing to the final applications of rubber, including tire engineering and manufacturing Contains important updates to several chapters, including elastomer synthesis, characterization, viscoelastic behavior, rheology, reinforcement, tire engineering, and recycling Includes a new chapter on the burgeoning field of bioelastomers

Novel Food Fermentation Technologies provides a comprehensive overview of innovations in food fermentation technologies and their application. Current novel technologies for microbial culture production and preservation are covered in detail, as are fermentation techniques for the production of bioactives from various food matrices, including food processing by-products and waste. Readers are provided with a close look at thermal and non-thermal technologies applicable to fermented food products. The text covers immobilization, microencapsulation technologies and novel preservation techniques for cultures in fermentation. In-depth studies of high pressure processing, pulsed electric field, power ultrasound and gamma irradiation in fermentation are provided in addition to novel thermal and non-thermal technologies and process analytical techniques. A wide variety of fermented products are covered, including meat, marine-based, grain-based, dairy and vegetable-based products. Current technologies for extraction of bioactives are examined, as are current innovations in fermented food packaging. Readers are presented with current and future challenges in food fermentation as well. As a comprehensive reference for food fermentation, this work provides up-to-date insights into emerging fermentation technologies which facilitate the processing of wholesome and safe food products.

This volume written by 25 experts from industry and research provides a thorough overview of commerically important and environmentally mobile organosilicon materials. It outlines the structure, properties and applications of the four most significant material classes, and summarizes their environmental entry, transport, fate and impact. Detection and analytical methods are discussed both in the context of environmental assay and ecotoxicity testing along with some of the challenges. Measurement/estimation techniques and data available for several eco-pertinent properties of selected organosilicon compounds are summarized and limitations of the estimation and expertimental methods discussed. The environmental laws/regulations/trends in the U.S., Europe and Japan are discussed, along with their relevance to organosilicon materials. The book concludes with a broad overview of the major markets and global silicone producers, reviewing the industry's stewardship initiatives, relevant HES (health, environmental and safety) organizations and global cooperation.

Over the past twenty years, the field of carbon structures has been invigorated by the discovery of fullerenes and carbon nanotubes. These nano-structured carbons have attracted a tremendous interest in the fundamental properties of discrete carbon molecules, leading to the discovery of novel complex crystalline and quasi-crystalline materials. As a consequence, a variety of applications have been developed, including technical and bio-medical materials and miniaturized tools.

"Diamond and Related Nanostructures" focuses on the advances in the area of diamond-like carbon nanostructures (hyper-structures built from fullerenes and/or carbon nanotube junctions) and other related carbon nanostructures. Each chapter contributes to the topic from different fields, ranging from theory to synthesis and properties investigation of these new materials.

This volume brings together the major findings in the field and provides a source of inspiration and understanding to advanced undergraduates, graduates, and researchers in the fields of Physics, Graph Theory, Crystallography, Computational and Synthetic Chemistry.

The?rsttwovolumesinthis"TemplatesinChemistry"serieshavefocused on templates that controlsolution-phase reactions. Among the templates d- cussed in these two volumes were convex and concave templates that mediate the formation of (macro)cyclic molecules and mechanically bound molecules withtheir intriguingintertwined topology.Also,three-dimensional templates that are used to imprint polymers and that organize compounds in the solid state for predestined reactions have been included in the earlier volumes. In the present volume, we extend thetemplate topologytosurfaces that act asmatricesforthecontrolledgrowthoftwo-dimensionalarrays.Naturally,the typical methods for the characterization of surfaces such as scanning probe microscopyare prominently represented in this volume. Differentlateralinteractionssuchascoordinativebondsorhydrogenbo- ing play a major role in assembling the 2D networks on surfaces in addition to the interaction of the samples with the underlying substrates. Many p- nomena that are also encountered in solution can be directly visualized on surfaces: Reversible self-assembly processes lead to the formation of large structures through multiple recognition of small building blocks and cul- nate in the engineering of crystals in two dimensions. Self-sorting processes drive the formation of highly ordered arrays through the geometric ?t of the available components. Either the surface itself is the template, for example, when clusters grow on metal oxide ?lms, or colloidal templates control the formationof macroporousnetworksonthe substrate. This volume highlightsa selection of actual complementary aspects of s- facetemplates.Webelievethatthescopeandthevarietyoftopicscoveredinthis volume will attract readers fromdifferent communities such as supramole- larchemistry,materialsciences,surfacechemistry,surfacephysicsandsurface technologyandwehopetheywillenjoythisnewvolumeonTemplatesinCh- istry.

This book explores the remarkable information correspondences and probability structures of proteins. Correspondences are pervasive in biochemistry and bioinformatics: proteins share homologies, folding patterns, and mechanisms. Probability structures are just as paramount: folded state graphics reflect Angstrom-scale maps of electron density. The author explores protein sequences (primary structures), both individually and in sets (systems) with the help of probability and information tools. This perspective will enhance the reader's knowledge of how an important class of molecules is designed and put to task in natural systems, and how we can approach class members in hands-on ways.