Chickens are many things: sources of meat and eggs, lovable pets, amusing images on merchandise, and a source of comfort at the end of a hard day. Whether we're considering joining the growing flock of backyard chicken-keepers or simply cheered by leafing through images of gorgeous poultry, our love for chickens is strong. The trend for backyard chickens has surged during the pandemic. Amazon searches for chick supplies are up 758%, with local hatcheries recording a 500% demand increase, as people look to reduce environmental impact, improve food traceability, connect with nature, or simply to relish the pure joy of chicken company. The Collins Backyard Chicken-keeper's Bible is the fourth title in this stunning and engaging series, and the perfect smallholder companion to The Beekeeper's Bible. It is packed with everything you need to fully embrace your new chicken-keeping lifestyle. A sumptuous aesthetic is paired with practical tips on identifying backyard breeds and supporting good chicken health, from basic brooding to common ailments, the best backyard breed for you to the right equipment for starting your own home flock, packaged into a beautiful, illustrative gift book. Discover the soft cuddliness of a bantam Silkie, the superb egg-sitting skills of a Plymouth Rock, the best method for constructing a chicken coop, and how to keep your chickens happy and thriving. With The Collins Backyard Chicken-keeper's Bible, discover more about these magnificent and beloved creatures.

A 29-volume set which contains all Charles Darwin's published works. Darwin was one of the most influential figures of the 19th century. His work remains a central subject of study in the history of ideas, the history of science, zoology, botany, geology and evolution.

Volumes 21 to 29 in a 29-volume set which contain all Charles Darwin's published works. Darwin was one of the most influential figures of the 19th century whose work remains a central subject of study in the history of ideas, the history of science, zoology, botany, geology and evolution.

The present book is a monograph about two groups of hypotrichous ciliates, namely the Amphisiellidae and the Trachelostylidae. It is the third of six volumes which - view the Hypotricha, one of the three major taxa of the spirotrichs. The first volume is about the Oxytrichidae, a rather large group, many species of which have 18 highly characteristically arranged frontal-ventral-transverse cirri and, much more importantly, a comparatively complex dorsal ciliature due to (oxytrichid) fragmen- tion of dorsal kineties during cell division (Berger 1999). The second volume deals with the Urostyloidea, which are characterised by a zigzag-arrangement of the ventral cirri (Berger 2006). Although this pattern is often very impressive, it is a relatively simple feature originating by a more or less distinct increase of the number of frontal-ventral-transverse cirri anlagen. These anlagen produce cirral pairs which are serially arranged in non-dividing specimens. Some - ers are likely astonished that the monograph on urostyloids does not include Urol- tus, a group of tailed species, which also have a distinct zigzagging cirral pattern. However, morphological and molecular data indicate that the zigzag pattern of U- leptus evolved independently, that is, convergently to that of the urostyloids. Thus, Uroleptus was excluded from the urostyloid review. A zigzag pattern is also known from some oxytrichids, for example, Neokeronopsis, Territricha, Pattersoniella, showing that this pattern evolved several times independently (Berger 1999, 2006, Foissner et al. 2004).

Volumes 11 to 20 in a 29-volume set which contain all Charles Darwin's published works. Darwin was one of the most influential figures of the 19th century whose work remains a central subject of study in the history of ideas, the history of science, zoology, botany, geology and evolution.

An interdisciplinary challenge to assumptions about animals and animality deeply embedded in our own ways of thought, exposing sensitive and largely unexplored aspects of the understanding of our common humanity.

Caterpillars are excellent model organisms for understanding how multiple selective forces shape the ecology and evolution of insects, and organisms in general. Recent research using the tools of modern molecular biology, genetics, metabolomics, microbial ecology, experiments conducted at a global level, network analysis, and statistical analyses of global data sets, combined with basic natural history, are yielding exciting new insights into caterpillar adaptations and ecology. The best way to view these research advances is within a framework of tri-trophic interactions. This is a timely topic for research given the central role of caterpillars and plants in the ecology and trophic structure of terrestrial communities. This book is unique in that it contains chapters from a team of experts on a diversity of key topics within caterpillar-plant interactions. This volume brings together contributions by researchers from around the globe, working in both tropical and temperate habitats, and in human-managed and more natural habitats. It is a significant contribution to our understanding of insect biology, and the role that insects, as represented by caterpillars, play in a world increasingly dominated by humans and one in which threats to insect biodiversity are mounting. Chapter 11 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. The Natural History of Caterpillar-Ant Associations" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Ever since the discovery of fossil remains of extinct animals associated with flint implements, bones and other animal remains have been providing invaluable information to the archaeologist. In the last 20 years many archaeologists and zoologists have taken to studying such "archaeofaunal" remains, and the science of "zoo-archaeology" has come into being. What was the nature of the environment in which our ancestors lived? In which season were sites occupied? When did our earliest ancestors start to hunt big game, and how efficient were they as hunters? Were early humans responsible for the extinction of so many species of large mammals 10-20,000 years ago? When, where and why were certain animals first domesticated? When did milking and horse-riding begin? Did the Romans influence our eating habits? What were sanitary conditions like in medieval England? And could the terrible pestilence which afflicted the English in the seventh century AD have been plague? These are some of the questions dealt with in this book. The book also describes the nature and development of bones and teeth, and some of the methods used in zoo-archaeology.

