Epigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and 'co-act' with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.

The IACUC Administrator's Guide to Animal Program Management supports IACUC administrators who assist with developing, managing, and overseeing a program of animal care and animal use. It provides many options and possibilities for specific operational practices (e.g., how to build a well-functioning IACUC, what a functional protocol template looks like) to satisfy regulatory requirements. The material provided is a compilation of several years of Best Practices (BP) meetings among IACUC administrators across the country. The BP meetings included representatives from the NIH/OLAW, AAALAC, and the USDA, whose presence and dialogue assured the BP discussion met or exceeded all regulatory or accreditation minimum standards. BP meeting attendees from private, public, governmental, and academic organizations have helped to shape and develop the information offered herein. It is through the insight of several hundred colleagues-their successes as well as their failures-that the authors have distilled suggestions and considerations for your local animal care and use program. This handbook complements other useful references and manuals regarding programmatic function-it is not intended to replace them. The primary difference you will find is the transparent and open nature of describing processes that have been time tested and proven to help you and your organization satisfy the regulatory requirements.

The suppression of apoptosis by the IGF system is critical for normal cell development, proliferation, differentiation and motility. Aberrations in IGF signalling mechanisms contribute to cell transformation, tumour progression and metastasis. Many questions remain to be answered as to how exactly the IGF system mediates its effects both in normal and tumour cells and how the IGF-1R interacting proteins and downstream signalling cascades are regulated. The importance of the IGF system is underscored by the significant interest in the development of anti-IGF therapies for IGF sensitive cancers. Future developments in cancer therapy are likely to focus on methods to target these therapies to diseased but not normal cells. 14. Acknowledgements We would like to thank Kurt Tidmore for preparing the illustrations. The Health Research Board of Ireland and Science Foundation Ireland are grateful acknowledged for funding. 15. References Adamo M., Roberts C. T., Jr. and LeRoith D. (1992) How distinct are the insulin and insul- like growth factor I signalling systems? Biofactors 3, 151-7. Adams T. E., Epa V. C., Garrett T. P. and Ward C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57, 1050-93. Adler V., Polotskaya A., Wagner F. and Kraft A. S. (1992) Affinity-purified c-Jun ami- terminal protein kinase requires serine/threonine phosphorylation for activity. J Biol Chem 267, 17001-5.

Animal cell technology has undergone a rapid transformation over the last decade from a research tool and highly specialised technology to a central resource for innovation in pharmaceutical research and development. These proceedings of the 14th Meeting of the European Society for Animal Cell Technology (Vilamoura, Portugal, May 1996) bring up to date the historical perspective of animal cell technology for the benefit of society, `From Vaccines to Genetic Medicine', and will charter this vital technology for the years to come. Strong contributions are grouped in the traditional ESACT areas of 'Cell and Physiology Engineering' dealing with cell state, including genetics, and its environment, and 'Animal Cell Process Engineering' covering integration of bioreaction with bioseparation coupled with on-line monitoring to improve protein production and consistency. Extensive coverage of metabolic engineering on synthesis, folding, assembly, transiting and secretion is dealt with in the session on 'Recombinant Proteins: Biosynthesis and Bioprocessing'. Two traditional but expanding areas of animal cell technology relevance are highlighted in the broad sessions of 'Animal Cells as Tools for Discovery and Testing' and 'Animal Cell Vaccines: Present and Future'. Two sessions finally cover the more recent domains of animal cell technology work - 'Tissue Engineering and Biomedical Devices' and 'Cells and Vectors for Genetic Medicine' - where one can foresee a very bright future.

Biological literature of the Roman imperial period remains somehow 'underestimated'. It is even quite difficult to speak of biological literature for this period at all: biology (apart from medicine) did not represent, indeed, a specific 'subgenre' of scientific literature. Nevertheless, writings as disparate as Philo of Alexandria's Alexander, Plutarch's De sollertia animalium or Bruta ratione uti, Aelian's De Natura Animalium, Oppian's Halieutika, Pseudo-Oppian's Kynegetika, and Basil of Caeserea's Homilies on the Creation engage with zoological, anatomic, or botanical questions. Poikile Physis examines how such writings appropriate, adapt, classify, re-elaborate and present biological knowledge which originated within the previous, mainly Aristotelian, tradition. It offers a holistic approach to these works by considering their reception of scientific material, their literary as well as rhetorical aspects, and their interaction with different socio-cultural conditions. The result of an interdisciplinary discussion among scholars of Greek studies, philosophy and history of science, the volume provides an initial analysis of forms and functions of biological literature in the imperial period.

The third edition of The Laboratory Rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. New information related to the husbandry and veterinary care of rats is provided including topics related to nutrition, reproduction, anesthesia and surgery, infectious and noninfectious disease, and the care of surgical and other fragile models. It is a premier source of information on the laboratory rat, this book will be of interest to veterinary and medical students, senior graduate students, postdocs and researchers who utilize animals in biomedical research.

