This text is an overall view of nematology because I believe the science should be treated as a unified discipline. The differences in the biological habits of nematodes do not justify the separation of plant nematologists and animal nematologists, since the separation is not a reflection of any difIerences inherent to nematodes. Therefore, the book is arranged with a format that in the beginning chapters illustrates the similarities and se- quence of development of morphological characters among nematodes regardless of their biological habits. The later chapters illustrate the in- tegration of the evolutionary development of the parasitie habit from related free-living forms. Nematology is probably the last major discipline to establish its inde- pendence from the parent science of zoology. This natural evolvement of nematology has occurred because of the overwhelming accumulation of sophisticated information and research that reflects the unique relation- ships of nematodes to other forms of plant and animal life as weH as their relationships in other facets of the environment. N ematodes are inverte- brate animals that, like insects, are unusual in their great numbers and varieties, their smaH size (generally microscopic), their high degree of internal organization, and their virtually ubiquitous distribution. They oc- cupy almost every ecological niehe, often causing disease of humans, other animals, and plants. These activities often result in debility, death, or in the impairment and loss of food supply with consequent loss to producers and consumers.

This volume contains the papers presented in the NATO Advanced Research Workshop "Activation of Hormone and Growth Factor Receptors: Molecular Mechanisms and Consequences" held in Nafplion, Greece on September 25-30, 1988. The objective of NATO ARW is to assess the state of-the-art in a given scientific area and to formulate recommendations for future research in emerging areas of science by promoting international scientific contacts. In the Nafplion meeting this objective was reached by an international group of speakers, senior Greek scientists and graduates involved in relevant research areas. The Workshop was made possible by the generous support of the Scientific Council of NATO. We thank Drs. G. Sinclair and L.V. daCunha, Directors of the NATO ARW's and ASI's (Advanced Study Institutes) respectively, for their wholehearted support and advice. The International Union of Biochemistry awarded additional travel grants leading to increased international participation. Furthermore, the Secretariat of Science and Technology, the Ministry of Culture and Sciences and the National Hellenic Research Foundation contributed financially and by supporting personnel. We sincerely thank all these organizations for their support. Our heartful thanks are also extended to the Mayor of the Municipality of Nafplion, Mr.

EMPHASIZES CONCEPTS. Animal Behavior: Concepts, Methods, and Applications, Third Edition, uses broad organizing concepts to provide a framework for understanding the science of animal behavior. In an engaging, question-driven style, Shawn E. Nordell and Thomas J. Valone offer readers a clear learning progression for understanding and evaluating empirical research examples. FOCUSES ON METHODOLOGY AND THE PROCESS OF SCIENCE. Featured studies illustrate each concept and emphasize the experimental designs and the hypothesis testing methods scientists use to address research questions. HIGHLIGHTS REAL-WORLD APPLICATIONS. Concepts are related to real life to help students understand the broader significance of animal behavior research, including applications to human behavior and conservation.

The study of coelenterates is now one of the most active fields of invertebrate zoology. There are many reasons for this, and not everyone would agree on them, but certain facts stand out fairly clearly. One of them is that many of the people who study coelenterates do so simply because they are interested in the animals for their own sake. This, however, would be true for other invertebrate groups and cannot by itself explain the current boom in coelenterate work. The main reasons for all this activity seem to lie in the considerable concentration of research effort and funding into three broad, general areas of biology: marine ecology, cellular-developmental biology and neurobiology, in all of which coelenterates have a key role to play. They are the dominant organisms, or are involved in an important way, in a variety of marine habitats, of which coral reefs are only one, and this automatically ensures their claims on the attention of ecologists and marine scientists. Secondly, the convenience of hydra and some other hydroids as experimental animals has long made them a natural choice for a variety of studies on growth, nutrition, symbiosis, morphogenesis and sundry aspects of cell biology. Finally, the phylogenetic position of the coelenterates as the lowest metazoans having a nervous system makes them uniquely interesting to those neurobiologists and behaviorists who hope to gain insights into the functioning of higher nervous systems by working up from the lowest level.

Parasites evolve under selective pressures which are different from those acting on free-living organisms. The aim of this textbook is to present these pressures and to show how they have shaped the ecology of parasites over evolutionary time. Broad theoretical concepts are explained simply and clearly and illustrated throughout with example organisms. The book will be an invaluable text for advanced undergraduate biologists who are studying evolutionary biology, ecology, population biology, parasitology and evoluationary ecology. It will also prove to be a valuable reference to postgraduate students and researchers in the same fields.