Receptor specific antibodies are excellent probes for a wide range of biological investigations on receptor structure and function. The hybridoma technology (Kohler and Milstein, 1975) has inevitably had a major impact on this field with most of the better known receptors now identified with monoclonal antibodies. This volume of the Receptors and Recognition series provides reviews of recent developments in this field and emphasizes in particular the new opportunities afforded by the judicious application of monoclonal reagents. It is assumed that most readers will be familiar with the now fairly routine methods of cell fusion, hybridoma cloning and selection for producing monoclonal antibodies and so few details of the basic technical procedures are described. Several good reviews on this topic are however available (see Galfre and Milstein, 1981; Goding, 1980; Yelton and Scharf, 1981; McMichael and Fabre, 1982). By no means all vertebrate receptor species are discussed here; omissions include antibodies to low density lipoprotein receptors (Beisiegel et al. , 1981; Kita et al. , 1981), prolactin and growth hormone receptors (Friesen etal. , 1982; Simpson et al. , 1983) and the hepatocyte asialoglycoprotein receptor (Schwartz et al. , 1981; Harford et al. , 1982). Nevertheless the coverage is comprehensive and critical and the individual chapters provided illustrate vividly the rapid progress being made.

Galapagos Giant Tortoises brings together researchers and conservationists to share the most up-to-date knowledge of Galapagos giant tortoises. Despite being icons of the world-famous Galapagos Archipelago and the target of more than 50 years of conservation research and management, Galapagos giant tortoise evolution and much of their ecology remained unknown until recently. This book documents the history, the pressing conservation issues, and success stories recovering several of the 15 different species of Galapagos tortoises from near extinction. The book begins with an overview of the history of the relationship between humans and Galapagos giant tortoises, starting from initial heavy exploitation of tortoises by pirates and whalers, and extending to the start of the modern conservation era in the 1960s. The book then shifts to biology, describing Galapagos tortoise evolution, taxonomy, ecology, habitats, reproduction, and behavior. Next the decades of conservation efforts and their results are reviewed, including issues of captive breeding, invasive species, introduced diseases, and de-extinction, as well as the current status and distribution of every species. The final portion of the book turns to four case studies of restoration, and then looks ahead to the future of all tortoise populations.The latest volume in the Biodiversity of the World: Conservation from Genes to Landscape series, Galapagos Giant Tortoises is a valuable resource for researchers and conservationists, as well as students of biology, wildlife conservation, and herpetology.

This book discusses the history of invertebrate fossil understanding and classification by exploring fossil studies between the 15th and 18th centuries. Before the modern age, the understanding of fossil findings went through several phases. The treatment by philologists, philosophers and historians of natural sciences involved religious, sometimes folkloristic, aspects before scientific ones. This work showcases and assesses these original findings by carrying out a bibliographical, and above all iconographical research, aimed at finding the first printed images of the objects that we now know as fossils. From here, the authors provide an understanding of the true nature of fossils by analyzing them through modern academic viewpoints, and describing each fossil group from a paleontological and taxonomic point of view, retracing their treatment in the course of the centuries. As a point of reference for each fossil group treated, the authors have considered indispensable the use of ancient prints as evidence of the first iconographic sources dedicated to fossils, starting from those in the late fifteenth century, dedicated to the most common groups of invertebrates without neglecting a necessary exception, the ichthyodontolites, fundamental in the discussion in Italy on the interpretation of the organic origin of fossils, and from the end of the sixteenth century to about half of the eighteenth century. The abundant iconographic apparatus used, often unpublished or specially reworked, is essential and functional to the understanding of the various aspects addressed, a visual complement to the text and vice versa, designed and used taking its cue from the need imposed on early scholars to document their discoveries visually. Among the chosen images there is no shortage of original attributions to fossil finds that have been poorly understood or misidentified until now. The English translation of this book from its Italian original manuscript was done with the help of artificial intelligence (machine translation by the service provider DeepL.com). A subsequent human revision of the content was done by the authors.