This volume reviews the historical roots and theoretical foundations of biological systematics in an approachable text. The author outlines the structure and main tasks of systematics. Conceptual history is characterized as a succession of scientific revolutions. The philosophical foundations of systematic research are briefly reviewed as well as the structure and content of taxonomic theories. Most important research programs in systematics are outlined. The book includes analysis of the principal problematic issues as "scientific puzzles" in systematics. This volume is intended for professional taxonomists, biologists of various specialties, students, as well as all those interested in the history and theory of biology and natural sciences. Key Features Considers the conceptual history of systematics as the framework of evolutionary epistemology Builds a hierarchically organized quasi-axiomatic system of taxonomic theory Contends that more reductionist taxonomic concepts are less objective Supports taxonomic pluralism by non-classic philosophy of science as a normal condition of systematics Documents that "taxonomic puzzles" result from conflict between monistic and pluralistic attitudes Related Titles de Queiroz, K. et al., eds. Phylonyms: A Companion to the PhyloCode (ISBN 978-1-1383-3293-5) Sigwart, J. D. What Species Mean: A User's Guide to the Units of Biodiversity (ISBN 978-1-4987-9937-9) Rieppel, O. Phylogenetic Systematics: Haeckel to Hennig (ISBN 978-1-4987-5488-0) Wilkins, J. S. Species: The Evolution of the Idea, 2nd ed. (ISBN 978-1-1380-5574-2)

Nitrogen fixation is a key component of the nitrogen cycle, one of the most fundamental cycles in the biosphere. Conversion of atmospheric nitrogen into organic nitrogen compounds can be carried out only by certain bacteria and blue-green algae (cyanobacteria). Some nitrogen fixing bacteria live symbiotically with leguminous plants such as peas, beans, clover, and certain tropical trees in nodules on the plants' roots, while others live independently in the soil and aquatic habitats. By the activity of these microorganisms, the soil is enriched with the nitrogen required for plant growth and function. Thus the topic is of considerable practical as well as fundamental importance. In Biological Nitrogen Fixation, the leading researchers in nitrogen fixation from all over the world contribute up-to-the-minute general reviews on all aspects of the subject, from the molecular biology and genetics to the biochemistry, physiology, and ecology of nitrogen fixation. This compendium of current research is an indispensable reference for all involved in nitrogen fixation research, and of use to all who deal indirectly with the subject. It will also serve as a thoroughly up-to-date textbook for graduate students in microbiology, plant science, biochemistry, molecular biology, plant pathology, agronomy, and genetics.

Many of the encounters between farming and wildlife, especially vertebrates, involve some level of conflict which can cause disadvantage to both the wildlife and the people involved. Through a series of WildCRU case-studies, this volume investigates the sources of the problems, and ultimately of the threats to conservation, discussing a variety of remedies and mitigations, and demonstrating the benefits of evidence-based, inter-disciplinary policy.

"The Freshwater Mussels of Tennessee . . . is indispensable to anyone, anywhere, working on this group. Parmalee and Bogan have written a work that sets the standard for future regional guides."--G. Thomas Watters, Ohio Biological Survey
"The Freshwater Mussels of Tennessee documents a tremendously diverse and unique mussel fauna that is rapidly being destroyed by modern development. Parmalee and Bogan set a new standard for state mussel surveys in their authoritative, thorough, and and highly readable account. The book will be of interest to biologists and conservationists worldwide and will appeal to anyone who cares about the preservation of natural resources in the southeastern United States."--Robert E. Warren, Illinois State Museum
With more than 150 species and subspecies recorded in the state, Tennessee has one of the most diverse freshwater mussel faunas in North America. Valuable as indicators of water quality, these mollusks have themselves become threatened as development encroaches on habitat--twenty-three are currently listed as endangered species and at least twelve have become extinct.
This is the first book for Tennessee to deal with this biologically and commercially significant group of mollusks. Its authors have been studying and writing about the mussels of Tennessee for more than twenty years and have undertaken a systematic organization of a large and complex body of information to bring order to a difficult field.
The book traces the long history of human exploitation of mussels, from aboriginal food gathering to the growth of the cultured pearl industry. It provides an interpretive context for its exhaustive species accounts with background material on biology, distribution, economic utilization, taxonomy, and conservation issues. The authors also review the life cycle of the mussel and describe its many remarkable traits, such as its shell formation and the strategies it employs during the larval stage in parasitizing fish.
The species accounts comprise 128 members of Family Unionidae--from pigtoes and pocketbooks to lilliputs and spikes--plus four additional species. The authors cover classification and synonymy, range and distribution, life history and ecology, and survival status. Particular attention is paid to shell description and structure to assist the reader in identification. Each species account includes a distribution map and color photos of two specimens.
The Freshwater Mussels of Tennessee is a major reference that encompasses historical and modern mussel collections and draws on conservation studies that span two centuries. It will stand as an authoritative guide to understanding Tennessee mollusks and as a benchmark in the study of these species worldwide.
The Authors: Paul W. Parmalee is professor emeritus of zooarchaeology and director emeritus of the McClung Museum at the University of Tennessee, Knoxville.
Arthur E. Bogan is curator of aquatic invertebrates at the North
Carolina State Museum of Natural Sciences, Raleigh.

