Products from Cells - Cells as Products This book ist he "lasting" product, a resource ofup to date information in the scientific literature fort he field ofanimal cell tec hnology, as it was presented during a pleasant and s timulating mee ting that was held in Lugano Switzerland in April 1999. "Products" appeartwice int he title oft he conference. This clearly indicates the fact that the focus oft he papers presented during this meeting was really the application ofn ew technologies (novel reactors or novel vectors, for example for the preparation and/ort he more efficient generation ofproducts ) that could be used, mainly, int he medical field. Classical approaches forthe use ofa nimal cells, for example forthe p r oduction of virus vaccines for human and animal health, still remain an important technology and still have, surprisingly, quite significant potential for further development and improvement. How ever, it appears that major technological advances an d major growth from an economical point ofview are occurring in other areas. Most importantly, protein production on the basis of recombinant DNA molecules transferred into a nimal cells, appears to be an ever increasing field of interest and innovation, even though the first production scheme with this technology was approved more than 15 years ago.

Epithelia are one of the commonest tissue types in the animal kingdom. Chapters from leading scientists in the major international research laboratories use examples from different systems to illustrate the form and function of epithelia. An important theme is the way in which epithelial cells differentiate to specialized tissue - reversal of this process occurs when cells become tumorigenic.

Contributors to this volume offer new research on extinction processes in birds, nest predation, and song systems, and describes a graphical model that helps predict the reproductive consequences of time allocation between the competing demands of guarding young birds and foraging for food. Current Ornithology is the only English-language publication currently devoted exclusively to extensive reviews and synthesis of topics pertaining to all aspects of the biology of birds. Chapters fall under such diverse rubrics as ecology, evolution, behavior, phylogeny, behavioral ecology, anatomy and physiology, and conservation biology. All authors are leading authorities on their subjects, and each chapter is refereed by experts in the topics covered. Although all chapters focus primarily on birds, some topics, such as the social cognition of birds as compared to primates (Volume 13), have significant application to disciplines outside of ornithology. Current Ornithology aims to provide an accessible, up-to-date, accurate source of data and to contribute to conceptual generalization and unification across the biological sciences.

This volume tries to map out the intriguing amalgam of the different, partly conflicting approaches that shaped early modern zoology. Early modern reading of the "Book of Nature" comprised, among others, the description of species in the literary tradition of antiquity, as well as empirical observations, vivisection, and modern eyewitness accounts; the "translation" of zoological species into visual art for devotion, prayer, and religious education, but also scientific and scholarly curiosity; theoretical, philosophical, and theological thinking regarding God's creation, the Flood, and the generation of animals; new attempts with respect to nomenclature and taxonomy; the discovery of unknown species in the New World; impressive Wunderkammer collections, and the keeping of exotic animals in princely menageries. The volume demonstrates that theology and philology played a pivotal role in the complex formation of this new science. Contributors include: Brian Ogilvie, Bernd Roling, Erik Jorink, Paul Smith, Sabine Kalff, Tamas Demeter, Amanda Herrin, Marrigje Rikken, Alexander Loose, Sophia Hendrikx, and Karl Enenkel.

How does science treat evidence from the edges? This fresh and entertaining look at the search for Sasquatch concerns more than just the startling and controversial nature of monsters and monster hunting in the late twentieth century, but the more important relationship between the professional scientists and amateur naturalists who hunt them-and their place in the history of science. The traditional heroic narrative of monster-hunting situates mainstream, academic scientists (the eggheads) as villains rejecting the existence of anomalous primates and cryptozoology as unworthy of study. It gives a privileged place to passionate amateur naturalists (the crackpots) who soldier on against great odds, and the obstinacy of the mainstream to bring knowledge of these creatures to light. Brian Regal shows this model to be inaccurate: many professional scientists eagerly sought anomalous primates, examining their traces and working out evolutionary paradigms to explain them. Even though scientific thinking held that anomalous primates-Bigfoot, Sasquatch, Yeti-did not and could not exist, these scientists risked their careers because they believed these creature to be a genuine biological reality.

Koval provides an interdisciplinary forum for the diverse studies involved in the stress biology of eukaryotic cells. Readers gain access to the most recent information available for eukaryotic systems ranging from plants to humans. For the student, this format introduces a source of potentially unifying concepts and hypotheses. Scientists will find a unique opportunity to conveniently examine the similarities among inducible responses initiated by a variety of agents.

