Of all the countless legendary beasts that have been conjured forth from the seemingly limitless capacity of the human imagination, none can remotely compare with the dragon for its sheer diversity of form, its symbolic significance, and its cross-cultural presence. Dragons are everywhere-still glimpsed in the living, breathing beasts around us that inspired and engendered their birth in our far-distant ancestors' dreams, and nightmares; perennially encountered in the myriad of traditional myths and folklore woven into the fabric of every creed and culture around the world; and ever-visible within the innumerable outpourings of artistic creation that have graced and enhanced our species' existence across all temporal, political, social, and geographical boundaries. So from where, and from what, has such widespread-indeed, worldwide-belief in these creatures stemmed? There can be no doubt that a major factor influencing the origin of the dragon is early humanity's observations and interactions with various distinctive and potentially inimical creatures of reality sharing our world. Equally thought-provoking is how and why the dragon has become so intimately associated with our own species. This multi-faceted monster of mythology is more than amply represented visually, for example, by artwork of every conceivable style, age, and category. And the dragon's status in religion, dreams, alchemy, psychology, astrology, literature, movies, and music is as compelling as it is complex. These many diverse but equally captivating themes are all fully explored in this spellbinding book's uniquely comprehensive coverage, and provide ample confirmation that there is no sign whatsoever of waning interest for what must surely be the most vibrant, tenacious, and fascinating creature that has never existed-the dragon.

In the noble and dangerous times of medieval France, the young knight Aubrey de Montdidier, nephew of the Count of Montargis, has been strangely murdered. His friend the brave Sieur DeNarsac, captain of the count's men-at-arms, and Thierry, a young page, must now solve the tragic mystery. Yet it is a magnificent white wolfhound by the name of Dragon -- Montdidier's faithful companion -- who brings an unexpected, shocking conclusion to the puzzle of his master's untimely death.New York Times best-selling authors Julie Andrews Edwards and Emma Walton Hamilton weave a tapestry of intrigue, power, loyalty, and friendship in this novel based on the captivating French legend of Montargis.

For many years I performed tissue culture in large scientific insti- tions that had a great deal of infrastructure. When I set up a tissue l- oratory outside such an infrastructure, however, I found there was a shortage of easily accessible information about the basic needs, reagents, and techniques for establishing such a facility. Much had to be done by trial and error or gleaned from originalpapers. Consequently, I felt that a methods book covering a wide variety of techniques from basic culture to the most sophisticated cell analysis would be a very valuable addition to the scientific literature. In the interim, several useful books (listed in Chapter I of this volume) did appear, but none entirely fitted the bill and some are now somewhat dated. Then, in 1984, the first of the Methods in Molecular Biology volumes from Humana Press was published with its step-by-step recipe approach. This format appealed to me, and so I c- tacted John Walker, the series editor, about including cell culture in this series. The result was that we embarked upon a single volume covering both plant and animal cell culture. Such was the richness of the material that this project soon divided itself into separate volumes on animal cell (Volume 5) and plant cell (Volume 6) culture. In this volume (Volume 5), therefore, we have aimed to describe a variety of basic techniques and culture conditions for a range of cell types.

What have we learnt about the Nile since the mid-1970s, the moment when Julian Rzoska decided that the time had come to publish a comprehensive volume about the biology, and the geological and cultural history of that great river? And what changes have meanwhile occurred in the basin? The human popu- tion has more than doubled, especially in Egypt, but also in East Africa. Locally, industrial development has taken place, and the Aswan High Dam was clearly not the last major infrastructure work that was carried out. More dams have been built, and some water diversions, like the Toshka lakes, have created new expanses of water in the middle of the Sahara desert. What are the effects of all this on the ec- ogy and economy of the Basin? That is what the present book sets out to explore, 33 years after the publi- tion of "The Nile: Biology of an Ancient River". Thirty-seven authors have taken up the challenge, and have written the "new" book. They come from 13 different countries, and 15 among them represent the largest Nilotic states (Egypt, Sudan, Ethiopia, Uganda, and Kenya). Julian Rzoska died in 1984, and most of the - authors of his book have now either disappeared or retired from research. Only Jack Talling and Samir Ghabbour were still available to participate again.