Recently there have been many advances in the understanding of the genetic basis of development and regular breakthroughs are being made in the field of tumour cell targeting. Both these areas of research are coming together in terms of their perception of programmed cell death. A broad introduction of the biological significance of cell death is followed by a major review of the significance of physiological cell death in tumours and the factors that influence it. The volume includes a consideration of the role and functions of lymphokines and their bearing on tumour cell targeting and cell killing. The interleukins, interferons and tumour necrotic factor (TNF) are presented in terms of their functional significance rather than in a sequential or systematic manner. This volume concentrates on the bases of biological or programmed cell death. Aspects of necrosis are, however, of necessity covered in comparative and technical terms. The central section on cell death in tumours is followed by a resume of the techniques employed in demonstrating cell death and this section closes with an appendix giving practical details of selected methods. It is hoped that the book may help potential research workers focus not only on the underlying molecular biology of programmed cell death but also provide impetus for the development of appropriate therapeutic regimes in tumour research.

An identification handbook containing descriptions of 974 species of non-gilled fungi in 277 genera and figures of 543 of them. There are two major keys to genera and a key to the species in each genus that contains more than one species. The fungi described and illustrated can nearly all be found in Great Britain. The book aims to stimulate interest in groups of fungi which have hitherto attracted relatively few workers. Resupinate fungi, club fungi, jelly fungi, brackets, earth stars, puffballs and so on are not difficult to identify with a little practice and many of them flourish and sporulate freely during the winter months and thus it is possible to study mycology all year round if all groups are studied. In this book measurements, except where otherwise stated, are in thousandths of a millimetre. Terms which may be unfamiliar are explained in the glossary and for quick reference genera in the two main sections are arranged in alphabetical order.

This edited volume is the first specialized book in English about the Swiss zoologist and anthropologist Adolf Portmann (1897-1982). It provides a clarification and update of Portmann's theoretical approach to the phenomenon of life, characterized by terms such as "inwardness" and "self-presentation." Portmann's concepts of secondary altriciality and the social uterus have become foundational in philosophical anthropology, providing a benchmark of the difference between humans and animals. In its content, this book brings together two approaches: historical and philosophical analysis of Portmann's studies in the life sciences and application of Portmann's thought in the fields of biology, anthropology, and biosemiotics. Significant attention is also paid to the methodological implications of his intended reform of biology. Besides contributions from contemporary biologists, philosophers, and historians of science, this volume also includes a translation of an original essay by Portmann and a previously unpublished manuscript from his most remarkable English-speaking interpreter, philosopher Marjorie Grene. Portmann's conception of life is unique in its focus on the phenomenal appearance of organisms. Confronted with the enormous amount of scientific knowledge being produced today, it is even clearer than it was during Portmann's lifetime that although biologists employ physical and chemical methods, biology itself is not (only) physics and chemistry. These exact methods must be applied according to what has meaning for living beings. If biology seeks to understand organisms as autonomous agents, it needs to take display and the interpretation of appearances as basic characteristics of life. The topic of this book is significantly relevant to the disciplines of theoretical biology, philosophy, philosophical anthropology, and biosemiotics. The recent epigenetic turn in biology, acknowledging the interconnections between organismal development, morphology and communication, presents an opportunity to revisit Portmann's work and to reconsider and update his primary ideas in the contemporary context.

W. French Anderson, M.D. The publication of this book comes at an opportune time for the young field of human gene therapy. After a decade of long struggle at the laboratory bench and many long hours under the harsh lights of the federal review process, gene therapy has emerged as a legitimate scientific discipline. It is now time to move away from the period of questioning whether gene therapy will be a useful part of the physician armamentarium to begin to actively teach the concepts and practices that make gene therapy a reality. This book is a comprehensive collection of chapters that describe the basic biology and potential application of viruses as gene transfer reagents. It is not a coincidence that a modified virus was the reagent used in the first human gene therapy trials. Viruses have evolved with the human species (and most likely with all forms of life) to be the masters of gene transfer.

Initially believed to be inactive molecules, glycans are now considered essential for life, both under normal and pathological conditions.

This volume of the series "Biology of Extracellular Matrix " reviews the most recent findings on the role of glycans in the development of diseases and the possible therapeutic use of this class of molecules. It shows how the interaction of glycans with growth factors, growth factor binding proteins, extracellular proteases, protease inhibitors, chemokines, morphogens, and adhesive proteins regulates inflammation, infection, cancer, atherosclerosis, thrombosis and embryonic stem cell biology. Furthermore, an extensive survey about the structure and pharmacological effects of unique marine glycosaminoglycans is discussed as well as the possibility of using these glycans as therapeutic agents.