The Veterinary Psychiatry of Cats introduces veterinary behavioral medicine and veterinary psychiatry using the domestic cat as its model. This book combines the most up-to-date understanding of biology of this beloved, revered and often maligned species with learnings from the fields of normal and abnormal psychology. Written by a leading expert in feline behavior, this book begins by assessing “normal” factors of feline behavior, from neuroanatomy, neuroendocrinology, cognitive and social abilities. Delving into psychiatry, it then discusses mental health disorders, hindered development, and trauma. Psychopharmacology, including medications and supplements, are also explained. The Veterinary Psychiatry of Cats finishes with a comprehensive view of feline welfare management, how to treat cats humanely and how to house them responsibly given their behaviors. This is an ideal resource for feline behavioral specialists, veterinarians and domestic animal researchers and practitioners, including veterinary technicians, students and even feline owners.

'This is a first-class book. If you are interested in wildlife and the outdoors, you will find it an essential addition to your natural-history library. The author's knowledge and enthusiasm come right through, and the illustrator's work greatly enhances the book's usefulness. Organization of the book makes identification easier than with other track books I know and should enable beginners to use the text with ease.'--Jim Rantz, Executive Director, The National Outdoor Leadership School.

This book is a collection of experimental studies demonstrating structure-function relationships in various biological systems having particular surface specialization to increase/decrease friction and adhesion. Studies on snake skin, adhesive pads, wing-interlocking devices and sticky mouthparts of insects as well as anti-adhesive and adhesive surfaces of plants are included in the volume containing four main subsections: (1) adhesion, (2) friction, (3) attachment-devices, (4) attachment-related behavior. Numerous experimental methods for characterizing tribological properties of biological surfaces at macro-, micro-, and nanoscale levels are demonstrated. This book is an excellent collection of publications on biotribology for both engineers and physicists working with biological systems as well as for biologists studying friction and adhesion. Inspirations from biology reported here may be also potentially interesting for biomimetics.

Ever since the discovery of fossil remains of extinct animals associated with flint implements, bones and other animal remains have been providing invaluable information to the archaeologist. In the last 20 years many archaeologists and zoologists have taken to studying such "archaeofaunal" remains, and the science of "zoo-archaeology" has come into being. What was the nature of the environment in which our ancestors lived? In which season were sites occupied? When did our earliest ancestors start to hunt big game, and how efficient were they as hunters? Were early humans responsible for the extinction of so many species of large mammals 10-20,000 years ago? When, where and why were certain animals first domesticated? When did milking and horse-riding begin? Did the Romans influence our eating habits? What were sanitary conditions like in medieval England? And could the terrible pestilence which afflicted the English in the seventh century AD have been plague? These are some of the questions dealt with in this book. The book also describes the nature and development of bones and teeth, and some of the methods used in zoo-archaeology.

The aim of this book is to re-evaluate the true pest status of many common species traditionally regarded as pests. It is based on a revised selection of papers presented at a symposium organized by the Mammal Society in London, November 1987. Many of the pests described are introduced, non-native species, which in the absence of natural predators have multiplied in numbers to become pests. In other cases, it is man's creation of an artificial concentrated environment, such as a single-crop agricultural field, a grain store or a timber plantation, that has generated the conditons for large population increases of pest species. Data are presented from a number of British and European studies on various mammalian pests, including deer, badgers, squirrels, rabbits and others. Some pests are shown to cause direct damage, for example by eating man's food products, while others cause indirect damage, by allowing secondary infections into plants or by being vectors for disease. Strategies of pest management are also considered.

This book is the lasting product, a resource of up-to-date information in the scientific literature for the field of animal cell technology, as it was presented during a pleasant and stimulating meeting in TylAsand, Sweden, in June 2001. The title of the meeting, From Target to Market, indicates the usefulness of Animal Cell Technology during all steps in the pharmaceutical development process. Following the biotech products reaching the market, it shows an upward trend in the contribution of biotech products to total New Molecular Entity output in the nineties, which continued until 1996 when biotech represented 25% of the annual output. Since then the proportion has been decreasing. A perceived hurdle from a market perspective is that a protein per definition is biodegradable and thus requires intravenous, or for some drugs subcutaneous administration. New promising administration technologies such as pulmonary delivery were highlighted at this meeting. The emphasis on project selection prior to entry in the development phase has triggered a portfolio management using more extensive preclinical data before a development decision is taken. Animal cells have become a very important tool in the drug discovery process. The next generation of products will evolve from applications such as gene therapy, novel vaccines, cell therapy, and gene regulation. Animal cell technology has a major role to play in the post-sequence era.