This book offers the reader an integrated point of view of fertilization in the animal kingdom. As the research at the molecular and cellular level is scarce compared to the huge diversity of animal species, for each phylum or class representative species have been chosen. Each phylum/class begins with a general description of the sexual and asexual reproduction strategies of the respective species, followed by a description of the reproductive cycle as well as of its reproductive system. The main focus is on the cellular and molecular aspects of fertilization of all the selected representative species, and the book is fully illustrated with photographs and drawings to facilitate understanding.

I have written this book because there is, as in almost all supraspecific ciliate taxa, an ur- gent need for an up-to-date revision of the oxytrichids, which are common in terrestrial, limnetic, and marine biotopes. The last comprehensive, illustrated guides to this group of hypotrichs were provided by KAHL (1932) and SmLER (1974b); however, as regards syn- onymy and faunistics, these works are outdated and not as detailed as EHRENBERG'S out- standing book from 1838. In KAHL's revision, the oxytrichids sensu stricto are described on about 30 pages, whereas in the present book the systematic section comprises about 830 pages. This extraordinary increase in page number is mainly due to the following points: (i) Species number increased from about SO in KAHL to about 170 in the present book. (ii) KAHL usually provided only a single illustration of each species, whereas almost all published illustrations on oxytrichid ciliates are included in my book. (iii) Modern, phylogenetic systematics of oxytrichids without morphogenetic data is impossible; conse- quentlY,*almost all detailed descriptions, usually dealing with the type species, have been included. (iv) Synonymy is discussed, and not only mentioned, as is unfortunately usual.

Strategies of Bacterial Interaction with Eukaryotic Cells *Tobias A. Oelschlaeger and Jorg Hacker 1. BENEFICIAL BACTERIAL-HOST INTERACTIONS Already during birth and soon thereafter mammals are colonized by bacte- ria belonging to the resident microbial flora. Cutaneous and mucosal sur- faces and the gastrointestinal tract are the areas which become colonized. These indigenous or autochthonous bacteria have a variety of beneficial effects on their hosts. They play a protective role by bacterial antagonism in fighting infections (Hoszowski and Truszczynski, 1997; Hentges, 1979). Pro- duction of vitamin K is another essential contribution of the resident microbial flora to the health of the host (Hill, 1997). Even more important, studies with germ-free animals demonstrated the involvement of the microbial flora on the development of the immune system. Such animals have underdeveloped and relatively undifferentiated lymphoid tissues and low concentrations of serum immune globulins ( Cebra et at., 1998). They TOBIAS A. OELSCHLAEGER and JORG HACKER Institut filr Molekulare lnfektionsbiologie, Universitiit Wiirzburg, 97070 Wiirzburg, Germany. *Corresponding author; Phone: (0)931-312150; FAX: (0)931-312578; E-mail: [email protected] xxix Tobias A. Oelschlaeger and Jorg Hacker also show defects in specific immune responsiveness and in nonspecific resistance induced by endotoxin, which may account for their lowered resis- tance. A more typical example of symbiotic interaction of bacteria with a host are bacteria like Ruminococcus in the gut of ruminants, essential for degradation of cellulose (Hobson, 1988). The closest benefical bacterial-host interactions are those of intracellular symbiotic bacteria and their host cells.

Wonderfully illustrated book, originally from 1749.

This introductory text lays particular emphasis on the relationship between development and behaviour. Indeed, the second part of the book is devoted to examining the role of factors present during development which influence the growth of the nervous system and subsequent behaviour. Throughout the subject matter is extensively illustrated in clear, colour diagrams, and each chapter ends with learning objectives and questions.

Although virology and immunology are now considered separate disciplines, history shows that these areas ofinvestigation always overlapped and one cannot really exist without the other. This trend has become particularly significant and fruitful in the past few years in the area of herpesvirus research. The genomes of the most important herpesviruses have been sequenced, a significant portion of their genes have been identified, and many secrets of regulation of gene expr- sion have been unraveled. Now this progress sets the stage for a true revolution in herpesvirus research: analysis of interactions between the host and the virus. Because herpesviruses can induce, suppress, and fool the immune system, the most productive herpesvirologists are also expert immunologists, and the current results ofthis interdisciplinary effort are truly remarkable. Because herpesviruses cause many important human diseases, the devel- ment of vaccines against these agents is a very significant goal. This effort is also very challenging because of the complexity of herpesviruses and the lack of sufficient information about immune responses. The remarkable ability of herpesviruses to escape immune responses is - other feature that brings immunology and virology together. Herpesviruses - code many proteins that interact with and down-regulate some key elements of the immune system. Thisproperty of herpesviruses represents amajor challenge in developing strategies against these viruses. On the positive side, these viral proteins also provide novel tools for analyzing specific immune reactions and molecular mechanisms.

Highlighting the latest research on Actualistic Taphonomy (AT), this book presents the outcomes of a meeting that took place in Montevideo, Uruguay, in October 2017. Its respective chapters offer valuable insights into South American archaeology, invertebrate and vertebrate fauna, and flora. In recent years, there has been a surge of new research on AT, as evidenced by numerous papers, talks, theses, etc. However, there are still very few AT books or even dedicated journal articles. Reflecting the discipline's newfound maturity, this book, written by South American authors, offers a unique resource for academics and students of Paleontology, Geology, and Biology around the world.

