This book examines how the growing knowledge of the huge range of protist-, animal-, and plant-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of biology. The establishment and maintenance of these interactions and their contributions to the health and survival of all partners relies on continuous cell-to-cell communication between them. This dialogue may be concerned with all aspects of the biology of both partners. The book includes chapters devoted to exploring, explaining, and exposing these dialogues across a broad spectrum of plant and animal eukaryotes to a broad field of biologists. Key Features Explores the nature of the interactions between eukaryotic hosts and their microbial symbionts Examines the links between prostist, animal, and plant evolution and microbial communities Reviews specific taxa and the microbial diversity associated with these taxa Illustrates the role microbes play in the physiology and etiology of several model species Includes chapters by an international team of leading scholars

Symposium on Behaviour and Ecology, Saarbrucken, FRG, 1979"

Recent Advances in the Synthesis of Morphine and Related Alkaloids; by N. Chida * Opioids in Preclinical and Clinical Trials; by H. Nagase and H. Fujii * Synthesis of 14-Alkoxymorphinan Derivatives and Their Pharmacological Actions; by H. Schmidhammer and M. Spetea * 14-Amino-4,5-Epoxymorphinan Derivatives and Their Pharmacological Actions; by J. W. Lewis and S. M. Husbands * Nonpeptidic Delta ( ) Opioid Agonists and Antagonists of the Diarylmethylpiperazine Class: What Have We Learned?; by S. N. Calderon * Synthesis of Neoclerodane Diterpenes and Their Pharmacological Effects; by K. M. Lovell, K. M. Prevatt-Smith, A. Lozama and T. E. Prisinzano * Synthesis of Novel Basic Skeletons Derived from Naltrexone; by H. Nagase and H. Fujii * Twin and Triplet Drugs in Opioid Research; by H. Fujii * 3D-Pharmacophore Identification for -Opioid Agonists Using Ligand-Based Drug-Design Techniques; by N. Yamaotsu and S. Hirono

Despite their rich fossil history, there are only four surviving species of sirenians or sea cows, the only fully aquatic herbivorous mammals. The three species of manatees and the dugong live in the coastal waters rivers and lakes of more than 80 tropical and subtropical countries and are all on the IUCN Red List of Threatened Species. This book examines sirenian conservation biology through the lens of their behavioral ecology and ethology. Sirenian feeding, diving, movement, social and reproductive behaviors are reviewed by an international team of scientists from eight countries, with an emphasis on data gathered in the past 15 years.

The polyphyletic Protozoa have explored the possibility of performing almost all metazoan functions with a few subcellular organelles. Their unicellularity and structural simplicity have (i) limited diversity to 32,950 species, (ii) restricted spatial distribution to aquatic habitats (94%, against 15% in Metazoa), (iii) demonstrated the ubiquitous dominance of clonality, (iv) reduced sexualization in 50% species, (v) facilitated the use of vegetative gametes in 40% species and (vi) secondary loss of sex in 10% species. With the fastest multiplication rates, i.e. once every 6-60 hours, they occur in high densities of 105-106 cell/ml. Their diverse and complicated life cycles are described in 30 types. Being risky, the cycle involves two hosts in < 2,000 parasitic species and injective transmission mode by sanguivorous insects and ticks in < 300 species. Their radial symmetry has accelerated diversity more than in radially symmetric less speciose Porifera (8,553 species), Cnidaria (10,856) and Echinodermata (7,000). In them, diversity is decelerated in the following descending order: symmetry > clonality > hermaphroditism > motility. Motility ranges from 2-3 m for Rhizopoda to 400-2,000 m for Ciliophora. Not surprisingly, 6,800 species of arcellinids, filosians and formainifers are testated or shelled. Within 1,229 sessile species, the peritrichid and suctorian ciliates are better adapted to coloniality. Unlike those of many Metazoa, the protozoan cyst is a dynamic stage, in which clonal or sexual reproduction occurs. Over 81% protozoans encyst, as it ensures (i) 90% survival during unfavorable conditions (against 15 in 12% non-encysted protozoans), (ii) genome transfer through generations, (iii) dispersal into new habitats and (iv) transmission to new hosts. Their mean body size ranges from 2 m to 2 mm - a range over 1,000-times - only 8% aquatic metazoans cover a similar size range. In comparison to 77% macrophagy in Metazoa, only 46% protozoans are macrophagous predators. Within motile microphagy, protozoans filter 3-2 times smaller food particle at 50% cheaper clearance cost. This efficiency has expanded microphagy to 15% in protozoans, against 3% in Metazoa. Hence, their turnover rate in trophic dynamics is twice faster than that of metazoans. Foraminifers serve as ecological sensitive indicators in petroleum exploration and rise in sea level. For the first time, incidences of clonality and meiosis as well as symbiosis and parasitism have been shown to hint at the origin and evolution of different protozoan taxonomic groups during the geological past.