This book is the first offour volumes in the Handbook of Zoology series which treat the systematics and biology of Coleoptera. With approximately 350,000 described species, Coleoptera are by far the most species-rich order of insects and the largest group of animals of comparable geological age. The beetle volumes will meet the demand of modern biologists seeking to answer questions about Coleoptera phylogeny, evolution, and ecology. This first Coleoptera volume covers the suborders Archostemata, Myxophaga and Adephaga, and the basal series of Polyphaga, with information on world distribution, biology, morphology of all life stages (including anatomy), phylogeny and comments on taxonomy.

Biotechnology is advancing at a rapid pace with numerous applications in medicine, industry, agriculture and environmental remediation. Recognizing this, government, industrial and academic research and development invest ment in biotechnology has expanded rapidly. The past decade has seen the emergence of applications of this technology with a dual-use potential. Mili tary applications focus on four major areas: biomedical technology, such as vaccine development and medical diagnostics; detection of toxins, chemicals and pathogens; material biotechnology; and biological decontamination, in cluding biodegradation and bioremediation. This conference emphasizes the non-medical applications of biotechnol ogy. The first two sessions focus on the synthesis and properties of molecules that may be used in detectors. The traditional approach to detection of chemical and biological agents relied on the development of specific assays or analyses for known agents. Advances in molecular biology have made possible the production of large quantities of toxins which were previously available in minute quantities, and the molecular engineering of toxins and pathogens with specific pharmacologic and physical-chemical properties. In addition to the traditional approaches to detection of specific known compounds, biotechnology now offers generic approaches to detection. Physiological targets, known as receptors, are primary targets for many drugs and toxins. Similarly, pathogens rely on receptors to gain access to cells. These receptors function as sensitive detectors, generating signals which are transduced and amplified."

This volume presents a comprehensive overview of what is understood about the similarities and differences among mammals in their sense of hearing, and the structures of the ear that condition and transform sound wave-forms. The goal of each chapter is to present what is known about the diversity of hearing functions among mammals so that we may better understand the relationships between the structures of ears and the hearing abilities of the animals most closely related to humans. This book will be invaluable to researchers, students, and clinicians in auditory research.

Microbiology may be described as one of the younger sciences with its history, as a precise subject, only dating as far back as Pasteur in the mid 1800s and his revelation both of the role of microorganisms in nature and their importance to human welfare. Medical scientists rapidly took up the challenge, with their area of microbiology flourishing and expanding almost in complete isolation from the rest of biology. We now know, of course, that microorganisms have always played an important, if not essential role, in the biosphere with fermented foods and beverages, plant and animal diseases and nutrient cycling foremost in their sphere of activities. Within the last twenty years, microbiology has received two enormous boosts with the developments in microbial genetics and genetic engineering probably being the most influential, and the greater awareness of pollution and environmental sustainability following a close second. In 1990, your editor had the privilege and pleasure of being elected as President of The Association of Applied Biologists in the United King dom and, as the topic for his three-day Presidential Conference, chose 'The exploitation of microorganisms in applied biology'. This meeting stimu lated great interest in a wide range of subject areas, from weed control to nematology, from plant breeding to plant pathology, from mushrooms to mycorrhiza. The proceedings of this meeting were published in Aspects of Applied Biology, No. 24, 1990."

Providing experimental methods and protocols for performing pheromone research in a variety of organisms ranging from invertebrates to vertebrates, Pheromone Signaling: Methods and Protocols covers a wide spectrum of experimental approaches necessary for handling pheromone molecules, measuring receptor response and neural activation, and analyzing behavioral output. A great deal of progress has been made in understanding the molecular mechanisms underlying pheromone action, largely due to the discovery of receptor genes, the advancement of imaging techniques, and key multi-disciplinary approaches including aspects of organic chemistry, biochemistry, molecular biology, electrophysiology, and behavioral science. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Pheromone Signaling: Methods and Protocols details the key methodologies utilized in laboratories all over the world, making them accessible to those who want to begin investigation in the area of pheromone research.

Myriapods are the only major zoological group for which a modern encyclopedic treatment has never been produced. In particular, this was the single major gap in the largest zoological treatise of the XIX century (Grasse's Traite de Zoologie), whose publication has recently been stopped. The two volumes of "The Myriapoda" fill that gap with an updated treatment in the English language. Volume II deals with the Diplopoda or millipedes. As in the previous volume, the treatment is articulated in chapters dealing with external and internal morphology, physiology, reproduction, development, distribution, ecology, phylogeny and taxonomy. All currently recognized suprageneric taxa and a very large selection of the genera are considered. All groups and features are extensively illustrated by line drawings and micrographs and living specimens of representative species of the main groups are presented in color photographs.