Helminths include one of the most diverse and geographically widespread groups of parasites which infect humans and animals. About 100 species have been reported from humans, usually producing asymptomatic infection or mild symptoms. However, about 20 species are of public health importance causing severe or even fatal infections. In many parts of Africa parasitic helminths are responsible for enormous economic losses, hampering rural development programmes and reducing the pace of economic growth. Many parasitic helminths are either zoonoses (diseases naturally transmitted between vertebrate animals and man) or have evolved from animal parasites. The modification of the environment through wars, famine and the ever expanding and increasingly mobile human population brings people into close contact with new environments and wildlife species which makes the study and control of zoonoses of special interest and complexity. In Africa, the transmission of helminth parasites is highly influenced by the ever changing social and cultural differences between diverse groups of peoples and their interaction with wild and domestic animals. It is not surprising, therefore, that approaches to the study and control of parasitic zoonoses require intersectoral cooperation between physicians, veterinarians, parasitologists, zoologists, demographers, anthropologists, engineers and economists to provide the breadth of knowledge and expertise required to develop our understanding of these diseases and to devise methods for their control. This book provides a selective compilation of parasitic helminths, many of which are zoonoses which create important economic and public health problems in Africa.

The system of the multicellular animals presented here is an alternative to the traditional classification which still operates with the categories of Carl v. Linné, including typological divisions in artificial species groups. In a new approach to the phylogenetic order in nature this book strives for an objective systematisation of the Metazoa. It seeks a new path in the field of research and academic teaching based on the theory and methodology of phylogenetic systematics. This third volume covers the Metazoa from the Nemathelminthes to the Mammalia.

The history of research on hog cholera (HC)/classical swine fever (CSF) can be roughly divided into three phases which are characterized by the methods available at the time for demonstrati ng the causati ve agent. Phase covered the period before the viral etiology of HC was discovered by de Schweinitz and Dorset (1904)*. Thereafter (Phase II) the detection of HC virus (HCV) was accomplished by laborious, time-consuming and costly pig inoculation experiments. This explains the extensive search for methods not only for detection but also for accurate infectivity titration as well as for applicable serological techniques to solve urgent problems concerning the pathogenesis, diagnosis, epidemiology and prophylaxis of HC. It was not before the late fifties that HC research entered Phase III when fluorescent antibody techniques offered not only the means for detection and titration of HCV in porcine cell cultures but also for more intensive research on hog cholera and its virus. And yet, there are a number of questions to be answered, e. g. on the genetic and antigenic relation of HCV to bovine viral diarrhea (BVD) virus. There are indications that Phase IV of HC research will bear the stamp of biotechnology. In view of this development it appears appropriate to give an up-dating and summarizing account of HC/CSF including comparative aspects of infections caused by structurally related viruses. The editIon of the present volume would have been impossible without the cooperation of several known scientists who instantly agreed when asked for contribution.

Nearly thirty million species of organisms are believed to now live on Earth. In addition to accumulating evidence from classical biology, paleontology and earth science, the recent progress of molecular biology has provided new insights into understanding how present-day organisms have evolved with such tremendous diversity. Molecular biological studies show us that all living forms, including "E. coli" and human beings, derive from a single ancestor that emerged some 4 billion years ago on Earth. This volume aims to discuss the motifs of organismic evolution from the viewpoints of biogeo-interactions and diversification of the genetic systems. Based on these fundamental understandings, the last section of this volume is devoted to human evolution that includes phylogeny of man as well as evolution of human culture. Such comprehensive discussion will give us a synthesized view of the evolution of life, that is undoubtedly one of the most important problems not only for science but also for human culture in general.

*The first book to bring together archaeological plant and animal analysis *Integrating different methodologies and issues from zooarchaeology and paleoethnobotany *Features a number of new voices in the field as well as established scholars In recent years, scholars have emphasized the need for more holistic subsistence analyses, and collaborative publications towards this endeavor have become more numerous in the literature. However, there are relatively few attempts to qualitatively integrate zooarchaeological (animal) and paleoethnobotanical (plant) data, and even fewer attempts to quantitatively integrate these two types of subsistence evidence. Given the vastly different methods used in recovering and quantifying these data, not to mention their different preservational histories, it is no wonder that so few have undertaken this problem. Integrating Zooarchaeology and Paleoethnobotany takes the lead in tackling this important issue by addressing the methodological limitations of data integration, proposing new methods and innovative ways of using established methods, and highlighting case studies that successfully employ these methods to shed new light on ancient foodways. The volume challenges the perception that plant and animal foodways are distinct and contends that the separation of the analysis of archaeological plant and animal remains sets up a false dichotomy between these portions of the diet. In advocating qualitative and quantitative data integration, the volume establishes a clear set of methods for (1) determining the suitability of data integration in any particular case, and (2) carrying out an integrated qualitative or quantitative approach.