This fully updated edition explores conceptual as well as technical guidelines for plant taxonomists and geneticists, such as the increasing use of next-generation sequencing (NGS) technologies for numerous applications in plant taxonomy. The volume provides molecular approaches to be used within an "integrative taxonomy" framework, combining a range of nucleic acid and cytogenetic data together with other crucial information (taxonomy, morphology, anatomy, ecology, reproductive biology, biogeography, paleobotany, etc.), which will help not only to best circumvent species delimitation but also to resolve the evolutionary processes in play. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Molecular Plant Taxonomy: Methods and Protocols, Second Edition is an ideal guide for researchers seeking a better understanding of evolutionary processes, at species and population level, through molecular techniques.

This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.

What was the state of wildlife in Britain and Ireland before modern records began? The Atlas of Early Modern Wildlife looks at the era before climate change, before the intensification of agriculture, before even the Industrial Revolution. In the sixteenth to eighteenth centuries, beavers still swim in the River Ness. Isolated populations of wolves and lynxes linger in the uplands. Sea eagles are widespread around the coasts. Wildcats and pine martens remain common in the Lake District. In this ground-breaking volume, the observations of early modern amateur naturalists, travellers and local historians are gathered together for the very first time. Drawing on more than 10,000 records from across Britain and Ireland, the book presents maps and notes on the former distribution of over 160 species, providing a new baseline against which to discuss subsequent declines and extinctions, expansions and introductions. A guide to identification describes the reliable and unreliable names of each species, including the pre-Linnaean scientific nomenclature, as well as local names in early modern English and, where used in the sources, Irish, Scots, Scottish Gaelic, Welsh, Cornish and Norn. Raising a good number of questions at the same time as it answers many others, this remarkable resource will be of great value to conservationists, archaeologists, historians and anyone with an interest in the natural heritage of Britain and Ireland.

This book provides reflection on the increasingly blurry boundaries that characterize the human-animal relationship. In the Anthropocene humans and animals have come closer together and this asks for rethinking old divisions. Firstly, new scientific insights and technological advances lead to a blurring of the boundaries between animals and humans. Secondly, our increasing influence on nature leads to a rethinking of the old distinction between individual animal ethics and collectivist environmental ethics. Thirdly, ongoing urbanization and destruction of animal habitats leads to a blurring between the categories of wild and domesticated animals. Finally, globalization and global climate change have led to the fragmentation of natural habitats, blurring the old distinction between in situ and ex situ conservation. In this book, researchers at the cutting edge of their fields systematically examine the broad field of human-animal relations, dealing with wild, liminal, and domestic animals, with conservation, and zoos, and with technologies such as biomimicry. This book is timely in that it explores the new directions in which our thinking about the human-animal relationship are developing. While the target audience primarily consists of animal studies scholars, coming from a wide range of disciplines including philosophy, sociology, psychology, ethology, literature, and film studies, many of the topics that are discussed have relevance beyond a purely theoretical one; as such the book also aims to inspire for example biologists, conservationists, and zoo keepers to reflect on their relationship with animals.

Animal cell technology is becoming an increasingly important part of biotechnology and many products are now used in human health care and for veterinary applications. However, there are many times more products actually in the developmental pipelines of the biotechnology industry, including various phases of clinical trials. The Proceedings of the 15th Meeting of the European Society for Animal Cell Technology (Tours, France, September 1997) presents the actual current state as well as New Developments and Applications in Animal Cell Technology for the benefit of society. These Proceedings represent both the current state and applications of animal cell technology and the way the technology is expanding into new areas to give a unique insight into new products and applications for human and animal health care.

This open access volume presents a comprehensive account of all aspects of biological invasions in South Africa, where research has been conducted over more than three decades, and where bold initiatives have been implemented in attempts to control invasions and to reduce their ecological, economic and social effects. It covers a broad range of themes, including history, policy development and implementation, the status of invasions of animals and plants in terrestrial, marine and freshwater environments, the development of a robust ecological theory around biological invasions, the effectiveness of management interventions, and scenarios for the future. The South African situation stands out because of the remarkable diversity of the country, and the wide range of problems encountered in its varied ecosystems, which has resulted in a disproportionate investment into both research and management. The South African experience holds many lessons for other parts of the world, and this book should be of immense value to researchers, students, managers, and policy-makers who deal with biological invasions and ecosystem management and conservation in most other regions.

The Evolutionary Ecology of Invasive Species offers new insights into the mechanisms that underlie rapid evolution in these species. The book provides a comprehensive overview of achievements in the field during the boom of information over the past two decades and includes discussions of possible future directions for the study of evolution in invasive species. Written by an international expert in invasion ecology, population genetics, and evolutionary biology, the book explores the roles of preadaptation, phenotypic plasticity, selection, and stochastic processes in driving rapid evolution. The book draws insights from a wide spectrum of invasive microbes, plants, and animals, covering many of the planet's biogeographic regions and discusses the evolutionary consequences for native species in response to biological invasions. A valuable resource to researchers and students in evolutionary biology, invasive species biology, and global change biology, this text suggests future research directions related to the evolutionary biology, impacts, and management of invasive species.