Increasing rate of species extinction in the present day will lead to a huge biodiversity crisis; eventually, this will lead to the paucity of non-renewable resources of energy making our Earth unsustainable in future. To save our mother planet from this crisis, studies need to be performed to discover abundant new fossil sites on Earth for continued access to oil-rich locations. Most importantly, a holistic approach is necessary in solving the present problem of biodiversity loss. This book presents newly developed quantitative models in understanding the biodiversity, evolution and ecology of extinct organisms. This will assist future earth scientists in understanding the natural and anthropogenic causes behind biodiversity crisis and ecosystem collapse. In addition, this study would be of great interest to exploration geologists and geophysicists in potentially unraveling natural resources from our sustainable Earth.

A New York Times Notable Book of 2020 'Bracing and enlightening' Science Culture is something exclusive to human beings, isn't it? Not so, says intrepid researcher Carl Safina. Becoming Wild reveals the rich cultures that survive in some of Earth's remaining wild places. By showing how sperm whales, scarlet macaws and chimpanzees teach and learn, Safina offers a fresh understanding of what is constantly going on beyond humanity, and how we're all connected. 'Becoming Wild demands that we wake up' Telegraph

This text features the proceedings of a workshop on Advances in Biological Treatment of Lignocellulosic Materials, held in Lisbon, Portugal, during 25-27 October 1989.

Animal cell technology is a growing discipline of cell biology which aims not only to understand structures, functions and behaviors of differentiated animal cells but also to uncover their abilities for industrial and medical purposes. The goal of animal cell technology includes clonal expansion of differentiated cells with useful abilities, optimization of their culture conditions on the industrial scale, modulation of their ability in order efficiently to produce medically and pharmaceutically important proteins, and application of animal cells to gene therapy and formation of artificial organs. This Volume gives the readers a complete review of the present state of the art in Japan, a country where this field is well advanced, as well as in Asia, Europe and the United States. The Proceedings will be useful for cell biologists, biochemists, molecular biologists, biochemical engineers and those in other disciplines related to animal cell culture, working in academic environments as well as in the biotechnology and pharmaceutical industries.

This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB). The conference was held in Copper Mountain, CO from July 11-16, 1999. It was a an extension of a New York Academy of Sciences meeting entitled "Primordial Immunity: Foundations for the Vertebrate Immune System" held on May 2-5,1993 at the Marine Biological Laboratories in Woods Hole, MA. The proceedings of that meeting were published in The Annals of the New York Academy of Sciences (volume 712). At that meeting all the attendes agreed that this type of conference (a relatively small focused gathering) allowed for participation by investigators at all levels of their careers. We further agreed that we should search for a forum that would allow this meeting to continue. The FASEB Summer Research Conference was an excellent vehicle for this type of meeting. Furthermore, this year's participants decided to continue this meeting as a regularly scheduled FASEB sponsored event. This was a unique conference in the sense that it focused upon mechanisms of development and defense in protostome and deuterostome invertebrates and lower vertebrates. There was a strong emphasis on evolutionary cell biology, phylogenetic inferences and the evolution of recognition and regulatory systems.

Knowledge of cholesterol and its interaction with protein molecules is of fundamental importance in both animal and human biology. This book contains 22 chapters, dealing in depth with structural and functional aspects of the currently known and extremely diverse unrelated families of cholesterol-binding and cholesterol transport proteins. By drawing together this range of topics the Editor has attempted to correlate this broad field of study for the first time. Technical aspects are given considerable emphasis, particularly in relation cholesterol reporter molecules and to the isolation and study of membrane cholesterol- and sphingomyelin-rich "raft" domains. Cell biological, biochemical and clinical topics are included in this book, which serve to emphasize the acknowledged and important benefits to be gained from the study of cholesterol and cholesterol-binding proteins within the biomedical sciences and the involvement of cholesterol in several clinical disorders. It is hoped that by presenting this topic in this integrated manner that an appreciation of the fact that there is much more that needs to be taken into account, studied and understood than the widely discussed "bad and good cholesterol" associated, respectively, with the low- and high-density lipoproteins, LDL and HDL. Content Level Professional/practitioner