The suppression of apoptosis by the IGF system is critical for normal cell development, proliferation, differentiation and motility. Aberrations in IGF signalling mechanisms contribute to cell transformation, tumour progression and metastasis. Many questions remain to be answered as to how exactly the IGF system mediates its effects both in normal and tumour cells and how the IGF-1R interacting proteins and downstream signalling cascades are regulated. The importance of the IGF system is underscored by the significant interest in the development of anti-IGF therapies for IGF sensitive cancers. Future developments in cancer therapy are likely to focus on methods to target these therapies to diseased but not normal cells. 14. Acknowledgements We would like to thank Kurt Tidmore for preparing the illustrations. The Health Research Board of Ireland and Science Foundation Ireland are grateful acknowledged for funding. 15. References Adamo M., Roberts C. T., Jr. and LeRoith D. (1992) How distinct are the insulin and insul- like growth factor I signalling systems? Biofactors 3, 151-7. Adams T. E., Epa V. C., Garrett T. P. and Ward C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57, 1050-93. Adler V., Polotskaya A., Wagner F. and Kraft A. S. (1992) Affinity-purified c-Jun ami- terminal protein kinase requires serine/threonine phosphorylation for activity. J Biol Chem 267, 17001-5.

Epigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and 'co-act' with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.

The IACUC Administrator's Guide to Animal Program Management supports IACUC administrators who assist with developing, managing, and overseeing a program of animal care and animal use. It provides many options and possibilities for specific operational practices (e.g., how to build a well-functioning IACUC, what a functional protocol template looks like) to satisfy regulatory requirements. The material provided is a compilation of several years of Best Practices (BP) meetings among IACUC administrators across the country. The BP meetings included representatives from the NIH/OLAW, AAALAC, and the USDA, whose presence and dialogue assured the BP discussion met or exceeded all regulatory or accreditation minimum standards. BP meeting attendees from private, public, governmental, and academic organizations have helped to shape and develop the information offered herein. It is through the insight of several hundred colleagues-their successes as well as their failures-that the authors have distilled suggestions and considerations for your local animal care and use program. This handbook complements other useful references and manuals regarding programmatic function-it is not intended to replace them. The primary difference you will find is the transparent and open nature of describing processes that have been time tested and proven to help you and your organization satisfy the regulatory requirements.

The Anthropocene is the "age of human influence", an epoch well known for its urban impact. More than half of all people already live in cities, and this proportion is expected to rise to almost 70 percent by 2050. Like other species in urban areas, bats must contend with the pressures of profound and irreversible land cover change and overcome certain unique challenges, such as the high density of roads, lights, glass, and free-ranging domestic animals. Research on urban bats in recent decades indicates that when it comes to urban life, some bats are synanthropes. In other words, although most species of bats are negatively impacted by urbanisation, many appear to not only succeed, but also thrive in cities and towns. This observation has inspired interesting questions about bats in relation to urbanisation. Which traits and behaviours equip bats for urban success? What features of urban areas increase the likelihood that bats will successfully persist there or even colonize new areas? And how does the success of urban bats affect co-habiting humans? Our book explores the interactions between bats and urban environments through case studies and reviews. Understanding how different species interact with urban environments can reveal potential opportunities to mitigate urban threats to bats and threats posed by bats to other urban organisms, including humans. With this book, we thus aspire to provide a knowledge base to help guide current and future efforts to conserve bats.

Animal cell technology has undergone a rapid transformation over the last decade from a research tool and highly specialised technology to a central resource for innovation in pharmaceutical research and development. These proceedings of the 14th Meeting of the European Society for Animal Cell Technology (Vilamoura, Portugal, May 1996) bring up to date the historical perspective of animal cell technology for the benefit of society, `From Vaccines to Genetic Medicine', and will charter this vital technology for the years to come. Strong contributions are grouped in the traditional ESACT areas of 'Cell and Physiology Engineering' dealing with cell state, including genetics, and its environment, and 'Animal Cell Process Engineering' covering integration of bioreaction with bioseparation coupled with on-line monitoring to improve protein production and consistency. Extensive coverage of metabolic engineering on synthesis, folding, assembly, transiting and secretion is dealt with in the session on 'Recombinant Proteins: Biosynthesis and Bioprocessing'. Two traditional but expanding areas of animal cell technology relevance are highlighted in the broad sessions of 'Animal Cells as Tools for Discovery and Testing' and 'Animal Cell Vaccines: Present and Future'. Two sessions finally cover the more recent domains of animal cell technology work - 'Tissue Engineering and Biomedical Devices' and 'Cells and Vectors for Genetic Medicine' - where one can foresee a very bright future.

The third edition of The Laboratory Rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. New information related to the husbandry and veterinary care of rats is provided including topics related to nutrition, reproduction, anesthesia and surgery, infectious and noninfectious disease, and the care of surgical and other fragile models. It is a premier source of information on the laboratory rat, this book will be of interest to veterinary and medical students, senior graduate students, postdocs and researchers who utilize animals in biomedical research.

A New York Times Notable Book of 2020 'Bracing and enlightening' Science Culture is something exclusive to human beings, isn't it? Not so, says intrepid researcher Carl Safina. Becoming Wild reveals the rich cultures that survive in some of Earth's remaining wild places. By showing how sperm whales, scarlet macaws and chimpanzees teach and learn, Safina offers a fresh understanding of what is constantly going on beyond humanity, and how we're all connected. 'Becoming Wild demands that we wake up' Telegraph