Introduction. Mono(ADP-ribosyl)Transferases and Related Enzymes: Emerging Gene Families; F. Koch-Nolte, F. Haag. Mono-ADP-ribosylation in Prokaryotes. Crystal Structure of Diphtheria Toxin Bound to Nicotinamide Adenine Dinucleotide; C.E. Bell, D. Eisenberg. Molecular Approaches to Eukaryotic Mono(ADP-ribosyl)Transferases. Sequence and Structural Links Between Distant ADp-ribosyltransferase Families; F. Bazan, F. Koch-Nolte. Moni(ADP-ribosyl)Transferases in the Immune System. Regulation of Cytotoxic T Cell Functions by a GPI-anchored Ecto-ADP-ribosyltransferase; J. Wang, et al. Mono-ADP-ribosylation in Other Animal Tissues. An ADP-Ribosyltransferase from Bovine Erythrocytes Apparently Specific for Cysteine Residues; S. van Heyningen, B. Saxty. Physiology of GPI-Anchored Proteins. Cell Surface Dynamics of GPI-anchored Proteins; F.R. Maxfield, S. Mayor. Relationship of ADP-Ribosyltransferases to NAD+ Glycohydrolases and ADP-ribosyl Cyclases. ADp-Ribose in Glycation and Glycoxidation Reactions; E.L. Jacobson, et al. Special Lecture Commemorating the Retirement of Professor Heinz-Gunter Thiele. Appendix. 28 Additional Lectures. 24 Poster Reports. Index.

Following the rapid developments in the UV-B measurement techniques and the rapidly growing research in the field in the late 80's and early 90's, we organized a large gathering of distinguished experts in a NATO Advanced Study Institute, held in Halkidiki, Greece on October, 2-11. 1995. The Institute was organized so as to include state of the art lectures on most aspects of solar ultraviolet radiation and its effects. This was achieved by extended lectures and discussions given in five sessions by 27 lecturers and a demonstration of filed measurements and calibration techniques at the end of the Institute. The ASI began with the sun and fundamentals on solar radiative emissions and their variability in time and continued with the interaction of solar Ultraviolet with the atmosphere through the complex scattering processes and photochemical reactions involved. Particular emphasis was given to changes in atmospheric composition imposed by different manifestations of the solar activity cycle. as well as on the modelling of radiative transfer through the atmosphere and the ocean under variable environmental conditions. Overviews on the ozone issue. its monitoring and variability were extensively discussed with emphasis on the observed acceleration of ozone decline in the early 90's. This acceleration had as a consequence, significant increases in UV-B radiation observed at a few world-wide distributed stations.

What was the state of wildlife in Britain and Ireland before modern records began? The Atlas of Early Modern Wildlife looks at the era before climate change, before the intensification of agriculture, before even the Industrial Revolution. In the sixteenth to eighteenth centuries, beavers still swim in the River Ness. Isolated populations of wolves and lynxes linger in the uplands. Sea eagles are widespread around the coasts. Wildcats and pine martens remain common in the Lake District. In this ground-breaking volume, the observations of early modern amateur naturalists, travellers and local historians are gathered together for the very first time. Drawing on more than 10,000 records from across Britain and Ireland, the book presents maps and notes on the former distribution of over 160 species, providing a new baseline against which to discuss subsequent declines and extinctions, expansions and introductions. A guide to identification describes the reliable and unreliable names of each species, including the pre-Linnaean scientific nomenclature, as well as local names in early modern English and, where used in the sources, Irish, Scots, Scottish Gaelic, Welsh, Cornish and Norn. Raising a good number of questions at the same time as it answers many others, this remarkable resource will be of great value to conservationists, archaeologists, historians and anyone with an interest in the natural heritage of Britain and Ireland.

The latest volume in this highly regarded series covers current advances in the fast-moving field of cell cycle research by gathering reviews otherwise scattered throughout the literature. Contributions encompass fields from cell and molecular biology to biochemistry.

Fetal development in the mouse is routinely and increasingly utilized for advancing translational research and medical innovation for human obstetrical care. This is the first and only manual to provide necessary content on how this should be handled for accurate and effective data collection. Detailed descriptions and examples demonstrate how researchers and clinicians can use murine fetal and obstetrical data to improve future human applications in diseases such as infertility, recurrent pregnancy loss, intrauterine fetal growth restriction, placental insufficiency, and intrauterine fetal demise, as well as organ-specific developmental disease.

R. Fuller 1.1 DEVELOPMENT OF COMMERCIAL PREPARATIONS The history of the probiotic effect has been well documented many times previously (see e.g. Bibel, 1982; Fuller, 1992). The consumption of fermented milks dates from pre-biblical times but the probiotic concept was born at the end of the last century with the work of Metchnikoff at the Pasteur Institute in Paris. In the century that has elapsed since Metchnikoff's work, the probiotic concept has been accepted by scientists and consumers throughout the world. Attempts to refine the practice from the use of traditional soured milks to preparations containing specific micro organisms have occupied the thoughts and endeavours of scientists in many different countries. But, in spite of the large amount of effort expended in attempting to explain and define the effect, it has to be admitted that little is known of the way in which probiotics operate. There are likely to be several different mechanisms because it seems highly improbable that a mode of action that explains resistance to microbial infection will also hold true for improved milk production or alleviation of lactose malabsorption."

The VIIth International Conference on Aspartic Proteinases was held in Banff, Alberta, Canada, from October 22 to 27, 1996. The venue was the Banff Centre in the Canadian Rockies, a setting well known worldwide for the scenic beauty and mountain grandeur. It was perhaps presumptuous of the organizers to call this the seventh Aspartic Proteinase Conference but it was felt that the meeting in 1982, organized by Tom Blundell and John Kay, was of an international stature and covered topics sufficiently broad to constitute a conference. Thus, there is a discontinuity in that the Gifu Conference organized by Prof. Kenji Takahashi was the fifth International Conference on Aspartic Proteinases. Officially, there has not been a sixth Conference and if there is confusion, it is the result of my desire to recognize the importance of the London meeting. Banffhosted 106 scientists from 14 different countries. There were 26 invited speak ers among the 44 oral presentations of the 7 main sessions. In addition, there were 53 con tributed poster presentations that spanned the whole range of interest in aspartic proteinases.