This work takes a critical look at the current concept of isotopic landscapes ("isoscapes") in bioarchaeology and its application in future research. It specifically addresses the research potential of cremated finds, a somewhat neglected bioarchaeological substrate, resulting primarily from the inherent osteological challenges and complex mineralogy associated with it. In addition, for the first time data mining methods are applied. The chapters are the outcome of an international workshop sponsored by the German Science Foundation and the Centre of Advanced Studies at the Ludwig-Maximilian-University in Munich. Isotopic landscapes are indispensable tracers for the monitoring of the flow of matter through geo/ecological systems since they comprise existing temporally and spatially defined stable isotopic patterns found in geological and ecological samples. Analyses of stable isotopes of the elements nitrogen, carbon, oxygen, strontium, and lead are routinely utilized in bioarchaeology to reconstruct biodiversity, palaeodiet, palaeoecology, palaeoclimate, migration and trade. The interpretive power of stable isotopic ratios depends not only on firm, testable hypotheses, but most importantly on the cooperative networking of scientists from both natural and social sciences. Application of multi-isotopic tracers generates isotopic patterns with multiple dimensions, which accurately characterize a find, but can only be interpreted by use of modern data mining methods.

Paul Shepard has been one of the most brilliant and original thinkers in the field of human evolution and ecology for more than forty years. His thought-provoking ideas on the role of animals in human thought, dreams, personal identity, and other psychological and religious contexts have been presented in a series of seminal writings, including "Thinking Animals," "The Tender Carnivore and the Sacred Game," and now "The Others," his most eloquent book to date."The Others" is a fascinating and wide-ranging examination of how diverse cultures have thought about, reacted to, and interacted with animals. Shepard argues that humans evolved watching other animal species, participating in their world, suffering them as parasites, wearing their feathers and skins, and making tools of their bones and antlers. For millennia, we have communicated their significance by dancing, sculpting, performing, imaging, narrating, and thinking them. The human species cannot be fully itself without these others.Shepard considers animals as others in a world where otherness of all kinds is in danger, and in which otherness is essential to the discovery of the true self. We must understand what to make of our encounters with animals, because as we prosper they vanish, and ultimately our prosperity may amount to nothing without them.

The field of DNA repair is vast and advancing rapidly. Recent investigations have begun to focus on the involvement of chromatin in the repair of broken DNA. Although I have no doubt that many breakthroughs in our understanding of chromatin, chromatin regulation, and DNA repair lie in our future, presently this is a new line in inquiry. As such there are many, many unanswered questions. Indeed, most of the correct questions have probably not even been asked yet. Here I have attempted to present a review of some of the current body of knowledge that may prove relevant to understanding the role of chromatin in DNA repair. Because the volume of research, and the relevant findings, come from a staggering array of labs, systems, and ideas I have focused primarily on findings developed from the study of the budding yeast Saccharomyces cerevisiae. Unfortunately, this means that I have left out a great deal of information. It is my hope, however, that the information I do detail, particularly in Chapter 1, will give a flavor for the scope of the problem and perhaps highlight some of the interesting directions this field is taking, or may one day take. I would also point out that the primary research that is presented herein is not in any way meant to represent the comprehensive scope of research being performed. To understand DNA repair will require investigation from innumerable labs, performed by innumerable researchers, moving in unexpected directions.

In this book, leading scientists in the fields of sensory biology, neuroscience, physics and engineering explore the basic operational principles and behavioral uses of flow sensing in animals and how they might be applied to engineering applications such as autonomous control of underwater or aerial vehicles.

Although humans possess no flow-sensing abilities, countless aquatic (e.g. fish, cephalopods and seals), terrestrial (e.g. crickets and spiders) and aerial (e.g. bats) animals have flow sensing abilities that underlie remarkable behavioral feats.These include the ability to follow silent hydrodynamic trails long after the trailblazer has left the scene, to form hydrodynamic images of their environment in total darkness, and to swim or fly efficiently and effortlessly in the face of destabilizing currents and winds.

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Dynamic Biological Organization is a fascinating account of the living organisms as dynamic systems, based on the concept that the spatio-temporal coherence of events within a living system result from the intrinsic dynamics of the processes taking place within that sysem. The authors of this important work, Miguel Aon and Sonia Cortassa have travelled widely to work in some of the leading research laboratories to accumulate a large information base on which to assemble this book. Taking a transdisciplinary approach, the authors draw on work at the interface of biochemistry, genetics, physiology, thermodynamics, kinetics and biomathematics, using mathematical models throughout to corroborate and analyze the biological complexity presented. Emphasizing biological processes occuring at the cellular level. Dynamic Biological Organization gives exciting insights into the experimental and theoretical applications of modern scientific paradigms to fundamental biological processes.

The Office of Health and Environmental Research (OHER) has supported and continues to support development of computational approaches in biology and medicine. OHER's Radiological and Chemical Physics Program initiated development of computational approaches to determine the effects produced by radiation of different quality (such as high energy electrons, protons, helium and other heavy ions, etc. ) in a variety of materials of biological interest-such as water, polymers and DNA; these include molecular excitations and sub-excitations and the production of ionization and their spatial and temporal distribution. In the past several years, significant advances have been made in computational methods for this purpose. In particular, codes based on Monte Carlo techniques have .been developed that provide a realistic description of track-structure produced by charged particles. In addition, the codes have become sufficiently sophisticated so that it is now possible to calculate the spatial and temporal distribution of energy deposition patterns in small volumes of subnanometer and nanometer dimensions. These dimensions or resolution levels are relevant for our understanding of mechanisms at the molecular level by which radiations affect biological systems. Since the Monte Carlo track structure codes for use in radiation chemistry and radiation biology are still in the developmental stage, a number of investigators have been exploring different strategies for improving these codes."